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Tytuł :
Circulation of gut-preactivated naïve CD8 T cells enhances antitumor immunity in B cell-defective mice.
Autorzy :
Akrami M; Department of Immunology and Genomic Medicine, Kyoto University Graduate School of Medicine, 606-8501 Kyoto, Japan.
Menzies R; Department of Immunology and Genomic Medicine, Kyoto University Graduate School of Medicine, 606-8501 Kyoto, Japan.
Chamoto K; Department of Immunology and Genomic Medicine, Kyoto University Graduate School of Medicine, 606-8501 Kyoto, Japan.
Miyajima M; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, 230-0045 Yokohama, Japan.
Suzuki R; Repertoire Genesis Incorporation, 567-0085 Ibaraki, Japan.; Department of Rheumatology and Clinical Immunology, National Hospital Organization Sagamihara Hospital, 252-0392 Sagamihara, Japan.
Sato H; Repertoire Genesis Incorporation, 567-0085 Ibaraki, Japan.
Nishii A; Laboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, 584-8540 Tondabayashi, Osaka, Japan.
Tomura M; Laboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, 584-8540 Tondabayashi, Osaka, Japan.
Fagarasan S; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, 230-0045 Yokohama, Japan.
Honjo T; Department of Immunology and Genomic Medicine, Kyoto University Graduate School of Medicine, 606-8501 Kyoto, Japan; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 22; Vol. 117 (38), pp. 23674-23683. Date of Electronic Publication: 2020 Sep 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Gastrointestinal Microbiome/*immunology
Interferon Type I/*immunology
Neoplasms, Experimental/*immunology
Animals ; Antigens, Ly/immunology ; Antigens, Ly/metabolism ; B-Lymphocytes ; Cell Line, Tumor ; Cells, Cultured ; Dysbiosis/immunology ; Immunoglobulin A/immunology ; Immunoglobulin A/metabolism ; Interferon Type I/metabolism ; Lymph Nodes/cytology ; Membrane Proteins/immunology ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis.
Autorzy :
Huang HY; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Rivas-Caicedo A; INSERM, U1016, Institut Cochin, 75014 Paris, France.; CNRS, UMR8104, Institut Cochin, 75014 Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Institut Cochin, 75014 Paris, France.
Renevey F; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Cannelle H; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Peranzoni E; INSERM, U1016, Institut Cochin, 75014 Paris, France.; CNRS, UMR8104, Institut Cochin, 75014 Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Institut Cochin, 75014 Paris, France.
Scarpellino L; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Hardie DL; Centre for Translational Inflammation Research, School of Immunity and Infection, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, United Kingdom.
Pommier A; INSERM, U1016, Institut Cochin, 75014 Paris, France.; CNRS, UMR8104, Institut Cochin, 75014 Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Institut Cochin, 75014 Paris, France.
Schaeuble K; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Favre S; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Vogt TK; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Arenzana-Seisdedos F; Unité de Pathogénie Virale, Département de Virologie, INSERM U819, Institut Pasteur, 75015 Paris, France.
Schneider P; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland.
Buckley CD; Centre for Translational Inflammation Research, School of Immunity and Infection, University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2WD, United Kingdom.; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom.
Donnadieu E; INSERM, U1016, Institut Cochin, 75014 Paris, France.; CNRS, UMR8104, Institut Cochin, 75014 Paris, France.; Université Paris Descartes, Sorbonne Paris Cité, Institut Cochin, 75014 Paris, France.
Luther SA; Department of Biochemistry, Center for Immunity and Infection, University of Lausanne, 1066 Epalinges, Switzerland; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 17; Vol. 115 (29), pp. E6826-E6835. Date of Electronic Publication: 2018 Jul 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibody Formation*
Homeostasis/*immunology
Lymph Nodes/*immunology
Plasma Cells/*immunology
Animals ; B-Cell Activating Factor/immunology ; Chemokine CXCL12/immunology ; Interleukin-6/immunology ; Lymph Nodes/cytology ; Male ; Mice ; Plasma Cells/cytology ; Stromal Cells/cytology ; Stromal Cells/immunology
Czasopismo naukowe
Tytuł :
Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating Staphylococcus aureus .
