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Tytuł:
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer
Autorzy:
Stefan Prekovic
Karianne Schuurman
Isabel Mayayo-Peralta
Anna G. Manjón
Mark Buijs
Selçuk Yavuz
Max D. Wellenstein
Alejandro Barrera
Kim Monkhorst
Anne Huber
Ben Morris
Cor Lieftink
Theofilos Chalkiadakis
Ferhat Alkan
Joana Silva
Balázs Győrffy
Liesbeth Hoekman
Bram van den Broek
Hans Teunissen
Donna O. Debets
Tesa Severson
Jos Jonkers
Timothy Reddy
Karin E. de Visser
William Faller
Roderick Beijersbergen
Maarten Altelaar
Elzo de Wit
Rene Medema
Wilbert Zwart
Pokaż więcej
Temat:
Animals
Antineoplastic Agents/pharmacology
Cell Cycle/genetics
Cell Line
Tumor
Cell Proliferation/drug effects
Cell Survival/drug effects
Chromatin/genetics
Chromatin Immunoprecipitation Sequencing
Chromosomal Proteins
Non-Histone/genetics
Cyclin-Dependent Kinase Inhibitor p57/genetics
Enhancer Elements
Genetic
Gene Expression Regulation
Neoplastic/drug effects
Glucocorticoids/pharmacology
Humans
Imidazoles/pharmacology
Immunohistochemistry
Lung Neoplasms/genetics
Mice
Proteomics
Pyrazines/pharmacology
RNA
Small Interfering
RNA-Seq
Receptor
IGF Type 1/metabolism
Receptors
Glucocorticoid/metabolism
Transcription Factors/genetics
Xenograft Model Antitumor Assays
SDG 3 - Good Health and Well-being
Article
Cancer genomics
Cell-cycle exit
Transcriptomics
Science
Cell Line, Tumor
Chromosomal Proteins, Non-Histone/genetics
Enhancer Elements, Genetic
Gene Expression Regulation, Neoplastic/drug effects
RNA, Small Interfering
Receptor, IGF Type 1/metabolism
Receptors, Glucocorticoid/metabolism
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Źródło:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1):4360. Nature Publishing Group
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d0bb100aa8c9a403670c6412a6143c
http://www.scopus.com/inward/record.url?scp=85110858166&partnerID=8YFLogxK
Szczegóły
Tytuł:
A KRAS-responsive long non-coding RNA controls microRNA processing
Autorzy:
Lei Shi
Peter Magee
Matteo Fassan
Sudhakar Sahoo
Hui Sun Leong
Dave Lee
Robert Sellers
Laura Brullé-Soumaré
Stefano Cairo
Tiziana Monteverde
Stefano Volinia
Duncan D. Smith
Gianpiero Di Leva
Francesca Galuppini
Athanasios R. Paliouras
Kang Zeng
Raymond O’Keefe
Michela Garofalo
Pokaż więcej
Temat:
Article
Long non-coding RNAs
Non-small-cell lung cancer
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
R735
lcsh:Science
lcsh:Q
A549 Cells
Animals
Carcinoma, Non-Small-Cell Lung/genetics
Cell Line, Tumor
Female
Gene Expression Profiling/methods
Gene Expression Regulation, Neoplastic
Gene Ontology
Humans
Kaplan-Meier Estimate
Lung Neoplasms/genetics
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
MicroRNAs/genetics
Proto-Oncogene Proteins p21(ras)/genetics
RNA, Long Noncoding/genetics
Xenograft Model Antitumor Assays/methods
respiratory tract diseases
digestive system diseases
neoplasms
Źródło:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Shi, L, Magee, P, Fassan, M, Sahoo, S, Leong, H S, Lee, D, Sellers, R, Brullé-Soumaré, L, Cairo, S, Monteverde, T, Volinia, S, Smith, D D, Di Leva, G, Galuppini, F, Paliouras, A R, Zeng, K, O'Keefe, R & Garofalo, M 2021, ' A KRAS-responsive long non-coding RNA controls microRNA processing ', Nature Communications, vol. 12, no. 1, 2038 . https://doi.org/10.1038/s41467-021-22337-3
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d51af05ca11b5e8f61a88aae8dfc0a6
http://europepmc.org/articles/PMC8016872
Szczegóły
Tytuł:
NF-κB-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN
Autorzy:
Arsenal Sezgin Alikanoglu
Sakir Akgun
Mustafa Yildiz
Osman N. Ozes
Ozge Can
Hakan Akca
Hakan Kucuksayan
Pokaż więcej
Temat:
Cancer Research
Pharmacology
Molecular Medicine
Cancer research
Oncogene
Transcriptional regulation
NFKB1
Metastasis
medicine.disease
medicine
Transcription factor
PI3K/AKT/mTOR pathway
microRNA
PTEN
biology.protein
biology
Carcinoma
Invasion
miR-548as-3p
Neoplasm metastasis
NF-kappa B
Non-small-cell lung
gelatinase B
immunoglobulin enhancer binding protein
microRNA 548as 3p
phosphatidylinositol 3 kinase
phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
protein kinase B
transcription factor Slug
transcription factor ZEB1
