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Wyszukujesz frazę ""M3 Muscarinic receptor"" wg kryterium: Wszystkie pola


Tytuł :
M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway.
Autorzy :
Jadeja RN; Digestive Health Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Chu X; Department of Gastroenterology, Hepatology and Nutrition, Geisinger Medical Center, Danville, PA 17822, USA.
Wood C; Department of Gastroenterology, Hepatology and Nutrition, Geisinger Medical Center, Danville, PA 17822, USA.
Bartoli M; Department of Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Khurana S; Digestive Health Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Gastroenterology, Hepatology and Nutrition, Geisinger Medical Center, Danville, PA 17822, USA. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2019 Nov; Vol. 169, pp. 113613. Date of Electronic Publication: 2019 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lipid Metabolism*
AMP-Activated Protein Kinases/*physiology
Calcium-Calmodulin-Dependent Protein Kinase Kinase/*physiology
Hepatocytes/*metabolism
Receptor, Muscarinic M3/*physiology
Animals ; Cells, Cultured ; Humans ; Mice ; PPAR alpha/physiology ; Phosphorylation ; Receptor, Muscarinic M1/physiology ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation.
Autorzy :
Yu H; Department of Medical Oncology and Laboratory of Molecular Targeted Therapy in Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Xia H; Department of Medical Oncology and Laboratory of Molecular Targeted Therapy in Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Tang Q; Department of Medical Oncology and Laboratory of Molecular Targeted Therapy in Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Xu H; Department of Medical Oncology and Laboratory of Molecular Targeted Therapy in Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Wei G; Department of Medical Oncology and Laboratory of Molecular Targeted Therapy in Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Chen Y; Department of Medical Oncology and Laboratory of Molecular Targeted Therapy in Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Dai X; Department of Medical Oncology and Laboratory of Molecular Targeted Therapy in Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Gong Q; Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Bi F; Department of Medical Oncology and Laboratory of Molecular Targeted Therapy in Oncology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
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Źródło :
Scientific reports [Sci Rep] 2017 Jan 19; Vol. 7, pp. 40802. Date of Electronic Publication: 2017 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*/drug effects
Acetylcholine/*metabolism
ErbB Receptors/*metabolism
Receptor, Muscarinic M3/*metabolism
Stomach Neoplasms/*metabolism
Acetylcholine/pharmacology ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; Drug Resistance, Neoplasm/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Heterografts ; Humans ; Mice ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Muscarinic M3/agonists ; Receptor, Muscarinic M3/antagonists & inhibitors ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Overexpression of M3 Muscarinic Receptor Suppressed Adverse Electrical Remodeling in Hypertrophic Myocardium Via Increasing Repolarizing K+ Currents.
Autorzy :
Chen X; Institute of Clinical Pharmacy, the Second Affiliated Hospital of Harbin Medical University (The University Key Laboratory of Drug Research, Heilongjiang Province), Harbin, China.
Bai Y; Institute of Clinical Pharmacy, the Second Affiliated Hospital of Harbin Medical University (The University Key Laboratory of Drug Research, Heilongjiang Province), Harbin, China.
Sun H; Institute of Clinical Pharmacy, the Second Affiliated Hospital of Harbin Medical University (The University Key Laboratory of Drug Research, Heilongjiang Province), Harbin, China.
Su Z; Institute of Clinical Pharmacy, the Second Affiliated Hospital of Harbin Medical University (The University Key Laboratory of Drug Research, Heilongjiang Province), Harbin, China.
Guo J; Institute of Clinical Pharmacy, the Second Affiliated Hospital of Harbin Medical University (The University Key Laboratory of Drug Research, Heilongjiang Province), Harbin, China.
Sun C; Institute of Clinical Pharmacy, the Second Affiliated Hospital of Harbin Medical University (The University Key Laboratory of Drug Research, Heilongjiang Province), Harbin, China.
