Temat: "Lymphocyte Specific Protein Tyrosine Kinase p56\(lck\)" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: LCK-SafeScreen-Model: An Advanced Ensemble Machine Learning Approach for Estimating the Binding Affinity between Compounds and LCK Target.
Autorzy:: Cheng Y; College of Pharmaceutical Sciences, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou 311402, China.; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Ji C; College of Pharmaceutical Sciences, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou 311402, China.
Xu J; College of Pharmaceutical Sciences, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou 311402, China.; Department of Pharmacy, Huzhou Central Hospital, Huzhou 313000, China.
Chen R; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Guo Y; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Bian Q; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Shen Z; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhang B; College of Pharmaceutical Sciences, Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou 311402, China.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2023 Nov 01; Vol. 28 (21). Date of Electronic Publication: 2023 Nov 01.
Typ publikacji:: Journal Article
MeSH Terms:: Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*/chemistry
Machine Learning*
Molecular Docking Simulation

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Skocz do pozycji: 2.

Tytuł:: Identification of Breast Cancer LCK Proto-Oncogene as a Master Regulator of TNBC Neutrophil Enrichment and Polarization.
Autorzy:: Al Qutami F; Department of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates.
Al Halabi W; Department of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates.
Hachim MY; Department of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 26; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 26.
Typ publikacji:: Journal Article
MeSH Terms:: Neutrophils*
Triple Negative Breast Neoplasms*/genetics
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*
Humans ; Antigen Presentation ; B-Lymphocytes ; Leukocytes

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Skocz do pozycji: 3.

Tytuł:: Integrative and Comprehensive Pan-Cancer Analysis of Lymphocyte-Specific Protein Tyrosine Kinase in Human Tumors.
Autorzy:: Han M; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, China.
Li Y; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, China.
Guo Y; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, China.
Zhu W; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, China.
Jiang J; National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an 710032, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Nov 13; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 13.
Typ publikacji:: Journal Article
MeSH Terms:: Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*/genetics
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*/metabolism
Neoplasms*/genetics
Humans ; Cell Line, Tumor ; Lymphocytes/metabolism

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Skocz do pozycji: 4.

Tytuł:: A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling.
Autorzy:: Schultz A; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Schnurra M; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
El-Bizri A; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Woessner NM; Faculty of Biology, Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79085 Freiburg, Germany.; Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79085 Freiburg, Germany.
Hartmann S; Faculty of Biology, Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79085 Freiburg, Germany.
Hartig R; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Minguet S; Faculty of Biology, Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79085 Freiburg, Germany.; Center of Chronic Immunodeficiency CCI, University Clinics and Medical Faculty, 79106 Freiburg, Germany.
Schraven B; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Center for Health and Medical Prevention (CHaMP), Otto-von-Guericke-University, 39120 Magdeburg, Germany.
Simeoni L; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Center for Health and Medical Prevention (CHaMP), Otto-von-Guericke-University, 39120 Magdeburg, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Sep 01; Vol. 11 (17). Date of Electronic Publication: 2022 Sep 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cysteine*/metabolism
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*/metabolism
ZAP-70 Protein-Tyrosine Kinase*/metabolism
Humans ; Jurkat Cells ; Phosphorylation ; Receptors, Antigen, T-Cell/metabolism

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Skocz do pozycji: 5.

Tytuł:: Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.
Autorzy:: Kästle M; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Merten C; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Hartig R; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.
Plaza-Sirvent C; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Department of Molecular Immunology, Ruhr-University Bochum, 44801 Bochum, Germany.
Schmitz I; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Department of Molecular Immunology, Ruhr-University Bochum, 44801 Bochum, Germany.
Bommhardt U; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Center for Health and Medical Prevention (CHaMP), Otto-von-Guericke University, 39120 Magdeburg, Germany.
Schraven B; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Center for Health and Medical Prevention (CHaMP), Otto-von-Guericke University, 39120 Magdeburg, Germany.
Simeoni L; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, 39120 Magdeburg, Germany.; Center for Health and Medical Prevention (CHaMP), Otto-von-Guericke University, 39120 Magdeburg, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 30; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 30.
Typ publikacji:: Journal Article
MeSH Terms:: Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*/genetics
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*/metabolism
Phospholipase C gamma*/immunology
Receptors, Antigen, T-Cell*/immunology
Thymus Gland*/immunology
src-Family Kinases*/immunology
Animals ; Mice ; Phosphorylation ; Signal Transduction ; src Homology Domains

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Skocz do pozycji: 6.

