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Wyszukujesz frazę ""Lysine"" wg kryterium: Temat


Tytuł:
Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues.
Autorzy:
Weirich S; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Stuttgart, Germany.
Ulu GT; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Stuttgart, Germany.
Chandrasekaran TT; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Stuttgart, Germany.
Kehl J; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Stuttgart, Germany.
Schmid J; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Stuttgart, Germany.
Dorscht F; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Stuttgart, Germany.
Kublanovsky M; The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Levy D; The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Jeltsch A; Institute of Biochemistry and Technical Biochemistry, Department of Biochemistry, University of Stuttgart, Stuttgart, Germany.
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Źródło:
Protein science : a publication of the Protein Society [Protein Sci] 2024 Feb; Vol. 33 (2), pp. e4897.
Typ publikacji:
Journal Article
MeSH Terms:
Glutamine*/metabolism
Lysine*/metabolism
Site-Specific DNA-Methyltransferase (Adenine-Specific)*/genetics
Humans ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Methylation ; Peptides/chemistry ; Protein Methyltransferases/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł:
Lysine Methylation-Dependent Proteolysis by the Malignant Brain Tumor (MBT) Domain Proteins.
Autorzy:
Sun H; Department of Chemistry and Biochemistry, Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, 4505 South Maryland Parkway, P.O. Box 454003, Las Vegas, NV 89154-4003, USA.
Zhang H; Department of Chemistry and Biochemistry, Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, 4505 South Maryland Parkway, P.O. Box 454003, Las Vegas, NV 89154-4003, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Lysine*/metabolism
Brain Neoplasms*
Humans ; Proteolysis ; Methylation ; Protein Processing, Post-Translational ; Histones/metabolism ; Ubiquitins/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Chromosomal Proteins, Non-Histone/metabolism
Czasopismo naukowe
Tytuł:
Protein lysine acetyltransferase CBP/p300: A promising target for small molecules in cancer treatment.
Autorzy:
Gou P; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhang W; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: .
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Źródło:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Feb; Vol. 171, pp. 116130. Date of Electronic Publication: 2024 Jan 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Lysine Acetyltransferases*
Neoplasms*
Lysine/metabolism ; Histone Acetyltransferases/metabolism ; Transcription Factors ; Nucleosomes
Czasopismo naukowe
Tytuł:
Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies.
Autorzy:
Nil Z; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Deshwar AR; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Huang Y; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Barish S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Zhang X; Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China; National Health Commission Key Laboratory for Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410005, China.
Choufani S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Le Quesne Stabej P; Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, the University of Auckland, Auckland, New Zealand.
Hayes I; Genetic Health Service New Zealand- Northern Hub, Auckland District Health Board, Auckland, New Zealand.
Yap P; Genetic Health Service New Zealand- Northern Hub, Auckland District Health Board, Auckland, New Zealand.
Haldeman-Englert C; Mission Fullerton Genetics Center, Asheville, NC 28803, USA.
Wilson C; Mission Fullerton Genetics Center, Asheville, NC 28803, USA.
Prescott T; Department of Medical Genetics, Telemark Hospital Trust, 3710 Skien, Norway.
Tveten K; Department of Medical Genetics, Telemark Hospital Trust, 3710 Skien, Norway.
Vøllo A; Department of Pediatrics, Hospital of Østfold, 1714 Grålum, Norway.
Haynes D; Division of Genetics, Arnold Palmer Hospital for Children - Orlando Health, Orlando, FL, USA; Clinical Genetics Service, Guy's Hospital, Guy's and St Thomas' NHS Trust, London, England, UK.
Wheeler PG; Division of Genetics, Arnold Palmer Hospital for Children - Orlando Health, Orlando, FL, USA.
Zon J; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada.
Cytrynbaum C; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
Jobling R; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada.
Blyth M; North of Scotland Regional Genetics Service, Clinical Genetics Centre, Ashgrove House, Foresterhill, Aberdeen, UK.
Banka S; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9WL Manchester, UK; Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Health Innovation Manchester, M13 9WL Manchester, UK.
Afenjar A; Service de génétique, CRMR des malformations et maladies congénitales du cervelet et CRMR déficience intellectuelle, hôpital Trousseau, AP-HP, Paris, France.
Mignot C; Sorbonne Université, Département de Génétique, Groupe Hospitalier Pitié-Salpêtrière and Hôpital Trousseau, Paris, France; Centre de Référence Déficiences Intellectuelles de Causes Rares, Paris, France.