Du Z; Institute of Clinical Pharmacy, the Second Affiliated Hospital of Harbin Medical University (The University Key Laboratory of Drug Research, Heilongjiang Province), Harbin, China.; Department of Clinical Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2017; Vol. 43 (3), pp. 915-925. Date of Electronic Publication: 2017 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Atrial Remodeling/*physiology
Cardiomegaly/*physiopathology
Potassium Channels, Inwardly Rectifying/*metabolism
Receptor, Muscarinic M3/*metabolism
Shal Potassium Channels/*metabolism
Action Potentials ; Animals ; Body Weight ; Cardiomegaly/metabolism ; Disease Models, Animal ; Echocardiography ; Heart/diagnostic imaging ; Heart/physiology ; Heart Ventricles/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Patch-Clamp Techniques ; Potassium/metabolism ; Receptor, Muscarinic M3/genetics ; Tibia/diagnostic imaging ; Tibia/physiology ; Up-Regulation
Czasopismo naukowe
Tytuł :
M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells.
Autorzy :
Mahati E; Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science.
Li P
Kurata Y
Maharani N
Ikeda N
Sakata S
Ogura K
Miake J
Aiba T
Shimizu W
Nakasone N
Ninomiya H
Higaki K
Yamamoto K
Nakai A
Shirayoshi Y
Hisatome I
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Źródło :
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2016 Nov 25; Vol. 80 (12), pp. 2443-2452. Date of Electronic Publication: 2016 Nov 01.
Typ publikacji :
Journal Article
MeSH Terms :
ERG1 Potassium Channel*/genetics
ERG1 Potassium Channel*/metabolism
Long QT Syndrome*/genetics
Long QT Syndrome*/metabolism
Mutation*
Signal Transduction*
DNA-Binding Proteins/*metabolism
Receptor, Muscarinic M3/*metabolism
Transcription Factors/*metabolism
Adolescent ; DNA-Binding Proteins/genetics ; HEK293 Cells ; Heat Shock Transcription Factors ; Humans ; Male ; Phosphorylation/genetics ; Protein Stability ; Receptor, Muscarinic M3/genetics ; Transcription Factors/genetics ; Transfection
SCR Disease Name :
Long Qt Syndrome 2
Czasopismo naukowe
Tytuł :
M3 muscarinic receptor in the ventral medial prefrontal cortex modulating the expression of contextual fear conditioning in rats.
Autorzy :
Fedoce AG; Department of Pharmacology, Ribeirao Preto School of Medicine, University of Sao Paulo, Av. Bandeirantes, 3900, CEP: 14049-900, Ribeirao Preto, SP, Brazil.; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Sao Paulo, Brazil.
Ferreira-Junior NC; Department of Pharmacology, Ribeirao Preto School of Medicine, University of Sao Paulo, Av. Bandeirantes, 3900, CEP: 14049-900, Ribeirao Preto, SP, Brazil.; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Sao Paulo, Brazil.
Reis DG; Department of Pharmacology, Ribeirao Preto School of Medicine, University of Sao Paulo, Av. Bandeirantes, 3900, CEP: 14049-900, Ribeirao Preto, SP, Brazil.; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Sao Paulo, Brazil.
Corrêa FM; Department of Pharmacology, Ribeirao Preto School of Medicine, University of Sao Paulo, Av. Bandeirantes, 3900, CEP: 14049-900, Ribeirao Preto, SP, Brazil.
Resstel LB; Department of Pharmacology, Ribeirao Preto School of Medicine, University of Sao Paulo, Av. Bandeirantes, 3900, CEP: 14049-900, Ribeirao Preto, SP, Brazil. .; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Sao Paulo, Brazil. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2016 Jan; Vol. 233 (2), pp. 267-80. Date of Electronic Publication: 2015 Oct 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Conditioning, Psychological*/drug effects
Fear/*psychology
Prefrontal Cortex/*metabolism
Receptor, Muscarinic M3/*metabolism
Animals ; Benzodiazepines/agonists ; Cholinesterase Inhibitors/pharmacology ; Emotions ; Male ; Muscarinic Antagonists/pharmacology ; Parasympathetic Nervous System/drug effects ; Prefrontal Cortex/drug effects ; Rats ; Rats, Wistar ; Receptor, Muscarinic M3/drug effects ; Synaptic Transmission/drug effects
Czasopismo naukowe
Tytuł :
The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells.