tumor necrosis factor
unclassified drug
messenger RNA
MIRN548 microRNA, human
PTEN protein, human
Article
binding site
bioinformatics
cancer tissue
cell invasion
chromatin immunoprecipitation
controlled study
DNA binding
gel mobility shift assay
gene expression
human
human cell
human tissue
MTT assay
NCI-H1299 cell line
non small cell lung cancer
promoter region
protein targeting
real time polymerase chain reaction
signal transduction
transcription initiation site
transcription regulation
upregulation
Western blotting
biosynthesis
cell survival
chemical structure
dose response
genetics
HEK293 cell line
lung tumor
metabolism
pathology
structure activity relation
Carcinoma, Non-Small-Cell Lung
Dose-Response Relationship, Drug
HEK293 Cells
Humans
Lung Neoplasms
MicroRNAs
Molecular Structure
PTEN Phosphohydrolase
RNA, Messenger
Structure-Activity Relationship
Up-Regulation
Carcinoma, Non-Small-Cell Lung/*genetics/metabolism/*pathology
Cell Survival
Lung Neoplasms/*genetics/metabolism/*pathology
MicroRNAs/biosynthesis/*genetics
NF-kappa B/*metabolism
PTEN Phosphohydrolase/*genetics/metabolism
RNA, Messenger/genetics/metabolism
Źródło:
Anti-Cancer Agents in Medicinal Chemistry. 19:1058-1068
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee1f8d04a6a79a5db3136a8e80be8d8
http://eurekaselect.com/article/download/169698
Szczegóły
Tytuł:
miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
Autorzy:
Jeon, Young-Jun
Kim, Taewan
Park, Dongju
Nuovo, Gerard J.
Rhee, Siyeon
Joshi, Pooja
Lee, Bum-Kyu
Jeong, Johan
Suh, Sung-suk
Grotzke, Jeff E.
Kim, Sung-Hak
Song, Jieun
Sim, Hosung
Kim, Yonghwan
Peng, Yong
Jeong, Youngtae
Garofalo, Michela
Zanesi, Nicola
Kim, Jonghwan
Liang, Guang
Nakano, Ichiro
Cresswell, Peter
Nana-Sinkam, Patrick
Cui, Ri
Croce, Carlo M.
Pokaż więcej
Temat:
Science
Activating Transcription Factor 6/genetics
Animals
Carcinoma, Non-Small-Cell Lung/genetics
Cell Line, Tumor
Cell Proliferation/genetics
Endoplasmic Reticulum-Associated Degradation/genetics
Endoribonucleases/genetics
Gene Expression Regulation, Neoplastic/genetics
Humans
In Situ Hybridization
Lung Neoplasms/genetics
Membrane Proteins/genetics
Mice
MicroRNAs/metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction/genetics
Tumor Suppressor Protein p53/genetics
Tumor Suppressor Proteins/genetics
Ubiquitin-Protein Ligases/genetics
Unfolded Protein Response/genetics
Xenograft Model Antitumor Assays
Article
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Cancer
medicine.disease
medicine
Suppressor
law.invention
law
Carcinoma
Unfolded protein response
Cancer research
microRNA
Cell
medicine.anatomical_structure
business.industry
business
Regulation of gene expression
Lung cancer
lcsh:Science
lcsh:Q
Źródło:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Jeon, Y-J, Kim, T, Park, D, Nuovo, G J, Rhee, S, Joshi, P, Lee, B-K, Jeong, J, Suh, S-S, Grotzke, J E, Kim, S-H, Song, J, Sim, H, Kim, Y, Peng, Y, Jeong, Y, Garofalo, M, Zanesi, N, Kim, J, Liang, G, Nakano, I, Cresswell, P, Nana-Sinkam, P, Cui, R & Croce, C M 2018, ' miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC ', Nature Communications, vol. 9, no. 1, pp. 5110 . https://doi.org/10.1038/s41467-018-07561-8
Nature Communications
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7959fee39af8d539bda5cccc973fa4c5
https://doaj.org/article/20aea16a00a84e518d6ba422033dbee0
Szczegóły
Tytuł:
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility
Autorzy:
Ma'en Obeidat
Michael P.A. Davies
Stephen Lam
Ghislaine Scelo
Linda Kachuri
Melinda C. Aldrich
Rebecca E. Graff
Gary E. Goodman
Heike Bickeböller
Neil E. Caporaso
Nima C. Emami
Sanjay Shete
Jonas Manjer
David C. Christiani
George Davey Smith
M. Dawn Teare
Sara R. Rashkin
Adonina Tardón
Lambertus A. Kiemeney
Matthew B. Schabath
John S. Witte
Christopher I. Amos
Maria Teresa Landi
Shanbeh Zienolddiny
Geoffrey Liu
Susanne M. Arnold
Chu Chen
John K. Field
Venkata S. K. Manem
David Zaridze
Yohan Bossé
Stig E. Bojesen
Richard M. Martin
Caroline L Relton
Eric J. Duell
Paolo Vineis
Loic Le Marchand
Philip C. Haycock
Gad Rennert
Jennifer A. Doherty
Mattias Johansson
Aage Haugen
Matthew T. Warkentin
Angeline S. Andrew
Demetrius Albanes
Paul Brennan
James McKay
