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Wyszukujesz frazę ""MAP Kinase Signaling System"" wg kryterium: Temat


Tytuł :
Gadd45α affects retinal ganglion cell injury in chronic ocular hypertension rats by regulating p38MAPK pathway.
Autorzy :
Sun RX; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Sun ZH; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Ren Q; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Li L; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Yin L; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Li F; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Su X; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Dec 30; Vol. 763, pp. 145030. Date of Electronic Publication: 2020 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System*
Cell Cycle Proteins/*metabolism
Ocular Hypertension/*metabolism
Retinal Ganglion Cells/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Apoptosis ; Cell Cycle Proteins/genetics ; Cells, Cultured ; Humans ; Male ; Oxidative Stress ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Clostridium difficile toxin B induces colonic inflammation through the TRIM46/DUSP1/MAPKs and NF-κB signalling pathway.
Autorzy :
Li Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai, China.
Xu S; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai, China.
Xu Q; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai, China.
Chen Y; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 452-462.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
MAP Kinase Signaling System*
Bacterial Proteins/*toxicity
Bacterial Toxins/*toxicity
Clostridium difficile/*metabolism
Colon/*metabolism
Dual Specificity Phosphatase 1/*metabolism
Extracellular Signal-Regulated MAP Kinases/*metabolism
Transcription Factor RelA/*metabolism
Cell Line ; Colon/pathology ; Humans ; Inflammation/metabolism ; Inflammation/microbiology ; Inflammation/pathology
Czasopismo naukowe
Tytuł :
Anti-antioxidant impacts of circZNF609 silence in HaCaT cells through regulating miR-145.
Autorzy :
Ge R; Department of Galactophore, Linyi Central Hospital, Linyi, China.
Gao G; Department of Galactophore, Linyi Central Hospital, Linyi, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 384-392.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
MAP Kinase Signaling System*
Oxidative Stress*
Antioxidants/*pharmacology
Keratinocytes/*metabolism
Pressure Ulcer/*metabolism
RNA, Circular/*metabolism
Skin/*metabolism
Cell Line ; Humans ; Hydrogen Peroxide/pharmacology ; Keratinocytes/pathology ; MicroRNAs/metabolism ; Pressure Ulcer/pathology ; Skin/pathology
Czasopismo naukowe
Tytuł :
IGFBP5 enhances the dentinogenesis potential of dental pulp stem cells via JNK and ErK signalling pathways.
Autorzy :
Hao J; Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.; Department of Endodontics, Capital Medical University School of Stomatology, Beijing, China.
Yang H; Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
Cao Y; Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
Zhang C; Department of Endodontics, Capital Medical University School of Stomatology, Beijing, China.
Fan Z; Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.
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Źródło :
Journal of oral rehabilitation [J Oral Rehabil] 2020 Dec; Vol. 47 (12), pp. 1557-1565. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System*
Osteogenesis*
Animals ; Cell Differentiation ; Cells, Cultured ; Dental Pulp ; Dentinogenesis ; Humans ; Mice ; Mice, Nude ; Stem Cells
Czasopismo naukowe
Tytuł :
Enhancement of lens extraction-induced MCP-1 upregulation and microglia response in long-term diabetes via c-jun, stat1 and ERK.
Autorzy :
Tang Y; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Yin H; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Wang W; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Zhang X; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Chu N; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Li S; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Yan C; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Fu Q; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Yao K; Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 15; Vol. 261, pp. 118360. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cataract Extraction*
MAP Kinase Signaling System*/drug effects
Chemokine CCL2/*metabolism
Diabetes Mellitus, Experimental/*genetics
Microglia/*pathology
Proto-Oncogene Proteins c-jun/*metabolism
STAT1 Transcription Factor/*metabolism
Up-Regulation/*genetics
Animals ; Glucose/toxicity ; Inflammation/genetics ; Inflammation/pathology ; Lipopolysaccharides/pharmacology ; Macrophage Activation/drug effects ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Mice, Inbred C57BL ; Microglia/drug effects ; Microglia/metabolism ; Retina/pathology ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Cyclophilin A inhibits trophoblast migration and invasion in vitro and vivo through p38/ERK/JNK pathways and causes features of preeclampsia in mice.
