Temat: "M2" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Biochemical Correction of GM2 Ganglioside Accumulation in AB-Variant GM2 Gangliosidosis.
Autorzy:: Deschenes NM; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Cheng C; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Ryckman AE; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Quinville BM; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Khanal P; Department of Pediatrics, Queen's University, Kingston, ON K7L 2V7, Canada.
Mitchell M; Department of Pediatrics, Queen's University, Kingston, ON K7L 2V7, Canada.
Chen Z; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Sangrar W; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Gray SJ; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Walia JS; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.; Department of Pediatrics, Queen's University, Kingston, ON K7L 2V7, Canada.; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 May 24; Vol. 24 (11). Date of Electronic Publication: 2023 May 24.
Typ publikacji:: Journal Article
MeSH Terms:: G(M2) Ganglioside*/metabolism
Gangliosidoses, GM2*/genetics
Humans ; Animals ; Mice ; Mutation ; Central Nervous System/metabolism ; Brain/metabolism ; G(M2) Activator Protein/genetics

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Skocz do pozycji: 2.

Tytuł:: β-Adrenergic Receptor Antagonism of Cholinergic Stimulation of Airway Smooth Muscle Contraction: An Old Receptor Requires a Fresh Look.
Autorzy:: Leblanc N; Department of Pharmacology, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.; Pokaż więcej
Źródło:: Function (Oxford, England) [Function (Oxf)] 2023 Feb 03; Vol. 4 (2), pp. zqad006. Date of Electronic Publication: 2023 Feb 03 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Comment
MeSH Terms:: Adrenergic beta-Antagonists*
Receptor, Muscarinic M2*
Receptors, Muscarinic ; Receptors, Adrenergic, beta ; Cholinergic Agents

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Skocz do pozycji: 3.

Tytuł:: GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects, and Current Therapies.
Autorzy:: Leal AF; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Benincore-Flórez E; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Solano-Galarza D; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Garzón Jaramillo RG; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Echeverri-Peña OY; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Suarez DA; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.; Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 110231, Colombia.
Alméciga-Díaz CJ; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Espejo-Mojica AJ; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Aug 27; Vol. 21 (17). Date of Electronic Publication: 2020 Aug 27.
Typ publikacji:: Journal Article; Review
MeSH Terms:: G(M2) Activator Protein/*genetics
Gangliosidoses, GM2/*pathology
beta-N-Acetylhexosaminidases/*genetics
1-Deoxynojirimycin/analogs & derivatives ; 1-Deoxynojirimycin/therapeutic use ; Blood-Brain Barrier ; Clinical Trials as Topic ; Diet, Ketogenic ; G(M2) Ganglioside/metabolism ; Gangliosidoses, GM2/genetics ; Gangliosidoses, GM2/metabolism ; Gangliosidoses, GM2/therapy ; Genetic Therapy ; Humans ; Mutation ; Pyrimethamine/therapeutic use ; Stem Cell Transplantation

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Skocz do pozycji: 4.

Tytuł:: Efficacy of Adeno-Associated Virus Serotype 9-Mediated Gene Therapy for AB-Variant GM2 Gangliosidosis.
Autorzy:: Vyas M; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Deschenes NM; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Osmon KJL; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Chen Z; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Ahmad I; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.
Kot S; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Thompson P; Department of Pediatrics, Queen's University, Kingston, ON K7L 2V7, Canada.
Richmond C; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Gray SJ; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Walia JS; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6, Canada.; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.; Department of Pediatrics, Queen's University, Kingston, ON K7L 2V7, Canada.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 27; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 27.
Typ publikacji:: Journal Article
MeSH Terms:: Tay-Sachs Disease*/therapy
Gangliosidoses, GM2*/genetics
Gangliosidoses, GM2*/therapy
Humans ; Animals ; Mice ; Dependovirus/genetics ; Serogroup ; G(M2) Activator Protein/genetics ; Genetic Therapy

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Skocz do pozycji: 5.