Autorzy :
Bogoslowski A; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4.
Butcher EC; The Center for Molecular Biology and Medicine, Palo Alto Veterans Institute for Research, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304.; Laboratory of Immunology and Vascular Biology, Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305.
Kubes P; Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4; .; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Mar 06; Vol. 115 (10), pp. 2449-2454. Date of Electronic Publication: 2018 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endothelium/*immunology
Lymph Nodes/*immunology
Lymphatic Vessels/*immunology
Neutrophils/*immunology
Staphylococcus aureus/*immunology
Animals ; Humans ; L-Selectin/metabolism ; Lymph Nodes/cytology ; Lymph Nodes/microbiology ; Mice ; Staphylococcal Infections/immunology
Czasopismo naukowe
Tytuł :
Corpora amylacea act as containers that remove waste products from the brain.
Autorzy :
Riba M; Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain.; Centros de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.
Augé E; Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain.; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain.; Centros de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.
Campo-Sabariz J; Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain.; Institut de Recerca en Nutrició i Seguretat Alimentàries (INSA-UB), Universitat de Barcelona, 08291 Barcelona, Spain.
Moral-Anter D; Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain.; Institut de Recerca en Nutrició i Seguretat Alimentàries (INSA-UB), Universitat de Barcelona, 08291 Barcelona, Spain.
Molina-Porcel L; Neurological Tissue Bank of the Biobanc-Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Ximelis T; Neurological Tissue Bank of the Biobanc-Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Ferrer R; Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain.; Institut de Recerca en Nutrició i Seguretat Alimentàries (INSA-UB), Universitat de Barcelona, 08291 Barcelona, Spain.
Martín-Venegas R; Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain.; Institut de Recerca en Nutrició i Seguretat Alimentàries (INSA-UB), Universitat de Barcelona, 08291 Barcelona, Spain.
Pelegrí C; Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain; .; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain.; Centros de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.
Vilaplana J; Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain; .; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain.; Centros de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Dec 17; Vol. 116 (51), pp. 26038-26048. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Waste Products*
Astrocytes/*metabolism
Inclusion Bodies/*metabolism
Neurodegenerative Diseases/*metabolism
Aged ; Aged, 80 and over ; Aging ; Astrocytes/immunology ; Brain/pathology ; Glymphatic System ; Humans ; Inclusion Bodies/immunology ; Lymph Nodes ; Lymphatic System ; Macrophages ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/pathology ; Phagocytosis ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.
Autorzy :
Patro SC; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702; .
Brandt LD; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
Bale MJ; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Halvas EK; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
Joseph KW; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
Shao W; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Wu X; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Guo S; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 65 Stockholm, Sweden.
Wiegand A; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Spindler J; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Raley C; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Hautman C; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Sobolewski M; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
Fennessey CM; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Hu WS; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Luke B; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Hasson JM; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Niyongabo A; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Capoferri AA; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Keele BF; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702.
Milush J; Department of Medicine, University of California, San Francisco, CA 94143.
Hoh R; Department of Medicine, University of California, San Francisco, CA 94143.
Deeks SG; Department of Medicine, University of California, San Francisco, CA 94143.
Maldarelli F; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Hughes SH; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
Coffin JM; Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111; .
Rausch JW; Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.
Mellors JW; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
Kearney MF; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Dec 17; Vol. 116 (51), pp. 25891-25899. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV-1/*genetics
Virus Integration/*genetics
Virus Replication/*genetics
Anti-Retroviral Agents/therapeutic use ; Base Sequence ; Cell Line ; DNA, Viral/genetics ; Drug Resistance, Viral ; HIV Infections/virology ; Humans ; Leukocytes, Mononuclear/virology ; Lymph Nodes/virology ; Mutation ; Proviruses/genetics ; Virus Integration/physiology
Czasopismo naukowe
Tytuł :
Excessive CD11c B cells promote aberrant T FH differentiation and affinity-based germinal center selection in lupus.
Autorzy :
Zhang W; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Zhang H; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Liu S; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Xia F; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Kang Z; Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China.
