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Wyświetlanie 1-10 z 10
Tytuł :
Optimization of a pre-metabolization procedure using rat liver S9 and cell-extracted S9 in the Ames fluctuation test.
Autorzy :
Shao Y; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany; Key Laboratory of the Three Gorges Reservoir Eco-environment, Ministry of Education, Chongqing University, Shazheng street 174, Shapingba, 400044 Chongqing, China. Electronic address: .
Schiwy A; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany; Department of Evolutionary Ecology and Ecotoxicology, Goethe University, Max-von-Laue-Str. 13, 60438 Frankfurt/Main, Germany.
Glauch L; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
Henneberger L; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
König M; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
Mühlenbrink M; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
Xiao H; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany.
Thalmann B; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany.
Schlichting R; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany.
Hollert H; Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany; Department of Evolutionary Ecology and Ecotoxicology, Goethe University, Max-von-Laue-Str. 13, 60438 Frankfurt/Main, Germany.
Escher BI; UFZ - Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoser Str. 15, 04318 Leipzig, Germany; EWOMIS GmbH, Schießstraße 26c, 63486 Bruchköbel, Germany; Eberhard Karls University of Tübingen, Environmental Toxicology, Centre for Applied Geosciences, 72074 Tubingen, Germany.
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Źródło :
The Science of the total environment [Sci Total Environ] 2020 Dec 20; Vol. 749, pp. 141468. Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Mutagens*
Salmonella typhimurium*/genetics
Animals ; Biotransformation ; Cell Extracts/pharmacology ; Liver ; Microsomes, Liver/metabolism ; Mutagenicity Tests ; Rats
Czasopismo naukowe
Tytuł :
Trout and Human Plasma Protein Binding of Selected Pharmaceuticals Informs the Fish Plasma Model.
Autorzy :
Henneberger L; Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Klüver N; Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Mühlenbrink M; Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.
Escher B; Helmholtz Centre for Environmental Research-UFZ, Leipzig, Germany.; Center for Applied Geoscience, Eberhard Karls University of Tübingen, Tübingen, Germany.
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Źródło :
Environmental toxicology and chemistry [Environ Toxicol Chem] 2020 Nov 17. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Experimental Exposure Assessment of Ionizable Organic Chemicals in In Vitro Cell-Based Bioassays.
Autorzy :
Huchthausen J; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
Mühlenbrink M; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
König M; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
Escher BI; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, 72074 Tübingen, Germany.
Henneberger L; Department of Cell Toxicology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2020 Jul 20; Vol. 33 (7), pp. 1845-1854. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay/*methods
Organic Chemicals/*toxicity
Humans ; Liposomes/chemistry ; MCF-7 Cells ; Oxidative Stress/drug effects ; PPAR gamma/metabolism ; Serum Albumin, Bovine/chemistry ; Solid Phase Microextraction ; Water/chemistry
Czasopismo naukowe
Tytuł :
Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro - In Vivo Extrapolation.
Autorzy :
Fischer FC; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Abele C; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Henneberger L; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Klüver N; Department Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
König M; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Mühlenbrink M; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Schlichting R; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Escher BI; Department Cell Toxicology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.; Centre for Applied Geoscience, Eberhard Karls University Tübingen, 72074 Tübingen, Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2020 Jul 20; Vol. 33 (7), pp. 1770-1779. Date of Electronic Publication: 2020 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay*
Models, Biological*
Benzopyrenes/*pharmacology
Cytochrome P-450 CYP1A1/*genetics
Cytochrome P-450 CYP1A1/*metabolism
Genes, Reporter ; HEK293 Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
Experimental Validation of Mass Balance Models for in Vitro Cell-Based Bioassays.
Autorzy :
Henneberger L; Department of Cell Toxicology , Helmholtz Centre for Environmental Research-UFZ , Permoserstr. 15 , 04318 Leipzig , Germany.
Mühlenbrink M; Department of Cell Toxicology , Helmholtz Centre for Environmental Research-UFZ , Permoserstr. 15 , 04318 Leipzig , Germany.
Heinrich DJ; Environmental Toxicology, Center for Applied Geoscience , Eberhard Karls University Tübingen , 72074 Tübingen , Germany.
Teixeira A; Safety & Environmental Assurance Centre , Colworth Science Park , Sharnbrook , Bedfordshire MK44 1LQ , U.K.
Nicol B; Safety & Environmental Assurance Centre , Colworth Science Park , Sharnbrook , Bedfordshire MK44 1LQ , U.K.
Escher BI; Department of Cell Toxicology , Helmholtz Centre for Environmental Research-UFZ , Permoserstr. 15 , 04318 Leipzig , Germany.; Environmental Toxicology, Center for Applied Geoscience , Eberhard Karls University Tübingen , 72074 Tübingen , Germany.
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Źródło :
Environmental science & technology [Environ Sci Technol] 2020 Jan 21; Vol. 54 (2), pp. 1120-1127. Date of Electronic Publication: 2020 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Organic Chemicals*
Serum Albumin, Bovine*
Biological Assay ; Hydrophobic and Hydrophilic Interactions ; Water
Czasopismo naukowe
Tytuł :
Quantification of freely dissolved effect concentrations in in vitro cell-based bioassays.
Autorzy :
Henneberger L; Department of Cell Toxicology, Helmholtz Centre for Environmental Research (UFZ), Permoserstr. 15, 04318, Leipzig, Germany. .
Mühlenbrink M; Department of Cell Toxicology, Helmholtz Centre for Environmental Research (UFZ), Permoserstr. 15, 04318, Leipzig, Germany.