Tytuł:: Balanced modulation of neuromuscular synaptic transmission via M1 and M2 muscarinic receptors during inhibition of cholinesterases.
Autorzy:: Lenina OA; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, Kazan, Russia, 420088.
Petrov KA; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, Kazan, Russia, 420088. .; Kazan Federal University, 18 Kremlyovskaya str, Kazan, Russia, 420008. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Feb 01; Vol. 12 (1), pp. 1688. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antidotes/*administration & dosage
Atropine/*administration & dosage
Cholinesterase Inhibitors/*adverse effects
Diamines/*administration & dosage
Muscarinic Antagonists/*administration & dosage
Muscle Weakness/*chemically induced
Muscle Weakness/*prevention & control
Paraoxon/*adverse effects
Parasympatholytics/*administration & dosage
Protective Agents/*administration & dosage
Receptor, Muscarinic M1/*metabolism
Receptor, Muscarinic M2/*metabolism
Synaptic Transmission/*drug effects
Animals ; Cholinesterase Inhibitors/administration & dosage ; Cholinesterases/metabolism ; Diaphragm/drug effects ; Disease Models, Animal ; Mice ; Muscle Contraction/drug effects ; Muscle Weakness/metabolism ; Paraoxon/administration & dosage ; Pirenzepine/administration & dosage ; Receptor, Muscarinic M1/antagonists & inhibitors ; Receptor, Muscarinic M2/antagonists & inhibitors ; Signal Transduction/drug effects ; Treatment Outcome

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Skocz do pozycji: 6.

Tytuł:: Long-Term-But Not Short-Term-Plasticity at the Mossy Fiber-CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice.
Autorzy:: Zheng F; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.
Wess J; Molecular Signaling Section, Laboratory of Biological Chemistry, NIDDK, NIH, Bethesda, MD 20892, USA.
Alzheimer C; Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Jul 19; Vol. 12 (14). Date of Electronic Publication: 2023 Jul 19.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
MeSH Terms:: Acetylcholine*
Mossy Fibers, Hippocampal*/physiology
Mice ; Animals ; Receptor, Muscarinic M1 ; Mice, Knockout ; Hippocampus ; Pyramidal Cells/physiology ; Receptor, Muscarinic M2/genetics

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Skocz do pozycji: 7.

Tytuł:: Allostery of atypical modulators at oligomeric G protein-coupled receptors.
Autorzy:: Shivnaraine RV; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada. .; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, B163 Beckman Center, 279 Campus Drive, Stanford, CA, 94305, USA. .
Kelly B; Departments of Computer Science, Molecular and Cellular Physiology, and Structural Biology, and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, 94305, USA.
Elmslie G; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.
Huang XP; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.; Department of Pharmacology, The National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Dong YJ; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada.
Seidenberg M; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA.
Wells JW; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada. .
Ellis J; Departments of Psychiatry and Pharmacology, Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, 17033, USA. .; Department of Psychiatry H073, Penn State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Apr 29; Vol. 11 (1), pp. 9265. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Receptor, Muscarinic M2/*metabolism
Tacrine/*pharmacology
Allosteric Regulation ; Allosteric Site ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Ligands ; Molecular Dynamics Simulation ; Receptor, Muscarinic M2/chemistry ; Receptor, Muscarinic M2/genetics

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Skocz do pozycji: 8.

Tytuł:: The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells.
Autorzy:: Lucianò AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Perciballi E; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.
Fiore M; Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Del Bufalo D; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, 00185 Rome, Italy.; Research Centre of Neurobiology Daniel Bovet, 00185 Rome, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Nov 10; Vol. 21 (22). Date of Electronic Publication: 2020 Nov 10.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Arecoline/*analogs & derivatives
Neuroblastoma/*drug therapy
Receptor, Muscarinic M2/*agonists
ATP-Binding Cassette Transporters/genetics ; Arecoline/administration & dosage ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/administration & dosage ; Doxorubicin/administration & dosage ; Drug Resistance, Neoplasm ; Gene Expression/drug effects ; Humans ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Receptor, Muscarinic M2/genetics

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Skocz do pozycji: 9.

