Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""MAP Kinase Kinase 1"" wg kryterium: Temat


Tytuł :
Identification and Characterization of a B-Raf Kinase α-Helix Critical for the Activity of MEK Kinase in MAPK Signaling.
Autorzy :
Nguyen D; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Lin LY; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Zhou JO; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Kibby E; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Sia TW; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Tillis TD; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Vapuryan N; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Xu MR; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Potluri R; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Shin Y; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Erler EA; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Bronkema N; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Boehlmer DJ; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Chung CD; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Burkhard C; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Zeng SH; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Grasso M; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Acevedo LA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Marmorstein R; Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Fera D; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, Pennsylvania 19081, United States.
Pokaż więcej
Źródło :
Biochemistry [Biochemistry] 2020 Dec 22; Vol. 59 (50), pp. 4755-4765. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Kinase 1/*chemistry
MAP Kinase Kinase 1/*metabolism
Proto-Oncogene Proteins B-raf/*chemistry
Proto-Oncogene Proteins B-raf/*metabolism
Allosteric Site ; Amino Acid Sequence ; Drug Discovery ; Drug Resistance, Neoplasm ; HEK293 Cells ; Humans ; In Vitro Techniques ; Kinetics ; MAP Kinase Kinase 1/genetics ; MAP Kinase Signaling System ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/metabolism ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutation ; Phosphorylation ; Protein Conformation, alpha-Helical ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins B-raf/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Static Electricity
Czasopismo naukowe
Tytuł :
Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders.
Autorzy :
Hu J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Wei J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Yim H; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Wang L; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Xie L; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Jin MS; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Kabir M; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Qin L; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Chen X; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Liu J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Jin J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 24; Vol. 63 (24), pp. 15883-15905. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
MAP Kinase Kinase 1/*antagonists & inhibitors
MAP Kinase Kinase 2/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Pyrrolidines/*pharmacology
Small Molecule Libraries/*pharmacology
Thiazoles/*pharmacology
Ubiquitin-Protein Ligases/*metabolism
Von Hippel-Lindau Tumor Suppressor Protein/*metabolism
Animals ; Cell Proliferation ; Humans ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/metabolism ; Mice ; Neoplasms/metabolism ; Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/chemistry ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacokinetics ; Proteolysis ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Proto-Oncogene Proteins B-raf/metabolism ; Pyrrolidines/chemistry ; Pyrrolidines/pharmacokinetics ; Signal Transduction ; Structure-Activity Relationship ; Thiazoles/chemistry ; Thiazoles/pharmacokinetics ; Tissue Distribution ; Tumor Cells, Cultured ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
Detecting mosaic variants in patients with somatic overgrowth syndromes using cell-free circulating DNA and deep sequencing.
Autorzy :
Shen W; Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA .; ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, ARUP Laboratories, Salt Lake City, Utah, USA.
Flores-Daboub J; Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Viskochil D; Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Dugan SL; Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Best HD; Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.; ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, ARUP Laboratories, Salt Lake City, Utah, USA.; Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Mao R; Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.; ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, ARUP Laboratories, Salt Lake City, Utah, USA.
Pokaż więcej
Źródło :
Journal of medical genetics [J Med Genet] 2020 Nov; Vol. 57 (11), pp. 794-796. Date of Electronic Publication: 2020 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mosaicism*
Class I Phosphatidylinositol 3-Kinases/*genetics
GTP-Binding Protein alpha Subunits/*genetics
MAP Kinase Kinase 1/*genetics
Proto-Oncogene Proteins p21(ras)/*genetics
Cell-Free Nucleic Acids/blood ; Cell-Free Nucleic Acids/genetics ; Child ; Child, Preschool ; Class I Phosphatidylinositol 3-Kinases/blood ; Female ; GTP-Binding Protein alpha Subunits/blood ; Genetic Predisposition to Disease ; Genetic Variation/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; MAP Kinase Kinase 1/blood ; Male ; Mutation/genetics ; Proto-Oncogene Proteins p21(ras)/blood
Czasopismo naukowe
Tytuł :
Oncogenic mutations within the β3-αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies.