Autorzy :
Legeay S; University Bretagne Loire, Université d'Angers, UFR santé, département pharmacie, Angers, France.
Clere N; University Bretagne Loire, Université d'Angers, UFR santé, département pharmacie, Angers, France.
Hilairet G; University Bretagne Loire, Université d'Angers, UFR santé, département pharmacie, Angers, France.
Do QT; GreenPharma S.A.S. 03 allée du titane, 45100 Orléans, France.
Bernard P; GreenPharma S.A.S. 03 allée du titane, 45100 Orléans, France.
Quignard JF; Inserm U1045-Centre de Recherche Cardio-Thoracique de Bordeaux, Université de Bordeaux, France.
Apaire-Marchais V; Laboratoire des Récepteurs et Canaux Ioniques Membranaires (RCIM), UPRES-EA 2647, USC INRA 1330, Angers, France.
Lapied B; Laboratoire des Récepteurs et Canaux Ioniques Membranaires (RCIM), UPRES-EA 2647, USC INRA 1330, Angers, France.
Faure S; University Bretagne Loire, Université d'Angers, UFR santé, département pharmacie, Angers, France.
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Źródło :
Scientific reports [Sci Rep] 2016 Jun 27; Vol. 6, pp. 28546. Date of Electronic Publication: 2016 Jun 27.
Typ publikacji :
Journal Article
MeSH Terms :
Allosteric Regulation/*drug effects
DEET/*pharmacology
Endothelial Cells/*drug effects
Insect Repellents/*pharmacology
Neovascularization, Pathologic/*chemically induced
Receptor, Muscarinic M3/*metabolism
Acetylcholine/pharmacology ; Animals ; Biological Availability ; Calcium Signaling/drug effects ; Cell Adhesion/drug effects ; Cell Line ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Endothelial Cells/metabolism ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Male ; Mice ; Mice, Nude ; Neovascularization, Pathologic/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Expression of the M3 Muscarinic Receptor on Orexin Neurons that Project to the Rostral Ventrolateral Medulla.
Autorzy :
Dai YW; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Lee YH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chen JY; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Lin YK; Biostatistic Center, Taipei Medical University, Taipei, Taiwan.
Hwang LL; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
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Źródło :
Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2016 May; Vol. 299 (5), pp. 660-8. Date of Electronic Publication: 2016 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypothalamus/*metabolism
Medulla Oblongata/*metabolism
Neurons/*metabolism
Orexins/*metabolism
Receptor, Muscarinic M3/*metabolism
Animals ; Hypothalamus/cytology ; Immunoenzyme Techniques ; Male ; Medulla Oblongata/cytology ; Neural Pathways ; Neurons/cytology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Activation of M3 muscarinic receptor by acetylcholine promotes non-small cell lung cancer cell proliferation and invasion via EGFR/PI3K/AKT pathway.
Autorzy :
Xu R; Department of Thoracic Surgery, Shengjing Hospital, China Medical University, No. 36 San Hao Street, Shenyang, 110004, Liaoning Province, China.
Shang C
Zhao J
Han Y
Liu J
Chen K
Shi W
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Źródło :
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2015 Jun; Vol. 36 (6), pp. 4091-100. Date of Electronic Publication: 2015 May 12.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*genetics
ErbB Receptors/*genetics
Interleukin-8/*genetics
Proto-Oncogene Proteins c-akt/*genetics
Receptor, Muscarinic M3/*genetics
Acetylcholine/administration & dosage ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; ErbB Receptors/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Interleukin-8/biosynthesis ; Neoplasm Invasiveness/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Muscarinic M3/biosynthesis ; Signal Transduction
Czasopismo naukowe
Tytuł :
The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection.