Iona Cheng
Philip Lazarus
Rayjean J. Hung
Yonathan Brhane
Pokaż więcej
Temat:
lcsh:Science
lcsh:Q
Science
Lung
Humans
Lung Neoplasms
Genetic Predisposition to Disease
Respiratory Function Tests
Vital Capacity
Forced Expiratory Volume
Prospective Studies
Phenotype
Polymorphism
Single Nucleotide
Adult
Aged
Middle Aged
Female
Male
Mendelian Randomization Analysis
Article
Cancer epidemiology
Genetics research
ICEP
Bristol Population Health Science Institute
Lung/physiopathology
Lung Neoplasms/genetics
Polymorphism, Single Nucleotide
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Càncer de pulmó
Carcinogènesi
Hàbit de fumar
Lung cancer
Carcinogenesis
Smoking
Vital capacity
Mendelian randomization
Oncology
medicine.medical_specialty
medicine
Adenocarcinoma
medicine.disease
medicine.anatomical_structure
FEV1/FVC ratio
Internal medicine
Lung cancer susceptibility
Pulmonary function testing
business.industry
business
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Epidemiology of cancer
Źródło:
Nature Communications, 11
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Kachuri, L, Johansson, M, Rashkin, S, Graff, R, Bossé, Y, Manem, V, Caporaso, N E, Landi, M T, Christiani, D C, Vineis, P, Liu, G, Scelo, G, Zaridze, D, Shete, S, Albanes, D, Aldrich, M, Tardon, A, Rennert, G, Chen, C, Goodman, G E, Doherty, J A, Bickeböller, H, Field, J K, Davis, M, Teare, M D, Kiemeney, L A L M, Bojesen, S E, Haugen, A, Zienolddiny, S, Lam, S, Le Marchand, L, Cheng, I, Schabath, M B, Duell, E J, Andrew, A S, Manjer, J, Lazarus, P, Arnold, S M, McKay, J D, Emami, N, Warkentin, M, Brhane, Y, Obeidat, M, Martin, R M, Relton, C L, Davey Smith, G, Haycock, P C, Amos, C I, Brennan, P, Witte, J S & Hung, R J 2020, ' Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility ', Nature Communications, vol. 11, no. 1, 27 (2020) . https://doi.org/10.1038/s41467-019-13855-2, https://doi.org/10.1038/s41467-019-13855-2
Scopus
NATURE COMMUNICATIONS
Kachuri, L, Johansson, M, Rashkin, S R, Graff, R E, Bossé, Y, Manem, V, Caporaso, N E, Landi, M T, Christiani, D C, Vineis, P, Liu, G, Scelo, G, Zaridze, D, Shete, S S, Albanes, D, Aldrich, M C, Tardón, A, Rennert, G, Chen, C, Goodman, G E, Doherty, J A, Bickeböller, H, Field, J K, Davies, M P, Dawn Teare, M, Kiemeney, L A, Bojesen, S E, Haugen, A, Zienolddiny, S, Lam, S, Le Marchand, L, Cheng, I, Schabath, M B, Duell, E J, Andrew, A S, Manjer, J, Lazarus, P, Arnold, S, McKay, J D, Emami, N C, Warkentin, M T, Brhane, Y, Obeidat, M, Martin, R M, Relton, C, Davey Smith, G, Haycock, P C, Amos, C I, Brennan, P, Witte, J S & Hung, R J 2020, ' Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility ', Nature Communications, vol. 11, 27 . https://doi.org/10.1038/s41467-019-13855-2
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f805efb8f10bc3ff61fe2005695020
http://hdl.handle.net/2066/216657
Szczegóły
Tytuł:
Circulating cell free DNA during definitive chemo-radiotherapy in non-small cell lung cancer patients – initial observations
Autorzy:
Seppo W. Langer
Jonathan W Langer
Florent Mouliere
Ivan R. Vogelius
Andreas Kjaer
Nitzan Rosenfeld
Dineika Chandrananda
Lise Barlebo Ahlborn
Lotte Nygård
Gitte F. Persson
Søren M. Bentzen
Barbara M. Fischer
Olga Østrup
Miglė Gabrielaite
Pokaż więcej
Temat:
Research Article
Medicine and health sciences
Biology and life sciences
Biochemistry
Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General
Medicine and Health Sciences
Oncology
Cancer Treatment
Radiation Therapy
Clinical Medicine
Clinical Oncology
Cancers and Neoplasms
Carcinomas
Squamous Cell Carcinomas
Cancer Chemotherapy
Pharmaceutics
Drug Therapy
Chemotherapy
Lung and Intrathoracic Tumors
Non-Small Cell Lung Cancer
Biology and Life Sciences
Anatomy
Body Fluids
Blood
Blood Plasma
Physiology
Adenocarcinomas
Medicine
Science
Adenocarcinoma/drug therapy
Aged
Aged, 80 and over
Antineoplastic Agents/therapeutic use
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Squamous Cell/drug therapy
Cell-Free Nucleic Acids/blood
Chemoradiotherapy
Female
Humans
Lung Neoplasms/genetics
Male
Middle Aged
Pilot Projects
Radiation, Ionizing
Tomography, X-Ray Computed
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Adenocarcinoma