Autorzy :
Hu H; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jiang J; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen Q; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wei S; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, China.
Liu M; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen X; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fan C; Institute of Neuroscience and Department of Neurology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ma J; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen W; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wang X; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: .
Zhong M; Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 15; Vol. 261, pp. 118351. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
MAP Kinase Signaling System*
Cyclophilin A/*metabolism
Pre-Eclampsia/*enzymology
Pre-Eclampsia/*pathology
Trophoblasts/*enzymology
Trophoblasts/*pathology
Adult ; Animals ; Down-Regulation/genetics ; Female ; Gene Knockdown Techniques ; Gene Silencing ; Humans ; Kidney/pathology ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Mice ; Placenta/enzymology ; Placenta/pathology ; Pregnancy ; Pregnancy Outcome
Czasopismo naukowe
Tytuł :
Ribosomal stress-surveillance: three pathways is a magic number.
Autorzy :
Vind AC; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
Genzor AV; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
Bekker-Jensen S; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Nov 04; Vol. 48 (19), pp. 10648-10661.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
MAP Kinase Signaling System*
Stress, Physiological*
Ribosomes/*metabolism
Animals ; Humans ; Protein Biosynthesis
Czasopismo naukowe
Tytuł :
Mycobacterium tuberculosis Rv1096, facilitates mycobacterial survival by modulating the NF-κB/MAPK pathway as peptidoglycan N-deacetylase.
Autorzy :
Lu Q; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
Zhang W; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
Fang J; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
Zheng J; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
Dong C; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China. Electronic address: .
Xiong S; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2020 Nov; Vol. 127, pp. 47-55. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Microbial Viability*
Amidohydrolases/*metabolism
Bacterial Proteins/*metabolism
Mycobacterium smegmatis/*cytology
Mycobacterium tuberculosis/*enzymology
NF-kappa B/*metabolism
Peptidoglycan/*metabolism
Animals ; Bacterial Proteins/chemistry ; Cytokines/metabolism ; Female ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Macrophages/immunology ; Macrophages/microbiology ; Macrophages/pathology ; Mice ; Mice, Inbred C57BL ; Mycobacterium smegmatis/growth & development ; Mycobacterium tuberculosis/growth & development ; Protein Domains ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
UNC-5 netrin receptor B regulates adipogenesis of human adipose-derived stem cells through JNK pathway.
Autorzy :
Hu X; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China.; Department of Stomatology, Shenzhen University General Hospital, Xili University Town, Shenzhen, China.
Liu X; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China.; National Engineering Lab for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, Beijing, China.
Lv L; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China.; National Engineering Lab for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, Beijing, China.
Zhang X; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China.; National Engineering Lab for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, Beijing, China.
Liu Y; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China.; National Engineering Lab for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, Beijing, China.
Zhang P; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China.; National Engineering Lab for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, Beijing, China.
Zhou Y; Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China.; National Engineering Lab for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, Beijing, China.
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Źródło :
Journal of oral rehabilitation [J Oral Rehabil] 2020 Nov; Vol. 47 Suppl 1, pp. 91-98. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Adipogenesis*
MAP Kinase Signaling System*
Animals ; Cell Differentiation ; Cells, Cultured ; Humans ; Mice ; Mice, Nude ; Netrin Receptors/physiology ; Osteogenesis ; Stem Cells
Czasopismo naukowe
Tytuł :
Inhibition of ssc-microRNA-140-5p ameliorates the Clostridium perfringens beta2 toxin-induced inflammatory response in IPEC-J2 cells via the ERK1/2 and JNK pathways by targeting VEGFA.
Autorzy :
Luo R; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: .
Yan Z; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: .
Yang Q; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: .
Huang X; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: .
Gao X; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: .
Wang P; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: .
Wang W; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: .