Tytuł:: The Tyrosine Phosphatase Activity of PTPN22 Is Involved in T Cell Development via the Regulation of TCR Expression.
Autorzy:: Bai B; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Li T; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Zhao J; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Zhao Y; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Zhang X; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Wang T; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Zhang N; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Wang X; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Ba X; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Xu J; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Yu Y; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.
Wang B; Key Laboratory of Bioresource Research and Development of Liaoning Province, College of Life Science and Health, Northeastern University, #195 Chuangxin Road, Hunnan Xinqu, Shenyang 110169, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 25; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 25.
Typ publikacji:: Journal Article
MeSH Terms:: Receptors, Antigen, T-Cell*/metabolism
src-Family Kinases*/metabolism
Animals ; Mice ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Mice, Transgenic ; Phosphorylation ; Protein Tyrosine Phosphatases/metabolism

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Skocz do pozycji: 7.

Tytuł:: New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011-2021) focussing on structure-activity relationship (SAR) and docking insights.
Autorzy:: Elkamhawy A; College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Ali EMH; Center for Biomaterials, Korea Institute of Science & Technology (KIST School), Seoul, Republic of Korea.; University of Science & Technology (UST), Daejeon, Republic of Korea.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt.
Lee K; College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1574-1602.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Drug Discovery*
Molecular Docking Simulation*
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Dose-Response Relationship, Drug ; Humans ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship

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Skocz do pozycji: 8.

Tytuł:: Separate signaling events control TCR downregulation and T cell activation in primary human T cells.
Autorzy:: van der Donk LEH; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Ates LS; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
van der Spek J; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Tukker LM; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Geijtenbeek TBH; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
van Heijst JWJ; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Neogene Therapeutics, Amsterdam, The Netherlands.; Pokaż więcej
Źródło:: Immunity, inflammation and disease [Immun Inflamm Dis] 2021 Mar; Vol. 9 (1), pp. 223-238. Date of Electronic Publication: 2020 Dec 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*/genetics
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)*/metabolism
Proto-Oncogene Proteins*/metabolism
Down-Regulation ; Humans ; Phosphorylation ; Proto-Oncogene Proteins c-fyn/genetics ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction

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Skocz do pozycji: 9.

Tytuł:: Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.
Autorzy:: Sripada A; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.
Sirohi K; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.
Michalec L; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.
Guo L; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.
McKay JT; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.
Yadav S; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.
Verma M; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.
Good J; Division of Pulmonary and Critical Care, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Rollins D; Division of Pulmonary and Critical Care, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Gorska MM; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Alam R; Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, Colorado, United States of America.; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2021 Mar 08; Vol. 19 (3), pp. e3001063. Date of Electronic Publication: 2021 Mar 08 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Asthma/*physiopathology
CSK Tyrosine-Protein Kinase/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*metabolism
Membrane Proteins/*metabolism
Adult ; Animals ; Asthma/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Cell Proliferation ; Disease Models, Animal ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/physiology ; MAP Kinase Signaling System/physiology ; Male ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Middle Aged ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction/physiology

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Skocz do pozycji: 10.

Tytuł:: Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails.
Autorzy:: Han SJ; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Division of Bio-Medical Science & Technology, KIST School, UST, Seoul, Republic of Korea.
Jung JE; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Department of Chemistry, Sogang University, Seoul, Republic of Korea.
Oh DH; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Department of Chemistry, Sogang University, Seoul, Republic of Korea.
Kim M; Drug Discovery Institute, inCerebro Co., Ltd., Seoul, Republic of Korea.
Kim JM; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.; Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Chung KS; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
Han HS; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.; Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
Lee JH; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.; Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
Lee KT; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.; Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Jeong HJ; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Park IH; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.; Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea.
Jeon E; Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Microbiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Shin JS; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.; Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea.; Department of Microbiology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hwang D; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Cho AE; Drug Discovery Institute, inCerebro Co., Ltd., Seoul, Republic of Korea.; Department of Bioinformatics, Korea University, Sejong, Republic of Korea.
Lee DH; Department of Chemistry, Sogang University, Seoul, Republic of Korea.
Sim T; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Republic of Korea.; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 1257-1277.
Typ publikacji:: Journal Article
MeSH Terms:: Peptidomimetics*/pharmacology
Animals ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) ; Mice ; Protein Kinase Inhibitors/pharmacology ; src-Family Kinases

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Skocz do pozycji: 11.

Tytuł:: The lymphocyte-specific protein tyrosine kinase-specific inhibitor A-770041 attenuates lung fibrosis via the suppression of TGF-β production in regulatory T-cells.
Autorzy:: Kagawa K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Sato S; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Koyama K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Imakura T; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Murakami K; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Yamashita Y; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Naito N; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Ogawa H; Department of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Kawano H; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Nishioka Y; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Oct 27; Vol. 17 (10), pp. e0275987. Date of Electronic Publication: 2022 Oct 27 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/drug therapy
Pulmonary Fibrosis*/metabolism
Mice ; Animals ; T-Lymphocytes, Regulatory ; Transforming Growth Factor beta1/metabolism ; Bleomycin ; Transforming Growth Factor beta/metabolism ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Mice, Inbred C57BL

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Skocz do pozycji: 12.

Tytuł:: Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling.
Autorzy:: Arulraj T; Centre for Systems Biology, School of Life Sciences, University of Hyderabad, Central University P.O., Hyderabad, Telangana, India.
Barik D; School of Chemistry, University of Hyderabad, Central University P.O., Hyderabad, Telangana, India.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Oct 24; Vol. 13 (10), pp. e0206232. Date of Electronic Publication: 2018 Oct 24 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Algorithms*
Models, Immunological*
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*immunology
Programmed Cell Death 1 Receptor/*immunology
Receptors, Antigen, T-Cell/*immunology
Signal Transduction/*immunology
CD28 Antigens/immunology ; CD28 Antigens/metabolism ; Computer Simulation ; Humans ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; Receptors, Antigen, T-Cell/metabolism

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Skocz do pozycji: 13.

Tytuł:: LCK as a Potential Therapeutic Target for Acute Rejection after Kidney Transplantation: A Bioinformatics Clue.
Autorzy:: Jia L; Department of Nephrology, Xuanwu Hospital of Capital Medical University, Changchun Street 45#, Beijing 100053, China.
Jia R; Central Hospital of Cangzhou, Xinhua Middle Street 201#, Cangzhou, Hebei Province 061001, China.
Li Y; Department of Nephrology, Xuanwu Hospital of Capital Medical University, Changchun Street 45#, Beijing 100053, China.
Li X; Department of Nephrology, Xuanwu Hospital of Capital Medical University, Changchun Street 45#, Beijing 100053, China.
Jia Q; Department of Nephrology, Xuanwu Hospital of Capital Medical University, Changchun Street 45#, Beijing 100053, China.
Zhang H; Department of Life Sciences, The National Natural Science Foundation of China, Shuangqing Road 83#, Beijing 100085, China.; Pokaż więcej
Źródło:: Journal of immunology research [J Immunol Res] 2018 Jun 07; Vol. 2018, pp. 6451298. Date of Electronic Publication: 2018 Jun 07 (Print Publication: 2018).
Typ publikacji:: Journal Article
MeSH Terms:: Kidney Transplantation*
Graft Rejection/*metabolism
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*metabolism
Cluster Analysis ; Computational Biology ; Data Mining ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Graft Rejection/enzymology ; Graft Rejection/genetics ; Graft Rejection/therapy ; Humans ; Kidney/enzymology ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/antagonists & inhibitors ; Lymphocytes/metabolism ; Oligonucleotide Array Sequence Analysis ; Protein Interaction Mapping ; Protein Interaction Maps ; Signal Transduction

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Skocz do pozycji: 14.

Tytuł:: Comprehensive Analysis of CD163 as a Prognostic Biomarker and Associated with Immune Infiltration in Glioblastoma Multiforme.
Autorzy:: Li H; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang, China.; Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang, China.
Wang D; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang, China.; Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang, China.
Yi B; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang, China.; Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang, China.
Cai H; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang, China.; Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang, China.
Xi Z; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang, China.; Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang, China.
Lou X; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang, China.; Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang, China.
Li Z; Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang, China.; Key Laboratory of Neuro-Oncology in Liaoning Province, Shenyang, China.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2021 Aug 05; Vol. 2021, pp. 8357585. Date of Electronic Publication: 2021 Aug 05 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: Up-Regulation*
Antigens, CD/*genetics
Antigens, Differentiation, Myelomonocytic/*genetics
Biomarkers, Tumor/*genetics
Brain Neoplasms/*genetics
Chitinases/*genetics
Gene Expression Profiling/*methods
Glioblastoma/*genetics
Receptors, Cell Surface/*genetics
Age Factors ; Brain Neoplasms/immunology ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Glioblastoma/immunology ; Humans ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics ; MicroRNAs/genetics ; Mutation ; Nuclear Proteins/genetics ; Prognosis ; Protein Interaction Maps ; Survival Analysis ; Transcription Factors/genetics

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Skocz do pozycji: 15.

Tytuł:: Immune gene expression networks in sepsis: A network biology approach.
Autorzy:: Kim KS; Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jekarl DW; Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Laboratory for Development and Evaluation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Yoo J; Laboratory for Development and Evaluation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Department of Laboratory Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee S; Laboratory for Development and Evaluation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Department of Laboratory Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim M; Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Laboratory for Development and Evaluation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim Y; Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Laboratory for Development and Evaluation Center, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2021 Mar 05; Vol. 16 (3), pp. e0247669. Date of Electronic Publication: 2021 Mar 05 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Adaptive Immunity*
Gene Expression Regulation/*immunology
Gene Regulatory Networks/*immunology
Sepsis/*genetics
Transcriptome/*immunology
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/immunology ; Antigen Presentation/genetics ; CD3 Complex/genetics ; CD3 Complex/immunology ; CD8 Antigens/genetics ; CD8 Antigens/immunology ; Complement System Proteins/genetics ; Complement System Proteins/immunology ; Computational Biology/methods ; Datasets as Topic ; Gene Expression Profiling ; Gene Ontology ; Humans ; Immunity, Innate ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/immunology ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Molecular Sequence Annotation ; Prognosis ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/immunology ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Sepsis/diagnosis ; Sepsis/immunology ; Sepsis/mortality ; Signal Transduction ; Survival Analysis

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Skocz do pozycji: 16.

Tytuł:: Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation.
Autorzy:: Weiße J; Junior Research Group 'RNA biology and pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Rosemann J; Junior Research Group 'RNA biology and pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Müller L; Institute of Molecular Medicine, Section for Pathobiochemistry, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Kappler M; Department of Oral and Maxillofacial Plastic Surgery, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Eckert AW; Department of Cranio Maxillofacial Surgery, Paracelsus Medical University, 90471, Nuremberg, Germany.
Glaß M; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Misiak D; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Hüttelmaier S; Institute of Molecular Medicine, Section for Molecular Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Ballhausen WG; Institute of Molecular Medicine, Section for Molecular Oncology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Hatzfeld M; Institute of Molecular Medicine, Section for Pathobiochemistry, Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany.
Haemmerle M; Institute of Pathology, Section for Experimental Pathology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06112, Halle, Germany.
Gutschner T; Junior Research Group 'RNA biology and pathogenesis', Faculty of Medicine, Martin Luther University Halle-Wittenberg, 06120, Halle, Germany. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2021 Jun 11; Vol. 20 (1), pp. 88. Date of Electronic Publication: 2021 Jun 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinoma, Squamous Cell/*pathology
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*genetics
Mouth Neoplasms/*pathology
Neoplasm Invasiveness/*genetics
Antineoplastic Agents/pharmacology ; Carcinoma, Squamous Cell/genetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/genetics ; Dasatinib/pharmacology ; Humans ; Mouth Neoplasms/genetics ; Neoplasm Invasiveness/pathology ; Transcriptome

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Skocz do pozycji: 17.

Tytuł:: Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling.
Autorzy:: Zareie P; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Szeto C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Farenc C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Gunasinghe SD; European Molecular Biology Laboratory (EMBL) Australia Node in Single Molecule Science and the ARC Centre of Excellence in Advanced Molecular Imaging, School of Medical Sciences, University of New South Wales, New South Wales, Australia.
Kolawole EM; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Nguyen A; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Blyth C; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Sng XYX; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Li J; Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jones CM; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Fulcher AJ; Monash Micro Imaging, Monash University, Clayton, Victoria, Australia.
Jacobs JR; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Wei Q; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Wojciech L; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Petersen J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Gascoigne NRJ; Immunology Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545.
Evavold BD; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Gaus K; European Molecular Biology Laboratory (EMBL) Australia Node in Single Molecule Science and the ARC Centre of Excellence in Advanced Molecular Imaging, School of Medical Sciences, University of New South Wales, New South Wales, Australia.
Gras S; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Rossjohn J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, UK.
La Gruta NL; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. .; Pokaż więcej
Źródło:: Science (New York, N.Y.) [Science] 2021 Jun 04; Vol. 372 (6546).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: CD8-Positive T-Lymphocytes/*immunology
Histocompatibility Antigen H-2D/*metabolism
Nucleocapsid Proteins/*metabolism
Orthomyxoviridae Infections/*immunology
Receptors, Antigen, T-Cell, alpha-beta/*metabolism
Animals ; CD3 Complex/metabolism ; CD8 Antigens/immunology ; CD8 Antigens/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Epitopes, T-Lymphocyte ; Female ; Histocompatibility Antigen H-2D/chemistry ; Histocompatibility Antigen H-2D/immunology ; Influenza A virus ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Major Histocompatibility Complex ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Nucleocapsid Proteins/chemistry ; Nucleocapsid Proteins/immunology ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Protein Binding ; Protein Conformation ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Signal Transduction

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Skocz do pozycji: 18.

Tytuł:: Loss of natural resistance to schistosome in T cell deficient rat.
Autorzy:: Lu L; Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.; Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan Province, China.
Hu J; Hunan Institute of Parasitic Diseases, Yueyang, Hunan Province, China.
Chao T; Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan Province, China.
Chen Z; Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.; Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.
Liu Z; Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.; Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.
Luo X; Hunan Institute of Parasitic Diseases, Yueyang, Hunan Province, China.
Liang Y; Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.; Laboratory of Mouse Genetics, Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, Henan Province, China.; Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.
He P; Hunan Institute of Parasitic Diseases, Yueyang, Hunan Province, China.
Zhang L; Laboratory of Genetic Regulators in the Immune System, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.; Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan Province, China.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Dec 21; Vol. 14 (12), pp. e0008909. Date of Electronic Publication: 2020 Dec 21 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Schistosomiasis japonica/*immunology
T-Lymphocytes/*physiology
Animals ; CD3 Complex/genetics ; CD3 Complex/metabolism ; CRISPR-Cas Systems ; Gene Deletion ; Gene Expression Regulation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Rats ; Rats, Sprague-Dawley ; Schistosoma japonicum/physiology

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Skocz do pozycji: 19.

Tytuł:: Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56 regulates T-cell activation independently of Lck/CD45 interactions.
Autorzy:: Kästle M; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Leipziger Str.44, Building 26, 39120, Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Merten C; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Leipziger Str.44, Building 26, 39120, Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Hartig R; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Leipziger Str.44, Building 26, 39120, Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Kaehne T; Institute of Experimental Internal Medicine, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.
Liaunardy-Jopeace A; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC-LMB, Cambridge, UK.
Woessner NM; Spemann Graduate School of Biology and Medicine (SGBM), Albert-Ludwigs-University Freiburg, Freiburg, Germany.; Faculty of Biology, Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center of Chronic Immunodeficiency CCI, University Clinics and Medical Faculty, Freiburg, Germany.
Schamel WW; Faculty of Biology, Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center of Chronic Immunodeficiency CCI, University Clinics and Medical Faculty, Freiburg, Germany.
James J; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC-LMB, Cambridge, UK.; Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Gibbet Hill, Coventry, UK.
Minguet S; Faculty of Biology, Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center of Chronic Immunodeficiency CCI, University Clinics and Medical Faculty, Freiburg, Germany.
Simeoni L; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Leipziger Str.44, Building 26, 39120, Magdeburg, Germany. .; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany. .
Schraven B; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University, Leipziger Str.44, Building 26, 39120, Magdeburg, Germany. .; Health Campus Immunology, Infectiology and Inflammation (GC-I3), Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany. .; Pokaż więcej
Źródło:: Cell communication and signaling : CCS [Cell Commun Signal] 2020 Nov 23; Vol. 18 (1), pp. 183. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: src Homology Domains*
Leukocyte Common Antigens/*metabolism
Lymphocyte Activation/*immunology
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*chemistry
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*metabolism
T-Lymphocytes/*immunology
Tyrosine/*metabolism
Amino Acid Sequence ; Animals ; Cell Line, Tumor ; HEK293 Cells ; Humans ; Kinetics ; Mice, Inbred C57BL ; Phosphorylation ; Protein Conformation ; Receptors, Antigen, T-Cell/metabolism ; Spleen/immunology ; Structure-Activity Relationship ; Substrate Specificity ; ZAP-70 Protein-Tyrosine Kinase/metabolism

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Tytuł:: Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors.
Autorzy:: Crean-Tate KK; Department of Gynecologic Oncology, Cleveland Clinic Foundation, Women's Health Institute, OH, Cleveland, USA. .; Department of Gynecologic Oncology, Sutter Cancer Center, 2800 L Street, Suite 300, CA, 95816, Sacramento, USA. .
Braley C; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Case Comprehensive Cancer Center, The Laura J. Fogarty Endowed Chair in Uterine Cancer Research, 9500 Euclid Avenue, NC10, OH, 44195, Cleveland, USA.
Dey G; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Case Comprehensive Cancer Center, The Laura J. Fogarty Endowed Chair in Uterine Cancer Research, 9500 Euclid Avenue, NC10, OH, 44195, Cleveland, USA.
Esakov E; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Case Comprehensive Cancer Center, The Laura J. Fogarty Endowed Chair in Uterine Cancer Research, 9500 Euclid Avenue, NC10, OH, 44195, Cleveland, USA.
Saygin C; Department of Internal Medicine, The Ohio State University, OH, Columbus, USA.
Trestan A; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Case Comprehensive Cancer Center, The Laura J. Fogarty Endowed Chair in Uterine Cancer Research, 9500 Euclid Avenue, NC10, OH, 44195, Cleveland, USA.
Silver DJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Case Comprehensive Cancer Center, The Laura J. Fogarty Endowed Chair in Uterine Cancer Research, 9500 Euclid Avenue, NC10, OH, 44195, Cleveland, USA.
Turaga SM; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Case Comprehensive Cancer Center, The Laura J. Fogarty Endowed Chair in Uterine Cancer Research, 9500 Euclid Avenue, NC10, OH, 44195, Cleveland, USA.
Connor EV; Department of Gynecologic Oncology, Billings Clinic Cancer Center, MT, Billings, USA.
DeBernardo R; Department of Gynecologic Oncology, Cleveland Clinic Foundation, Women's Health Institute, OH, Cleveland, USA.
Michener CM; Department of Gynecologic Oncology, Cleveland Clinic Foundation, Women's Health Institute, OH, Cleveland, USA.
Rose PG; Department of Gynecologic Oncology, Cleveland Clinic Foundation, Women's Health Institute, OH, Cleveland, USA.
Lathia J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Case Comprehensive Cancer Center, The Laura J. Fogarty Endowed Chair in Uterine Cancer Research, 9500 Euclid Avenue, NC10, OH, 44195, Cleveland, USA.
Reizes O; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Case Comprehensive Cancer Center, The Laura J. Fogarty Endowed Chair in Uterine Cancer Research, 9500 Euclid Avenue, NC10, OH, 44195, Cleveland, USA. .; Pokaż więcej
Źródło:: Journal of ovarian research [J Ovarian Res] 2021 Apr 22; Vol. 14 (1), pp. 55. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji:: Journal Article
MeSH Terms:: Carcinoma, Endometrioid/*drug therapy
Cisplatin/*therapeutic use
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/*antagonists & inhibitors
Ovarian Neoplasms/*drug therapy
Animals ; Carcinoma, Endometrioid/mortality ; Cisplatin/pharmacology ; Female ; Humans ; Mice ; Ovarian Neoplasms/mortality ; Survival Analysis

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