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Lung Neoplasms
Antineoplastic Agents
Cell-Free Nucleic Acids
Multidisciplinary
Lung cancer
medicine.disease
medicine
Radiation therapy
medicine.medical_treatment
business.industry
business
Urology
medicine.medical_specialty
Carcinoma
Ionizing radiation
Circulating Cell-Free DNA
Blood plasma
Biochemistry, Genetics and Molecular Biology(all)
Źródło:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231884 (2020)
Nygård, L, Ahlborn, L B, Persson, G F, Chandrananda, D, Langer, J W, Fischer, B M, Langer, S W, Gabrielaite, M, Kjær, A, Rosenfeld, N, Mouliere, F, Østrup, O, Vogelius, I R & Bentzen, S M 2020, ' Circulating cell free DNA during definitive chemo-radiotherapy in non-small cell lung cancer patients-initial observations ', PLoS ONE, vol. 15, no. 4, e0231884 . https://doi.org/10.1371/journal.pone.0231884
PLoS ONE, 15(4):e0231884. Public Library of Science
Opis pliku:
application/pdf; Electronic-eCollection
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9d7c03d47711ee165c20e518db09e3
https://www.repository.cam.ac.uk/handle/1810/304848
Szczegóły
Tytuł:
Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors
Autorzy:
Ayeni, Deborah
Miller, Braden
Kuhlmann, Alexandra
Ho, Ping-Chih
Robles-Oteiza, Camila
Gaefele, Mmaserame
Levy, Stellar
de Miguel, Fernando J.
Perry, Curtis
Guan, Tianxia
Krystal, Gerald
Lockwood, William
Zelterman, Daniel
Homer, Robert
Liu, Zongzhi
Kaech, Susan
Politi, Katerina
Pokaż więcej
Temat:
Research Article
Lung cancer
EGFR
Targeted therapies
Immunotherapies
Mouse models
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
lcsh:RC254-282
Animals
Antineoplastic Agents/therapeutic use
ErbB Receptors/genetics
ErbB Receptors/immunology
Erlotinib Hydrochloride/therapeutic use
Lung Neoplasms/drug therapy
Lung Neoplasms/genetics
Lung Neoplasms/immunology
Mice, Transgenic
Mutation
Oncogenes
Protein Kinase Inhibitors/therapeutic use
T-Lymphocytes/drug effects
T-Lymphocytes/immunology
Tumor Microenvironment/drug effects
Tumor Microenvironment/immunology
Cancer Research
Pharmacology
Oncology
Molecular Medicine
Immunology
Immunology and Allergy
Cancer research
Oncogene
medicine.disease
medicine
Tyrosine kinase
business.industry
business
Erlotinib
medicine.drug
Immune system
Tumor microenvironment
CD40
biology.protein
biology
Epidermal growth factor receptor
respiratory tract diseases
Źródło:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Journal for immunotherapy of cancer, vol. 7, no. 1, pp. 172
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2f07589f052ce53139b4376d5454b5
http://europepmc.org/articles/PMC6617639
Szczegóły
Tytuł:
OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations
Autorzy:
Maria E. Riveiro
Francesco Bertoni
Kay Noel
Ivo Kwee
Eric Raymond
Keyvan Rezai
Elodie Odore
Maurizio D'Incalci
Ramiro Vázquez
Andrea Rinaldi
Esteban Cvitkovic
Roberta Frapolli
Giorgio Inghirami
Lucile Astorgues-Xerri
Mohamed Bekradda
Pokaż więcej
Temat:
Research Paper
OTX015 (MK-8628)
bromodomain
NSCLC
SCLC
KRAS
Acetanilides/pharmacology
Animals
Antineoplastic Agents/pharmacology
Carcinoma, Non-Small-Cell Lung/drug therapy
Carcinoma, Non-Small-Cell Lung/genetics
Cell Cycle Checkpoints
Cell Line, Tumor
Cell Proliferation
Female
Gene Expression Regulation
Heterocyclic Compounds, 3-Ring/pharmacology
Humans
Lung Neoplasms/drug therapy
Lung Neoplasms/genetics
Mice
Mice, Nude
Mutation/genetics
Protein-Serine-Threonine Kinases/antagonists & inhibitors
Receptor Protein-Tyrosine Kinases/genetics
Small Cell Lung Carcinoma/drug therapy
Small Cell Lung Carcinoma/genetics
Xenograft Model Antitumor Assays
Oncology
Lymphoma
medicine.disease
medicine
Cancer research
BET inhibitor
Cancer
business.industry
business
Stem cell marker
medicine.disease_cause
Cell growth
Immunology
Anaplastic lymphoma kinase
Tumor progression
Źródło:
Oncotarget
Oncotarget, vol. 7, no. 51, pp. 84675-84687
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baf689a029b4ea760bd7e7c1a28109c
http://europepmc.org/articles/PMC5354535
Szczegóły
Tytuł:
Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer
Autorzy:
Theelen, Willemijn S. M. E.
Kuilman, Thomas
Schulze, Katja
Zou, Wei
Krijgsman, Oscar
Peters, Dennis D. G. C.