Autorzy :
Zhang B; Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chen Y; Geneplus-Beijing, Beijing, China.; Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Dai P; Geneplus-Beijing, Beijing, China.; Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Yu H; Department of Respiratory Medicine, Wuxi People's Hospital, Wuxi, China.
Ma J; Geneplus-Beijing, Beijing, China.
Chen C; Geneplus-Beijing, Beijing, China.; Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Zhang Y; Geneplus-Beijing, Beijing, China.; Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Guan Y; Geneplus-Beijing, Beijing, China.; Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Chen R; Geneplus-Beijing, Beijing, China.
Liu T; Geneplus-Beijing, Beijing, China.; Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Wang J; Department of Computer Science and Technology, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Yang L; Geneplus-Beijing, Beijing, China.
Yi X; Geneplus-Beijing, Beijing, China.
Xia X; Geneplus-Beijing, Beijing, China.
Ma H; Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Pokaż więcej
Źródło :
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Oct; Vol. 8 (10), pp. e1395. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Mutation*
MAP Kinase Kinase 1/*genetics
Neoplasms/*genetics
Proto-Oncogene Proteins B-raf/*genetics
Receptor, ErbB-2/*genetics
Antineoplastic Agents/therapeutic use ; Conserved Sequence ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/chemistry ; ErbB Receptors/genetics ; Humans ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/chemistry ; Neoplasms/drug therapy ; Protein Domains ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Proto-Oncogene Proteins B-raf/chemistry ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/chemistry
Czasopismo naukowe
Tytuł :
MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC.
Autorzy :
Franklin DA; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sharick JT; Department of Biomedical Engineering, School of Engineering, Vanderbilt University, Nashville, Tennessee, USA.; Morgridge Institute for Research, University of Wisconsin-Madison, Wisconsin, USA.
Ericsson-Gonzalez PI; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Sanchez V; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Dean PT; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Opalenik SR; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Cairo S; Xentech, Genopole Campus 3, Evry, France.
Judde JG; Xentech, Genopole Campus 3, Evry, France.
Lewis MT; Baylor College of Medicine, Houston, Texas, USA.
Chang JC; Department of Radiation Oncology, Houston Methodist Research Institute, Houston, Texas, USA.
Sanders ME; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology and.
Cook RS; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville Tennessee, USA.
Skala MC; Morgridge Institute for Research, University of Wisconsin-Madison, Wisconsin, USA.; Department of Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Wisconsin, USA.
Bordeaux J; Navigate BioPharma Services, Inc., Carlsbad, California, USA.
Orozco Bender J; Navigate BioPharma Services, Inc., Carlsbad, California, USA.
Vaupel C; Navigate BioPharma Services, Inc., Carlsbad, California, USA.
Geiss G; NanoString Technologies, Seattle, Washington, USA.
Hinerfeld D; NanoString Technologies, Seattle, Washington, USA.
Balko JM; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.
Pokaż więcej
Źródło :
JCI insight [JCI Insight] 2020 Aug 06; Vol. 5 (15). Date of Electronic Publication: 2020 Aug 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Glycolysis*
Antineoplastic Agents/*pharmacology
MAP Kinase Kinase 1/*metabolism
Myeloid-Derived Suppressor Cells/*pathology
Triple Negative Breast Neoplasms/*pathology
ras Proteins/*metabolism
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Drug Resistance, Neoplasm ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/genetics ; Mice ; Mice, Nude ; Myeloid-Derived Suppressor Cells/drug effects ; Myeloid-Derived Suppressor Cells/metabolism ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; ras Proteins/antagonists & inhibitors ; ras Proteins/genetics
Czasopismo naukowe
Tytuł :
Tight junction protein claudin-1 is downregulated by TGF-β1 via MEK signaling in benign prostatic epithelial cells.