Tytuł:: GM2 gangliosidosis AB variant: first case of late onset and review of the literature.
Autorzy:: Ganne B; Cytogenetic, medical genetic and reproductive biology department, Hôpital de la Mère et de l'Enfant, CHU Dupuytren, 87042 Limoges, France, Limoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France. .
Dauriat B; Cytogenetic, medical genetic and reproductive biology department, Hôpital de la Mère et de l'Enfant, CHU Dupuytren, 87042 Limoges, France, Limoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France.
Richard L; Department of Neurology, National Reference Center for 'Rare Peripheral Neuropathies', Dupuytren University Hospital (CHU Limoges), University of Limoges, 2 Avenue Martin Luther King, 87042, Limoges Cedex, France.
Lamari F; APHP Sorbonne University; Pitié-Salpêtrière University Hospital, DMU Biogem; Metabolic Biochemistry Department, 75013, Paris, France.
Ghorab K; Department of Neurology, National Reference Center for 'Rare Peripheral Neuropathies', Dupuytren University Hospital (CHU Limoges), University of Limoges, 2 Avenue Martin Luther King, 87042, Limoges Cedex, France.
Magy L; Department of Neurology, National Reference Center for 'Rare Peripheral Neuropathies', Dupuytren University Hospital (CHU Limoges), University of Limoges, 2 Avenue Martin Luther King, 87042, Limoges Cedex, France.
Benkirane M; Rare Diseases Laboratory of Genetics EA7402, University Institute of Clinical Research, Montpellier University, CHU Montpellier, Montpellier, France, PhyMedExp UMR9214 CNRS-UM U1046 INSERM, Montpellier, France.
Perani A; Cytogenetic, medical genetic and reproductive biology department, Hôpital de la Mère et de l'Enfant, CHU Dupuytren, 87042 Limoges, France, Limoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France.
Marquet V; Cytogenetic, medical genetic and reproductive biology department, Hôpital de la Mère et de l'Enfant, CHU Dupuytren, 87042 Limoges, France, Limoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France.
Calvas P; Reference Centre for Rare Genetics Diseases in Ophthalmology, Purpan Hospital, Toulouse University, 31052, Toulouse, France.
Yardin C; Cytogenetic, medical genetic and reproductive biology department, Hôpital de la Mère et de l'Enfant, CHU Dupuytren, 87042 Limoges, France, Limoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France.
Bourthoumieu S; Cytogenetic, medical genetic and reproductive biology department, Hôpital de la Mère et de l'Enfant, CHU Dupuytren, 87042 Limoges, France, Limoges University, CNRS, XLIM, UMR 7252, F-87000, Limoges, France.; Pokaż więcej
Źródło:: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2022 Nov; Vol. 43 (11), pp. 6517-6527. Date of Electronic Publication: 2022 Aug 04.
Typ publikacji:: Review; Case Reports; Journal Article
MeSH Terms:: Gangliosidoses, GM2*/genetics
Humans ; Male ; Young Adult ; G(M2) Activator Protein/genetics ; G(M2) Ganglioside/metabolism ; Gangliosides ; Mutation/genetics

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Skocz do pozycji: 10.

Tytuł:: Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse model.
Autorzy:: Sengul T; İzmir Institute of Technology, Department of Molecular Biology and Genetics, İzmir, Turkey.
Can M; İzmir Institute of Technology, Department of Molecular Biology and Genetics, İzmir, Turkey.
Ateş N; İzmir Institute of Technology, Department of Molecular Biology and Genetics, İzmir, Turkey.
Seyrantepe V; İzmir Institute of Technology, Department of Molecular Biology and Genetics, İzmir, Turkey.; İzmir Institute of Technology, IYTEDEHAM, İzmir, Turkey.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Mar 16; Vol. 18 (3), pp. e0280650. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Autophagy*/physiology
Tay-Sachs Disease*/metabolism
Tay-Sachs Disease*/pathology
Animals ; Mice ; beta-N-Acetylhexosaminidases/genetics ; beta-N-Acetylhexosaminidases/metabolism ; Brain/metabolism ; Brain/pathology ; G(M2) Ganglioside/therapeutic use ; Hexosaminidase A/metabolism ; Disease Models, Animal

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Skocz do pozycji: 11.