Cornelissen, Sten
Monkhorst, Kim
Sarma, Pranamee
Sumiyoshi, Teiko
Amler, Lukas C.
Willems, Stefan M.
Blaauwgeers, Johannes L. G.
van Noesel, Carel J. M.
Peeper, Daniel S.
van den Heuvel, Michel M.
Kowanetz, Marcin
Pokaż więcej
Temat:
Medicine
Science
Agricultural and Biological Sciences(all)
Biochemistry
Genetics and Molecular Biology(all)
Journal Article
Research Article
Biology and Life Sciences
Genetics
Gene Expression
Medicine and Health Sciences
Oncology
Cancers and Neoplasms
Lung and Intrathoracic Tumors
Non-Small Cell Lung Cancer
Molecular Biology
Molecular Biology Techniques
Molecular Biology Assays and Analysis Techniques
Gene Expression and Vector Techniques
Protein Expression
Research and Analysis Methods
Histochemistry and Cytochemistry Techniques
Immunohistochemistry Techniques
Immunologic Techniques
Cell biology
Cellular types
Animal cells
Blood cells
White blood cells
T cells
Cytotoxic T cells
Immune cells
Immunology
Immune Response
Mutation
Insertion Mutation
Biomarkers
Biochemistry, Genetics and Molecular Biology(all)
Adult
Aged
Aged, 80 and over
B7-H1 Antigen/genetics
CD8-Positive T-Lymphocytes/immunology
Carcinoma, Non-Small-Cell Lung/genetics
Female
Gene Expression Regulation, Neoplastic/immunology
Humans
Immunity, Cellular
Interferon-gamma/genetics
Lung Neoplasms/genetics
Male
Middle Aged
Neoplasm Proteins/genetics
Neoplasm Staging
Programmed Cell Death 1 Receptor/genetics
Signal Transduction/genetics
Multidisciplinary
Lung cancer
medicine.disease
medicine
Biology
Cancer research
Immunohistochemistry
Cytotoxic T cell
Regulation of gene expression
Cancer immunotherapy
medicine.medical_treatment
Immune system
Gene expression
CD8
80 and over
Carcinoma
Non-Small-Cell Lung/genetics
Gene Expression Regulation
Neoplastic/immunology
Immunity
Cellular
Źródło:
PLoS ONE, Vol 14, Iss 5, p e0216864 (2019)
PLoS ONE
PLoS ONE, 14(5). Public Library of Science
PLoS ONE, 14(5). PUBLIC LIBRARY SCIENCE
PLoS ONE, 14(5):e0216864. Public Library of Science
PLoS One, 14
Opis pliku:
image/pdf; application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c9e935a597303c8ca691ca860f905c
https://doaj.org/article/71ec07804c5045b0afac420650e42855
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activity of Afatinib in Heavily Pretreated Patients With ERBB2 Mutation-Positive Advanced NSCLC: Findings From a Global Named Patient Use Program
Autorzy:
Robert M. Lorence
P. Carriere
Oliver Gautschi
Wei-Yu Liao
Jin-Yuan Shih
Vito Spataro
Hovav Nechushtan
Alessandra Curioni-Fontecedro
Gee-Chen Chang
James Chih-Hsin Yang
Solange Peters
Agnieszka Cseh
Mojca Unk
Pokaż więcej
Temat:
Adult
Afatinib/therapeutic use
Aged
Aged, 80 and over
Antineoplastic Agents/therapeutic use
Carcinoma, Non-Small-Cell Lung/drug therapy
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Non-Small-Cell Lung/pathology
Female
Follow-Up Studies
Humans
Lung Neoplasms/drug therapy
Lung Neoplasms/genetics
Lung Neoplasms/pathology
Male
Middle Aged
Mutation
Prognosis
Receptor, ErbB-2/genetics
Retrospective Studies
Salvage Therapy
Afatinib
ERBB2 mutation
NSCLC
Clinic for Oncology and Hematology
610 Medicine & health
Pulmonary and Respiratory Medicine
Oncology
medicine.drug
medicine
business.industry
business
Discontinuation
Erlotinib
medicine.medical_specialty
Gefitinib
Exon
Internal medicine
medicine.disease_cause
Receptor tyrosine kinase
biology.protein
biology
Disease control
neoplasms
Źródło:
Journal of thoracic oncology, vol. 13, no. 12, pp. 1897-1905
Peters, Solange; Curioni-Fontecedro, Alessandra; Nechushtan, Hovav; Shih, Jin-Yuan; Liao, Wei-Yu; Gautschi, Oliver; Spataro, Vito; Unk, Mojca; Chih-Hsin Yang, James; Lorence, Robert M; Carrière, Philippe; Cseh, Agnieszka; Chang, Gee-Chen (2018). Activity of Afatinib in Heavily Pretreated Patients With ERBB2 Mutation-Positive Advanced NSCLC: Findings From a Global Named Patient Use Program. Journal of Thoracic Oncology, 13(12):1897-1905.