Autorzy :
Wang K; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Pascal LE; Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Li F; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Chen W; Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Dhir R; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Balasubramani GK; Department of Epidemiology, Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
DeFranco DB; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Yoshimura N; Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
He D; Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang Z; Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Pokaż więcej
Źródło :
The Prostate [Prostate] 2020 Oct; Vol. 80 (14), pp. 1203-1215. Date of Electronic Publication: 2020 Jul 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Claudin-1/*metabolism
MAP Kinase Kinase 1/*metabolism
Prostatic Hyperplasia/*metabolism
Transforming Growth Factor beta1/*metabolism
Cell Line ; Claudin-1/biosynthesis ; Claudin-1/genetics ; Down-Regulation ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Flavonoids/pharmacology ; Gene Knockdown Techniques ; Humans ; Immunohistochemistry ; MAP Kinase Kinase 1/antagonists & inhibitors ; Male ; Permeability ; Prostatic Hyperplasia/genetics ; Prostatic Hyperplasia/pathology ; Protein Kinase Inhibitors/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Snail Family Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Upregulation of secreted phosphoprotein 1 affects malignant progression, prognosis, and resistance to cetuximab via the KRAS/MEK pathway in head and neck cancer.
Autorzy :
Liu K; School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Center of Yu Zhenkun Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Hu H; School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Center of Yu Zhenkun Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Jiang H; School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Center of Yu Zhenkun Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Liu C; Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang H; Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Center of Yu Zhenkun Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Gong S; Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Center of Yu Zhenkun Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Wei D; Department of Otorhinolaryngology, Key Laboratory of Otolaryngology, Qilu Hospital, Shandong University, NHFPC (Shandong University), Jinan, Shandong, China.
Yu Z; School of Medicine, Southeast University, Nanjing, Jiangsu, China.; Department of Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Center of Yu Zhenkun Otolaryngology Head and Neck Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Pokaż więcej
Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Oct; Vol. 59 (10), pp. 1147-1158. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Biomarkers, Tumor/*metabolism
Cetuximab/*pharmacology
Head and Neck Neoplasms/*pathology
MAP Kinase Kinase 1/*metabolism
Osteopontin/*metabolism
Proto-Oncogene Proteins p21(ras)/*metabolism
Animals ; Antineoplastic Agents, Immunological/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Humans ; MAP Kinase Kinase 1/genetics ; Mice ; Mice, Nude ; Neoplasm Invasiveness ; Osteopontin/genetics ; Prognosis ; Proto-Oncogene Proteins p21(ras)/genetics ; Signal Transduction ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
CircRNA ZFR stimulates the proliferation of hepatocellular carcinoma through upregulating MAP2K1.
Autorzy :
Cedric BC; Department of Clinical Laboratory Medicine, and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China. .
Souraka TDM
Feng YL
Kisembo P
Tu JC
Pokaż więcej
Źródło :
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2020 Oct; Vol. 24 (19), pp. 9924-9931.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
MAP Kinase Kinase 1/*metabolism
RNA, Circular/*metabolism
Carcinoma, Hepatocellular/pathology ; Cell Proliferation ; Cells, Cultured ; Female ; Humans ; Liver Neoplasms/pathology ; MAP Kinase Kinase 1/genetics ; Male ; Middle Aged ; RNA, Circular/genetics
Czasopismo naukowe
Tytuł :
Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling.
Autorzy :
Fish JE; From the Toronto General Hospital Research Institute (J.E.F., E.B., D.G., P.V.D., Z.C.), University Health Network, Canada.; Peter Munk Cardiac Centre (J.E.F.), University Health Network, Canada.; Department of Laboratory Medicine and Pathobiology (J.E.F., D.G.), University of Toronto, Canada.
Flores Suarez CP; Cardiovascular Research Institute (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., J.D.W.), Baylor College of Medicine, Houston, TX.; Department of Molecular Physiology and Biophysics (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., T.S.S., C.S.W., J.D.W.), Baylor College of Medicine, Houston, TX.