Tytuł:: Serum anti-GM2 and anti-GalNAc-GD1a ganglioside IgG antibodies are biomarkers for immune-mediated polyneuropathies in cats.
Autorzy:: Halstead SK; Neuroimmunology Laboratories, School of Infection and Immunity, University of Glasgow, Glasgow, UK.
Jackson M; School of Cancer Sciences, University of Glasgow, Bearsden, UK.
Bianchi E; Department of Veterinary Science, University of Parma, Parma, Italy.
Rupp S; Tierklinik Hofheim, Germany.
Granger N; Queen Mother Hospital for Animals, Royal Veterinary College, University of London, Hatfield, UK.; CVS Referrals, Bristol Veterinary Specialists, Bristol, UK.
Menchetti M; Neurology and Neurosurgery Division, San Marco Veterinary Clinic and Laboratory, Veggiano, Italy.
Galli G; Neurology and Neurosurgery Division, San Marco Veterinary Clinic and Laboratory, Veggiano, Italy.
Freeman P; Queens Veterinary School Hospital, Dept of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Kaczmarska A; Small Animal Hospital, School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Bhatti SFM; Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Brocal J; Anderson Moores Veterinary Specialists, Hursley, UK.
José-López R; Hamilton Specialist Referrals-IVC Evidensia, High Wycombe, UK.
Tipold A; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Foundation, Hannover, Germany.
Gutierrez Quintana R; Small Animal Hospital, School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Ives EJ; Anderson Moores Veterinary Specialists, Hursley, UK.
Liatis T; Queen Mother Hospital for Animals, Royal Veterinary College, University of London, Hatfield, UK.; Small Animal Hospital, School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Nessler J; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Foundation, Hannover, Germany.
Rusbridge C; School of Veterinary Medicine, The University of Surrey, Guildford, UK.
Willison HJ; Neuroimmunology Laboratories, School of Infection and Immunity, University of Glasgow, Glasgow, UK.
Rupp A; Division of Pathology, Public Health and Disease Investigation, School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.; Pokaż więcej
Źródło:: Journal of the peripheral nervous system : JPNS [J Peripher Nerv Syst] 2023 Mar; Vol. 28 (1), pp. 32-40. Date of Electronic Publication: 2023 Jan 16.
Typ publikacji:: Case Reports; Research Support, Non-U.S. Gov't
MeSH Terms:: Guillain-Barre Syndrome*
Polyneuropathies*/diagnosis
Polyneuropathies*/veterinary
Humans ; Cats ; Animals ; Dogs ; Galactosylceramides ; G(M1) Ganglioside ; Gangliosides ; Immunoglobulin G ; Biomarkers ; Autoantibodies ; G(M2) Ganglioside

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Skocz do pozycji: 12.

Tytuł:: Ganglioside GM3 prevents high fat diet-induced hepatosteatosis via attenuated insulin signaling pathway.
Autorzy:: Tajima O; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.
Fujita Y; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.; Department of Clinical Laboratory, Aichi Medical University Hospital, Nagakute, Japan.
Ohmi Y; Department of Clinical Engineering, Chubu University College of Life and Health Sciences, Kasugai, Japan.
Furukawa K; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.
Furukawa K; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2023 Feb 24; Vol. 18 (2), pp. e0281414. Date of Electronic Publication: 2023 Feb 24 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: G(M3) Ganglioside*
Insulin Resistance*
Mice ; Animals ; Insulin/metabolism ; Diet, High-Fat ; Signal Transduction ; Gangliosides/metabolism ; Insulin, Regular, Human ; G(M2) Ganglioside

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Skocz do pozycji: 13.

Tytuł:: The metronomic combination of paclitaxel with cholinergic agonists inhibits triple negative breast tumor progression. Participation of M2 receptor subtype.
Autorzy:: Español AJ; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Salem A; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.
Di Bari M; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.
Sanchez Y; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, Rome, Italy.; Center of Neurobiology Daniel Bovet, Sapienza University of Rome, Rome, Italy.
Sales ME; Center of Pharmacological and Botanical Studies (CEFYBO), CONICET, Buenos Aires, Argentine.; Department of Pharmacology, School of Medicine, University of Buenos Aires, Buenos Aires, Argentine.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Sep 10; Vol. 15 (9), pp. e0226450. Date of Electronic Publication: 2020 Sep 10 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Cholinergic Agonists/*administration & dosage
Paclitaxel/*administration & dosage
Receptor, Muscarinic M2/*metabolism
Triple Negative Breast Neoplasms/*drug therapy
ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Administration, Metronomic ; Animals ; Arecoline/administration & dosage ; Arecoline/analogs & derivatives ; Carbachol/administration & dosage ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Down-Regulation/drug effects ; ErbB Receptors/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice ; Neoplasm Proteins/metabolism ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology ; RNA, Small Interfering/metabolism ; Receptor, Muscarinic M2/agonists ; Receptor, Muscarinic M2/genetics ; Triple Negative Breast Neoplasms/blood supply ; Triple Negative Breast Neoplasms/pathology ; Vascular Endothelial Growth Factor A/metabolism ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 14.

Tytuł:: CRISPR/nCas9-Based Genome Editing on GM2 Gangliosidoses Fibroblasts via Non-Viral Vectors.
Autorzy:: Leal AF; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Cifuentes J; Department of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Quezada V; Department of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Benincore-Flórez E; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Cruz JC; Department of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Reyes LH; Grupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, Colombia.
Espejo-Mojica AJ; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Alméciga-Díaz CJ; Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 14; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 14.
Typ publikacji:: Journal Article
MeSH Terms:: Gangliosidoses, GM2*/genetics
Gangliosidoses, GM2*/metabolism
Gangliosidoses, GM2*/therapy
Tay-Sachs Disease*/genetics
Tay-Sachs Disease*/metabolism
Tay-Sachs Disease*/therapy
Deoxyribonuclease I/metabolism ; Fibroblasts/metabolism ; G(M2) Activator Protein ; G(M2) Ganglioside/genetics ; G(M2) Ganglioside/metabolism ; Gene Editing ; Globosides/metabolism ; Glycosaminoglycans/metabolism ; Hexosaminidase A/metabolism ; Humans ; Lipopolysaccharides/metabolism ; Liposomes/metabolism ; beta-N-Acetylhexosaminidases/metabolism

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Skocz do pozycji: 15.

Tytuł:: GM2-GM3 gangliosides ratio is dependent on GRP94 through down-regulation of GM2-AP cofactor in brain metastasis cells.
Autorzy:: Bedia C; Laboratory of Molecular and Translational Oncology, Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Centre de Recerca Biomèdica CELLEX, Barcelona, E-08036, Spain. .; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain. .
Badia M; Laboratory of Molecular and Translational Oncology, Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Centre de Recerca Biomèdica CELLEX, Barcelona, E-08036, Spain.
Muixí L; Biological Clues of the Invasive and Metastatic Phenotype Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, E-08908, Spain.
Levade T; INSERM UMR 1037, Centre de Recherches en Cancérologie de Toulouse (CRCT), 31037, Toulouse, France.
Tauler R; Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain.
Sierra A; Laboratory of Molecular and Translational Oncology, Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Centre de Recerca Biomèdica CELLEX, Barcelona, E-08036, Spain.; Centre d'Estudis Sanitaris i Socials-CESS, University of Vic - Central University of Catalonia (UVic-UCC), Vic, E-08500, Spain.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Oct 02; Vol. 9 (1), pp. 14241. Date of Electronic Publication: 2019 Oct 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brain Neoplasms/*secondary
Carcinoma/*secondary
G(M2) Activator Protein/*biosynthesis
G(M2) Ganglioside/*analysis
G(M3) Ganglioside/*analysis
Membrane Glycoproteins/*physiology
Neoplasm Proteins/*physiology
Animals ; Brain Neoplasms/metabolism ; Carcinoma/metabolism ; Cell Line, Tumor ; Culture Media, Conditioned/chemistry ; Down-Regulation ; Female ; G(M2) Activator Protein/genetics ; Gene Expression Regulation, Neoplastic ; Genes, Reporter ; Humans ; Lipidomics ; Lysosomes/metabolism ; Membrane Glycoproteins/antagonists & inhibitors ; Membrane Glycoproteins/genetics ; Mice ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; RNA Interference ; RNA, Small Interfering/genetics ; Triple Negative Breast Neoplasms/pathology ; beta-Hexosaminidase alpha Chain/biosynthesis ; beta-Hexosaminidase alpha Chain/genetics

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Skocz do pozycji: 16.

Tytuł:: GM2 ganglioside accumulation causes neuroinflammation and behavioral alterations in a mouse model of early onset Tay-Sachs disease.
Autorzy:: Demir SA; Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430, Izmir, Turkey.
Timur ZK; Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430, Izmir, Turkey.
Ateş N; Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430, Izmir, Turkey.
Martínez LA; Institute of Neurological Science and Psychiatry, Hacettepe University, Sihhiye, 06100, Ankara, Turkey.
Seyrantepe V; Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430, Izmir, Turkey. .; Pokaż więcej
Źródło:: Journal of neuroinflammation [J Neuroinflammation] 2020 Sep 20; Vol. 17 (1), pp. 277. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji:: Journal Article
MeSH Terms:: Disease Models, Animal*
Brain/*metabolism
G(M2) Ganglioside/*metabolism
Inflammation Mediators/*metabolism
Retina/*metabolism
Tay-Sachs Disease/*metabolism
Animals ; Brain/pathology ; G(M2) Ganglioside/genetics ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/pathology ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Neurons/metabolism ; Neurons/pathology ; Retina/pathology ; Tay-Sachs Disease/genetics ; Tay-Sachs Disease/pathology

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Skocz do pozycji: 17.

