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Wyszukujesz frazę ""Lysosomes"" wg kryterium: Temat


Tytuł:
The Apical Endocytic-Lysosomal Apparatus in CLCN5 Mutations with Phenotypic-Genotypic Correlations in Three Cases.
Autorzy:
Kalmár T; Department of Pediatrics, Albert Szent-Györgyi Medical School and Health Center, University of Szeged, 6720 Szeged, Hungary.
Jakab D; Department of Pediatrics, Albert Szent-Györgyi Medical School and Health Center, University of Szeged, 6720 Szeged, Hungary.
Maróti Z; Department of Pediatrics, Albert Szent-Györgyi Medical School and Health Center, University of Szeged, 6720 Szeged, Hungary.
Lakatos O; Department of Pediatrics, University of Pécs, 7624 Pécs, Hungary.
Vas T; Department of Internal Medicine, University of Pécs, 7624 Pécs, Hungary.
Bereczki C; Department of Pediatrics, Albert Szent-Györgyi Medical School and Health Center, University of Szeged, 6720 Szeged, Hungary.
Iványi B; Institute of Pathology, Albert Szent-Györgyi Medical School and Health Center, University of Szeged, 6720 Szeged, Hungary.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 12; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 12.
Typ publikacji:
Case Reports
MeSH Terms:
Lysosomes*
Glomerulosclerosis, Focal Segmental*
Male ; Humans ; Mutation ; Frameshift Mutation ; Mutation, Missense ; Proteinuria
Raport
Tytuł:
Fluorogenic Rhodamine Probes with Pyrrole Substitution Enables STED and Lifetime Imaging of Lysosomes in Live Cells.
Autorzy:
Zhou Y; Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, P. R. China.
Wang Q; Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, P. R. China.
Chanmungkalakul S; Fluorescence Research Group, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore.
Wu X; Fluorescence Research Group, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore.
Xiao H; Colledge of Life Science, Shaanxi Normal University, Xi'an, 710119, P. R. China.
Miao R; Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, P. R. China.
Liu X; Fluorescence Research Group, Singapore University of Technology and Design, 8 Somapah Road, Singapore, 487372, Singapore.
Fang Y; Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, P. R. China.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Mar 12; Vol. 30 (15), pp. e202303707. Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorescent Dyes*/chemistry
Lysosomes*/chemistry
Humans ; Rhodamines/chemistry ; HeLa Cells ; Microscopy, Fluorescence/methods
Czasopismo naukowe
Tytuł:
Lysosomal enzyme trafficking: from molecular mechanisms to human diseases.
Autorzy:
Braulke T; Department of Osteology and Biomechanics, Cell Biology of Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Carette JE; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Palm W; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: .
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Źródło:
Trends in cell biology [Trends Cell Biol] 2024 Mar; Vol. 34 (3), pp. 198-210. Date of Electronic Publication: 2023 Jul 18.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Carrier Proteins*/metabolism
Lysosomes*/metabolism
Humans
Czasopismo naukowe
Tytuł:
Three-Four Photon Transition Mn(II) Complex Monitoring Lysosome-Related ATP in Real Time via Fluorescence Lifetime Imaging.
Autorzy:
Li Y; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Zhang Q; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Wang Q; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Wang X; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Wang J; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Zhu X; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Chen X; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Wang S; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Sun X; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.
Zhou H; School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Key Laboratory of Structure and Functional Regulation of Hybrid Materials Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, and Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Anhui University, Hefei 230601, P. R. China.; School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, P. R. China.
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Źródło:
Analytical chemistry [Anal Chem] 2024 Feb 27; Vol. 96 (8), pp. 3535-3543. Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Lysosomes*
Fluorescent Dyes*
Microscopy, Fluorescence/methods ; Optical Imaging ; Photons ; Microscopy, Fluorescence, Multiphoton/methods
Czasopismo naukowe
Tytuł:
A SPLICS reporter reveals [Formula: see text]-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation.
Autorzy:
Giamogante F; Department of Biomedical Sciences (DSB), University of Padova, Padova, Italy.
Barazzuol L; Department of Biomedical Sciences (DSB), University of Padova, Padova, Italy.
Maiorca F; Department of Biology (DIBIO), University of Padova, Padova, Italy.
Poggio E; Department of Biology (DIBIO), University of Padova, Padova, Italy.