Autorzy :
Darby M; Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa.
Schnoeller C; Department of Life Sciences, Sir Ernst Chain Building, South Kensington Campus, Imperial College London, London, United Kingdom.
Vira A; Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa.
Culley FJ; National Heart and Lung Institute, St.Mary's Campus, Praed Street, Imperial College London, London, United Kingdom.
Bobat S; Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom.
Logan E; Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa.
Kirstein F; Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa.
Wess J; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Cunningham AF; Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom.
Brombacher F; Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa.
Selkirk ME; Department of Life Sciences, Sir Ernst Chain Building, South Kensington Campus, Imperial College London, London, United Kingdom.
Horsnell WG; Institute of Infectious Disease and Molecular Medicine, International Centre for Genetic Engineering and Biotechnology and Division of Immunology, University of Cape Town, Cape Town, South Africa.
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Źródło :
PLoS pathogens [PLoS Pathog] 2015 Jan 28; Vol. 11 (1), pp. e1004636. Date of Electronic Publication: 2015 Jan 28 (Print Publication: 2015).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptive Immunity/*genetics
Nippostrongylus/*immunology
Receptor, Muscarinic M3/*physiology
Salmonella Infections, Animal/*immunology
Salmonella typhimurium/*immunology
Strongylida Infections/*immunology
Animals ; Cells, Cultured ; Lymphocyte Activation/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Salmonella Infections, Animal/genetics ; Signal Transduction/genetics ; Signal Transduction/immunology ; Strongylida Infections/genetics ; Th1 Cells/immunology ; Th2 Cells/immunology
Czasopismo naukowe
Tytuł :
M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency.
Autorzy :
Kan W; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Adjobo-Hermans M; Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.
Burroughs M; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Faibis G; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Malik S; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Tall GG; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Smrcka AV; Departments of Pharmacology and Physiology and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Biochemistry and Biophysics and University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Aab Institute of Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 and. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2014 Apr 18; Vol. 289 (16), pp. 11206-11218. Date of Electronic Publication: 2014 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Membrane/*metabolism
GTP-Binding Protein alpha Subunits, Gq-G11/*metabolism
Phospholipase C beta/*metabolism
Receptor, Muscarinic M3/*metabolism
Signal Transduction/*physiology
Animals ; CHO Cells ; Cell Membrane/genetics ; Cricetinae ; Cricetulus ; GTP-Binding Protein alpha Subunits, Gq-G11/genetics ; Humans ; Phospholipase C beta/genetics ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Receptor, Muscarinic M3/genetics
Czasopismo naukowe
Tytuł :
Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation.
Autorzy :
Hu J; From the Molecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892.
Hu K
Liu T
Stern MK
Mistry R
Challiss RA
Costanzi S
Wess J
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2013 Nov 29; Vol. 288 (48), pp. 34777-90. Date of Electronic Publication: 2013 Oct 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Conformation*
Protein Multimerization*
Receptor, Muscarinic M3/*chemistry
Receptor, Muscarinic M3/*metabolism
Amino Acid Sequence ; Animals ; Binding Sites ; COS Cells ; Chlorocebus aethiops ; Cysteine/chemistry ; Mutagenesis, Site-Directed ; Phosphatidylinositols/chemistry ; Phosphatidylinositols/metabolism ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Receptor, Muscarinic M3/genetics
Czasopismo naukowe
Tytuł :
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.
Autorzy :
Del Bello F; Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Bonifazi A; Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Quaglia W; Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
Mazzolari A; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy.
Barocelli E; Dipartimento di Farmacia, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Bertoni S; Dipartimento di Farmacia, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Matucci R; Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università degli Studi di Firenze, Viale G. Pieraccini 6, 50139 Firenze, Italy.
Nesi M; Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università degli Studi di Firenze, Viale G. Pieraccini 6, 50139 Firenze, Italy.