Zhang Y; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Liu Y; Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China.
Xiao H; Key Laboratory of Molecular Virology and Immunology, Vaccine Center, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 200031 Shanghai, China.
Chen L; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Huang C; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
Shen N; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200001 Shanghai, China.
Xu H; Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, 200003 Shanghai, China.
Li F; Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; .; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Sep 10; Vol. 116 (37), pp. 18550-18560. Date of Electronic Publication: 2019 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocyte Subsets/*immunology
B-Lymphocytes/*immunology
Germinal Center/*immunology
Lupus Erythematosus, Systemic/*immunology
T-Lymphocytes, Helper-Inducer/*immunology
Adult ; Animals ; Autoimmunity/immunology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/metabolism ; CD11 Antigens/metabolism ; Case-Control Studies ; Cell Differentiation/immunology ; Disease Models, Animal ; Female ; Humans ; Lupus Erythematosus, Systemic/genetics ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/immunology ; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases/genetics ; Signal Transduction/immunology ; T-Box Domain Proteins/metabolism
Czasopismo naukowe
Tytuł :
Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes.
Autorzy :
Lok LSC; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Dennison TW; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, United Kingdom.
Mahbubani KM; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.; National Institute of Health Research Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, United Kingdom.
Chilvers ER; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; .; National Heart and Lung Institute, Imperial College London, London W12 0NN, United Kingdom.
Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, United Kingdom; .; National Institute of Health Research Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Sep 17; Vol. 116 (38), pp. 19083-19089. Date of Electronic Publication: 2019 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
Dendritic Cells/*immunology
Lymph Nodes/*immunology
Lymphatic Vessels/*immunology
Lymphocyte Activation/*immunology
Neutrophils/*immunology
Animals ; Cell Movement ; Female ; Histocompatibility Antigens Class II/immunology ; Histocompatibility Antigens Class II/metabolism ; Humans ; Interferon-gamma ; Mice ; Mice, Inbred C57BL ; Phenotype
Czasopismo naukowe
Tytuł :
SLAMF9 regulates pDC homeostasis and function in health and disease.
Autorzy :
Sever L; Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Radomir L; Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Stirm K; Department of Chronic Inflammation and Cancer, German Cancer Research Center, 69120 Heidelberg, Germany.
Wiener A; Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Schottlender N; Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Lewinsky H; Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Barak AF; Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Friedlander G; Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, 76100 Rehovot, Israel.
Ben-Dor S; Life Science Core Facilities, Department of Biochemistry, Weizmann Institute of Science, 76100 Rehovot, Israel.
Becker-Herman S; Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel.
Shachar I; Department of Immunology, Weizmann Institute of Science, 76100 Rehovot, Israel; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Aug 13; Vol. 116 (33), pp. 16489-16496. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease*
Health*
Homeostasis*
Dendritic Cells/*metabolism
Signaling Lymphocytic Activation Molecule Family/*metabolism
Animals ; Bone Marrow/metabolism ; Cell Differentiation ; Gene Expression Regulation ; Lymph Nodes/metabolism ; Lymphocyte Activation/immunology ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, CCR5/metabolism ; Signaling Lymphocytic Activation Molecule Family/deficiency ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination.
Autorzy :
Boopathy AV; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Mandal A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Kulp DW; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037.; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104.; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.
Menis S; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037.; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.
Bennett NR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Watkins HC; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Wang W; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139.
Martin JT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Thai NT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
He Y; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Schief WR; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037.; International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge, MA 02139.
Hammond PT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; .; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Irvine DJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; .; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037.; Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge, MA 02139.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Material Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Aug 13; Vol. 116 (33), pp. 16473-16478. Date of Electronic Publication: 2019 Jul 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Humoral*
Needles*
Prostheses and Implants*
Vaccination*
Delayed-Action Preparations/*pharmacology
Animals ; Antibody Formation/immunology ; Antigens/immunology ; Bombyx ; Germinal Center/immunology ; Lymph Nodes/immunology ; Mice, Inbred BALB C ; Silk ; Skin
Czasopismo naukowe
Tytuł :
Clonal Vγ6 T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection.