Boudreau E; From the Toronto General Hospital Research Institute (J.E.F., E.B., D.G., P.V.D., Z.C.), University Health Network, Canada.
Herman AM; Cardiovascular Research Institute (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., J.D.W.), Baylor College of Medicine, Houston, TX.; Department of Molecular Physiology and Biophysics (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., T.S.S., C.S.W., J.D.W.), Baylor College of Medicine, Houston, TX.
Gutierrez MC; Cardiovascular Research Institute (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., J.D.W.), Baylor College of Medicine, Houston, TX.; Department of Molecular Physiology and Biophysics (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., T.S.S., C.S.W., J.D.W.), Baylor College of Medicine, Houston, TX.; Graduate Program in Developmental Biology (M.C.G., J.D.W.), Baylor College of Medicine, Houston, TX.
Gustafson D; From the Toronto General Hospital Research Institute (J.E.F., E.B., D.G., P.V.D., Z.C.), University Health Network, Canada.; Department of Laboratory Medicine and Pathobiology (J.E.F., D.G.), University of Toronto, Canada.
DiStefano PV; From the Toronto General Hospital Research Institute (J.E.F., E.B., D.G., P.V.D., Z.C.), University Health Network, Canada.
Cui M; Cardiovascular Research Institute (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., J.D.W.), Baylor College of Medicine, Houston, TX.; Department of Molecular Physiology and Biophysics (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., T.S.S., C.S.W., J.D.W.), Baylor College of Medicine, Houston, TX.
Chen Z; From the Toronto General Hospital Research Institute (J.E.F., E.B., D.G., P.V.D., Z.C.), University Health Network, Canada.
De Ruiz KB; Cardiovascular Research Institute (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., J.D.W.), Baylor College of Medicine, Houston, TX.; Department of Molecular Physiology and Biophysics (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., T.S.S., C.S.W., J.D.W.), Baylor College of Medicine, Houston, TX.
Schexnayder TS; Department of Molecular Physiology and Biophysics (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., T.S.S., C.S.W., J.D.W.), Baylor College of Medicine, Houston, TX.; and Advanced Technology Cores (T.S.S., C.S.W.), Baylor College of Medicine, Houston, TX.
Ward CS; Department of Molecular Physiology and Biophysics (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., T.S.S., C.S.W., J.D.W.), Baylor College of Medicine, Houston, TX.; and Advanced Technology Cores (T.S.S., C.S.W.), Baylor College of Medicine, Houston, TX.
Radovanovic I; Krembil Research Institute (I.R.), University Health Network, Canada.; Division of Neurosurgery, Sprott Department of Surgery (I.R.), University Health Network, Canada.; Department of Surgery (I.R.), University of Toronto, Canada.
Wythe JD; Cardiovascular Research Institute (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., J.D.W.), Baylor College of Medicine, Houston, TX.; Department of Molecular Physiology and Biophysics (C.P.F.S., A.M.H., M.C.G., M.C., K.B.D.R., T.S.S., C.S.W., J.D.W.), Baylor College of Medicine, Houston, TX.; Graduate Program in Developmental Biology (M.C.G., J.D.W.), Baylor College of Medicine, Houston, TX.