Piergentili A; Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy. Electronic address: .
Vistoli G; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Aug 01; Vol. 24 (15), pp. 3255-9. Date of Electronic Publication: 2014 Jun 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dioxanes/*pharmacology
Muscarinic Agonists/*pharmacology
Receptor, Muscarinic M2/*agonists
Receptor, Muscarinic M3/*agonists
Animals ; Binding Sites/drug effects ; Dioxanes/chemistry ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Conformation ; Muscarinic Agonists/chemistry ; Rats ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Upregulation of M₃ muscarinic receptor inhibits cardiac hypertrophy induced by angiotensin II.
Autorzy :
Liu Y; Department of Pharmacology (State-Province key lab of China), Harbin Medical University, Heilongjiang 150081, China. .
Wang S
Wang C
Song H
Han H
Hang P
Jiang Y
Wei L
Huo R
Sun L
Gao X
Lu Y
Du Z
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Źródło :
Journal of translational medicine [J Transl Med] 2013 Sep 12; Vol. 11, pp. 209. Date of Electronic Publication: 2013 Sep 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*/drug effects
Cardiomegaly/*metabolism
Receptor, Muscarinic M3/*metabolism
Angiotensin II/administration & dosage ; Animals ; Blood Pressure ; Body Weight ; Cardiomegaly/chemically induced ; Cardiomegaly/enzymology ; Cardiomegaly/physiopathology ; Disease Models, Animal ; Down-Regulation ; Enzyme Activation ; Heart Rate ; MAP Kinase Signaling System ; Mice ; Mice, Transgenic ; Myocardium/enzymology ; Myocardium/pathology ; Organ Specificity ; Rats ; Rats, Wistar ; Receptor, Angiotensin, Type 1/metabolism
Czasopismo naukowe
Tytuł :
Effects of modulating M3 muscarinic receptor activity on azoxymethane-induced liver injury in mice.
Autorzy :
Khurana S; Division of Gastroenterology & Hepatology, VA Maryland Health Care System and University of Maryland School of Medicine, Baltimore, MD, United States. />Jadeja R
Twaddell W
Cheng K
Rachakonda V
Saxena N
Raufman JP
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2013 Jul 15; Vol. 86 (2), pp. 329-38. Date of Electronic Publication: 2013 May 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Azoxymethane/*toxicity
Liver/*drug effects
Receptor, Muscarinic M3/*drug effects
Animals ; Base Sequence ; DNA Primers ; Immunohistochemistry ; Liver/metabolism ; Mice ; Nitrosation ; Pilocarpine/pharmacology ; Polymerase Chain Reaction ; Receptor, Muscarinic M3/genetics ; Receptor, Muscarinic M3/physiology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Evidence for M2 and M3 muscarinic receptor involvement in cholinergic excitatory junction potentials through synergistic activation of cation channels in the longitudinal muscle of mouse ileum.
Autorzy :
Matsuyama H; Laboratory of Pharmacology, Department of Veterinary Medicine, Faculty of Applied Biological Science, Gifu University, Gifu, Japan.
Tanahashi Y
Kitazawa T
Yamada M
Komori S
Unno T
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Źródło :
Journal of pharmacological sciences [J Pharmacol Sci] 2013; Vol. 121 (3), pp. 227-36. Date of Electronic Publication: 2013 Feb 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Action Potentials*/drug effects
Chloride Channels/*metabolism
Cholinergic Neurons/*physiology
Ileum/*cytology
Muscle, Smooth/*cytology
Myocytes, Smooth Muscle/*metabolism
Neuromuscular Junction/*physiology
Receptor, Muscarinic M2/*physiology
Receptor, Muscarinic M3/*physiology
Animals ; Cells, Cultured ; Chloride Channels/physiology ; Electric Stimulation ; Female ; Male ; Mice ; Mice, Knockout ; Pertussis Toxin/pharmacology
Czasopismo naukowe
Tytuł :
Activated Ito cells of cirrhotic liver express M3 muscarinic receptor after thioacetamide exposure.
Autorzy :
Norasingha A; Medical Diagnostic Department, Thammasat University Hospital, Thammasat University (Rangsit Campus), Pathumthani, Thailand. />Pradidarcheep W
Chayaburakul K
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Źródło :
Journal of the Medical Association of Thailand = Chotmaihet thangphaet [J Med Assoc Thai] 2012 Jan; Vol. 95 Suppl 1, pp. S178-82.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatic Stellate Cells/*metabolism
Hepatocytes/*metabolism
Liver Cirrhosis/*metabolism
Receptor, Muscarinic M3/*metabolism
Animals ; Male ; Rats ; Signal Transduction
Czasopismo naukowe
Tytuł :
PMA increases M3 muscarinic receptor levels and decreases retinal cells proliferation through a change in the levels of cell-cycle regulatory proteins.
Autorzy :
Braga LE; Departamento de Fisiologia e Farmacologia, Instituto Biomédico, UFF, Rua Hernani Pires de Mello, 101, Niterói CEP 24210-130, RJ, Brazil.
Granja MG
da Silva GM
Giestal-de-Araujo E
dos Santos AA
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Źródło :
Neuroscience letters [Neurosci Lett] 2013 Aug 29; Vol. 550, pp. 29-34. Date of Electronic Publication: 2013 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation/*drug effects
Phorbol Esters/*pharmacology
Receptor, Muscarinic M3/*metabolism
Retinal Neurons/*drug effects
Animals ; Cells, Cultured ; Cyclin D1/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Rats ; Retinal Neurons/metabolism ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Minireview: Novel aspects of M3 muscarinic receptor signaling in pancreatic β-cells.
Autorzy :
Nakajima K; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.
Jain S
Ruiz de Azua I
McMillin SM
Rossi M
Wess J
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Źródło :
Molecular endocrinology (Baltimore, Md.) [Mol Endocrinol] 2013 Aug; Vol. 27 (8), pp. 1208-16. Date of Electronic Publication: 2013 Jul 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Review
MeSH Terms :
Diabetes Mellitus, Type 2/*prevention & control
Glucose Intolerance/*prevention & control
Hypoglycemic Agents/*pharmacology
Insulin-Secreting Cells/*metabolism
Receptor, Muscarinic M3/*metabolism
Animals ; Blood Glucose/drug effects ; Diabetes Mellitus, Type 2/drug therapy ; Extracellular Signal-Regulated MAP Kinases/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; GTP-Binding Proteins/metabolism ; Glucose Intolerance/drug therapy ; Insulin Receptor Substrate Proteins/drug effects ; Insulin Receptor Substrate Proteins/metabolism ; Insulin-Secreting Cells/drug effects ; Mice ; Mice, Knockout ; Receptor, Muscarinic M3/drug effects ; Receptor, Muscarinic M3/genetics ; Signal Transduction ; Type C Phospholipases/drug effects ; Type C Phospholipases/metabolism
Czasopismo naukowe
Tytuł :
Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling.
Autorzy :
Wang HJ; Department of Biological Sciences, Missouri University of Science & Technology, 400 W, 11th St, Rolla MO 65409, USA.
Martin AG
Chao PK
Reichard RA
Martin AL
Huang YW
Chan MH
Aronstam RS
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Źródło :
Journal of biomedical science [J Biomed Sci] 2013 Feb 23; Vol. 20, pp. 11. Date of Electronic Publication: 2013 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biphenyl Compounds/*administration & dosage
Calcium/*metabolism
Calcium Signaling/*drug effects
Lignans/*administration & dosage
Receptor, Muscarinic M3/*metabolism
Animals ; CHO Cells ; Cricetinae ; Cytoplasm/drug effects ; Cytoplasm/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Inositol 1,4,5-Trisphosphate/metabolism ; Ion Transport/drug effects
Czasopismo naukowe

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