Autorzy :
Marchitto MC; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Dillen CA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Liu H; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Miller RJ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Archer NK; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Ortines RV; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Alphonse MP; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Marusina AI; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817.
Merleev AA; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817.
Wang Y; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Pinsker BL; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Byrd AS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Brown ID; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Ravipati A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Zhang E; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Cai SS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
Limjunyawong N; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; The Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Dong X; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; The Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Yeaman MR; Division of Molecular Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502.; Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA 90502.; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095.; Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90502.
Simon SI; Department of Biomedical Engineering, University of California, Davis, CA 95616.
Shen W; Cytokines and Immunity Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Durum SK; Cytokines and Immunity Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
O'Brien RL; Department of Biomedical Research, National Jewish Health, Denver, CO 80206.; Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Aurora, CO 80206.
Maverakis E; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817.
Miller LS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231; .; Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21287.; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 May 28; Vol. 116 (22), pp. 10917-10926. Date of Electronic Publication: 2019 May 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Interleukin-17/*physiology
Staphylococcal Infections/*immunology
Staphylococcus aureus/*pathogenicity
T-Lymphocyte Subsets/*immunology
T-Lymphocytes/*immunology
Animals ; Disease Models, Animal ; Humans ; Lymph Nodes/immunology ; Mice ; Staphylococcal Infections/microbiology
Czasopismo naukowe
Tytuł :
Knockout of both miR-15/16 loci induces acute myeloid leukemia.
Autorzy :
Lovat F; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Fassan M; Department of Medicine, Surgical Pathology and Cytopathology Unit, University of Padua, 35128 Padua, Italy.
Sacchi D; Department of Medicine, Surgical Pathology and Cytopathology Unit, University of Padua, 35128 Padua, Italy.
Ranganathan P; Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210.
Palamarchuk A; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Bill M; Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210.
Karunasiri M; Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210.
Gasparini P; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Nigita G; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Distefano R; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Veneziano D; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Dorrance AM; Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210.
Garzon R; Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210.
Croce CM; Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210; .; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Dec 18; Vol. 115 (51), pp. 13069-13074. Date of Electronic Publication: 2018 Nov 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Myeloid, Acute/*etiology
MicroRNAs/*physiology
Animals ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Cyclins/metabolism ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Spleen/metabolism ; Spleen/pathology
Czasopismo naukowe
Tytuł :
Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation.
Autorzy :
Krummel MF; Department of Pathology, University of California, San Francisco, CA 94143; .
Mahale JN; The Kennedy Institute of Rheumatology, University of Oxford, OX3 7FY Oxford, United Kingdom.
Uhl LFK; The Kennedy Institute of Rheumatology, University of Oxford, OX3 7FY Oxford, United Kingdom.
Hardison EA; Department of Pathology, University of California, San Francisco, CA 94143.
Mujal AM; Department of Pathology, University of California, San Francisco, CA 94143.
Mazet JM; The Kennedy Institute of Rheumatology, University of Oxford, OX3 7FY Oxford, United Kingdom.
Weber RJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Gartner ZJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Gérard A; Department of Pathology, University of California, San Francisco, CA 94143; .; The Kennedy Institute of Rheumatology, University of Oxford, OX3 7FY Oxford, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Nov 06; Vol. 115 (45), pp. 11585-11590. Date of Electronic Publication: 2018 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*drug effects
Cell Differentiation/*drug effects
Integrins/*immunology
Interferon-gamma/*pharmacology
Paracrine Communication/*immunology
Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/microbiology ; Cell Differentiation/immunology ; Cellular Microenvironment ; Immunologic Memory ; Immunological Synapses ; Interferon-gamma/immunology ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Killer Cells, Natural/microbiology ; Listeria monocytogenes/growth & development ; Listeria monocytogenes/immunology ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Lymphocyte Activation/drug effects ; Mice ; Mice, Inbred C57BL ; Primary Cell Culture ; Signal Transduction ; Spleen/cytology ; Spleen/immunology ; Tetradecanoylphorbol Acetate/pharmacology
Czasopismo naukowe
Tytuł :
Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease.