Pokaż więcej
Źródło :
Circulation research [Circ Res] 2020 Aug 28; Vol. 127 (6), pp. 727-743. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Video-Audio Media
MeSH Terms :
Gain of Function Mutation*
Endothelial Cells/*enzymology
Intracranial Arteriovenous Malformations/*genetics
MAP Kinase Kinase 1/*metabolism
Proto-Oncogene Proteins p21(ras)/*genetics
Animals ; Cells, Cultured ; Disease Models, Animal ; Endothelial Cells/pathology ; Female ; Genetic Predisposition to Disease ; Human Umbilical Vein Endothelial Cells/enzymology ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Intracranial Arteriovenous Malformations/enzymology ; Intracranial Arteriovenous Malformations/pathology ; Intracranial Hemorrhages/enzymology ; Intracranial Hemorrhages/genetics ; Intracranial Hemorrhages/pathology ; MAP Kinase Kinase 1/antagonists & inhibitors ; Male ; Mice, Transgenic ; Permeability ; Phenotype ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Signal Transduction ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish Proteins
Czasopismo naukowe
Tytuł :
Successful BRAF/MEK inhibition in a patient with BRAF -mutated extrapancreatic acinar cell carcinoma.
Autorzy :
Busch E; Department of Medical Oncology, University Hospital Heidelberg, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, 69120, Germany.
Kreutzfeldt S; Department of Translational Medical Oncology, NCT Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Agaimy A; Institute of Pathology, University Hospital Erlangen, Erlangen, 91054, Germany.
Mechtersheimer G; Institute of Pathology, University Hospital Heidelberg, Heidelberg, 69120, Germany.
Horak P; Department of Translational Medical Oncology, NCT Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Brors B; Division of Applied Bioinformatics, DKFZ and NCT Heidelberg, Heidelberg, 69120, Germany.; German Cancer Consortium.
Hutter B; Division of Applied Bioinformatics, DKFZ and NCT Heidelberg, Heidelberg, 69120, Germany.; Molecular Diagnostics Program, NCT Heidelberg and DKFZ, Heidelberg, 69120, Germany.
Fröhlich M; Division of Applied Bioinformatics, DKFZ and NCT Heidelberg, Heidelberg, 69120, Germany.; Molecular Diagnostics Program, NCT Heidelberg and DKFZ, Heidelberg, 69120, Germany.
Uhrig S; Division of Applied Bioinformatics, DKFZ and NCT Heidelberg, Heidelberg, 69120, Germany.; Molecular Diagnostics Program, NCT Heidelberg and DKFZ, Heidelberg, 69120, Germany.
Mayer P; Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, 69120, Germany.
Schröck E; NCT Partner Site Dresden, University Cancer Center (UCC) Dresden, Dresden, 01307, Germany.; Institute of Clinical Genetics, Technical University of Dresden, Dresden, 01307, Germany.
Stenzinger A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, 69120, Germany.
Glimm H; NCT Partner Site Dresden, University Cancer Center (UCC) Dresden, Dresden, 01307, Germany.
Jäger D; Department of Medical Oncology, University Hospital Heidelberg, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, 69120, Germany.
Springfeld C; Department of Medical Oncology, University Hospital Heidelberg, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, 69120, Germany.
Fröhling S; Department of Translational Medical Oncology, NCT Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.; German Cancer Consortium.
Zschäbitz S; Department of Medical Oncology, University Hospital Heidelberg, National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, 69120, Germany.
Pokaż więcej
Źródło :
Cold Spring Harbor molecular case studies [Cold Spring Harb Mol Case Stud] 2020 Aug 25; Vol. 6 (4). Date of Electronic Publication: 2020 Aug 25 (Print Publication: 2020).
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Acinar Cell/*genetics
MAP Kinase Kinase 1/*genetics
Proto-Oncogene Proteins B-raf/*genetics
Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; MAP Kinase Kinase 1/metabolism ; Male ; Mitogen-Activated Protein Kinase Kinases/genetics ; Mutation ; Pancreatic Neoplasms/genetics ; Precision Medicine ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/metabolism
Czasopismo naukowe
Tytuł :
Endothelial MAP2K1 mutations in arteriovenous malformation activate the RAS/MAPK pathway.
Autorzy :
Smits PJ; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA.
Konczyk DJ; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA.
Sudduth CL; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA.
Goss JA; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA.