Robin-Renaldo F; AP-HP, Sorbonne Université, Service de Neurpoédiatrie, Hôpital Trousseau, Paris, France.
Keren B; AP-HP, Hôpital de la Pitié-Salpêtrière, Département de Génétique, 75013 Paris, France.
Kanca O; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Mao X; National Health Commission Key Laboratory for Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410005, China; Clinical Research Center for Placental Medicine in Hunan Province, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410005, China.
Wegner DJ; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sisco K; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shinawi M; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wangler MF; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Weksberg R; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada; Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Yamamoto S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Costain G; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: .
Bellen HJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: .
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Corporate Authors:
Undiagnosed Disease Network
Źródło:
American journal of human genetics [Am J Hum Genet] 2023 Nov 02; Vol. 110 (11), pp. 1919-1937. Date of Electronic Publication: 2023 Oct 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Histone-Lysine N-Methyltransferase*/genetics
Developmental Disabilities*/genetics
Congenital Abnormalities*/genetics
Humans ; Gain of Function Mutation ; Histones/genetics ; Histones/metabolism ; Lysine ; Methylation ; Methyltransferases/genetics ; Neoplasms/genetics ; Drosophila/genetics ; Drosophila Proteins/genetics
Czasopismo naukowe
Tytuł:
(R)-PFI-2 Analogues as Substrates and Inhibitors of Histone Lysine Methyltransferase SETD7.
Autorzy:
Porzberg MRB; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark.; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen (The, Netherlands.
Lenstra DC; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen (The, Netherlands.
Damen E; Symeres Netherlands B.V., Kerkenbos 1013, 6546 BB, Nijmegen (The, Netherlands.
Blaauw RH; Symeres Netherlands B.V., Kerkenbos 1013, 6546 BB, Nijmegen (The, Netherlands.
Rutjes FPJT; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen (The, Netherlands.
Wegert A; Symeres Netherlands B.V., Kerkenbos 1013, 6546 BB, Nijmegen (The, Netherlands.
Mecinović J; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark.
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Źródło:
ChemMedChem [ChemMedChem] 2023 Dec 01; Vol. 18 (23), pp. e202300457. Date of Electronic Publication: 2023 Nov 10.
Typ publikacji:
Journal Article
MeSH Terms:
Histone-Lysine N-Methyltransferase*
Histones*
Humans ; Lysine ; Pyrrolidines/pharmacology ; Pyrrolidines/chemistry
Czasopismo naukowe
Tytuł:
Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry.
Autorzy:
Pollin G; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI Center, Medical College of Wisconsin, Milwaukee, WI, U.S.A.
De Assuncao TM; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI Center, Medical College of Wisconsin, Milwaukee, WI, U.S.A.
Doria Jorge S; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, U.S.A.
Chi YI; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI Center, Medical College of Wisconsin, Milwaukee, WI, U.S.A.
Charlesworth MC; Medical Genome Facility, Proteomics Core, Mayo Clinic, Rochester, MN, U.S.A.
Madden B; Medical Genome Facility, Proteomics Core, Mayo Clinic, Rochester, MN, U.S.A.
Iovanna J; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.
Zimmermann MT; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Clinical and Translational Sciences Institute, Medical College of Wisconsin, Milwaukee, WI, U.S.A.
Urrutia R; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI Center, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, U.S.A.
Lomberk G; Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI Center, Medical College of Wisconsin, Milwaukee, WI, U.S.A.; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, U.S.A.
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Źródło:
Bioscience reports [Biosci Rep] 2023 Oct 31; Vol. 43 (10).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Histones*/genetics
Histones*/metabolism
Lysine*/metabolism
Humans ; Cell Cycle ; Cell Division ; Carcinogenesis ; Histocompatibility Antigens ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism
Czasopismo naukowe
Tytuł:
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
Autorzy:
Abini-Agbomson S; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Gretarsson K; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.
Shih RM; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA.
Hsieh L; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Lou T; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
De Ioannes P; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Vasilyev N; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Lee R; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Wang M; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
Simon MD; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Armache JP; Department of Biochemistry and Molecular Biology and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.
Nudler E; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Narlikar G; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Liu S; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA.
Lu C; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, USA.