Xie K; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: .
Gun S; College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China; Gansu Research Center for Swine Production Engineering and Technology, Lanzhou 730070, China. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2020 Nov; Vol. 127, pp. 12-20. Date of Electronic Publication: 2020 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*/drug effects
Bacterial Toxins/*toxicity
Inflammation/*enzymology
Inflammation/*genetics
MicroRNAs/*antagonists & inhibitors
Vascular Endothelial Growth Factor A/*metabolism
Animals ; Apoptosis/drug effects ; Base Sequence ; Cell Line ; Cell Survival/drug effects ; Clostridium perfringens/physiology ; Ileum/metabolism ; Ileum/microbiology ; Ileum/pathology ; Inflammation/pathology ; L-Lactate Dehydrogenase/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Reproducibility of Results ; Swine
Czasopismo naukowe
Tytuł :
Adipose-derived stem cells promote diabetic wound healing via the recruitment and differentiation of endothelial progenitor cells into endothelial cells mediated by the VEGF-PLCγ-ERK pathway.
Autorzy :
Chen L; Department of Burns and Plastic, Affiliated Hospital of North Sichuan Medical College, PR China. Electronic address: .
Zheng Q; Office of Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, 637000, PR China.
Liu Y; Department of Burns and Plastic, Affiliated Hospital of North Sichuan Medical College, PR China.
Li L; Department of Burns and Plastic, Affiliated Hospital of North Sichuan Medical College, PR China.
Chen X; Department of Burns and Plastic, Affiliated Hospital of North Sichuan Medical College, PR China.
Wang L; Department of Burns and Plastic, Affiliated Hospital of North Sichuan Medical College, PR China.
Wang L; Department of Burns and Plastic, Affiliated Hospital of North Sichuan Medical College, PR China.
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Oct 15; Vol. 692, pp. 108531. Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Experimental*/metabolism
Diabetes Mellitus, Experimental*/pathology
Diabetes Mellitus, Experimental*/therapy
Diabetic Angiopathies*/metabolism
Diabetic Angiopathies*/pathology
Diabetic Angiopathies*/therapy
MAP Kinase Signaling System*
Stem Cell Transplantation*
Wound Healing*
Adipose Tissue/*metabolism
Phospholipase C gamma/*metabolism
Stem Cells/*metabolism
Vascular Endothelial Growth Factor A/*biosynthesis
Adipose Tissue/pathology ; Allografts ; Animals ; Rats ; Rats, Sprague-Dawley ; Stem Cells/pathology
Czasopismo naukowe
Tytuł :
ERas regulates cell proliferation and epithelial-mesenchymal transition by affecting Erk/Akt signaling pathway in pancreatic cancer.
Autorzy :
Liu Y; Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China.
Qin P; Department of Instrument Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Wu R; Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China.
Du L; Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. .
Li F; Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. .
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Źródło :
Human cell [Hum Cell] 2020 Oct; Vol. 33 (4), pp. 1186-1196. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation/*genetics
Epithelial-Mesenchymal Transition/*genetics
Gene Expression Regulation, Neoplastic/*genetics
MAP Kinase Signaling System/*genetics
Oncogene Protein p21(ras)/*genetics
Oncogene Protein p21(ras)/*physiology
Pancreatic Neoplasms/*genetics
Pancreatic Neoplasms/*pathology
Proto-Oncogene Proteins c-akt/*genetics
Proto-Oncogene Proteins c-akt/*metabolism
Signal Transduction/*genetics
Animals ; Cell Line, Tumor ; Cell Movement/genetics ; Disease Progression ; Humans ; MAP Kinase Signaling System/physiology ; Male ; Mice, Nude ; Molecular Targeted Therapy ; Neoplasm Invasiveness/genetics ; Oncogene Protein p21(ras)/metabolism ; Pancreatic Neoplasms/therapy ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/therapeutic use ; Signal Transduction/physiology ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains.