Greene AK; Department of Plastic & Oral Surgery, Boston Children's Hospital, Harvard Medical School, USA. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Aug 20; Vol. 529 (2), pp. 450-454. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Arteriovenous Malformations/*genetics
Endothelial Cells/*metabolism
MAP Kinase Kinase 1/*genetics
Mitogen-Activated Protein Kinases/*metabolism
ras Proteins/*metabolism
Arteriovenous Malformations/metabolism ; Arteriovenous Malformations/pathology ; Cells, Cultured ; Endothelial Cells/pathology ; Enzyme Activation ; Human Umbilical Vein Endothelial Cells ; Humans ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Signaling System ; Point Mutation
Czasopismo naukowe
Tytuł :
BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes.
Autorzy :
Peiffer L; Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany.; Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Farahpour F; Bioinformatics and Computational Biophysics, University Duisburg-Essen, Essen, Germany.
Sriram A; Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany.; Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Spassova I; Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany.
Hoffmann D; Bioinformatics and Computational Biophysics, University Duisburg-Essen, Essen, Germany.
Kubat L; Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany.
Stoitzner P; Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.
Gambichler T; Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany.
Sucker A; Department of Dermatology, University Hospital of Essen, Essen, Germany.
Ugurel S; Department of Dermatology, University Hospital of Essen, Essen, Germany.
Schadendorf D; Department of Dermatology, University Hospital of Essen, Essen, Germany.
Becker JC; Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany. .; Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. .; Department of Dermatology, University Hospital of Essen, Essen, Germany. .
Pokaż więcej
Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Jun; Vol. 70 (6), pp. 1635-1647. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Reprogramming*
Lymphocytes, Tumor-Infiltrating/*immunology
MAP Kinase Kinase 1/*antagonists & inhibitors
Melanoma/*immunology
Protein Kinase Inhibitors/*therapeutic use
Proto-Oncogene Proteins B-raf/*antagonists & inhibitors
Biomarkers, Tumor/analysis ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphocytes, Tumor-Infiltrating/drug effects ; Melanoma/drug therapy ; Melanoma/metabolism ; Melanoma/pathology ; Prognosis ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; T Cell Transcription Factor 1/genetics ; T Cell Transcription Factor 1/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Selumetinib: First Approval.
Autorzy :
Markham A; Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. .
Keam SJ; Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
Pokaż więcej
Źródło :
Drugs [Drugs] 2020 Jun; Vol. 80 (9), pp. 931-937.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Approval*
MAP Kinase Kinase 1/*antagonists & inhibitors
MAP Kinase Kinase 2/*antagonists & inhibitors
Neurofibromatosis 1/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Humans ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/metabolism ; Molecular Structure ; Neurofibromatosis 1/metabolism ; Protein Kinase Inhibitors/chemistry
Czasopismo naukowe
Tytuł :
[Identification of a de novo MAP2K1 gene variant in an affected patient with Cardio-facio-cutaneous syndrome].
Autorzy :
Wang Q; Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong 523120, China. .
Chen P
Peng Q
Liu J
Huang Y
Tang Z
Liu Y
Yuan H
Pokaż więcej
Źródło :
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2020 May 10; Vol. 37 (5), pp. 567-569.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Ectodermal Dysplasia*/genetics
Facies*
Failure to Thrive*/genetics
Genetic Variation*
Heart Defects, Congenital*/genetics
MAP Kinase Kinase 1*/genetics
China ; Genetic Association Studies ; Heterozygote ; Humans ; Infant ; Male ; Mutation ; Whole Exome Sequencing
SCR Disease Name :
Cardiofaciocutaneous syndrome
Czasopismo naukowe
Tytuł :
Computational Study on the Effect of Inactivating/Activating Mutations on the Inhibition of MEK1 by Trametinib.