Esposito A; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Department of Medical and Translational Science, Federico II University, Naples, Italy.
Masato A; Department of Biology (DIBIO), University of Padova, Padova, Italy.; UK-Dementia Research Institute at UCL, University College London, London, UK.
Napolitano G; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Department of Medical and Translational Science, Federico II University, Naples, Italy.
Vagnoni A; Department of Basic and Clinical Neurosciences, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Calì T; Department of Biomedical Sciences (DSB), University of Padova, Padova, Italy. .; Padova Neuroscience Center (PNC), University of Padova, Padova, Italy. .; Study Center for Neurodegeneration (CESNE), University of Padova, Padova, Italy. .
Brini M; Department of Biology (DIBIO), University of Padova, Padova, Italy. .; Study Center for Neurodegeneration (CESNE), University of Padova, Padova, Italy. .; Department of Pharmaceutical and Pharmacological Sciences (DSF), University of Padova, Padova, Italy. .
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Źródło:
Nature communications [Nat Commun] 2024 Feb 19; Vol. 15 (1), pp. 1516. Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article
MeSH Terms:
Lysosomes*/metabolism
Mitochondria*/metabolism
Mitochondrial Membranes*/metabolism
Autophagy ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Membrane Proteins/metabolism ; Mitophagy/genetics ; alpha-Synuclein/metabolism ; Active Transport, Cell Nucleus/genetics
Czasopismo naukowe
Tytuł:
Fast detection of hypobromous acid in cells and the water environment using a lysosome-targeted fluorescent probe.
Autorzy:
Du QR; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. .
Peng M; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. .
Tian Y; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. .
Yao X; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. .
Zheng J; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. .
Peng Y; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. .
Wang YW; School of Chemistry & School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. .
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Źródło:
Organic & biomolecular chemistry [Org Biomol Chem] 2024 Feb 07; Vol. 22 (6), pp. 1219-1224. Date of Electronic Publication: 2024 Feb 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluorescent Dyes*
Lysosomes*
Bromates ; Water
Czasopismo naukowe
Tytuł:
Loss of Dja2 accompanies pH deviation in lysosomes and lysosome-related organelles.
Autorzy:
Terada K; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Endo M; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kiyonari H; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamic Research, Kobe, Japan.
Takeda N; Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan.
Oike Y; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
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Źródło:
Journal of cellular physiology [J Cell Physiol] 2024 Feb; Vol. 239 (2), pp. e31174. Date of Electronic Publication: 2023 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
Lysosomes*/metabolism
Protons*
Animals ; Mice ; Biological Transport ; Hydrogen-Ion Concentration ; Macrophages, Alveolar ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł:
Organelle morphology and positioning orchestrate physiological and disease-associated processes.
Autorzy:
Jerabkova-Roda K; Tumor Biomechanics, INSERM UMR_S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France; Equipe Labellisée Ligue Contre le Cancer, France. Electronic address: .
Marwaha R; Tata Institute of Fundamental Research Hyderabad (TIFR-H), Hyderabad, 500 046, India.
Das T; Tata Institute of Fundamental Research Hyderabad (TIFR-H), Hyderabad, 500 046, India.
Goetz JG; Tumor Biomechanics, INSERM UMR_S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France; Equipe Labellisée Ligue Contre le Cancer, France.
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Źródło:
Current opinion in cell biology [Curr Opin Cell Biol] 2024 Feb; Vol. 86, pp. 102293. Date of Electronic Publication: 2023 Dec 13.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Organelles*/metabolism
Lysosomes*/metabolism
Homeostasis
Czasopismo naukowe
Tytuł:
Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control.
Autorzy:
Wible DJ; Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Parikh Z; Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Cho EJ; Targeted Therapeutic Drug Discovery and Development Program, Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA.
Chen MD; Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Jeter CR; Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.
Mukhopadhyay S; Division of Pharmacology & Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA.
Dalby KN; Targeted Therapeutic Drug Discovery and Development Program, Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA.
Varadarajan S; Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3BX, UK.
Bratton SB; Department of Epigenetics & Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA. .
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Źródło:
Cell death & disease [Cell Death Dis] 2024 Jan 22; Vol. 15 (1), pp. 80. Date of Electronic Publication: 2024 Jan 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Lysosomes*
Endosomes*
Hydrazones*
Morpholines*
Pyrimidines*
Phosphatidylinositol Phosphates ; Imidazoles/pharmacology
Czasopismo naukowe
Tytuł:
Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity.
