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Wyszukujesz frazę ""Lymphocytes, Tumor-Infiltrating"" wg kryterium: Temat


Tytuł :
MK-6, a novel not-α IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance.
Autorzy :
Kobayashi M; Division of Tumor Immunobiology, Miyagi Cancer Center Research Institute, Natori, Japan.; Division of Tumor Immunobiology, Tohoku University Graduate School of Medicine, Sendai, Japan.; Division of Respiratory Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Respiratory Medicine, Miyagi Cancer Center Hospital, Natori, Japan.
Kojima K; Department of Microbiology and Immunology, Shinshu University School of Medicine, Matsumoto, Japan.
Murayama K; Division of Biomedical Measurements and Diagnostics, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan.
Amano Y; Department of Microbiology and Immunology, Shinshu University School of Medicine, Matsumoto, Japan.
Koyama T; Division of Tumor Immunobiology, Miyagi Cancer Center Research Institute, Natori, Japan.; Division of Tumor Immunobiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ogama N; Division of Tumor Immunobiology, Miyagi Cancer Center Research Institute, Natori, Japan.
Takeshita T; Department of Microbiology and Immunology, Shinshu University School of Medicine, Matsumoto, Japan.
Fukuhara T; Division of Respiratory Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Respiratory Medicine, Miyagi Cancer Center Hospital, Natori, Japan.
Tanaka N; Division of Tumor Immunobiology, Miyagi Cancer Center Research Institute, Natori, Japan.; Division of Tumor Immunobiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Nov; Vol. 112 (11), pp. 4478-4489. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
CD4-Positive T-Lymphocytes/*drug effects
Cell Proliferation/*drug effects
Immunologic Factors/*pharmacology
Lymphocytes, Tumor-Infiltrating/*drug effects
T-Lymphocytes, Regulatory/*drug effects
Animals ; CD4-Positive T-Lymphocytes/cytology ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Half-Life ; Immunity, Cellular ; Interleukin Receptor Common gamma Subunit/metabolism ; Interleukin-2/adverse effects ; Interleukin-2/metabolism ; Interleukin-2/therapeutic use ; Interleukin-2 Receptor alpha Subunit/metabolism ; Interleukin-2 Receptor beta Subunit/metabolism ; Lymphocytes, Tumor-Infiltrating/cytology ; Lymphocytes, Tumor-Infiltrating/physiology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Phosphorylation ; STAT5 Transcription Factor/metabolism ; Serum Albumin/metabolism ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/physiology ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes.
Autorzy :
Wu W; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Liu Y; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008.
Zeng S; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008. .; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China. .
Han Y; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008. .; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China. .
Shen H; Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008. .; Key Laboratory for Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 410008. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China. .
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Źródło :
Journal of hematology & oncology [J Hematol Oncol] 2021 Oct 07; Vol. 14 (1), pp. 160. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Microsatellite Instability*
Immunotherapy/*methods
Interferon-gamma/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Neoplasms/*therapy
Animals ; Humans ; Interferon-gamma/genetics ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer.
Autorzy :
Meyer HJ; Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany. .
Höhn AK; Department of Pathology, University of Leipzig, Leipzig, Germany.
Surov A; Department of Radiology and Nuclear Medicine, University of Magdeburg, Magdeburg, Germany.
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Źródło :
Cancer imaging : the official publication of the International Cancer Imaging Society [Cancer Imaging] 2021 Nov 20; Vol. 21 (1), pp. 60. Date of Electronic Publication: 2021 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Head and Neck Neoplasms*/diagnostic imaging
Lymphocytes, Tumor-Infiltrating*
Contrast Media ; Humans ; Magnetic Resonance Imaging ; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging
Czasopismo naukowe
Tytuł :
The EZH2 inhibitor tazemetostat upregulates the expression of CCL17/TARC in B-cell lymphoma and enhances T-cell recruitment.