Autorzy :
Zhu J; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Li C; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Yang H; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Guo X; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Huang T; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Han W; Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 21; Vol. 21 (6). Date of Electronic Publication: 2020 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*chemistry
MAP Kinase Kinase 1/*chemistry
Protein Kinase Inhibitors/*chemistry
Pyridones/*chemistry
Pyrimidinones/*chemistry
Allosteric Site/genetics ; Antineoplastic Agents/pharmacology ; Catalysis/drug effects ; Hydrogen Bonding ; Ligands ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/genetics ; Molecular Docking Simulation ; Mutation ; Protein Binding/genetics ; Protein Conformation/drug effects ; Protein Kinase Inhibitors/pharmacology ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; Static Electricity ; Thermodynamics
Czasopismo naukowe
Tytuł :
MEK Inhibition Reverses Aberrant Signaling in Melanoma Cells through Reorganization of NRas and BRAF in Self Nanoclusters.
Autorzy :
Yakovian O; Racah Institute of Physics, The Hebrew University, Jerusalem, Israel.
Sajman J; Racah Institute of Physics, The Hebrew University, Jerusalem, Israel.
Arafeh R; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Neve-Oz Y; Racah Institute of Physics, The Hebrew University, Jerusalem, Israel.
Alon M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Samuels Y; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Sherman E; Racah Institute of Physics, The Hebrew University, Jerusalem, Israel. .
Pokaż więcej
Źródło :
Cancer research [Cancer Res] 2021 Mar 01; Vol. 81 (5), pp. 1279-1292. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
GTP Phosphohydrolases/*metabolism
Melanoma/*drug therapy
Melanoma/*metabolism
Membrane Proteins/*metabolism
Proto-Oncogene Proteins B-raf/*metabolism
Skin Neoplasms/*drug therapy
Skin Neoplasms/*metabolism
Cell Line, Tumor ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Epidermal Growth Factor/pharmacology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; GTP Phosphohydrolases/genetics ; Humans ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/metabolism ; Membrane Proteins/genetics ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins B-raf/genetics ; Pyridones/pharmacology ; Pyrimidinones/pharmacology ; Signal Transduction/drug effects ; Single Molecule Imaging
SCR Disease Name :
Melanoma, Cutaneous Malignant
Czasopismo naukowe
Tytuł :
Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Autorzy :
Park E; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Rawson S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Li K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Kim BW; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Ficarro SB; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Pino GG; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Sharif H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Marto JA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jeon H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. .; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. .
Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. .; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. .
Pokaż więcej
Źródło :
Nature [Nature] 2019 Nov; Vol. 575 (7783), pp. 545-550. Date of Electronic Publication: 2019 Oct 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cryoelectron Microscopy*
14-3-3 Proteins/*antagonists & inhibitors
14-3-3 Proteins/*chemistry
MAP Kinase Kinase 1/*antagonists & inhibitors
MAP Kinase Kinase 1/*chemistry
Proto-Oncogene Proteins B-raf/*antagonists & inhibitors
Proto-Oncogene Proteins B-raf/*chemistry
14-3-3 Proteins/genetics ; 14-3-3 Proteins/metabolism ; Binding Sites ; Cell Transformation, Neoplastic/genetics ; Humans ; MAP Kinase Kinase 1/genetics ; MAP Kinase Kinase 1/metabolism ; Models, Molecular ; Mutation ; Phosphorylation ; Protein Binding ; Protein Domains ; Protein Multimerization ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism
Czasopismo naukowe
Tytuł :
Arthritis associated to cardio-facio-cutaneous syndrome related to a MAP2K1 mutation.
Autorzy :
Bochet P; Department of rheumatology, North hospital, university hospital of St-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.
Ramond F; Service de génétique clinique, chromosomique et moléculaire, CHU-hôpital Nord, 42270 Saint-Étienne, France.
Touraine R; Service de génétique clinique, chromosomique et moléculaire, CHU-hôpital Nord, 42270 Saint-Étienne, France.
Thomas T; Department of rheumatology, North hospital, university hospital of St-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France; SAINBIOSE, Inserm U1059, university of Lyon, Saint-Etienne, 42023 Saint-Étienne, France.