Autorzy :
Häusler D; Institute of Neuropathology, University Medical Center, 37099 Göttingen, Germany.
Häusser-Kinzel S; Institute of Neuropathology, University Medical Center, 37099 Göttingen, Germany.
Feldmann L; Institute of Neuropathology, University Medical Center, 37099 Göttingen, Germany.
Torke S; Institute of Neuropathology, University Medical Center, 37099 Göttingen, Germany.
Lepennetier G; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
Bernard CCA; Monash Regenerative Medicine Institute, Monash University, 3800 Melbourne, Australia.; Multiple Sclerosis Research Group, Monash University, 3800 Melbourne, Australia.
Zamvil SS; Department of Neurology, University of California, San Francisco, CA 94158.; Program in Immunology, University of California, San Francisco, CA 94158.
Brück W; Institute of Neuropathology, University Medical Center, 37099 Göttingen, Germany.
Lehmann-Horn K; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81675 Munich, Germany.
Weber MS; Institute of Neuropathology, University Medical Center, 37099 Göttingen, Germany; .; Department of Neurology, University Medical Center, 37099 Göttingen, Germany.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Sep 25; Vol. 115 (39), pp. 9773-9778. Date of Electronic Publication: 2018 Sep 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD20/*immunology
B-Lymphocytes/*immunology
Encephalomyelitis, Autoimmune, Experimental/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/therapeutic use ; Bone Marrow Cells/immunology ; Encephalomyelitis, Autoimmune, Experimental/therapy ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Mice ; Mice, Inbred C57BL ; Myelin Sheath/immunology ; Spleen/cytology ; Spleen/immunology
Czasopismo naukowe
Tytuł :
SIRPα dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen.
Autorzy :
Saito Y; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; .
Respatika D; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Komori S; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Washio K; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.; Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Nishimura T; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Kotani T; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Murata Y; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Okazawa H; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Ohnishi H; Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Gunma 371-8514, Japan.
Kaneko Y; Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Yui K; Division of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
Yasutomo K; Department of Immunology and Parasitology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima 770-8503, Japan.
Nishigori C; Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Nojima Y; Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Matozaki T; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Nov 21; Vol. 114 (47), pp. E10151-E10160. Date of Electronic Publication: 2017 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendritic Cells/*immunology
Fibroblasts/*immunology
Homeostasis/*immunology
Receptors, Immunologic/*immunology
Receptors, Tumor Necrosis Factor, Type I/*immunology
Spleen/*immunology
Animals ; CD4 Antigens/genetics ; CD4 Antigens/immunology ; CD47 Antigen/genetics ; CD47 Antigen/immunology ; Cell Survival ; Dendritic Cells/cytology ; Fibroblasts/cytology ; Gene Expression Regulation ; Homeostasis/genetics ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Immunologic/genetics ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Signal Transduction ; Spleen/cytology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology
Czasopismo naukowe
Tytuł :
Metabolic control of regulatory T cell (Treg) survival and function by Lkb1.
Autorzy :
He N; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Fan W; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Henriquez B; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Yu RT; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Atkins AR; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Liddle C; Storr Liver Centre, Westmead Institute for Medical Research and Sydney Medical School, Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia.
Zheng Y; Nomis Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037.
Downes M; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037; .
Evans RM; Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037; .; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Nov 21; Vol. 114 (47), pp. 12542-12547. Date of Electronic Publication: 2017 Nov 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immune Tolerance*
Autoimmune Diseases/*immunology
Energy Metabolism/*immunology
Homeostasis/*immunology
Protein-Serine-Threonine Kinases/*immunology
T-Lymphocytes, Regulatory/*immunology
AMP-Activated Protein Kinases/genetics ; AMP-Activated Protein Kinases/immunology ; Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/metabolism ; Autoimmune Diseases/pathology ; CD4 Lymphocyte Count ; Cell Proliferation ; Cell Survival ; Energy Metabolism/genetics ; Gene Expression Regulation/immunology ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/immunology ; Mitochondria/pathology ; Protein-Serine-Threonine Kinases/deficiency ; Protein-Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/immunology ; Signal Transduction ; Spleen/immunology ; Spleen/metabolism ; Spleen/pathology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism ; T-Lymphocytes, Cytotoxic/pathology ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/pathology
Czasopismo naukowe
Tytuł :
Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration.