Autorzy :
Yuan H; Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nishikori M; Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Otsuka Y; Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Arima H; Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kitawaki T; Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takaori-Kondo A; Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Nov; Vol. 112 (11), pp. 4604-4616. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Lymphocytes, Tumor-Infiltrating*
Benzamides/*pharmacology
Biphenyl Compounds/*pharmacology
Chemokine CCL17/*metabolism
Enhancer of Zeste Homolog 2 Protein/*antagonists & inhibitors
Lymphoma, Large B-Cell, Diffuse/*metabolism
Morpholines/*pharmacology
Pyridones/*pharmacology
Cell Line, Tumor ; Cell Movement ; Chemokine CCL17/genetics ; Databases, Factual ; Humans ; Jumonji Domain-Containing Histone Demethylases/genetics ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Promoter Regions, Genetic ; Reed-Sternberg Cells ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Expression of VISTA on tumor-infiltrating immune cells correlated with short intravesical recurrence in non-muscle-invasive bladder cancer.
Autorzy :
Seo WI; Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Lee CH; Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Jung SJ; Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, 75 Bokji-ro, Busanjin-gu, Busan, 47392, Republic of Korea. .
Lee DS; Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.; Paik Institute of Clinical Research, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Park HY; Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, 75 Bokji-ro, Busanjin-gu, Busan, 47392, Republic of Korea.
Jeong DH; Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.; Paik Institute of Clinical Research, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Kim W; Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Chung JI; Department of Urology, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Choi I; Department of Microbiology and Immunology, Innovative Therapeutics Research Institute, Inje University College of Medicine, Busan, Korea.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Nov; Vol. 70 (11), pp. 3113-3122. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
B7 Antigens/*metabolism
Biomarkers, Tumor/*immunology
Lymphocytes, Tumor-Infiltrating/*metabolism
Neoplasm Recurrence, Local/*metabolism
Urinary Bladder Neoplasms/*pathology
Aged ; Biomarkers, Tumor/metabolism ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Middle Aged ; Neoplasm Recurrence, Local/immunology ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Smoking History Predicts High Presence of TILs and Efficacy of PD-1 Blockade in PD-L1 Expression-negative Non-small Cell Lung Cancer Patients.
Autorzy :
Shimoda Y; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.; Cancer Medicine, Cooperative Graduate School, The Jikei University Graduate School of Medicine, Tokyo, Japan.
Yoshida T; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan; .; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
Shirasawa M; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Mizuno T; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Jo H; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Matsumoto Y; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Shinno Y; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Okuma Y; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Goto Y; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Horinouchi H; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Yamamoto N; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
Yatabe Y; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
Ohe Y; Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.; Cancer Medicine, Cooperative Graduate School, The Jikei University Graduate School of Medicine, Tokyo, Japan.
Motoi N; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Nov; Vol. 41 (11), pp. 5739-5747.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Smokers*
B7-H1 Antigen/*antagonists & inhibitors
CD8-Positive T-Lymphocytes/*drug effects
Carcinoma, Non-Small-Cell Lung/*drug therapy
Immune Checkpoint Inhibitors/*therapeutic use
Lung Neoplasms/*drug therapy
Lymphocytes, Tumor-Infiltrating/*drug effects
Nivolumab/*therapeutic use
Smoking/*adverse effects
Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/immunology ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/mortality ; Female ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Lung Neoplasms/immunology ; Lung Neoplasms/mortality ; Lymphocytes, Tumor-Infiltrating/immunology ; Male ; Middle Aged ; Nivolumab/adverse effects ; Progression-Free Survival ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Smoking/immunology ; Time Factors
Czasopismo naukowe
Tytuł :
Development and validation of a PD-L1/PD-1/CD8 axis-based classifier to predict cancer survival of upper tract urothelial carcinoma after radical nephroureterectomy.
Autorzy :
Chen J; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Zhong W; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Yang M; Department of Urology, Yan' an Hospital of Kunming City, Kunming Medical University, Kunming, People's Republic of China.
Hou W; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Wang X; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Xia K; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Yu H; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Yang M; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Zhou B; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Wang B; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China. .; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. .
Huang J; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China. .; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. .
Lin T; Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen (Zhongshan) University, Guangzhou, 510120, People's Republic of China. .; Kashgar Prefecture First People's Hospital of Kashi, Xinjiang, People's Republic of China. .; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Sep; Vol. 70 (9), pp. 2657-2668. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor*
B7-H1 Antigen/*metabolism
CD8-Positive T-Lymphocytes/*metabolism
Lymphocytes, Tumor-Infiltrating/*metabolism
Programmed Cell Death 1 Receptor/*metabolism
Urethral Neoplasms/*etiology
Urethral Neoplasms/*mortality
Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/genetics ; CD8-Positive T-Lymphocytes/immunology ; Disease Susceptibility ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Nephroureterectomy ; Nomograms ; Prognosis ; Programmed Cell Death 1 Receptor/genetics ; ROC Curve ; Urethral Neoplasms/metabolism ; Urethral Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Metabolic profiles of regulatory T cells in the tumour microenvironment.
Autorzy :
Rao D; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
Verburg F; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
Renner K; Department of Internal Medicine III, Hematology and Medical Oncology, University Hospital Regensburg, Regensburg, Germany.
Peeper DS; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.
Lacroix R; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.
Blank CU; Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. .; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Sep; Vol. 70 (9), pp. 2417-2427. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Energy Metabolism*
Metabolome*
Tumor Microenvironment*/immunology
Lymphocytes, Tumor-Infiltrating/*metabolism
Neoplasms/*metabolism
T-Lymphocytes, Regulatory/*metabolism
Animals ; Disease Susceptibility ; Glycolysis ; Humans ; Immunomodulation ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/pathology ; Metabolomics/methods ; Mitochondria/genetics ; Mitochondria/metabolism ; Neoplasms/etiology ; Neoplasms/pathology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology
Czasopismo naukowe
Tytuł :
Functional HPV-specific PD-1 stem-like CD8 T cells in head and neck cancer.
Autorzy :
Eberhardt CS; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.; Centre for Vaccinology, University Hospitals Geneva, Geneva, Switzerland.; Division of General Pediatrics, Department of Pediatrics, Gynecology & Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Kissick HT; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Patel MR; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA, USA.
Cardenas MA; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Prokhnevska N; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Obeng RC; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Nasti TH; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Griffith CC; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.
Im SJ; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Immunology, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Wang X; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Shin DM; Division of General Pediatrics, Department of Pediatrics, Gynecology & Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Carrington M; Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD, USA.; Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Chen ZG; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Sidney J; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.
Sette A; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Saba NF; Winship Cancer Institute of Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Wieland A; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA. .; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. .
Ahmed R; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA. .; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. .; Winship Cancer Institute of Emory University, Atlanta, GA, USA. .
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Źródło :
Nature [Nature] 2021 Sep; Vol. 597 (7875), pp. 279-284. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Alphapapillomavirus/*immunology
CD8-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*immunology
Head and Neck Neoplasms/*immunology
Head and Neck Neoplasms/*virology
Lymphocytes, Tumor-Infiltrating/*immunology
Programmed Cell Death 1 Receptor/*metabolism
Stem Cells/*cytology
Alphapapillomavirus/isolation & purification ; CD8-Positive T-Lymphocytes/classification ; CD8-Positive T-Lymphocytes/metabolism ; Cancer Vaccines/immunology ; Cell Differentiation ; Cell Proliferation ; DNA-Binding Proteins/immunology ; Humans ; Lymphocytes, Tumor-Infiltrating/classification ; Lymphocytes, Tumor-Infiltrating/cytology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Oncogene Proteins, Viral/immunology ; Papillomavirus Infections/immunology ; Papillomavirus Infections/virology ; Papillomavirus Vaccines/immunology ; RNA-Seq ; Receptors, Antigen, T-Cell/immunology ; Single-Cell Analysis ; Stem Cells/immunology ; T Cell Transcription Factor 1/metabolism ; T-Lymphocytes/immunology ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Interplay of stromal tumor-infiltrating lymphocytes, normal colonic mucosa, cancer-associated fibroblasts, clinicopathological data and the immunoregulatory molecules of patients diagnosed with colorectal cancer.
Autorzy :
Zadka Ł; Department of Human Morphology and Embryology, Division of Histology and Embryology, Chałubińskiego 6a, 50-368, Wrocław, Poland. .
Chabowski M; Department of Clinical Proceedings, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland.; Department of Surgery, 4Th Military Teaching Hospital, Wroclaw, Poland.
Grybowski D; Department of Surgery, University of Chicago, Chicago, USA.
Piotrowska A; Department of Human Morphology and Embryology, Division of Histology and Embryology, Chałubińskiego 6a, 50-368, Wrocław, Poland.
Dzięgiel P; Department of Human Morphology and Embryology, Division of Histology and Embryology, Chałubińskiego 6a, 50-368, Wrocław, Poland.
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Sep; Vol. 70 (9), pp. 2681-2700. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cancer-Associated Fibroblasts/*immunology
Cancer-Associated Fibroblasts/*metabolism
Colorectal Neoplasms/*etiology
Colorectal Neoplasms/*metabolism
Intestinal Mucosa/*immunology
Intestinal Mucosa/*metabolism
Lymphocytes, Tumor-Infiltrating/*immunology
Lymphocytes, Tumor-Infiltrating/*metabolism
Antigens, Neoplasm ; Biomarkers, Tumor ; Cancer-Associated Fibroblasts/pathology ; Cell Communication ; Colorectal Neoplasms/diagnosis ; Humans ; Immunohistochemistry ; Immunomodulation ; Immunophenotyping ; Intestinal Mucosa/pathology ; Lymphocytes, Tumor-Infiltrating/pathology ; Models, Biological ; Neoplasm Staging ; Tissue Array Analysis ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Landscape of toll-like receptors expression in tumor microenvironment of triple negative breast cancer (TNBC): Distinct roles of TLR4 and TLR8.
Autorzy :
Roychowdhury A; Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, India.
Jondhale M; Department of Molecular and Cellular Biology, National Institute for Research on Reproductive Health, Mumbai, India.
Saldanha E; Medical Oncology Molecular Laboratory, Medical Oncology Department, Tata Memorial Hospital, Mumbai, India.
Ghosh D; Department of Life Science & Biotechnology, Jadavpur University, Kolkata, India.
Kumar Panda C; Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, India.
Chandrani P; Medical Oncology Molecular Laboratory, Medical Oncology Department, Tata Memorial Hospital, Mumbai, India; Centre for Computational Biology, Bioinformatics and Crosstalk Laboratory, ACTREC-Tata MemorialCentre, Navi Mumbai, India; Homi Bhabha National Institute, Mumbai, India.
Mukherjee N; Department of Molecular and Cellular Biology, National Institute for Research on Reproductive Health, Mumbai, India. Electronic address: .
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Źródło :
Gene [Gene] 2021 Aug 05; Vol. 792, pp. 145728. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Lymphocytes, Tumor-Infiltrating/*immunology
Toll-Like Receptor 4/*genetics
Toll-Like Receptor 8/*genetics
Triple Negative Breast Neoplasms/*genetics
Tumor Microenvironment/*genetics
Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Line, Tumor ; Computational Biology/methods ; Databases, Factual ; Female ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Lymphocytes, Tumor-Infiltrating/classification ; Lymphocytes, Tumor-Infiltrating/pathology ; Molecular Sequence Annotation ; Neoplasm Proteins/classification ; Neoplasm Proteins/genetics ; Neoplasm Proteins/immunology ; Paclitaxel/therapeutic use ; Signal Transduction ; Toll-Like Receptor 4/immunology ; Toll-Like Receptor 8/immunology ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/mortality ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells.
Autorzy :
Manukian G; Department of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Kivolowitz C; Department of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
DeAngelis T; Department of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Shastri AA; Department of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Savage JE; Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Camphausen K; Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Rodeck U; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.
Zarif JC; Department of Oncology, Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Simone NL; Department of Radiation Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address: .
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Źródło :
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2021 Aug 01; Vol. 110 (5), pp. 1341-1349. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Caloric Restriction*
Lymphocytes, Tumor-Infiltrating/*radiation effects
T-Lymphocytes, Regulatory/*radiation effects
Triple Negative Breast Neoplasms/*radiotherapy
Tumor Microenvironment/*radiation effects
Adult ; Aged ; Animals ; CD4-Positive T-Lymphocytes/chemistry ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/radiation effects ; CD8-Positive T-Lymphocytes/chemistry ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/radiation effects ; Combined Modality Therapy/methods ; Disease Progression ; Female ; Flow Cytometry ; Forkhead Transcription Factors ; Humans ; Interleukin Receptor Common gamma Subunit/blood ; Interleukin-10 Receptor beta Subunit/blood ; Interleukin-2 Receptor alpha Subunit ; Lymphocyte Depletion/methods ; Lymphocytes, Tumor-Infiltrating/cytology ; Lymphocytes, Tumor-Infiltrating/immunology ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Programmed Cell Death 1 Receptor/metabolism ; Random Allocation ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology ; Transforming Growth Factor beta2/blood ; Transforming Growth Factor beta3/blood ; Triple Negative Breast Neoplasms/blood ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/mortality ; Tumor Microenvironment/immunology
Czasopismo naukowe
Tytuł :
Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia.
Autorzy :
Zahran AM; Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Shibl A; Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Rayan A; Clinical Oncology Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Mohamed MAEH; Clinical Oncology Department, Faculty of Medicine, Assiut University, Assiut, 71516, Egypt.
Osman AMM; Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Saad K; Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt. .
Mahmoud KH; Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ghandour AMA; Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Elsayh KI; Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
El-Badawy O; Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
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Źródło :
Scientific reports [Sci Rep] 2021 Jul 22; Vol. 11 (1), pp. 15039. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lymphocytes, Tumor-Infiltrating/*immunology
Lymphocytes, Tumor-Infiltrating/*metabolism
Myeloid-Derived Suppressor Cells/*immunology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*etiology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*pathology
T-Lymphocytes, Regulatory/*immunology
T-Lymphocytes, Regulatory/*metabolism
Adolescent ; Age Factors ; Biomarkers ; Case-Control Studies ; Child ; Child, Preschool ; Disease Susceptibility ; Female ; Humans ; Immunophenotyping ; Infant ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Myeloid-Derived Suppressor Cells/metabolism ; Myeloid-Derived Suppressor Cells/pathology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Prognosis ; T-Lymphocytes, Regulatory/pathology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Abundant intratumoral fibrosis prevents lymphocyte infiltration into peritoneal metastases of colorectal cancer.
Autorzy :
Wang E; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Shibutani M; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Nagahara H; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Fukuoka T; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Iseki Y; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Okazaki Y; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Kashiwagi S; Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Tanaka H; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Maeda K; Department of Gastroenterological Surgery, Osaka City General Hospital, Miyakojima-ku, Osaka, Japan.
Hirakawa K; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Ohira M; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
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Źródło :
PloS one [PLoS One] 2021 Jul 22; Vol. 16 (7), pp. e0255049. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/pathology
Colorectal Neoplasms*/immunology
Colorectal Neoplasms*/pathology
Lymphocytes, Tumor-Infiltrating*/immunology
Lymphocytes, Tumor-Infiltrating*/pathology
Peritoneal Neoplasms*/immunology
Peritoneal Neoplasms*/pathology
Peritoneal Neoplasms*/secondary
Collagen/*immunology
Neoplasm Proteins/*immunology
Adult ; Aged ; Female ; Fibrosis ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells.
Autorzy :
Vito A; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Salem O; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
El-Sayes N; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
MacFawn IP; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Portillo AL; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Milne K; Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Harrington D; Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Ashkar AA; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Wan Y; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.; Department of Medicine, McMaster University, Hamilton, ON, Canada.
Workenhe ST; Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Nelson BH; Deeley Research Centre, BC Cancer, Victoria, BC, Canada.; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Bruno TC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Mossman KL; McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. .; Department of Medicine, McMaster University, Hamilton, ON, Canada. .
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Źródło :
Communications biology [Commun Biol] 2021 Jul 12; Vol. 4 (1), pp. 859. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*drug effects
Immune Checkpoint Inhibitors/*therapeutic use
Immunotherapy/*methods
Lymphocytes, Tumor-Infiltrating/*drug effects
Myeloid-Derived Suppressor Cells/*drug effects
Triple Negative Breast Neoplasms/*therapy
Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Line, Tumor ; Chlorocebus aethiops ; Combined Modality Therapy ; Female ; Humans ; Immune Checkpoint Inhibitors/immunology ; Kaplan-Meier Estimate ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Mice, Inbred C57BL ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Oncolytic Virotherapy/methods ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/pathology ; Vero Cells
Czasopismo naukowe
Tytuł :
Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC).
Autorzy :
Farrag MS; Department of Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt. .
Abdelwahab K; Department of Surgical Oncology, Mansoura Oncology Center, Mansoura University, Mansoura, Egypt.
Farrag NS; Department of Community Medicine and Public Health, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Elrefaie WE; Department of Obstetrics and Gynecology, Port Said Faculty of Medicine, Port Said University, Port Said, Egypt.
Emarah Z; Department of Medical Oncology, Mansoura Oncology Center, Mansoura University, Mansoura, Egypt.
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Źródło :
Journal of the Egyptian National Cancer Institute [J Egypt Natl Canc Inst] 2021 Jul 09; Vol. 33 (1), pp. 16. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
B7-H1 Antigen*/analysis
B7-H1 Antigen*/genetics
B7-H1 Antigen*/metabolism
Carcinoma*/mortality
Carcinoma*/therapy
CD8-Positive T-Lymphocytes/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Ovarian Neoplasms/*therapy
Adult ; Egypt ; Female ; Humans ; Immunohistochemistry ; Lymphocytes, Tumor-Infiltrating/chemistry ; Lymphocytes, Tumor-Infiltrating/pathology ; Middle Aged ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/mortality ; Prognosis ; Programmed Cell Death 1 Receptor ; Survival Analysis
Czasopismo naukowe
Tytuł :
5-Aminolevulinic acid/sodium ferrous citrate enhanced the antitumor effects of programmed cell death-ligand 1 blockade by regulation of exhausted T cell metabolism in a melanoma model.
Autorzy :
Hu X; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Que W; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Hirano H; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.; Hasumi International Research Foundation, Tokyo, Japan.
Wang Z; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Nozawa N; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Ishii T; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Ishizuka M; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Ito H; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Takahashi K; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Nakajima M; SBI Pharmaceuticals Co., Ltd., Tokyo, Japan.
Tanaka T; Neopharma Japan Co., Ltd., Tokyo, Japan.
Zhu P; Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Guo WZ; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li XK; Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.; Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Jul; Vol. 112 (7), pp. 2652-2663. Date of Electronic Publication: 2021 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Aminolevulinic Acid/*pharmacology
B7-H1 Antigen/*antagonists & inhibitors
Citric Acid/*pharmacology
Ferrous Compounds/*pharmacology
Lymphocyte Activation/*drug effects
Lymphocytes, Tumor-Infiltrating/*drug effects
Mitochondria/*drug effects
Adenosine Triphosphate/metabolism ; Animals ; Cell Line, Tumor ; Combined Modality Therapy ; Female ; Heme Oxygenase-1/metabolism ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Ki-67 Antigen/metabolism ; Lymphocyte Count ; Lymphocytes, Tumor-Infiltrating/cytology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Melanoma, Experimental/immunology ; Melanoma, Experimental/metabolism ; Melanoma, Experimental/pathology ; Melanoma, Experimental/therapy ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Nuclear Respiratory Factor 1/metabolism ; Oxygen Consumption/drug effects ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Sirtuin 1/metabolism
Czasopismo naukowe
Tytuł :
A Systematic Review and Meta-Analysis on the Significance of TIGIT in Solid Cancers: Dual TIGIT/PD-1 Blockade to Overcome Immune-Resistance in Solid Cancers.
Autorzy :
Hosseinkhani N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Shadbad MA; Research Center for Evidence-Based Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614766, Iran.
Asghari Jafarabadi M; Department of Statistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan 4513956184, Iran.; Center for the Development of Interdisciplinary Research in Islamic Sciences and Health Sciences, Tabriz University of Medical Sciences, Tabriz 4513956184, Iran.
Karim Ahangar N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Asadzadeh Z; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Mohammadi SM; Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan 4513956184, Iran.
Lotfinejad P; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Alizadeh N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Brunetti O; Medical Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II' of Bari, 70124 Bari, Italy.
Fasano R; Medical Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II' of Bari, 70124 Bari, Italy.
Silvestris N; Medical Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II' of Bari, 70124 Bari, Italy.; Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari, 70124 Bari, Italy.
Baradaran B; Research Center for Evidence-Based Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166614766, Iran.; Department of Immunology, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz 5166614766, Iran.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 27; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 27.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Tumor Escape*
CD8-Positive T-Lymphocytes/*immunology
Lymphocytes, Tumor-Infiltrating/*immunology
Neoplasm Proteins/*immunology
Neoplasms/*immunology
Programmed Cell Death 1 Receptor/*immunology
Receptors, Immunologic/*immunology
CD8-Positive T-Lymphocytes/pathology ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Immunotherapy ; Lymphocytes, Tumor-Infiltrating/pathology ; Neoplasms/pathology ; Neoplasms/therapy
Czasopismo naukowe
Tytuł :
Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer.
Autorzy :
Barmpoutis P; Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom.; Centre for Medical Image Computing, University College London, London, United Kingdom.
Di Capite M; Department of Histopathology, Norfolk and Norwich University Hospital, Norwich, United Kingdom.
Kayhanian H; Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom.
Waddingham W; Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom.
Alexander DC; Centre for Medical Image Computing, University College London, London, United Kingdom.
Jansen M; Department of Pathology, UCL Cancer Institute, University College London, London, United Kingdom.
Kwong FNK; Department of Histopathology, Norfolk and Norwich University Hospital, Norwich, United Kingdom.
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Źródło :
PloS one [PLoS One] 2021 Sep 23; Vol. 16 (9), pp. e0256907. Date of Electronic Publication: 2021 Sep 23 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Image Processing, Computer-Assisted/*statistics & numerical data
Immunohistochemistry/*methods
Lung Neoplasms/*pathology
Lymphocytes, Tumor-Infiltrating/*pathology
Tertiary Lymphoid Structures/*pathology
Automation, Laboratory ; Cell Count ; Coloring Agents ; Eosine Yellowish-(YS) ; Hematoxylin ; Humans ; Lung Neoplasms/diagnostic imaging ; Lymphocytes, Tumor-Infiltrating/immunology ; Sensitivity and Specificity ; Tertiary Lymphoid Structures/diagnostic imaging ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
Czasopismo naukowe

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