König M; Department of Cell Toxicology, Helmholtz Centre for Environmental Research (UFZ), Permoserstr. 15, 04318, Leipzig, Germany.
Schlichting R; Department of Cell Toxicology, Helmholtz Centre for Environmental Research (UFZ), Permoserstr. 15, 04318, Leipzig, Germany.
Fischer FC; Department of Cell Toxicology, Helmholtz Centre for Environmental Research (UFZ), Permoserstr. 15, 04318, Leipzig, Germany.
Escher BI; Department of Cell Toxicology, Helmholtz Centre for Environmental Research (UFZ), Permoserstr. 15, 04318, Leipzig, Germany.; Environmental Toxicology, Center for Applied Geoscience, Eberhard Karls University Tübingen, 72074, Tübingen, Germany.
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Źródło :
Archives of toxicology [Arch Toxicol] 2019 Aug; Vol. 93 (8), pp. 2295-2305. Date of Electronic Publication: 2019 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Assay/*methods
Solid Phase Microextraction/*methods
Cell Survival/drug effects ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; In Vitro Techniques ; Oxidative Stress/drug effects ; PPAR gamma/metabolism ; Solubility
Czasopismo naukowe
Tytuł :
Combined Ion-Trapping and Mass Balance Models To Describe the pH-Dependent Uptake and Toxicity of Acidic and Basic Pharmaceuticals in Zebrafish Embryos ( Danio rerio).
Autorzy :
Bittner L; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.
Klüver N; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.
Henneberger L; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.
Mühlenbrink M; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.
Zarfl C; Eberhard Karls University of Tübingen , Center for Applied Geoscience , Hölderlinstrasse 12 , 72074 Tübingen , Germany.
Escher BI; Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15 , 04318 Leipzig , Germany.; Eberhard Karls University of Tübingen , Center for Applied Geoscience , Hölderlinstrasse 12 , 72074 Tübingen , Germany.
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Źródło :
Environmental science & technology [Environ Sci Technol] 2019 Jul 02; Vol. 53 (13), pp. 7877-7886. Date of Electronic Publication: 2019 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Water Pollutants, Chemical*
Zebrafish*
Animals ; Diclofenac ; Embryo, Nonmammalian ; Hydrogen-Ion Concentration
Czasopismo naukowe
Tytuł :
Thermal proteome profiling allows quantitative assessment of interactions between tetrachloroethene reductive dehalogenase and trichloroethene.
Autorzy :
Türkowsky D; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Lohmann P; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Mühlenbrink M; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
Schubert T; Department of Applied and Ecological Microbiology, Institute of Microbiology, Friedrich Schiller University, 07743 Jena, Germany.
Adrian L; Department of Isotope Biogeochemistry, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany; Chair of Geobiotechnology, Technische Universität Berlin, Ackerstraße 76, 13355 Berlin, Germany.
Goris T; Department of Applied and Ecological Microbiology, Institute of Microbiology, Friedrich Schiller University, 07743 Jena, Germany.
Jehmlich N; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany.
von Bergen M; Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research-UFZ, Permoserstraße 15, 04318 Leipzig, Germany; Institute of Biochemistry, Faculty of Life Sciences, University of Leipzig, Brüderstraße 34, Germany. Electronic address: .
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Źródło :
Journal of proteomics [J Proteomics] 2019 Feb 10; Vol. 192, pp. 10-17. Date of Electronic Publication: 2018 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hot Temperature*
Bacterial Proteins/*chemistry
Campylobacteraceae/*enzymology
Oxidoreductases/*chemistry
Tetrachloroethylene/*chemistry
Bacterial Proteins/metabolism ; Oxidoreductases/metabolism ; Tetrachloroethylene/metabolism
SCR Organism :
Sulfurospirillum multivorans
Czasopismo naukowe
Tytuł :
C18-Coated Solid-Phase Microextraction Fibers for the Quantification of Partitioning of Organic Acids to Proteins, Lipids, and Cells.
Autorzy :
Henneberger L; Department of Cell Toxicology , Helmholtz Centre for Environmental Research - UFZ , Permoserstr. 15 , 04318 Leipzig , Germany.
Mühlenbrink M; Department of Cell Toxicology , Helmholtz Centre for Environmental Research - UFZ , Permoserstr. 15 , 04318 Leipzig , Germany.
Fischer FC; Department of Cell Toxicology , Helmholtz Centre for Environmental Research - UFZ , Permoserstr. 15 , 04318 Leipzig , Germany.
Escher BI; Department of Cell Toxicology , Helmholtz Centre for Environmental Research - UFZ , Permoserstr. 15 , 04318 Leipzig , Germany.; Environmental Toxicology, Center for Applied Geoscience , Eberhard Karls University Tübingen , 72074 Tübingen , Germany.
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Źródło :
Chemical research in toxicology [Chem Res Toxicol] 2019 Jan 22; Vol. 32 (1), pp. 168-178. Date of Electronic Publication: 2019 Jan 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Solid Phase Microextraction*
Phospholipids/*chemistry
Serum Albumin, Bovine/*chemistry
2,4-Dichlorophenoxyacetic Acid/analysis ; Animals ; Cattle ; Cells, Cultured ; Diclofenac/analysis ; Genistein/analysis ; HEK293 Cells ; Humans ; Ibuprofen/analysis ; Kinetics ; Liposomes/chemistry ; Naproxen/analysis ; Torsemide/analysis ; Warfarin/analysis
Czasopismo naukowe
    Wyświetlanie 1-10 z 10

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