Autorzy:
Yu Y; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.; Huffington Center on Aging, Baylor College of Medicine, Houston, United States.
Gao SM; Developmental Biology Graduate Program, Baylor College of Medicine, Houston, United States.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Guan Y; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.; Molecular and Cellular Biology Graduate Program, Baylor College of Medicine, Houston, United States.
Hu PW; Huffington Center on Aging, Baylor College of Medicine, Houston, United States.
Zhang Q; Huffington Center on Aging, Baylor College of Medicine, Houston, United States.
Liu J; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.
Jing B; State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.
Zhao Q; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Sabatini DM; Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic.
Abu-Remaileh M; Institute for Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Stanford, United States.; Department of Chemical Engineering and Genetics, Stanford University, Stanford, United States.
Jung SY; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Wang MC; Huffington Center on Aging, Baylor College of Medicine, Houston, United States.; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
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Źródło:
ELife [Elife] 2024 Jan 19; Vol. 13. Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Proteomics*
Lysosomes*/metabolism
Intracellular Membranes/metabolism ; Proteome/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
Uncovering impaired mitochondrial and lysosomal function in adipose-derived stem cells from obese individuals with altered biological activity.
Autorzy:
Wang B; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. Box 329#, Shanghai, 200237, People's Republic of China.; State Key Laboratory of Oncogenes and Related Genes, and Renji-MedX Clinical Stem Cell Research Center RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People's Republic of China.
Zhang G; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. Box 329#, Shanghai, 200237, People's Republic of China.; State Key Laboratory of Oncogenes and Related Genes, and Renji-MedX Clinical Stem Cell Research Center RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People's Republic of China.
Hu Y; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. Box 329#, Shanghai, 200237, People's Republic of China.
Mohsin A; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. Box 329#, Shanghai, 200237, People's Republic of China.
Chen Z; State Key Laboratory of Oncogenes and Related Genes, and Renji-MedX Clinical Stem Cell Research Center RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People's Republic of China.
Hao W; State Key Laboratory of Oncogenes and Related Genes, and Renji-MedX Clinical Stem Cell Research Center RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People's Republic of China.
Li Z; Department of Respiratory Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Xuhui District, Shanghai, 200235, People's Republic of China. .
Gao WQ; State Key Laboratory of Oncogenes and Related Genes, and Renji-MedX Clinical Stem Cell Research Center RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People's Republic of China. .; Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China. .
Guo M; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., P.O. Box 329#, Shanghai, 200237, People's Republic of China. guo_.
Xu H; State Key Laboratory of Oncogenes and Related Genes, and Renji-MedX Clinical Stem Cell Research Center RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People's Republic of China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2024 Jan 08; Vol. 15 (1), pp. 12. Date of Electronic Publication: 2024 Jan 08.
Typ publikacji:
Journal Article
MeSH Terms:
Lysosomes*
Obesity*/therapy
Humans ; Phagocytosis ; Adiposity ; Antioxidants ; Stem Cells
Czasopismo naukowe
Tytuł:
A surge of cytosolic calcium dysregulates lysosomal function and impairs autophagy flux during cupric chloride-induced neuronal death.
Autorzy:
Kim Y; Department of Systems Biology Yonsei University College of Life Science and Biotechnology, Seoul, Korea.
Lee Y; Glycosylation Network Research Center, Yonsei University, Seoul, Korea.
Choo M; Department of Systems Biology Yonsei University College of Life Science and Biotechnology, Seoul, Korea.
Yun N; Department of Systems Biology Yonsei University College of Life Science and Biotechnology, Seoul, Korea; GNT Pharma Science Technology Center for Health, Incheon, Korea.
Cho JW; Department of Systems Biology Yonsei University College of Life Science and Biotechnology, Seoul, Korea; Glycosylation Network Research Center, Yonsei University, Seoul, Korea. Electronic address: .
Oh YJ; Department of Systems Biology Yonsei University College of Life Science and Biotechnology, Seoul, Korea; GNT Pharma Science Technology Center for Health, Incheon, Korea. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105479. Date of Electronic Publication: 2023 Nov 21.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*/drug effects
Autophagy*/genetics
Calcium*/metabolism
Copper*/pharmacology
Dopaminergic Neurons*/cytology
Dopaminergic Neurons*/drug effects
Dopaminergic Neurons*/metabolism
Dopaminergic Neurons*/ultrastructure
Lysosomes*/metabolism
Animals ; Mice ; Cell Line ; Cell Survival/drug effects ; Cytosol/metabolism
Czasopismo naukowe
Tytuł:
Phospholipid-inspired alkoxylation induces crystallization and cellular uptake of luminescent COF nanocarriers.