Autorzy :
Caucheteux SM; Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Torabi-Parizi P
Paul WE
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Jan 29; Vol. 110 (5), pp. 1821-6. Date of Electronic Publication: 2013 Jan 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
CD4-Positive T-Lymphocytes/*immunology
Cell Movement/*immunology
Lung/*immunology
Lymph Nodes/*immunology
Adoptive Transfer ; Animals ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/transplantation ; Cell Proliferation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/immunology ; DNA-Binding Proteins/metabolism ; Female ; Flow Cytometry ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Immunophenotyping ; L-Selectin/immunology ; L-Selectin/metabolism ; Lung/metabolism ; Lymph Nodes/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microscopy, Confocal ; Receptors, CCR7/genetics ; Receptors, CCR7/immunology ; Receptors, CCR7/metabolism ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł :
In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors.
Autorzy :
Torcellan T; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, Darlinghurst, NSW 2010, Australia.
Hampton HR; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, Darlinghurst, NSW 2010, Australia.
Bailey J; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Tomura M; Laboratory of Immunology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi City, Osaka Prefecture 584-8540, Japan.
Brink R; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, Darlinghurst, NSW 2010, Australia.
Chtanova T; Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; .; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, Darlinghurst, NSW 2010, Australia.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 May 30; Vol. 114 (22), pp. 5677-5682. Date of Electronic Publication: 2017 May 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Carcinoma, Lewis Lung/*immunology
Cell Movement/*immunology
Lymphocyte Activation/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
T-Lymphocytes, Regulatory/*immunology
Animals ; Cell Line, Tumor ; Dendritic Cells/immunology ; Immunotherapy, Adoptive/methods ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophils/immunology
Czasopismo naukowe
Tytuł :
Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma.
Autorzy :
Tang J; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Salloum D; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Carney B; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Chemistry, Hunter College of the City University of New York, New York, NY 10028.; PhD Program in Chemistry, The Graduate Center of the City University of New York, New York, NY 10018.
Brand C; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Kossatz S; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Sadique A; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Lewis JS; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Weber WA; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Wendel HG; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Reiner T; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065; .; Department of Radiology, Weill Cornell Medical College, New York, NY 10065.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Sep 05; Vol. 114 (36), pp. E7441-E7449. Date of Electronic Publication: 2017 Aug 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Lymph Nodes/*pathology
Lymphoma, Large B-Cell, Diffuse/*pathology
Animals ; Cell Line, Tumor ; Female ; Fluorodeoxyglucose F18/administration & dosage ; Humans ; Mice ; Mice, Inbred C57BL ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/administration & dosage
Czasopismo naukowe
Tytuł :
Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells.
Autorzy :
Mandl JN; Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Liou R
Klauschen F
Vrisekoop N
Monteiro JP
Yates AJ
Huang AY
Germain RN
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Oct 30; Vol. 109 (44), pp. 18036-41. Date of Electronic Publication: 2012 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms :
Antigens/*immunology
CD4-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*cytology
Lymph Nodes/*cytology
CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Humans ; Lymph Nodes/immunology
Czasopismo naukowe
Tytuł :
Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells.
Autorzy :
Pizzolla A; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
Wang Z; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
Groom JR; Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3000, Australia.
Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
Brooks AG; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
Reading PC; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.; WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia.
Wakim LM; Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria 3000, Australia; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 May 16; Vol. 114 (20), pp. 5225-5230. Date of Electronic Publication: 2017 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Immunity, Mucosal/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Administration, Intranasal ; Animals ; Immunization ; Influenza A virus/immunology ; Influenza Vaccines/immunology ; Lymph Nodes/physiology ; Lymphoid Tissue/metabolism ; Mice ; Mice, Inbred C57BL ; Nasal Mucosa/metabolism ; Nasal Mucosa/physiology ; Orthomyxoviridae Infections/immunology ; Respiratory Tract Infections ; Vaccination
Czasopismo naukowe

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