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a46737805b345849c87401cd2e9620
https://serval.unil.ch/notice/serval:BIB_29FF3A29D783
Szczegóły
Tytuł:
Associations between primary tumor RAS, BRAF and PIK3CA mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer
Autorzy:
Christensen, Troels Dreier
Palshof, Jesper Andreas
Larsen, Finn Ole
Poulsen, Tim Svenstrup
Høgdall, Estrid
Pfeiffer, Per
Jensen, Benny Vittrup
Yilmaz, Mette Karen
Nielsen, Dorte
Pokaż więcej
Temat:
Adult
Aged
Aged, 80 and over
Class I Phosphatidylinositol 3-Kinases/genetics
Colorectal Neoplasms/drug therapy
Drug Resistance, Neoplasm/drug effects
Female
Humans
Lung Neoplasms/genetics
Male
Middle Aged
Mutation
Ovarian Neoplasms/genetics
Peritoneal Neoplasms/genetics
Proto-Oncogene Proteins B-raf/genetics
Retrospective Studies
Skin Neoplasms/genetics
ras Proteins/genetics
neoplasms
digestive system diseases
Źródło:
Christensen, T D, Palshof, J A, Larsen, F O, Poulsen, T S, Høgdall, E, Pfeiffer, P, Jensen, B V, Yilmaz, M K & Nielsen, D 2018, ' Associations between primary tumor RAS, BRAF and PIK3CA mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer ', Acta Oncologica, vol. 57, no. 8, pp. 1057-1062 . https://doi.org/10.1080/0284186X.2018.1433322
Dostępność:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4a3f3e56a8cb88abbdd353419d4ed2de
https://portal.findresearcher.sdu.dk/da/publications/46efde4a-78bc-4c38-ad3a-4a7fdcb9afc9
Szczegóły
Tytuł:
Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study
Autorzy:
Gadgeel, S
Peters, S
Mok, T
Shaw, A T
Kim, D W
Ou, S I
Pérol, M
Wrona, A
Novello, S
Rosell, R
Zeaiter, A
Liu, T
Nüesch, E
Balas, B
Camidge, D R
Pokaż więcej
Temat:
Oncology
Hematology
medicine.medical_specialty
medicine
Radiation therapy
medicine.medical_treatment
business.industry
business
Clinical endpoint
Hazard ratio
Carcinoma
medicine.disease
Internal medicine
Lung cancer
Anaplastic lymphoma kinase
Alectinib
Crizotinib
medicine.drug
Original articles
CNS tumors
alectinib
ALK-positive
CNS
NSCLC
Adult
Aged
Aged, 80 and over
Anaplastic Lymphoma Kinase/antagonists & inhibitors
Anaplastic Lymphoma Kinase/genetics
Brain/diagnostic imaging
Brain/drug effects
Brain/radiation effects
Brain Neoplasms/diagnostic imaging
Brain Neoplasms/genetics
Brain Neoplasms/secondary
Brain Neoplasms/therapy
Carbazoles/pharmacology
Carbazoles/therapeutic use
Carcinoma, Non-Small-Cell Lung/diagnostic imaging
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Non-Small-Cell Lung/secondary
Carcinoma, Non-Small-Cell Lung/therapy
Chemoradiotherapy/methods
Crizotinib/pharmacology
Crizotinib/therapeutic use
Disease Progression
Female
Humans
Lung/diagnostic imaging
Lung/drug effects
Lung/radiation effects
Lung Neoplasms/diagnostic imaging
Lung Neoplasms/genetics
Lung Neoplasms/pathology
Lung Neoplasms/therapy
Magnetic Resonance Imaging
Male
Middle Aged
Piperidines/pharmacology
Piperidines/therapeutic use
Treatment Outcome
Tumor Burden/drug effects
Tumor Burden/radiation effects
Young Adult
Źródło:
Annals of Oncology
Annals of oncology, vol. 29, no. 11, pp. 2214-2222
Opis pliku:
application/pdf
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202d9467b40c9c8632a07affb6261137
Szczegóły
Tytuł:
Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Autorzy:
Xuemei, J.
Bossé
Landi, M.T.
Gui, J.
Xiao, X.
Qian, D.
Joubert, P.
Lamontagne, M.
Yafang, L.
Gorlov, I.
de Biasi, M.
Han, Y.
Gorlova, O.
Hung, R.J.
Xifeng, W.
McKay, J.
Zong, X.
Carreras-Torres, R.
Christiani, D.C.
Caporaso, N.
Johansson, M.
Liu, G.
Bojesen, S.E.
Le Marchand, L.
Albanes, D.
Bickebö
ller, H.
Aldrich, M.C.
Bush, W.S.
Tardon, A.
Rennert, G.
Chen, C.
Teare, M.D.
Field, J.K.
Kiemeney, L.A.
Lazarus, P.
Haugen, A.
Lam, S.
Schabath, M.B.
Andrew, A.S.
Shen, H.
Hong, Y.
Yuan, J.
Bertazzi, P.A.
Pesatori, A.C.
Yuanqing, Y.
Diao, N.
Li, S.
Zhang, R.
Brhane, Y.
Leighl, N.
Johansen, J.S.
Mellemgaard, A.
Saliba, W.
Haiman, C.
Wilkens, L.
Fernandez-Somoano, A.
Fernandez-Tardon, G.
van der Heijden, E.H.F.M.
Kim, J.H.
Dai, J.
Zhibin, H.
Davies, M.P.A.