Tytuł:: Cross Interaction between M2 Muscarinic Receptor and Notch1/EGFR Pathway in Human Glioblastoma Cancer Stem Cells: Effects on Cell Cycle Progression and Survival.
Autorzy:: Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Alessandrini F; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Spinello Z; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Fiore M; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Caffarelli E; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Laneve P; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Dini L; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Conti L; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.; Research center of Neurobiology, Sapienza, University of Rome, 00185 Rome, Italy.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Mar 09; Vol. 9 (3). Date of Electronic Publication: 2020 Mar 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*/drug effects
Cell Cycle/*physiology
Cell Proliferation/*physiology
Glioblastoma/*pathology
Receptor, Muscarinic M2/*metabolism
Receptor, Notch1/*metabolism
Brain Neoplasms/genetics ; Cell Division/physiology ; Cell Line, Tumor ; ErbB Receptors/metabolism ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Humans ; Neoplastic Stem Cells/pathology ; Receptor, Muscarinic M2/genetics

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Skocz do pozycji: 18.

Tytuł:: M2 Receptor Activation Counteracts the Glioblastoma Cancer Stem Cell Response to Hypoxia Condition.
Autorzy:: Cristofaro I; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Limongi C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Piscopo P; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Crestini A; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Guerriero C; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.
Fiore M; IBPM, Institute of Molecular Biology and Pathology, CNR, 00185 Rome, Italy.
Conti L; Department of Cellular, Computational and Integrative Biology-CIBIO, University of Trento, 38123 Trento, Italy.
Confaloni A; Depatment of Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy.
Tata AM; Department of Biology and Biotechnologies Charles Darwin, Sapienza, University of Rome, 00185 Rome, Italy.; Research center of Neuroscience, Sapienza, University of Rome, 00185 Rome, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Mar 02; Vol. 21 (5). Date of Electronic Publication: 2020 Mar 02.
Typ publikacji:: Journal Article
MeSH Terms:: Brain Neoplasms/*metabolism
Glioblastoma/*metabolism
Neoplastic Stem Cells/*metabolism
Oxygen/*metabolism
Receptor, Muscarinic M2/*metabolism
Brain Neoplasms/genetics ; Cell Hypoxia ; Glioblastoma/genetics ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Receptor, Muscarinic M2/genetics ; Tumor Cells, Cultured

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Skocz do pozycji: 19.

Tytuł:: Sodium ions allosterically modulate the M2 muscarinic receptor.
Autorzy:: Friedman S; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel.
Tauber M; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel.
Ben-Chaim Y; Department of Natural and Life Sciences, The Open University of Israel, Ra'anana, Israel. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Jul 07; Vol. 10 (1), pp. 11177. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Allosteric Site*
Receptor, Muscarinic M2/*metabolism
Sodium/*metabolism
Acetylcholine/metabolism ; Allosteric Regulation ; Animals ; Receptor, Muscarinic M2/chemistry ; Xenopus

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Skocz do pozycji: 20.

Tytuł:: Associations of common genetic risk variants of the muscarinic acetylcholine receptor M2 with cardiac autonomic dysfunction in patients with schizophrenia.
Autorzy:: Refisch A; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Komatsuzaki S; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Ungelenk M; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Chung HY; Department of Neurology, Section Translational Neuroimmunology, Jena University Hospital, Jena, Germany.
Schumann A; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Schilling SS; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Jantzen W; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Schröder S; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.
Mühleisen TW; Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.; Medical Faculty, Cécile and Oskar Vogt Institute of Brain Research, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Biomedicine, Human Genomics Research Group, University of Basel, Basel, Switzerland.
Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Hübner CA; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Bär KJ; Department of Psychosomatic Medicine and Psychotherapy, Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC)1, Jena University Hospital, Jena, Germany.; Pokaż więcej
Źródło:: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2023 Jan; Vol. 24 (1), pp. 1-11. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Schizophrenia*/drug therapy
Schizophrenia*/genetics
Antipsychotic Agents*/adverse effects
Humans ; Genome-Wide Association Study ; Receptor, Muscarinic M2/genetics ; Polymorphism, Single Nucleotide ; Heart Rate/physiology

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