- Tytuł:
-
Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via
endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo. - Autorzy:
- Źródło:
- BioFactors (Oxford, England) [Biofactors] 2017 Nov; Vol. 43 (6), pp. 836-846. Date of Electronic Publication: 2017 Oct 19.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Anti-Inflammatory Agents/*pharmacology
Apoptosis/*drug effectsEndoplasmic Reticulum Stress /*drug effects
Hepatic Stellate Cells/*drug effects
Liver Cirrhosis/*drug therapy
Saponins/*pharmacology
Triterpenes/*pharmacology
Animals ; Apoptosis/genetics ; Carbon Tetrachloride ; Cell Line ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Cyclin E/genetics ; Cyclin E/metabolism ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase 6/genetics ; Cyclin-Dependent Kinase 6/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Gene Expression Regulation ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Male ; Mice ; Mice, Inbred ICR ; Oncogene Proteins/genetics ; Oncogene Proteins/metabolism ; Signal Transduction ; Unfolded Protein Response/drug effects ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism
Czasopismo naukowe