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Wyszukujesz frazę ""MAP Kinase Kinase 1"" wg kryterium: Temat


Tytuł:
Oncoprotein HBXIP promotes tumorigenesis through MAPK/ERK pathway activation in non-small cell lung cancer.
Autorzy:
Zhang J; Department of Breast Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Sun B; Department of Outpatient Office, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Ruan X; Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Hou X; Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Zhi J; Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Meng X; Department of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Zheng X; Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Gao M; Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
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Źródło:
Cancer biology & medicine [Cancer Biol Med] 2021 Feb 15; Vol. 18 (1), pp. 105-119.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MAP Kinase Signaling System*
Adaptor Proteins, Signal Transducing/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Animals ; Carcinogenesis ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/pathology ; MAP Kinase Kinase 1/metabolism ; Male ; Mice ; Mice, Nude ; Oncogene Proteins/metabolism ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells.
Autorzy:
Kim SM; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States of America.
Yokoyama T; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States of America.; Department of Animal Science, Kobe University, Kobe, Hyogo, Japan.
Ng D; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States of America.
Ulu F; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States of America.
Yamazaki Y; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States of America.
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Źródło:
PloS one [PLoS One] 2019 Nov 04; Vol. 14 (11), pp. e0224628. Date of Electronic Publication: 2019 Nov 04 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Gene Expression Regulation, Developmental/*physiology
Germ Cells/*physiology
MAP Kinase Signaling System/*physiology
Meiosis/*physiology
Tretinoin/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Butadienes/pharmacology ; Cells, Cultured ; Culture Media/metabolism ; Embryo, Mammalian ; Female ; Gene Expression Regulation, Developmental/drug effects ; Germ Cells/drug effects ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/antagonists & inhibitors ; MAP Kinase Kinase 2/metabolism ; MAP Kinase Signaling System/drug effects ; Male ; Meiosis/drug effects ; Mice ; Mice, Transgenic ; Nitriles/pharmacology ; Primary Cell Culture ; Sex Differentiation/drug effects ; Sex Differentiation/physiology
Czasopismo naukowe
Tytuł:
MicroRNA‑125a‑5p controls the proliferation, apoptosis, migration and PTEN/MEK1/2/ERK1/2 signaling pathway in MCF‑7 breast cancer cells.
Autorzy:
Liang Z; Department of Vascular Thyroid Breast Surgery, Institute of Neurology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.
Pan Q; Guangdong Key Laboratory of Age‑Related Cardiac and Cerebral Diseases, Institute of Neurology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.
Zhang Z; Department of Vascular Thyroid Breast Surgery, Institute of Neurology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.
Huang C; Department of Vascular Thyroid Breast Surgery, Institute of Neurology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.
Yan Z; Department of Vascular Thyroid Breast Surgery, Institute of Neurology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.
Zhang Y; Department of Vascular Thyroid Breast Surgery, Institute of Neurology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.
Li J; Department of Vascular Thyroid Breast Surgery, Institute of Neurology, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.
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Źródło:
Molecular medicine reports [Mol Med Rep] 2019 Nov; Vol. 20 (5), pp. 4507-4514. Date of Electronic Publication: 2019 Sep 24.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis*
Cell Movement*
Cell Proliferation*
MAP Kinase Signaling System*
Breast Neoplasms/*metabolism
MicroRNAs/*metabolism
RNA, Neoplasm/*metabolism
Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; MAP Kinase Kinase 1/genetics ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/genetics ; MAP Kinase Kinase 2/metabolism ; MCF-7 Cells ; MicroRNAs/genetics ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; RNA, Neoplasm/genetics
Czasopismo naukowe
Tytuł:
Ghrelin prevents cardiac cell apoptosis during cardiac remodelling post experimentally induced myocardial infarction in rats via activation of Raf-MEK1/2-ERK1/2 signalling.
Autorzy:
Eid RA; a Department of Pathology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
Alkhateeb MA; b Department of Basic Medical Sciences, College of Medicine , King Saud bin Abdulaziz University for Health Sciences , Riyadh , Saudi Arabia.
Al-Shraim M; a Department of Pathology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
Eleawa SM; c Department of Applied Medical Sciences, College of Health Sciences , PAAET , Kuwait.
Shatoor AS; d Cardiology section, Department of Medicine, College of Medicine , King Khalid University , Abha , Saudi Arabia.
El-Kott AF; e Department of Biology, College of Science , King Khalid University , Abha , Saudi Arabia.
Zaki MSA; f Department of Anatomy, College of Medicine , King Khalid University , Abha , Saudi Arabia.
Shatoor KA; g College of Medicine , King Khalid University , Abha , Saudi Arabia.
Bin-Jaliah I; h Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
Al-Hashem FH; h Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
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Źródło:
Archives of physiology and biochemistry [Arch Physiol Biochem] 2019 May; Vol. 125 (2), pp. 93-103. Date of Electronic Publication: 2018 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Ghrelin/*pharmacology
MAP Kinase Signaling System/*drug effects
Myocardial Infarction/*pathology
Myocardium/*pathology
Ventricular Remodeling/*drug effects
Animals ; Biomarkers/metabolism ; Cytoprotection/drug effects ; Disease Models, Animal ; Fibrosis ; Hemodynamics/drug effects ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/metabolism ; Male ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Myocardial Infarction/metabolism ; Myocardial Infarction/physiopathology ; Myocardium/enzymology ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; raf Kinases/metabolism
Czasopismo naukowe
Tytuł:
Quercetin suppresses the chymotrypsin-like activity of proteasome via inhibition of MEK1/ERK1/2 signaling pathway in hepatocellular carcinoma HepG2 cells.
Autorzy:
Ding Y; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Chen X; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Wang B; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Yu B; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Ge J; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Shi X; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.; Department of Hepatobiliary & Laparascopic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
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Źródło:
Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2018 May; Vol. 96 (5), pp. 521-526. Date of Electronic Publication: 2018 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*pathology
Chymotrypsin/*metabolism
Liver Neoplasms/*pathology
MAP Kinase Signaling System/*drug effects
Proteasome Endopeptidase Complex/*metabolism
Quercetin/*pharmacology
Apoptosis/drug effects ; Cell Survival/drug effects ; Enzyme Activation/drug effects ; Hep G2 Cells ; Humans ; MAP Kinase Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism
Czasopismo naukowe
Tytuł:
Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway.
Autorzy:
Ma X; Department of Cardiology, Affiliated Nanhua Hospital of University of South China, Hengyang, 421001, China.; Institute of Cardiovascular disease, Key Laboratory for Atherosclerology of Human Province, University of South China, Hengyang, 421001, China.
Liu Y; Institute of Cardiovascular disease, Key Laboratory for Atherosclerology of Human Province, University of South China, Hengyang, 421001, China.
Tan Y; Department of Pathology, Changde Vocational Technical College, Changde, 415000, China.
Qu K; Institute of Cardiovascular disease, Key Laboratory for Atherosclerology of Human Province, University of South China, Hengyang, 421001, China.
He X; Women and Children Healthcare Hospital of Zhu zhou, Zhuzhou, 412000, China.
Zhang H; Department of Pathology, The First Affiliated Hospital of University of South China, Hengyang, 421001, China. .
Wang Z; Institute of Cardiovascular disease, Key Laboratory for Atherosclerology of Human Province, University of South China, Hengyang, 421001, China. .
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Źródło:
Lipids in health and disease [Lipids Health Dis] 2017 Nov 25; Vol. 16 (1), pp. 223. Date of Electronic Publication: 2017 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Allyl Compounds/*pharmacology
Apolipoproteins A/*genetics
Gene Expression/*drug effects
Hypolipidemic Agents/*pharmacology
MAP Kinase Signaling System/*drug effects
Sulfides/*pharmacology
Apolipoproteins A/metabolism ; Binding Sites ; Drug Evaluation, Preclinical ; Enzyme Activation ; Hep G2 Cells ; Humans ; MAP Kinase Kinase 1/metabolism ; Phosphorylation ; Promoter Regions, Genetic ; Protein Processing, Post-Translational ; ets-Domain Protein Elk-1/metabolism
Czasopismo naukowe
Tytuł:
Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect.
Autorzy:
Yeh CC; Cardiothoracic Translational Research Laboratory, University of California, San Francisco, San Francisco, CA, USA.
Fan Y; Cardiothoracic Translational Research Laboratory, University of California, San Francisco, San Francisco, CA, USA.
Yang YL; Cardiothoracic Translational Research Laboratory, University of California, San Francisco, San Francisco, CA, USA.
Mann MJ; Cardiothoracic Translational Research Laboratory, University of California, San Francisco, San Francisco, CA, USA. .; Division of Cardiothoracic Surgery, 500 Parnassus Avenue, Suite W420, San Francisco, CA, 94143, USA. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2017 Nov 24; Vol. 24 (1), pp. 89. Date of Electronic Publication: 2017 Nov 24.
Typ publikacji:
Journal Article
MeSH Terms:
Heart Septal Defects, Atrial/*genetics
MAP Kinase Kinase 1/*genetics
MAP Kinase Signaling System/*genetics
Animals ; Disease Models, Animal ; Female ; Heart Atria/physiopathology ; Humans ; Male ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł:
Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease.
Autorzy:
Kamionek M; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Ahmadi Moghaddam P; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Sakhdari A; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Kovach AE; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Welch M; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Meng X; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Dresser K; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Tomaszewicz K; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Cosar EF; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Mark EJ; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Fraire AE; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Hutchinson L; Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
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Źródło:
Histopathology [Histopathology] 2016 Sep; Vol. 69 (3), pp. 499-509. Date of Electronic Publication: 2016 Apr 29.
Typ publikacji:
Journal Article
MeSH Terms:
Histiocytosis, Langerhans-Cell/*genetics
Lung Diseases/*genetics
MAP Kinase Signaling System/*genetics
Adolescent ; Adult ; Aged ; DNA Mutational Analysis ; Female ; High-Throughput Nucleotide Sequencing ; Histiocytosis, Langerhans-Cell/etiology ; Histiocytosis, Langerhans-Cell/pathology ; Humans ; Immunohistochemistry ; Lung Diseases/etiology ; Lung Diseases/pathology ; MAP Kinase Kinase 1/genetics ; Male ; Middle Aged ; Mutation ; Polymerase Chain Reaction ; Proto-Oncogene Proteins B-raf/genetics ; Real-Time Polymerase Chain Reaction ; Smoking/adverse effects ; Young Adult ; ras Proteins/genetics
Czasopismo naukowe
Tytuł:
Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways.
Autorzy:
Cheng Y; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Lin CH; Gradual Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chen JY; Gradual Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Li CH; Gradual Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Liu YT; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Chen BC; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
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Źródło:
PloS one [PLoS One] 2016 Aug 03; Vol. 11 (8), pp. e0160593. Date of Electronic Publication: 2016 Aug 03 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Connective Tissue Growth Factor/*genetics
Fibroblasts/*metabolism
Hypoxia/*genetics
Lung/*metabolism
MAP Kinase Signaling System/*physiology
Cells, Cultured ; Connective Tissue Growth Factor/metabolism ; Humans ; Hypoxia/metabolism ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase Kinase 1/metabolism ; MAP Kinase Signaling System/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Primary Cell Culture ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Transcription Factor AP-1/metabolism ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism ; Zinc Finger Protein Gli2
Czasopismo naukowe
Tytuł:
Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis.
Autorzy:
Cursons J; Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, Parkville, VIC Australia, 3010 ; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Australia, 3010.
Angel CE; Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand ; School of Biological Sciences, University of Auckland, Auckland, New Zealand.
Hurley DG; Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, Parkville, VIC Australia, 3010.
Print CG; Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand ; School of Biological Sciences, University of Auckland, Auckland, New Zealand ; Bioinformatics Institute, University of Auckland, Auckland, New Zealand ; Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Dunbar PR; Maurice Wilkins Centre, University of Auckland, Auckland, New Zealand ; School of Biological Sciences, University of Auckland, Auckland, New Zealand.
Jacobs MD; Department of Biology, New Zealand International College, ACG New Zealand, Auckland, New Zealand.
Crampin EJ; Systems Biology Laboratory, Melbourne School of Engineering, University of Melbourne, Parkville, VIC Australia, 3010 ; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Australia, 3010 ; School of Mathematics and Statistics, University of Melbourne, Parkville, Australia, 3010 ; School of Medicine, University of Melbourne, Parkville, Australia, 3010.
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Źródło:
GigaScience [Gigascience] 2015 Dec 14; Vol. 4, pp. 63. Date of Electronic Publication: 2015 Dec 14 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MAP Kinase Signaling System*
Extracellular Signal-Regulated MAP Kinases/*metabolism
Keratinocytes/*metabolism
Epidermal Cells ; Epidermis/metabolism ; Fluorescence ; Fos-Related Antigen-2/metabolism ; Humans ; Image Processing, Computer-Assisted ; MAP Kinase Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Transcription Factor AP-1/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Relapsing pneumonitis due to two distinct inhibitors of the MAPK/ERK pathway: report of a case.
Autorzy:
Giraud V; AP-HP, Department of Pulmonary Medicine and Thoracic Oncology, Hôpital A. Paré, Boulogne, & université de Versailles SQY, Boulogne, France. .; Service de Pneumologie et d'Oncologie Thoracique, Hôpital Ambroise Paré, 9, avenue Charles de Gaulle, Boulogne, 92 104, France. .
Longvert C; AP-HP, Department of Dermatology, Hôpital A. Paré, Boulogne, France. .
Houlle-Crepin S; AP-HP, Department of Pathology, Hôpital A. Paré, Boulogne, France. .
Danel C; AP-HP, Department of Pathology, Hôpital Bichat Claude Bernard, Paris, France. .
Labrune S; AP-HP, Department of Pulmonary Medicine and Thoracic Oncology, Hôpital A. Paré, Boulogne, & université de Versailles SQY, Boulogne, France. .
Camus P; Department of Pulmonary Medicine, CHU Le Bocage and www.pneumotox.com, Dijon, 21079, France. .
Saiag P; AP-HP, Department of Dermatology, Hôpital A. Paré, Boulogne, France. .
Chinet T; AP-HP, Department of Pulmonary Medicine and Thoracic Oncology, Hôpital A. Paré, Boulogne, & université de Versailles SQY, Boulogne, France. .
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Źródło:
BMC cancer [BMC Cancer] 2015 Oct 19; Vol. 15, pp. 732. Date of Electronic Publication: 2015 Oct 19.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Indoles/*adverse effects
MAP Kinase Signaling System/*drug effects
Pneumonia/*chemically induced
Protein Kinase Inhibitors/*adverse effects
Pyridones/*adverse effects
Pyrimidinones/*adverse effects
Sulfonamides/*adverse effects
Bronchoalveolar Lavage Fluid/cytology ; Humans ; MAP Kinase Kinase 1/antagonists & inhibitors ; Male ; Melanoma/drug therapy ; Middle Aged ; Pneumonia/diagnosis ; Pneumonia/metabolism ; Recurrence ; Tomography, X-Ray Computed ; Vemurafenib
Czasopismo naukowe
Czasopismo naukowe
Tytuł:
MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.
Autorzy:
Evans C; Signalling Programme, The Babraham Institute, Cambridge, Cambridgeshire, United Kingdom.
Cook SJ
Coleman MP
Gilley J
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Źródło:
PloS one [PLoS One] 2013 Oct 04; Vol. 8 (10), pp. e76505. Date of Electronic Publication: 2013 Oct 04 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Axons/*drug effects
Axons/*metabolism
Butadienes/*pharmacology
MAP Kinase Signaling System/*drug effects
Nitriles/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Wallerian Degeneration/*metabolism
Animals ; Cell Line ; Enzyme Stability/drug effects ; Humans ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 2/antagonists & inhibitors ; MAP Kinase Kinase 5/antagonists & inhibitors ; Nicotinamide-Nucleotide Adenylyltransferase/metabolism ; Phenotype ; Rats ; Superior Cervical Ganglion/drug effects ; Superior Cervical Ganglion/metabolism ; Wallerian Degeneration/drug therapy
Czasopismo naukowe
Tytuł:
NS5ATP9 contributes to inhibition of cell proliferation by hepatitis C virus (HCV) nonstructural protein 5A (NS5A) via MEK/extracellular signal regulated kinase (ERK) pathway.
Autorzy:
Wang Q; Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. .
Wang Y
Li Y
Gao X
Liu S
Cheng J
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2013 May 21; Vol. 14 (5), pp. 10539-51. Date of Electronic Publication: 2013 May 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation*
MAP Kinase Signaling System*
Carrier Proteins/*metabolism
Extracellular Signal-Regulated MAP Kinases/*metabolism
MAP Kinase Kinase 1/*metabolism
Viral Nonstructural Proteins/*metabolism
Blotting, Western ; Carrier Proteins/genetics ; Cell Line, Tumor ; Cell Survival ; DNA-Binding Proteins ; Hep G2 Cells ; Humans ; Phosphorylation ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł:
Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
Autorzy:
Lopez J; Centre de Recherche en Cancérologie de Lyon, Université Lyon 1 - Inserm U1052 - CNRS UMR5286, Centre Léon Bérard, Bâtiment Cheney D, 28 rue Laënnec, Lyon 69373 Cedex 08, France.
Hesling C
Prudent J
Popgeorgiev N
Gadet R
Mikaelian I
Rimokh R
Gillet G
Gonzalo P
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Źródło:
Cell death and differentiation [Cell Death Differ] 2012 Sep; Vol. 19 (9), pp. 1459-69. Date of Electronic Publication: 2012 Mar 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
MAP Kinase Signaling System*
Proteolysis*
Adaptor Proteins, Signal Transducing/*metabolism
Apoptosis Regulatory Proteins/*metabolism
Membrane Proteins/*metabolism
Mitochondrial Proteins/*metabolism
Mitogen-Activated Protein Kinase 1/*metabolism
Mitogen-Activated Protein Kinase 3/*metabolism
src-Family Kinases/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Apoptosis Regulatory Proteins/genetics ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Enzyme Activation/drug effects ; Enzyme Activation/genetics ; Enzyme Inhibitors/pharmacology ; Humans ; MAP Kinase Kinase 1/genetics ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/genetics ; MAP Kinase Kinase 2/metabolism ; Membrane Proteins/genetics ; Mice ; Mitochondrial Proteins/genetics ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 3/genetics ; NIH 3T3 Cells ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Oncogene Protein p21(ras)/genetics ; Oncogene Protein p21(ras)/metabolism ; Staurosporine/pharmacology ; Thapsigargin/pharmacology ; raf Kinases/genetics ; raf Kinases/metabolism ; src-Family Kinases/genetics
Czasopismo naukowe
Tytuł:
The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models.
Autorzy:
Holt SV; Oncology iMED, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, UK. />Logié A
Odedra R
Heier A
Heaton SP
Alferez D
Davies BR
Wilkinson RW
Smith PD
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Źródło:
British journal of cancer [Br J Cancer] 2012 Feb 28; Vol. 106 (5), pp. 858-66. Date of Electronic Publication: 2012 Feb 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Benzimidazoles/*administration & dosage
MAP Kinase Kinase 1/*antagonists & inhibitors
MAP Kinase Kinase 2/*antagonists & inhibitors
MAP Kinase Signaling System/*drug effects
Neoplasms, Experimental/*drug therapy
Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Benzimidazoles/pharmacology ; Benzimidazoles/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dacarbazine/administration & dosage ; Dacarbazine/analogs & derivatives ; Dacarbazine/pharmacology ; Dacarbazine/therapeutic use ; Docetaxel ; Female ; Humans ; Mice ; Mice, Nude ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Neoplasms, Experimental/pathology ; Organophosphates/administration & dosage ; Organophosphates/pharmacology ; Organophosphates/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Quinazolines/administration & dosage ; Quinazolines/pharmacology ; Quinazolines/therapeutic use ; Taxoids/administration & dosage ; Taxoids/pharmacology ; Taxoids/therapeutic use ; Temozolomide ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate.
Autorzy:
Santos SD; European Molecular Biology Laboratory (EMBL), Cell Biology and Biophysics, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
Verveer PJ
Bastiaens PI
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Źródło:
Nature cell biology [Nat Cell Biol] 2007 Mar; Vol. 9 (3), pp. 324-30. Date of Electronic Publication: 2007 Feb 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Extracellular Signal-Regulated MAP Kinases/*metabolism
Intercellular Signaling Peptides and Proteins/*pharmacology
MAP Kinase Signaling System/*physiology
Animals ; Cell Cycle/drug effects ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Proliferation/drug effects ; Epidermal Growth Factor/pharmacology ; Flow Cytometry ; MAP Kinase Kinase 1/genetics ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Signaling System/drug effects ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Models, Biological ; Monte Carlo Method ; Nerve Growth Factor/pharmacology ; PC12 Cells ; Phosphorylation/drug effects ; Protein Kinase C/antagonists & inhibitors ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Proto-Oncogene Proteins c-raf/genetics ; Proto-Oncogene Proteins c-raf/metabolism ; RNA, Small Interfering/genetics ; Rats ; Receptor, trkA/antagonists & inhibitors ; Tetradecanoylphorbol Acetate/pharmacology
Czasopismo naukowe
Tytuł:
Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-κB and PKC/JNK pathways.
Autorzy:
Hsieh CP; Orthopaedic Surgery Department and Hyperbaric Center, Changhua Christian Hospital, Changhua, Taiwan, ROC.
Chiou YL
Lin CY
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Źródło:
Connective tissue research [Connect Tissue Res] 2010 Dec; Vol. 51 (6), pp. 497-509. Date of Electronic Publication: 2010 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation*
Bone Regeneration/*physiology
Hyperbaric Oxygenation/*methods
MAP Kinase Kinase 1/*physiology
MAP Kinase Signaling System/*physiology
NF-kappa B/*physiology
Osteoblasts/*metabolism
3T3 Cells ; Animals ; Cell Cycle/physiology ; Cell Line, Transformed ; Fibroblast Growth Factor 2/genetics ; Fibroblast Growth Factor 2/physiology ; Fracture Healing/physiology ; Fractures, Bone/metabolism ; Fractures, Bone/pathology ; Fractures, Bone/therapy ; Mice ; Mitogen-Activated Protein Kinase 3/physiology ; Mitogen-Activated Protein Kinase 8/metabolism ; Osteoblasts/enzymology ; Protein Kinase C/metabolism
Czasopismo naukowe
Tytuł:
Mitogen-activated protein kinase (MAPK) signalling pathways in HepG2 cells infected with a virulent strain of Klebsiella pneumoniae.
Autorzy:
Wu JH; Department of Microbiology and Immunology, Graduate Institute of Basic Medical Science, College of Medicine, Chang Gung University, Kwei San, Tao Yuan 333, Taiwan. />Hong LC
Tsai YY
Chen HW
Chen WX
Wu TS
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Źródło:
Cellular microbiology [Cell Microbiol] 2006 Sep; Vol. 8 (9), pp. 1467-74.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Klebsiella pneumoniae/*pathogenicity
MAP Kinase Signaling System/*physiology
Mitogen-Activated Protein Kinases/*metabolism
Apoptosis/drug effects ; Apoptosis/physiology ; Blotting, Western/methods ; Butadienes/pharmacology ; Cell Line, Tumor ; Enzyme Inhibitors/pharmacology ; Flavonoids/pharmacology ; Humans ; Imidazoles/pharmacology ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/antagonists & inhibitors ; MAP Kinase Kinase 2/metabolism ; MAP Kinase Signaling System/drug effects ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Models, Biological ; Nitriles/pharmacology ; Pyridines/pharmacology ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 4/metabolism ; Virulence ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe

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