Autorzy:
Zhang W; College of Materials Science and Engineering, Hunan University, 2 Lushan S Rd, Changsha, 410082, PR China.
Xiang S; College of Materials Science and Engineering, Hunan University, 2 Lushan S Rd, Changsha, 410082, PR China.
Han Y; College of Materials Science and Engineering, Hunan University, 2 Lushan S Rd, Changsha, 410082, PR China.
Wang H; College of Materials Science and Engineering, Hunan University, 2 Lushan S Rd, Changsha, 410082, PR China.
Deng Y; College of Materials Science and Engineering, Hunan University, 2 Lushan S Rd, Changsha, 410082, PR China.
Bian P; Lanzhou University Second Hospital, No. 82 Cuiyingmen, Lanzhou, 730030, PR China. Electronic address: ery_.
Bando Y; Australian Institute for Innovative Materials, University of Wollongong, Squires Way, North Wollongong, New South Wales, 2500, Australia; Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Golberg D; Centre for Materials Science and School of Chemistry and Physics, Queensland University of Technology (QUT), 2 George Street, Brisbane, 4000, QLD, Australia; Research Centre for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki, 305, Japan.
Weng Q; College of Materials Science and Engineering, Hunan University, 2 Lushan S Rd, Changsha, 410082, PR China. Electronic address: .
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Źródło:
Biomaterials [Biomaterials] 2024 Apr; Vol. 306, pp. 122503. Date of Electronic Publication: 2024 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Luminescence*
Lysosomes*
Crystallization ; Biological Transport ; Apoptosis
Czasopismo naukowe
Tytuł:
Copper-independent lysosomal localisation of the Wilson disease protein ATP7B.
Autorzy:
Maji S; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India.
Pirozzi M; Institute of Endocrinology and Experimental Oncology, Napoli, Italy.
Ruturaj; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India.
Pandey R; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India.
Ghosh T; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India.
Das S; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India.
Gupta A; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India.
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Źródło:
Traffic (Copenhagen, Denmark) [Traffic] 2023 Dec; Vol. 24 (12), pp. 587-609. Date of Electronic Publication: 2023 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Copper*/metabolism
Lysosomes*/metabolism
Copper-Transporting ATPases/metabolism ; Protein Transport ; Exocytosis
Czasopismo naukowe
Tytuł:
Nutrient-regulated control of lysosome function by signaling lipid conversion.
Autorzy:
Ebner M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Puchkov D; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
López-Ortega O; Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.
Muthukottiappan P; Institute for Biochemistry and Molecular Biology, Medical Faculty, Rheinische Friedrich-Wilhelms-University of Bonn, 53115 Bonn, Germany.
Su Y; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Schmied C; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Zillmann S; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Nikonenko I; Department of Basic Neurosciences and the Center for Neuroscience, CMU, University of Geneva, 1211 Geneva 4, Switzerland.
Koddebusch J; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Dornan GL; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Lucht MT; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Koka V; Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.
Jang W; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Koch PA; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Wallroth A; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Lehmann M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Brügger B; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Pende M; Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.
Winter D; Institute for Biochemistry and Molecular Biology, Medical Faculty, Rheinische Friedrich-Wilhelms-University of Bonn, 53115 Bonn, Germany.
Haucke V; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany; Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: .
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Źródło:
Cell [Cell] 2023 Nov 22; Vol. 186 (24), pp. 5328-5346.e26. Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lysosomes*/metabolism
Signal Transduction*
Mechanistic Target of Rapamycin Complex 1/metabolism ; Nutrients ; Cell Physiological Phenomena
Czasopismo naukowe
Tytuł:
Stress granules plug and stabilize damaged endolysosomal membranes.
Autorzy:
Bussi C; The Francis Crick Institute, London, UK. .
Mangiarotti A; Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
Vanhille-Campos C; Institute of Science and Technology Austria, Klosterneuburg, Austria.; Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, UK.
Aylan B; The Francis Crick Institute, London, UK.
Pellegrino E; The Francis Crick Institute, London, UK.