Marotte H; Department of rheumatology, North hospital, university hospital of St-Étienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France; SAINBIOSE, Inserm U1059, university of Lyon, Saint-Etienne, 42023 Saint-Étienne, France. Electronic address: .
Pokaż więcej
Źródło :
Joint bone spine [Joint Bone Spine] 2020 Mar; Vol. 87 (2), pp. 169. Date of Electronic Publication: 2019 Sep 27.
Typ publikacji :
Journal Article
MeSH Terms :
Arthritis*/genetics
Ectodermal Dysplasia*/genetics
MAP Kinase Kinase 1*/genetics
Facies ; Failure to Thrive ; Heart Defects, Congenital ; Humans ; Mutation
SCR Disease Name :
Cardiofaciocutaneous syndrome
Czasopismo naukowe
Tytuł :
rAAV9-Mediated MEK1 Gene Expression Restores Post-conditioning Protection Against Ischemia Injury in Hypertrophic Myocardium.
Autorzy :
Chen Y; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China.
Liu F; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China.; Clinical Medical Research Institute, Xinjiang Medical University, Urumqi, 830054, China.
Chen BD; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China.; Clinical Medical Research Institute, Xinjiang Medical University, Urumqi, 830054, China.
Li XM; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China.
Huang Y; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China.
Yu ZX; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China.
Gao XL; College of Pharmacy, Xinjiang Medical University, Urumqi, China.
He CH; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China.; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China.
Yang YN; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China. .; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China. .
Ma YT; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China. .; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China. .
Gao XM; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Disease in Central Asia, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, China. .; Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, China. .; Clinical Medical Research Institute, Xinjiang Medical University, Urumqi, 830054, China. .; Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, 830054, China. .
Pokaż więcej
Źródło :
Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2020 Feb; Vol. 34 (1), pp. 3-14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Transfer Techniques*
Genetic Vectors*
Ischemic Postconditioning*
Dependovirus/*genetics
Hypertrophy, Left Ventricular/*therapy
MAP Kinase Kinase 1/*biosynthesis
Myocardial Infarction/*prevention & control
Myocardial Reperfusion Injury/*prevention & control
Myocardium/*enzymology
Animals ; Apoptosis ; Disease Models, Animal ; Enzyme Induction ; Hypertrophy, Left Ventricular/enzymology ; Hypertrophy, Left Ventricular/genetics ; Hypertrophy, Left Ventricular/pathology ; Isolated Heart Preparation ; MAP Kinase Kinase 1/genetics ; Male ; Mice, Inbred C57BL ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Myocardial Infarction/enzymology ; Myocardial Infarction/genetics ; Myocardial Infarction/pathology ; Myocardial Reperfusion Injury/enzymology ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/pathology ; Myocardium/pathology ; Phosphorylation ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism
Czasopismo naukowe
Tytuł :
Trametinib in the treatment of multiple malignancies harboring MEK1 mutations.
Autorzy :
Lian T; Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China; Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Li C; Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. Electronic address: .
Wang H; Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China; Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin, China. Electronic address: .
Pokaż więcej
Źródło :
Cancer treatment reviews [Cancer Treat Rev] 2019 Dec; Vol. 81, pp. 101907. Date of Electronic Publication: 2019 Oct 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Mutation*
Antineoplastic Agents/*therapeutic use
MAP Kinase Kinase 1/*genetics
Protein Kinase Inhibitors/*therapeutic use
Pyridones/*therapeutic use
Pyrimidinones/*therapeutic use
Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Animals ; Antineoplastic Agents/pharmacology ; Asian Continental Ancestry Group/genetics ; Histiocytosis, Langerhans-Cell/drug therapy ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/virology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/metabolism ; Mice ; NIH 3T3 Cells ; Neoplasms/drug therapy ; Neoplasms/genetics ; Protein Kinase Inhibitors/pharmacology ; Pyridones/pharmacology ; Pyrimidinones/pharmacology
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies