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Wyszukujesz frazę ""Lymphocytes, Tumor-Infiltrating"" wg kryterium: Temat


Tytuł :
Modulation of SRSF2 expression reverses the exhaustion of TILs via the epigenetic regulation of immune checkpoint molecules.
Autorzy :
Wang Z; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Li K; Department of Nuclear Medicine, Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan, 250014, China.
Chen W; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Wang X; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Huang Y; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Wang W; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Wu W; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China.; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China.
Cai Z; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China. .; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China. .
Huang W; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, International Cancer Center, Shenzhen University School of Medicine, Shenzhen, 518039, China. .; Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen, 518035, China. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Sep; Vol. 77 (17), pp. 3441-3452. Date of Electronic Publication: 2019 Dec 14.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenesis, Genetic*
Lymphocytes, Tumor-Infiltrating/*metabolism
Serine-Arginine Splicing Factors/*metabolism
CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CTLA-4 Antigen/genetics ; CTLA-4 Antigen/metabolism ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Histones/metabolism ; Humans ; Interferon-gamma/metabolism ; Jurkat Cells ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/cytology ; Lymphocytes, Tumor-Infiltrating/immunology ; Promoter Regions, Genetic ; RNA Interference ; RNA, Small Interfering/metabolism ; STAT3 Transcription Factor/metabolism ; Serine-Arginine Splicing Factors/antagonists & inhibitors ; Serine-Arginine Splicing Factors/genetics ; Tumor Microenvironment ; p300-CBP Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Characterization of immunoreactivity with whole-slide imaging and digital analysis in high-grade serous ovarian cancer.
Autorzy :
Jäntti T; Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.
Luhtala S; Department of Pathology, Seinäjoki Central Hospital, Seinäjoki, Finland.
Mäenpää J; Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.; Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.
Staff S; Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland.; Tays Cancer Centre, Tampere University Hospital, Tampere, Finland.; Department of Gynecology and Obstetrics, Tampere University Hospital, Tampere, Finland.
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Źródło :
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2020 Nov; Vol. 42 (11), pp. 1010428320971404.
Typ publikacji :
Journal Article
MeSH Terms :
CD8 Antigens/*blood
Carcinoma, Ovarian Epithelial/*blood
Granzymes/*blood
Lymphocytes, Tumor-Infiltrating/*metabolism
Adult ; Aged ; Antigens, CD/blood ; Antigens, Differentiation, Myelomonocytic/blood ; CD4 Antigens/blood ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Carcinoma, Ovarian Epithelial/drug therapy ; Carcinoma, Ovarian Epithelial/epidemiology ; Carcinoma, Ovarian Epithelial/pathology ; Disease-Free Survival ; Drug Resistance, Neoplasm/drug effects ; Female ; Forkhead Transcription Factors/blood ; Humans ; Kaplan-Meier Estimate ; Lymphocytes, Tumor-Infiltrating/pathology ; Middle Aged ; Receptors, Cell Surface/blood ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Tytuł :
In vitro 4-1BB stimulation promotes expansion of CD8 tumor-infiltrating lymphocytes from various sarcoma subtypes.
Autorzy :
Nielsen M; Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital Herlev, Herlev, Denmark.
Krarup-Hansen A; Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark.
Hovgaard D; Department of Orthopedic Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Petersen MM; Department of Orthopedic Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Loya AC; Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Westergaard MCW; Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital Herlev, Herlev, Denmark.
Svane IM; Department of Oncology, National Center for Cancer Immune Therapy (CCIT-DK), Copenhagen University Hospital Herlev, Herlev, Denmark.
Junker N; Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Nov; Vol. 69 (11), pp. 2179-2191. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Cell Culture Techniques/*methods
Lymphocytes, Tumor-Infiltrating/*immunology
Sarcoma/*immunology
4-1BB Ligand/pharmacology ; Adult ; Aged ; Aged, 80 and over ; CD8-Positive T-Lymphocytes/drug effects ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/drug effects ; Male ; Middle Aged ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Exploratory open-label clinical study to determine the S-588410 cancer peptide vaccine-induced tumor-infiltrating lymphocytes and changes in the tumor microenvironment in esophageal cancer patients.
Autorzy :
Daiko H; Esophageal Surgery Division, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. .
Marafioti T; Department of Cellular Pathology, University College London Hospital, London, UK.
Fujiwara T; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Shirakawa Y; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Nakatsura T; Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Kato K; Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
Puccio I; Department of Cellular Pathology, University College London Hospital, London, UK.
Hikichi T; R&D Department, Cancer Precision Medicine, Inc., Kawasaki, Japan.
Yoshimura S; R&D Department, Cancer Precision Medicine, Inc., Kawasaki, Japan.
Nakagawa T; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka, Japan.
Furukawa M; Biostatistics Department, Shionogi & Co., Ltd., Osaka, Japan.
Stoeber K; Business Development, Shionogi & Co., Ltd., London, UK.
Nagira M; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka, Japan.
Ide N; Project Management Department, Shionogi & Co., Ltd., Osaka, Japan.
Kojima T; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Nov; Vol. 69 (11), pp. 2247-2257. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study
MeSH Terms :
Cancer Vaccines/*therapeutic use
Esophageal Neoplasms/*drug therapy
Esophageal Neoplasms/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Aged ; Antigens, Neoplasm/immunology ; Female ; HLA-A24 Antigen/immunology ; Humans ; Lymphocytes, Tumor-Infiltrating/drug effects ; Male ; Middle Aged ; T-Lymphocytes, Cytotoxic/drug effects ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Vaccines, Subunit/therapeutic use
Czasopismo naukowe
Tytuł :
Infiltration of T cells promotes the metastasis of ovarian cancer cells via the modulation of metastasis-related genes and PD-L1 expression.
Autorzy :
Wang JJ; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region of China.
Siu MK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region of China.
Jiang YX; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region of China.
Chan DW; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region of China.
Cheung AN; Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region of China.
Ngan HY; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region of China.
Chan KK; Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region of China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Nov; Vol. 69 (11), pp. 2275-2289. Date of Electronic Publication: 2020 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*metabolism
Carcinoma, Ovarian Epithelial/*pathology
Lymphocytes, Tumor-Infiltrating/*immunology
Neoplasm Invasiveness/*pathology
Tumor Escape/*immunology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Carcinoma, Ovarian Epithelial/immunology ; Carcinoma, Ovarian Epithelial/metabolism ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; Middle Aged ; Neoplasm Invasiveness/genetics ; Tumor Cells, Cultured ; Tumor Microenvironment/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
PD-L1 and IDO1 expression and tumor-infiltrating lymphocytes in osteosarcoma patients: comparative study of primary and metastatic lesions.
Autorzy :
Toda Y; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Kohashi K; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Yamada Y; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Yoshimoto M; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Ishihara S; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Ito Y; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Iwasaki T; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Yamamoto H; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Matsumoto Y; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Nakashima Y; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Mawatari M; Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, Saga, Japan.
Oda Y; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2020 Oct; Vol. 146 (10), pp. 2607-2620. Date of Electronic Publication: 2020 May 09.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
B7-H1 Antigen/*biosynthesis
Bone Neoplasms/*immunology
Indoleamine-Pyrrole 2,3,-Dioxygenase/*biosynthesis
Lymphocytes, Tumor-Infiltrating/*immunology
Osteosarcoma/*immunology
Adolescent ; Adult ; B7-H1 Antigen/immunology ; Bone Neoplasms/enzymology ; Bone Neoplasms/pathology ; Bone Neoplasms/secondary ; Child ; Female ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/immunology ; Lymphocytes, Tumor-Infiltrating/enzymology ; Male ; Middle Aged ; Neoplasm Staging ; Osteosarcoma/enzymology ; Osteosarcoma/pathology ; Osteosarcoma/secondary ; Prognosis ; T-Lymphocyte Subsets/immunology ; Tumor Microenvironment/immunology ; Young Adult
Czasopismo naukowe
Tytuł :
Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype.
Autorzy :
Takada K; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. .
Toyokawa G; Department of Thoracic Surgery, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.
Kinoshita F; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Jogo T; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Kohashi K; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Wakasu S; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Ono Y; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Tanaka K; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Oba T; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Osoegawa A; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Tagawa T; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Azuma K; Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahimachi, Kurume-shi, Fukuoka, 830-0011, Japan.
Okamoto I; Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Shimokawa M; Department of Biostatistics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.
Oda Y; Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Mori M; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2020 Oct; Vol. 146 (10), pp. 2639-2650. Date of Electronic Publication: 2020 May 14.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*immunology
B7-H1 Antigen/*biosynthesis
CD8-Positive T-Lymphocytes/*immunology
Indoleamine-Pyrrole 2,3,-Dioxygenase/*biosynthesis
Lung Neoplasms/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Programmed Cell Death 1 Ligand 2 Protein/*biosynthesis
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/pathology ; Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/immunology ; CD8-Positive T-Lymphocytes/pathology ; ErbB Receptors/genetics ; Female ; Humans ; Immunohistochemistry ; Indoleamine-Pyrrole 2,3,-Dioxygenase/immunology ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Programmed Cell Death 1 Ligand 2 Protein/immunology ; Retrospective Studies
Czasopismo naukowe
Tytuł :
[Monitoring Tumor Infiltrating Lymphocytes by Peripheral Blood in Lung Cancer Patients].
Autorzy :
Muto S; Dept. of Chest Surgery, Fukushima Medical University, School of Medicine.
Yamaguchi H
Mine H
Takagi H
Ozaki Y
Watanabe M
Inoue T
Yamaura T
Fukuhara M
Okabe N
Matsumura Y
Hasegawa T
Osugi J
Hoshino M
Higuchi M
Shio Y
Suzuki H
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Źródło :
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2020 Sep; Vol. 47 (9), pp. 1287-1291.
Typ publikacji :
Journal Article
MeSH Terms :
Lung Neoplasms*/drug therapy
Lymphocytes, Tumor-Infiltrating*
Biomarkers, Tumor ; CD8-Positive T-Lymphocytes ; Humans ; Prognosis ; T-Lymphocytes, Cytotoxic ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Tumor-infiltrating CD39 T cells determine poor prognosis and immune evasion in clear cell renal cell carcinoma patients.
Autorzy :
Qi Y; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xia Y; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Lin Z; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Qu Y; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Qi Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Chen Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhou Q; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Zeng H; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Wang J; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Chang Y; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Bai Q; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wang Y; Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhu Y; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Xu L; Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen L; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China.
Kong Y; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
Zhang W; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Dai B; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Liu L; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. .
Guo J; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. .
Xu J; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2020 Aug; Vol. 69 (8), pp. 1565-1576. Date of Electronic Publication: 2020 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Apyrase/*metabolism
CD8-Positive T-Lymphocytes/*immunology
Carcinoma, Renal Cell/*immunology
Immune Evasion/*immunology
Kidney Neoplasms/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Tumor Microenvironment/*immunology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apyrase/antagonists & inhibitors ; Biomarkers, Tumor/analysis ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/metabolism ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Female ; Follow-Up Studies ; Humans ; Immune Evasion/drug effects ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Lymphocytes, Tumor-Infiltrating/drug effects ; Lymphocytes, Tumor-Infiltrating/metabolism ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate ; Tumor Microenvironment/drug effects ; Young Adult
Czasopismo naukowe
Tytuł :
Bispecific antibodies enhance tumor-infiltrating T cell cytotoxicity against autologous HER-2-expressing high-grade ovarian tumors.
Autorzy :
Oberg HH; Institute of Immunology, Christian-Albrechts University of Kiel, Kiel, Germany.
Janitschke L; Institute of Immunology, Christian-Albrechts University of Kiel, Kiel, Germany.
Sulaj V; Institute of Immunology, Christian-Albrechts University of Kiel, Kiel, Germany.
Weimer J; Department of Gynecology and Obstetrics, UKSH, Campus Kiel, Kiel, Germany.
Gonnermann D; Institute of Immunology, Christian-Albrechts University of Kiel, Kiel, Germany.
Hedemann N; Department of Gynecology and Obstetrics, UKSH, Campus Kiel, Kiel, Germany.
Arnold N; Department of Gynecology and Obstetrics, UKSH, Campus Kiel, Kiel, Germany.; Institute of Clinical Molecular Biology, UKSH, CAU Kiel, Kiel, Germany.
Kabelitz D; Institute of Immunology, Christian-Albrechts University of Kiel, Kiel, Germany.
Peipp M; Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, UKSH, CAU Kiel, Kiel, Germany.
Bauerschlag D; Department of Gynecology and Obstetrics, UKSH, Campus Kiel, Kiel, Germany.
Wesch D; Institute of Immunology, Christian-Albrechts University of Kiel, Kiel, Germany.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Jun; Vol. 107 (6), pp. 1081-1095. Date of Electronic Publication: 2019 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*pharmacology
Antineoplastic Agents, Immunological/*pharmacology
Carcinoma, Ovarian Epithelial/*immunology
Lymphocytes, Tumor-Infiltrating/*drug effects
Ovarian Neoplasms/*immunology
Receptor, ErbB-2/*genetics
T-Lymphocytes, Cytotoxic/*drug effects
Adult ; Ascites/genetics ; Ascites/immunology ; Ascites/pathology ; Ascites/surgery ; CD3 Complex/genetics ; CD3 Complex/immunology ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/pathology ; Carcinoma, Ovarian Epithelial/surgery ; Coculture Techniques ; Cytotoxicity, Immunologic/drug effects ; Female ; Gene Expression ; Humans ; Lymphocyte Count ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/pathology ; Middle Aged ; Neoplasm Grading ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Primary Cell Culture ; Receptor, ErbB-2/immunology ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/pathology
Czasopismo naukowe
Tytuł :
Effects of B7-H3 expression on tumour-infiltrating immune cells and clinicopathological characteristics in non-small-cell lung cancer.
Autorzy :
Yim J; Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea.
Koh J; Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kim S; Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.
Song SG; Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea.
Ahn HK; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.
Kim YA; Department of Pathology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Jeon YK; Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea. Electronic address: .
Chung DH; Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: .
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Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2020 Jul; Vol. 133, pp. 74-85. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7 Antigens/*metabolism
Carcinoma, Non-Small-Cell Lung/*diagnosis
Lung Neoplasms/*diagnosis
Lymphocytes, Tumor-Infiltrating/*metabolism
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Cohort Studies ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms/metabolism ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lymphocyte Count ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Comprehensive single institute experience with melanoma TIL: Long term clinical results, toxicity profile, and prognostic factors of response.
Autorzy :
Besser MJ; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Israel.; Wohl Institute of Translational Medicine, Sheba Medical Center, Israel.
Itzhaki O; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Ben-Betzalel G; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Zippel DB; Department of Surgery C, Sheba Medical Center, Israel.; Department of Surgery, Sackler School of Medicine, Tel Aviv University, Israel.
Zikich D; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Kubi A; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Brezinger K; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Nissani A; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Levi M; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Zeltzer LA; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Ben-Nun A; Department of Thoracic Surgery, Sheba Medical Center, Israel.
Asher N; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
Shimoni A; Department of Bone Marrow Transplantation, Sheba Medical Center, Israel.
Nagler A; Department of Bone Marrow Transplantation, Sheba Medical Center, Israel.
Markel G; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.; Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Israel.
Shapira-Frommer R; Oncology Division, Sheba Medical Center, Israel.
Schachter J; Ella Lemelbaum Institute for Immuno Oncology, Sheba Medical Center, Ramat Gan, Israel.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Jul; Vol. 59 (7), pp. 736-744. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*adverse effects
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Lymphocytes, Tumor-Infiltrating/*drug effects
Melanoma/*drug therapy
Melanoma/*pathology
CD8-Positive T-Lymphocytes/drug effects ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/adverse effects ; Female ; Follow-Up Studies ; Humans ; Interleukin-2/administration & dosage ; Interleukin-2/adverse effects ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Prognosis ; Progression-Free Survival ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Vidarabine/administration & dosage ; Vidarabine/adverse effects ; Vidarabine/analogs & derivatives
Czasopismo naukowe
Tytuł :
Utilizing Automated Breast Cancer Detection to Identify Spatial Distributions of Tumor-Infiltrating Lymphocytes in Invasive Breast Cancer.
Autorzy :
Le H; Department of Computer Science, Stony Brook University, Stony Brook, New York. Electronic address: .
Gupta R; Department of Biomedical Informatics, Stony Brook Medicine, Stony Brook, New York; Department of Pathology, Stony Brook University Hospital, Stony Brook, New York.
Hou L; Department of Computer Science, Stony Brook University, Stony Brook, New York.
Abousamra S; Department of Computer Science, Stony Brook University, Stony Brook, New York.
Fassler D; Department of Pathology, Stony Brook University Hospital, Stony Brook, New York.
Torre-Healy L; Department of Biomedical Informatics, Stony Brook Medicine, Stony Brook, New York.
Moffitt RA; Department of Biomedical Informatics, Stony Brook Medicine, Stony Brook, New York; Department of Pathology, Stony Brook University Hospital, Stony Brook, New York.
Kurc T; Department of Biomedical Informatics, Stony Brook Medicine, Stony Brook, New York.
Samaras D; Department of Computer Science, Stony Brook University, Stony Brook, New York.
Batiste R; Department of Pathology, Stony Brook University Hospital, Stony Brook, New York.
Zhao T; Department of Pathology, Stony Brook University Hospital, Stony Brook, New York.
Rao A; Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan.
Van Dyke AL; Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Sharma A; Department of Biomedical Informatics, Emory University, Atlanta, Georgia.
Bremer E; Department of Biomedical Informatics, Stony Brook Medicine, Stony Brook, New York.
Almeida JS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Saltz J; Department of Biomedical Informatics, Stony Brook Medicine, Stony Brook, New York.
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Źródło :
The American journal of pathology [Am J Pathol] 2020 Jul; Vol. 190 (7), pp. 1491-1504. Date of Electronic Publication: 2020 Apr 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Deep Learning*
Breast Neoplasms/*pathology
Lymphocytes, Tumor-Infiltrating/*pathology
Breast Neoplasms/immunology ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; SEER Program
Czasopismo naukowe
Tytuł :
PD-1/PD-L1 expression and tumor-infiltrating lymphocytes are prognostically favorable in advanced high-grade serous ovarian carcinoma.
Autorzy :
Martin de la Fuente L; Department of Clinical Sciences, Division of Oncology and Pathology, Lund University and Skåne University Hospital, Lund, Sweden. .
Westbom-Fremer S; Department of Clinical Sciences, Division of Oncology and Pathology, Lund University and Skåne University Hospital, Lund, Sweden.; Department of Surgical Pathology, Division of Laboratory Medicine, Skåne University Hospital, Lund, Sweden.
Arildsen NS; Department of Clinical Sciences, Division of Oncology and Pathology, Lund University and Skåne University Hospital, Lund, Sweden.
Hartman L; Department of Clinical Sciences, Division of Oncology and Pathology, Lund University and Skåne University Hospital, Lund, Sweden.
Malander S; Department of Clinical Sciences, Division of Oncology and Pathology, Lund University and Skåne University Hospital, Lund, Sweden.
Kannisto P; Department of Obstetrics and Gynaecology Lund, Skåne University Hospital, Lund University, Lund, Sweden.
Måsbäck A; Department of Surgical Pathology, Division of Laboratory Medicine, Skåne University Hospital, Lund, Sweden.
Hedenfalk I; Department of Clinical Sciences, Division of Oncology and Pathology, Lund University and Skåne University Hospital, Lund, Sweden.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2020 Jul; Vol. 477 (1), pp. 83-91. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen/*immunology
Lymphocytes, Tumor-Infiltrating/*pathology
Neoplasms, Glandular and Epithelial/*pathology
Ovarian Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Cystadenocarcinoma, Serous/diagnosis ; Cystadenocarcinoma, Serous/immunology ; Cystadenocarcinoma, Serous/pathology ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Middle Aged ; Neoplasms, Glandular and Epithelial/immunology ; Ovarian Neoplasms/immunology ; Prognosis ; Programmed Cell Death 1 Receptor/immunology
Czasopismo naukowe
Tytuł :
Reply to letters to the editor: Discordance in estrogen receptor and change of Ki67 between primary site and metastatic site of recurrent breast cancer.
Autorzy :
Watanabe J; Division of Breast Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Shizuoka, 4118777, Japan. .
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2020 Jul; Vol. 182 (2), pp. 513-514. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Letter; Comment
MeSH Terms :
Lymphocytes, Tumor-Infiltrating*
Neoplasm Recurrence, Local*
Estrogens ; Furans ; Humans ; Ketones ; Ki-67 Antigen ; Lymphocyte Count
Opinia redakcyjna
Tytuł :
Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration.
Autorzy :
Terkelsen T; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Russo F; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gromov P; Breast Cancer Biology Group, Genome Integrity Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Haakensen VD; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gromova I; Breast Cancer Biology Group, Genome Integrity Unit, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.
Krogh A; Unit of Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Papaleo E; Computational Biology Laboratory, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. .; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. .
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Źródło :
Breast cancer research : BCR [Breast Cancer Res] 2020 Jun 30; Vol. 22 (1), pp. 73. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocytes, Tumor-Infiltrating/*immunology
MicroRNAs/*genetics
Triple Negative Breast Neoplasms/*genetics
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; Extracellular Fluid/metabolism ; Female ; Follow-Up Studies ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; MicroRNAs/metabolism ; Neoplasm Grading ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/pathology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Racial differences in CD8 T cell infiltration in breast tumors from Black and White women.
Autorzy :
Abdou Y; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Attwood K; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Cheng TD; Department of Epidemiology, University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA.
Yao S; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Bandera EV; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA.; Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Zirpoli GR; Slone Epidemiology Center, Boston University Medical Campus, Boston, MA, USA.
Ondracek RP; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Stein L; Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Bshara W; Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Khoury T; Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Ambrosone CB; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Omilian AR; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. .
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Źródło :
Breast cancer research : BCR [Breast Cancer Res] 2020 Jun 09; Vol. 22 (1), pp. 62. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
African Americans*
European Continental Ancestry Group*
Breast Neoplasms/*ethnology
Breast Neoplasms/*immunology
CD8-Positive T-Lymphocytes/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Adult ; Aged ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; CD8-Positive T-Lymphocytes/pathology ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Lymphocytes, Tumor-Infiltrating/pathology ; Middle Aged ; Prognosis ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Survival Rate ; Women's Health ; Young Adult
Czasopismo naukowe
Tytuł :
Mitotic activity index and CD25+ lymphocytes predict risk of stage progression in non-muscle invasive bladder cancer.
Autorzy :
Lillesand M; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
Kvikstad V; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.; Department of Mathematics and Natural Science, University of Stavanger, Stavanger, Norway.
Mangrud OM; Department of Pathology, Innlandet Hospital, Lillehammer, Norway.
Gudlaugsson E; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
van Diermen-Hidle B; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
Skaland I; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
Baak JPA; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.; Jan Baak AS, Tananger, Norway.
Janssen EAM; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.; Department of Mathematics and Natural Science, University of Stavanger, Stavanger, Norway.
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Źródło :
PloS one [PLoS One] 2020 Jun 02; Vol. 15 (6), pp. e0233676. Date of Electronic Publication: 2020 Jun 02 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Mitotic Index*
Carcinoma, Transitional Cell/*pathology
Lymphocytes, Tumor-Infiltrating/*immunology
Neoplasm Recurrence, Local/*diagnosis
Urinary Bladder Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Transitional Cell/genetics ; Carcinoma, Transitional Cell/immunology ; Disease Progression ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Interleukin-2 Receptor alpha Subunit/metabolism ; Kaplan-Meier Estimate ; Ki-67 Antigen/metabolism ; Lymphocytes, Tumor-Infiltrating/metabolism ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/immunology ; Neoplasm Staging ; Prognosis ; Reproducibility of Results ; Urinary Bladder/pathology ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/mortality
Czasopismo naukowe
Tytuł :
Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer.
Autorzy :
Roberti MP; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France.
Yonekura S; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.; Université Paris-Saclay, Le Kremlin-Bicêtre cedex, France.
Duong CPM; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Picard M; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.; Unit Biology and Genetics of the Bacterial Cell Wall, Institut Pasteur Paris, Paris, France.
Ferrere G; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Tidjani Alou M; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Rauber C; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.; Université Paris-Saclay, Le Kremlin-Bicêtre cedex, France.
Iebba V; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Lehmann CHK; Department of Dermatology, Laboratory of Dendritic Cell Biology, Medical Immunology Campus Erlangen, University Hospital of Erlangen, Friedrich-Alexander-University (FAU) of Erlangen-Nürnberg, Erlangen, Germany.
Amon L; Department of Dermatology, Laboratory of Dendritic Cell Biology, Medical Immunology Campus Erlangen, University Hospital of Erlangen, Friedrich-Alexander-University (FAU) of Erlangen-Nürnberg, Erlangen, Germany.
Dudziak D; Department of Dermatology, Laboratory of Dendritic Cell Biology, Medical Immunology Campus Erlangen, University Hospital of Erlangen, Friedrich-Alexander-University (FAU) of Erlangen-Nürnberg, Erlangen, Germany.
Derosa L; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France.
Routy B; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.; Université Paris-Saclay, Le Kremlin-Bicêtre cedex, France.
Flament C; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France.
Richard C; Department of Medical Oncology, Center GF Leclerc, Dijon, France.; Plateform Transfer in Biological Oncology, Dijon, France.
Daillère R; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Fluckiger A; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Van Seuningen I; Inserm UMR-S 1172, Jean-Pierre Aubert Research Center, CHU Lille, University of Lille, Lille, France.
Chamaillard M; Laboratory of Cell Physiology, INSERM U1003, University of Lille, Lille, France.
Vincent A; Inserm UMR-S 1172, Jean-Pierre Aubert Research Center, CHU Lille, University of Lille, Lille, France.
Kourula S; Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Opolon P; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
Ly P; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Pizzato E; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Becharef S; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
Paillet J; Université Paris-Saclay, Le Kremlin-Bicêtre cedex, France.; Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.; Cell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
Klein C; Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.
Marliot F; Laboratory of Integrative Cancer Immunology, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.; Service d'Immunologie Biologique, Hôpital Européen Georges Pompidou, Paris, France.
Pietrantonio F; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
Benoist S; Service de Chirurgie Digestive et Oncologique, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Scoazec JY; Departement de Biologie et Pathologie Médicales, Gustave Roussy Cancer Campus, Villejuif, France.
Dartigues P; Departement de Biologie et Pathologie Médicales, Gustave Roussy Cancer Campus, Villejuif, France.
Hollebecque A; Departement de Médicine Oncologique, Gustave Roussy Cancer Campus, Villejuif, France.
Malka D; Departement de Médicine Oncologique, Gustave Roussy Cancer Campus, Villejuif, France.
Pagès F; Laboratory of Integrative Cancer Immunology, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.; Service d'Immunologie Biologique, Hôpital Européen Georges Pompidou, Paris, France.
Galon J; Laboratory of Integrative Cancer Immunology, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.; Service d'Immunologie Biologique, Hôpital Européen Georges Pompidou, Paris, France.
Gomperts Boneca I; Unit Biology and Genetics of the Bacterial Cell Wall, Institut Pasteur Paris, Paris, France.; INSERM, Equipe Avenir, Paris, France.
Lepage P; Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
Ryffel B; Molecular Immunology and Embryology, UMR 7355, CNRS, University of Orleans, Orléans, France.
Raoult D; Unité des Rickettsies, Faculté de Médecine, Université de la Méditerranée, Marseille, France.
Eggermont A; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.; Departement de Médicine Oncologique, Gustave Roussy Cancer Campus, Villejuif, France.
Vanden Berghe T; Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Ghiringhelli F; Department of Medical Oncology, Center GF Leclerc, Dijon, France.; Plateform Transfer in Biological Oncology, Dijon, France.
Vandenabeele P; Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Methusalem Program, Ghent University, Ghent, Belgium.
Kroemer G; Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France.; Cell Biology and Metabolomics Platforms, Gustave Roussy Cancer Campus, Villejuif, France.; Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de, Paris, France.; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
Zitvogel L; Gustave Roussy Cancer Campus (GRCC), Villejuif, France. .; Institut National de la Santé Et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France. .; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France. .; Université Paris-Saclay, Le Kremlin-Bicêtre cedex, France. .; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China. .
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Źródło :
Nature medicine [Nat Med] 2020 Jun; Vol. 26 (6), pp. 919-931. Date of Electronic Publication: 2020 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*drug therapy
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Colonic Neoplasms/*drug therapy
Gastrointestinal Microbiome/*immunology
Ileum/*drug effects
Lymphocytes, Tumor-Infiltrating/*drug effects
Oxaliplatin/*pharmacology
Adenocarcinoma/immunology ; Adenocarcinoma/microbiology ; Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Animals ; Antineoplastic Agents/therapeutic use ; Apoptosis/immunology ; Bacteroides fragilis ; Cell Line, Tumor ; Colonic Neoplasms/immunology ; Colonic Neoplasms/microbiology ; Colonic Neoplasms/pathology ; Epithelial Cells/drug effects ; Epithelial Cells/immunology ; Epithelial Cells/pathology ; Female ; Firmicutes ; Gastrointestinal Microbiome/physiology ; Humans ; Ileum/immunology ; Ileum/microbiology ; Ileum/pathology ; Immunogenic Cell Death/drug effects ; Immunogenic Cell Death/immunology ; Immunologic Surveillance/drug effects ; Immunologic Surveillance/immunology ; Interleukin-12/immunology ; Intestinal Mucosa ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Mice ; Middle Aged ; Oxaliplatin/therapeutic use ; Prognosis ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Receptors, Interleukin-1 Type I/immunology ; T-Lymphocytes, Helper-Inducer/drug effects ; T-Lymphocytes, Helper-Inducer/immunology
Czasopismo naukowe
Tytuł :
Tumor-infiltrating Lymphocyte Score Based on FDG PET/CT for Predicting the Effect of Neoadjuvant Chemotherapy in Breast Cancer.
Autorzy :
Sasada S; Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan .
Kimura Y; Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Emi A; Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Masumoto N; Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Kadoya T; Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Arihiro K; Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan.
Okada M; Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 2020 Jun; Vol. 40 (6), pp. 3395-3400.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorodeoxyglucose F18*
Positron Emission Tomography Computed Tomography*/methods
Breast Neoplasms/*diagnostic imaging
Breast Neoplasms/*pathology
Lymphocytes, Tumor-Infiltrating/*pathology
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; ROC Curve ; Treatment Outcome ; Tumor Microenvironment ; Young Adult
Czasopismo naukowe

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