Marcus, M.W.
Brunnströ
m, H.
Manjer, J.
Melander, O.
Muller, D.C.
Overvad, K.
Trichopoulou, A.
Tumino, R.
Doherty, J.
Goodman, G.E.
Cox, A.
Taylor, F.
Woll, P.
Brü
ske, I.
Manz, J.
Muley, T.
Risch, A.
Rosenberger, A.
Grankvist, K.
Shepherd, F.
Tsao, M.
Arnold, S.M.
Haura, E.B.
Bolca, C.
Holcatova, I.
Janout, V.
Kontic, M.
Lissowska, J.
Mukeria, A.
Ognjanovic, S.
Orlowski, T.M.
Scelo, G.
Swiatkowska, B.
Zaridze, D.
Bakke, P.
Skaug, V.
Zienolddiny, S.
Duell, E.J.
Butler, L.M.
Koh, W.
Gao, Y.
Houlston, R.
McLaughlin, J.
Stevens, V.
Nickle, D.C.
Obeidat, M.
Timens, W.
Zhu, B.
Song, L.
Artigas, M.S.
Tobin, M.D.
Wain, L.V.
Fangyi, G.
Byun, J.
Kamal, A.
Zhu, D.
Tyndale, R.F.
Wei, W.
Chanock, S.
Brennan, P.
Amos, C.I.
Pokaż więcej
Temat:
Medical Genetics
Medicinsk genetik
lcsh:Science
lcsh:Q
Adolescent
Adult
Aged
Child
Child, Preschool
Chromosomes, Human, Pair 15
Cohort Studies
Female
Gene Ontology
Gene Regulatory Networks
Humans
Infant
Infant, Newborn
Lung Neoplasms
Male
Middle Aged
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Reproducibility of Results
Risk Factors
Smoking
Young Adult
Genetic Predisposition to Disease
Chemistry (all)
Biochemistry, Genetics and Molecular Biology (all)
Physics and Astronomy (all)
Settore MED/44 - Medicina del Lavoro
Article
Càncer de pulmó
Factors de risc en les malalties
Lung cancer
Risk factors in diseases
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
GENOME-WIDE ASSOCIATION
SET ENRICHMENT ANALYSIS
NICOTINE DEPENDENCE
AFRICAN-AMERICANS
GENETIC-VARIANTS
CA2+ TRANSPORT
LOCI
SMOKING
EXPRESSION
ADENOCARCINOMA
MD Multidisciplinary
Genome-Wide
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Single-nucleotide polymorphism
Quantitative trait locus
medicine.disease
medicine
Biology
Genome-wide association study
Locus (genetics)
Genetics
Expression quantitative trait loci
KEGG
Gated channel activity
Chromosomes, Human, Pair 15/genetics
Lung Neoplasms/genetics
Quantitative Trait Loci/genetics
Smoking/adverse effects
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Źródło:
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
WOS:000441381200005
Ji, X, Bossé, Y, Landi, M T, Gui, J, Xiao, X, Qian, D, Joubert, P, Lamontagne, M, Li, Y, Gorlov, I, de Biasi, M, Han, Y, Gorlova, O, Hung, R J, Wu, X, McKay, J, Zong, X, Carreras-Torres, R, Christiani, D C, Caporaso, N, Johansson, M, Liu, G, Bojesen, S E, Le Marchand, L, Albanes, D, Bickeböller, H, Aldrich, M C, Bush, W S, Tardon, A, Rennert, G, Chen, C, Teare, M D, Field, J K, Kiemeney, L A, Lazarus, P, Haugen, A, Lam, S, Schabath, M B, Andrew, A S, Shen, H, Hong, Y-C, Yuan, J-M, Bertazzi, P A, Pesatori, A C, Ye, Y, Diao, N, Su, L, Zhang, R, Brhane, Y, Leighl, N, Johansen, J S, Mellemgaard, A, Saliba, W, Haiman, C, Wilkens, L, Fernandez-Somoano, A, Fernandez-Tardon, G, van der Heijden, E H F M, Kim, J H, Dai, J, Hu, Z, Davies, M P A, Marcus, M W, Brunnström, H, Manjer, J, Melander, O, Muller, D C, Overvad, K, Trichopoulou, A, Tumino, R, Doherty, J, Goodman, G E, Cox, A, Taylor, F, Woll, P, Brüske, I, Manz, J, Muley, T, Risch, A, Rosenberger, A, Grankvist, K, Johansson, M, Shepherd, F, Tsao, M-S, Arnold, S M, Haura, E B, Bolca, C, Holcatova, I, Janout, V, Kontic, M, Lissowska, J, Mukeria, A, Ognjanovic, S, Orlowski, T M, Scelo, G, Swiatkowska, B, Zaridze, D, Bakke, P, Skaug, V, Zienolddiny, S, Duell, E J, Butler, L M, Koh, W-P, Gao, Y-T, Houlston, R, McLaughlin, J, Stevens, V, Nickle, D C, Obeidat, M, Timens, W, Zhu, B, Song, L, Artigas, M S, Tobin, M D, Wain, L V, Gu, F, Byun, J, Kamal, A, Zhu, D, Tyndale, R F, Wei, W-Q, Chanock, S, Brennan, P & Amos, C I 2018, ' Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk ', Nature Communications, vol. 9, no. 1, pp. 3221 . https://doi.org/10.1038/s41467-018-05074-y