Armache KJ; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2023 Aug 17; Vol. 83 (16), pp. 2872-2883.e7.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
Histone-Lysine N-Methyltransferase*/genetics
Histones*/genetics
Chromatin/genetics ; Cryoelectron Microscopy ; Heterochromatin/genetics ; Lysine ; Nucleosomes/genetics ; Humans
Czasopismo naukowe
Tytuł:
Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD-L1 cascade.
Autorzy:
Lv J; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Wu Q; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Li K; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Bai K; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Yu H; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhuang J; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Sun H; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Yang H; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Yang X; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Lu Q; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
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Źródło:
International journal of biological sciences [Int J Biol Sci] 2023 Jul 16; Vol. 19 (12), pp. 3744-3761. Date of Electronic Publication: 2023 Jul 16 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lysine*
Urinary Bladder Neoplasms*/metabolism
Humans ; Mice ; Animals ; Methyltransferases/genetics ; Methyltransferases/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Cell Transformation, Neoplastic ; Carcinogenesis ; Cell Proliferation/genetics ; Tumor Microenvironment ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł:
Radical SAM Enzyme PylB Generates a Lysyl Radical Intermediate in the Biosynthesis of Pyrrolysine by Using SAM as a Cofactor.
Autorzy:
Ma B; Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
Britt RD; Department of Chemistry, University of California, Davis, Davis, California 95616, United States.
Tao L; Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
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Źródło:
Journal of the American Chemical Society [J Am Chem Soc] 2024 Mar 13; Vol. 146 (10), pp. 6544-6556. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Lysine*/*analogs & derivatives
Lysine*/chemistry
S-Adenosylmethionine*
Genetic Code ; Amides/metabolism
Czasopismo naukowe
Tytuł:
Comparative Study of the Effects of Dietary-Free and -Bound Nε-Carboxymethyllysine on Gut Microbiota and Intestinal Barrier.
Autorzy:
Yuan X; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Liu J; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Nie C; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Ma Q; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Wang C; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Liu H; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Chen Z; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Zhang M; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Li J; College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
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Źródło:
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Mar 06; Vol. 72 (9), pp. 5014-5025. Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Lysine*/*analogs & derivatives
Lysine*/metabolism
Gastrointestinal Microbiome*
Animals ; Mice ; Intestines ; Diet
Czasopismo naukowe
Tytuł:
Quantitative Acetylomics Reveals Substrates of Lysine Acetyltransferase GCN5 in Adult and Aging Drosophila .
Autorzy:
Li J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Cao Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Yang Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Ma H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhao J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.; Shanghai Key Laboratory of Aging Studies, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.
Liu N; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.; Shanghai Key Laboratory of Aging Studies, 100 Hai Ke Rd., Pudong, Shanghai 201210, China.
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Źródło:
Journal of proteome research [J Proteome Res] 2023 Sep 01; Vol. 22 (9), pp. 2909-2924. Date of Electronic Publication: 2023 Aug 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Histone Acetyltransferases*/metabolism
Lysine Acetyltransferases*/metabolism
Drosophila Proteins*/metabolism
Animals ; Acetylation ; Drosophila ; Lysine/metabolism
Czasopismo naukowe
Tytuł:
Regulation of EBNA1 protein stability and DNA replication activity by PLOD1 lysine hydroxylase.
Autorzy:
Dheekollu J; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Wiedmer A; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Soldan SS; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Castro-Muñoz LJ; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Chen C; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Tang HY; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Speicher DW; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
Lieberman PM; The Wistar Institute, Philadelphia, Pennsylvania, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Jun 01; Vol. 19 (6), pp. e1010478. Date of Electronic Publication: 2023 Jun 01 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase*/genetics
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase*/metabolism
Epstein-Barr Virus Infections*/genetics
Humans ; Herpesvirus 4, Human/genetics ; Lysine/genetics ; Proteomics ; DNA Replication ; Epstein-Barr Virus Nuclear Antigens/metabolism ; Virus Replication ; Protein Stability ; Plasmids ; Replication Origin
Czasopismo naukowe
Tytuł:
Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP.
Autorzy:
Feng Z; Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.; School of Pharmacy, Guilin Medical University, Zhiyuan Road, Lingui District, Guilin 541199, China.
Yang C; Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Zhang Y; Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Li H; Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.; School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Fang W; Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Wang J; The Department of Biliary-Pancreatic Surgery, The First People's Hospital of Foshan, Foshan 528000, China.
Nie Y; Clinical Research Institute, The First People's Hospital of Foshan, Foshan 528000, China.
Wang CY; School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Liu Z; School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Jiang Z; School of Pharmacy, Guilin Medical University, Zhiyuan Road, Lingui District, Guilin 541199, China.
Wang J; Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Wang Y; Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2023 Jun 22; Vol. 66 (12), pp. 8086-8102. Date of Electronic Publication: 2023 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lysine*
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/therapeutic use
Enzyme Inhibitors*/chemistry
Humans ; Histones/metabolism ; Structure-Activity Relationship ; Histone-Lysine N-Methyltransferase
Czasopismo naukowe
Tytuł:
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Autorzy:
Tang M; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Chen G; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Tu B; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hu Z; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Huang Y; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
DuFort CC; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Wan X; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Mao Z; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Liu Y; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China.
Zhu WG; Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University International Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.
Lu W; Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
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Źródło:
Science advances [Sci Adv] 2023 Jun 16; Vol. 9 (24), pp. eade6624. Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:
Journal Article
MeSH Terms:
CD8-Positive T-Lymphocytes*
DNA End-Joining Repair*
Ku Autoantigen*/metabolism
Histone-Lysine N-Methyltransferase*/metabolism
Chromatin ; Lysine
Czasopismo naukowe
Tytuł:
SET7 methylates the deubiquitinase OTUB1 at Lys to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis.
Autorzy:
Deng H; College of Life Science, Wuhan University, Wuhan, P. R. China; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China.
Jia S; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Tang J; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Rong F; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Xu C; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Chen X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Wang Z; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Zhu C; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Sun X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Liao Q; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Liu W; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China.
Li W; College of Life Science, Wuhan University, Wuhan, P. R. China. Electronic address: .
Xiao W; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China; Hubei Hongshan Laboratory, Wuhan, P. R. China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, P. R. China. Electronic address: .
Liu X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, P. R. China; University of Chinese Academy of Sciences, Beijing, P. R. China; Hubei Hongshan Laboratory, Wuhan, P. R. China. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 103054. Date of Electronic Publication: 2023 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Deubiquitinating Enzymes*/metabolism
Ferroptosis*
Histone-Lysine N-Methyltransferase*/metabolism
Ubiquitin-Conjugating Enzymes*
Lysine/metabolism ; Protein Binding ; Reactive Oxygen Species/metabolism ; Ubiquitination ; Humans
Czasopismo naukowe
Tytuł:
The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots.
Autorzy:
Giannattasio T; University of Rome 'Tor Vergata', Section of Anatomy, Via Montpellier, 1, 00133, Rome, Italy.
Testa E; University of Rome 'Tor Vergata', Section of Anatomy, Via Montpellier, 1, 00133, Rome, Italy.
Palombo R; Laboratory of Molecular and Cellular Neurobiology, Fondazione Santa Lucia, CERC, 00143, Rome, Italy.
Chellini L; Laboratory of Molecular and Cellular Neurobiology, Fondazione Santa Lucia, CERC, 00143, Rome, Italy.
Franceschini F; University of Rome 'Tor Vergata', Section of Anatomy, Via Montpellier, 1, 00133, Rome, Italy.
Crevenna Á; European Molecular Biology Laboratory, Neurobiology and Epigenetics Unit, Monterotondo, Italy.
Petkov PM; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Paronetto MP; Laboratory of Molecular and Cellular Neurobiology, Fondazione Santa Lucia, CERC, 00143, Rome, Italy. .; Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis 6, 00135, Rome, Italy. .
Barchi M; University of Rome 'Tor Vergata', Section of Anatomy, Via Montpellier, 1, 00133, Rome, Italy. .
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Źródło:
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2023 Mar 26; Vol. 80 (4), pp. 107. Date of Electronic Publication: 2023 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
Lysine*/genetics
RNA-Binding Protein FUS*/genetics
Animals ; Male ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Homologous Recombination ; DNA/metabolism ; Meiosis/genetics ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
Targeting Epigenetic Changes Mediated by Members of the SMYD Family of Lysine Methyltransferases.
Autorzy:
Padilla A; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1617, USA.
Manganaro JF; Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.
Huesgen L; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1617, USA.
Roess DA; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1617, USA.
Brown MA; Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523-1005, USA.; Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523-1678, USA.; Graduate Degree Program in Ecology, Department of Ethnic Studies, Global Health and Health Disparities, Colorado School of Public Health, Colorado State University, Fort Collins, CO 80523-1612, USA.
Crans DC; Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA.; Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523-1005, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 20; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Epigenesis, Genetic*
Histone-Lysine N-Methyltransferase*/metabolism
Humans ; DNA-Binding Proteins/metabolism ; Histones/metabolism ; Lysine/metabolism ; Transcription Factors/metabolism ; Neoplasms/genetics
Czasopismo naukowe
Tytuł:
Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition.
Autorzy:
Maghsoud Y; Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas 75080, United States.
Vázquez-Montelongo EA; Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Yang X; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Liu C; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Jing Z; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Lee J; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.
Harger M; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Smith AK; Department of Chemistry, University of North Texas, Denton, Texas 76201, United States.
Espinoza M; Department of Chemistry, University of North Texas, Denton, Texas 76201, United States.
Guo HF; Department of Molecular and Cellular Biochemistry, College of Medicine, The University of Kentucky, Lexington, Kentucky 40536, United States.
Kurie JM; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77005, United States.
Dalby KN; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.
Ren P; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Cisneros GA; Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas 75080, United States.; Department of Physics, The University of Texas at Dallas, Richardson, Texas 75080, United States.
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Źródło:
Journal of chemical information and modeling [J Chem Inf Model] 2023 Feb 13; Vol. 63 (3), pp. 986-1001. Date of Electronic Publication: 2023 Jan 30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hydroxylysine*
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase*/antagonists & inhibitors
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase*/chemistry
Collagen/chemistry ; Collagen/metabolism ; Ferrous Compounds ; Lysine/metabolism
Czasopismo naukowe
Tytuł:
The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization.
Autorzy:
Dashti P; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
van de Peppel J; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Thaler R; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Paradise CR; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Stein GS; Department of Biochemistry, University of Vermont, Burlington, VT, USA.
Montecino MA; Institute of Biomedical Sciences, Universidad Andres Bello, Santiago, Chile.
van Leeuwen JPTM; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
van der Eerden BJ; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Dudakovic A; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address: .
van Wijnen AJ; Department of Biochemistry, University of Vermont, Burlington, VT, USA. Electronic address: .
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Źródło:
Gene [Gene] 2023 Jan 30; Vol. 851, pp. 146928. Date of Electronic Publication: 2022 Sep 30.
Typ publikacji:
Journal Article
MeSH Terms:
Enhancer of Zeste Homolog 2 Protein*/genetics
Enhancer of Zeste Homolog 2 Protein*/metabolism
Lysine*/metabolism
Mice ; Animals ; Humans ; Methyltransferases/metabolism ; RNA, Small Interfering/metabolism ; Calcium/metabolism ; MYND Domains ; Osteoblasts/metabolism ; Histones/metabolism ; Cell Proliferation/genetics ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism
Czasopismo naukowe
Tytuł:
Structural and Energetic Origin of Different Product Specificities and Activities for SETD3 and Its Mutants on the Methylation of the β-Actin H73K Peptide: Insights from a QM/MM Study.
Autorzy:
Zhao YY; Chemistry and Material Science Faculty, Shandong Agricultural University, Taian 271018, P. R. China.
Xu XL; Chemistry and Material Science Faculty, Shandong Agricultural University, Taian 271018, P. R. China.
Deng H; Chemistry and Material Science Faculty, Shandong Agricultural University, Taian 271018, P. R. China.
Wang KN; Chemistry and Material Science Faculty, Shandong Agricultural University, Taian 271018, P. R. China.
Rahman A; Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, United States.
Ma Y; Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, United States.
Shaik F; Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, United States.
Wang CM; Network Technology Center, Fushun Vocational Technical Institute, Fushun 110172, P. R. China.
Qian P; Chemistry and Material Science Faculty, Shandong Agricultural University, Taian 271018, P. R. China.; Key Laboratory of Agricultural Film Application of Ministry of Agriculture and Rural Affairs, Taian 271018, P. R. China.
Guo H; Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, United States.
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Źródło:
Journal of chemical theory and computation [J Chem Theory Comput] 2023 Jan 10; Vol. 19 (1), pp. 349-362. Date of Electronic Publication: 2022 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Histone-Lysine N-Methyltransferase*/genetics
Histone-Lysine N-Methyltransferase*/chemistry
Actins*/chemistry
Methylation ; Lysine/chemistry ; Molecular Dynamics Simulation ; Peptides/metabolism
Czasopismo naukowe

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