Athanasiadi N; The Francis Crick Institute, London, UK.
Fearns A; The Francis Crick Institute, London, UK.
Rodgers A; The Francis Crick Institute, London, UK.
Franzmann TM; Center for Molecular and Cellular Bioengineering, Biotechnology Center, Technische Universität Dresden, Dresden, Germany.
Šarić A; Institute of Science and Technology Austria, Klosterneuburg, Austria.
Dimova R; Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
Gutierrez MG; The Francis Crick Institute, London, UK. .
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Źródło:
Nature [Nature] 2023 Nov; Vol. 623 (7989), pp. 1062-1069. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Endosomes*/metabolism
Endosomes*/microbiology
Endosomes*/pathology
Intracellular Membranes*/metabolism
Intracellular Membranes*/microbiology
Intracellular Membranes*/pathology
Lysosomes*/metabolism
Lysosomes*/microbiology
Lysosomes*/pathology
Stress Granules*/metabolism
Macrophages*/metabolism
Macrophages*/microbiology
Macrophages*/pathology
Humans ; Endosomal Sorting Complexes Required for Transport/metabolism ; Mycobacterium tuberculosis/metabolism ; In Vitro Techniques
Czasopismo naukowe
Tytuł:
Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy.
Autorzy:
Lee YY; Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Ha J; Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Kim YS; Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Ramani S; Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Sung S; Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Gil ES; Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Choo OS; Department of Otorhinolaryngology-Head and Neck Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Republic of Korea.
Jang JH; Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Choung YH; Department of Otolaryngology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.; Department of Medical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 15; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*
Lysosomes*/metabolism
Hearing Loss*/metabolism
Animals ; Mice ; Atorvastatin/pharmacology ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Signal Transduction ; Cholesterol/metabolism
Czasopismo naukowe
Tytuł:
Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair.
Autorzy:
Corkery D; Department of Chemistry, Umeå University, Umeå Centre for Microbial Research, Umeå, SE-90187, Sweden.
Ursu A; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
Lucas B; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
Grigalunas M; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
Kriegler S; Physical Chemistry I - Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Oliva R; Physical Chemistry I - Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Present address: Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, Naples, 80126, Italy.
Dec R; Physical Chemistry I - Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Koska S; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
Pahl A; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
Sievers S; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
Ziegler S; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
Winter R; Physical Chemistry I - Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Wu YW; Department of Chemistry, Umeå University, Umeå Centre for Microbial Research, Umeå, SE-90187, Sweden.
Waldmann H; Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, Dortmund, 44227, Germany.
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Źródło:
Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Dec 14; Vol. 24 (24), pp. e202300579. Date of Electronic Publication: 2023 Nov 07.
Typ publikacji:
Journal Article
MeSH Terms:
Autophagy*
Lysosomes*
Biological Transport ; Galectin 3 ; Endosomal Sorting Complexes Required for Transport/metabolism
Czasopismo naukowe
Tytuł:
Screening of four lysosome-related genes in sepsis based on RNA sequencing technology.
Autorzy:
Chen G; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Department of Emergency Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Zhang W; Department of Endocrinology and Metabolism, The Traditional Chinese Medicine Hospital of Luzhou City, Luzhou, Sichuan, China.
Wang C; Department of Emergency Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Chen M; Department of Emergency Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Hu Y; Department of Emergency Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Wang Z; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. .
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Źródło:
BMC immunology [BMC Immunol] 2023 Dec 06; Vol. 24 (1), pp. 50. Date of Electronic Publication: 2023 Dec 06.
Typ publikacji:
Meta-Analysis; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lysosomes*/genetics
Sepsis*/genetics
Humans ; Gene Ontology ; Guanine Nucleotide Exchange Factors ; Sequence Analysis, RNA ; Prognosis
Czasopismo naukowe
Tytuł:
V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation.
Autorzy:
Sun Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Wang X; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Yang X; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Wang L; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Ding J; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Wang CC; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang H; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Wang X; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: .
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Źródło:
Developmental cell [Dev Cell] 2023 Dec 04; Vol. 58 (23), pp. 2761-2775.e5. Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article
MeSH Terms:
Adenosine Triphosphatases*/metabolism
Lysosomes*/metabolism
Protein Transport/physiology ; Golgi Apparatus/metabolism ; Endoplasmic Reticulum/metabolism ; Autophagy
Czasopismo naukowe

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