Ji, X, Bossé, Y, Landi, M T, Gui, J, Xiao, X, Qian, D, Joubert, P, Lamontagne, M, Li, Y, Gorlov, I, de Biasi, M, Han, Y, Gorlova, O, Hung, R J, Wu, X, McKay, J, Zong, X, Carreras-Torres, R, Christiani, D C, Caporaso, N, Johansson, M, Liu, G, Bojesen, S E, Le Marchand, L, Albanes, D, Bickeböller, H, Aldrich, M C, Bush, W S, Tardon, A, Rennert, G, Chen, C, Teare, M D, Field, J K, Kiemeney, L A, Lazarus, P, Haugen, A, Lam, S, Schabath, M B, Andrew, A S, Shen, H, Hong, Y-C, Yuan, J-M, Bertazzi, P A, Pesatori, A C, Ye, Y, Diao, N, Su, L, Zhang, R, Brhane, Y, Leighl, N, Johansen, J S, Mellemgaard, A, Saliba, W, Haiman, C, Wilkens, L, Fernandez-Somoano, A, Fernandez-Tardon, G, van der Heijden, E H F M, Kim, J H, Dai, J, Hu, Z, Davies, M P A, Marcus, M W, Brunnström, H, Manjer, J, Melander, O, Muller, D C, Overvad, K, Trichopoulou, A, Tumino, R, Doherty, J, Goodman, G E, Cox, A, Taylor, F, Woll, P, Brüske, I, Manz, J, Muley, T, Risch, A, Rosenberger, A, Grankvist, K, Johansson, M, Shepherd, F, Tsao, M-S, Arnold, S M, Haura, E B, Bolca, C, Holcatova, I, Janout, V, Kontic, M, Lissowska, J, Mukeria, A, Ognjanovic, S, Orlowski, T M, Scelo, G, Swiatkowska, B, Zaridze, D, Bakke, P, Skaug, V, Zienolddiny, S, Duell, E J, Butler, L M, Koh, W-P, Gao, Y-T, Houlston, R, McLaughlin, J, Stevens, V, Nickle, D C, Obeidat, M, Timens, W, Zhu, B, Song, L, Artigas, M S, Tobin, M D, Wain, L V, Gu, F, Byun, J, Kamal, A, Zhu, D, Tyndale, R F, Wei, W-Q, Chanock, S, Brennan, P & Amos, C I 2018, ' Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk ', Nature Communications, vol. 9, 3221 . https://doi.org/10.1038/s41467-018-05074-y
Nature Communications, 9(1):3221. Nature Publishing Group
Opis pliku:
application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe74a3a0ba767156af3d5458f896e112
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-151046
Szczegóły
Tytuł:
Downregulation of SATB2 is critical for induction of epithelial-to-mesenchymal transition and invasion of NSCLC cells
Autorzy:
Hakan Kucuksayan
Osman N. Ozes
Hakan Akca
Pokaż więcej
Temat:
Cancer Research
Pulmonary and Respiratory Medicine
Oncology
CD44
biology.protein
biology
Cancer cell
Transforming growth factor beta
Immunology
Gentamicin protection assay
Homeobox protein NANOG
Cell culture
A549 cell
Epithelial–mesenchymal transition
Cancer research
Biomarkers
Carcinoma, Non-Small-Cell Lung/*genetics/*pathology
Cell Adhesion Molecules, Neuronal/*genetics
Cell Line, Tumor
Cell Transformation, Neoplastic/genetics
Epithelial-Mesenchymal Transition/*genetics
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Gene Silencing
Humans
Lung Neoplasms/*genetics/*pathology
Neoplasm Invasiveness
Neoplastic Stem Cells/metabolism
EMT
Invasion
NSCLC
SATB2
Stemness
TGF-β
Hermes antigen
octamer transcription factor 4
small interfering RNA
special at rich binding protein 2
transcription factor
transcription factor NANOG
transcription factor Slug
transcription factor Sox2
transcription factor Twist
transcription factor ZEB1
transforming growth factor beta
unclassified drug
biological marker
nerve cell adhesion molecule
STAB2 protein, human
A549 cell line
Article
cell culture
cell invasion
controlled study
down regulation
epithelial mesenchymal transition
fibroblast
gene silencing
human
human cell
morphology
non small cell lung cancer
priority journal
protein expression
upregulation
Western blotting
cancer stem cell
cell transformation
gene expression regulation
genetics
lung tumor
metabolism
pathology
tumor cell line
tumor invasion
Carcinoma, Non-Small-Cell Lung
Cell Adhesion Molecules, Neuronal
Cell Transformation, Neoplastic
Epithelial-Mesenchymal Transition
Lung Neoplasms
Neoplastic Stem Cells
embryonic structures
Źródło:
Lung Cancer. 98:122-129
Dostępność:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d6ee95e302bd153e61ced45b7ba3f8
https://api.elsevier.com/content/article/PII:S0169500216303580?httpAccept=text/xml
Szczegóły
Wyświetlanie 1-20 z 54

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