Autorzy :
Zárate-Potes A; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Yang W; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Pees B; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Schalkowski R; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Segler P; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Andresen B; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Haase D; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Nakad R; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Rosenstiel P; Institute for Clinical Molecular Biology (IKMB), Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Tetreau G; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Colletier JP; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France.
Schulenburg H; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.; Max Planck Institute for Evolutionary Biology, Ploen, Germany.
Dierking K; Department of Evolutionary Ecology and Genetics, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 24; Vol. 16 (9), pp. e1008826. Date of Electronic Publication: 2020 Sep 24 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Transcription, Genetic*
Bacillus thuringiensis/*metabolism
Bacterial Infections/*metabolism
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
GATA Transcription Factors/*metabolism
Animals ; Bacillus thuringiensis/pathogenicity ; Bacterial Infections/genetics ; Bacterial Infections/microbiology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/microbiology ; Caenorhabditis elegans Proteins/genetics ; GATA Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
Autorzy :
Kastelberg B; Nutritional Immunology and Molecular Medicine Institute, Blacksburg, Virginia, United States of America.
Tubau-Juni N; Nutritional Immunology and Molecular Medicine Institute, Blacksburg, Virginia, United States of America.
Ayubi T; Nutritional Immunology and Molecular Medicine Institute, Blacksburg, Virginia, United States of America.
Leung A; Nutritional Immunology and Molecular Medicine Institute, Blacksburg, Virginia, United States of America.
Leber A; Nutritional Immunology and Molecular Medicine Institute, Blacksburg, Virginia, United States of America.
Hontecillas R; Nutritional Immunology and Molecular Medicine Institute, Blacksburg, Virginia, United States of America.
Bassaganya-Riera J; Nutritional Immunology and Molecular Medicine Institute, Blacksburg, Virginia, United States of America.
Kale SD; Nutritional Immunology and Molecular Medicine Institute, Blacksburg, Virginia, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 21; Vol. 16 (9), pp. e1008854. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aspergillus fumigatus/*immunology
Dendritic Cells/*immunology
MAP Kinase Signaling System/*immunology
Mitochondrial Proteins/*immunology
Pulmonary Aspergillosis/*immunology
Th2 Cells/*immunology
Animals ; Cell Line ; Cytokines/genetics ; Cytokines/immunology ; MAP Kinase Kinase 4/genetics ; MAP Kinase Kinase 4/immunology ; MAP Kinase Signaling System/genetics ; Mice ; Mice, Knockout ; Mitochondrial Proteins/genetics ; Neutrophils/immunology ; Neutrophils/pathology ; Pulmonary Aspergillosis/genetics ; Pulmonary Aspergillosis/pathology ; Th2 Cells/pathology ; Transcription Factors/genetics ; Transcription Factors/immunology ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/immunology
Czasopismo naukowe
Tytuł :
New vistas in malignant mesothelioma: MicroRNA architecture and NRF2/MAPK signal transduction.
Autorzy :
Gandhi M; SVKM's Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, VL Mehta Road, Vile Parle (West), Mumbai 400 056, India.
Nair S; SVKM's Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, VL Mehta Road, Vile Parle (West), Mumbai 400 056, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 15; Vol. 257, pp. 118123. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
MAP Kinase Signaling System*
Lung Neoplasms/*metabolism
Mesothelioma/*metabolism
MicroRNAs/*metabolism
NF-E2-Related Factor 2/*metabolism
Animals ; Biomarkers, Tumor ; Humans
SCR Disease Name :
Mesothelioma, Malignant
Czasopismo naukowe
Tytuł :
Mechanical stretching of pulmonary vein stimulates matrix metalloproteinase-9 and transforming growth factor-β1 through stretch-activated channel/MAPK pathways in pulmonary hypertension due to left heart disease model rats.
Autorzy :
Zhang H; Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, P.R. China.
Huang W; Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, P.R. China.
Liu H; Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, P.R. China.
Zheng Y; Department of Cardiac Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, P.R. China.
Liao L; Department of Medical Laboratory, Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, P.R. China.
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Źródło :
PloS one [PLoS One] 2020 Sep 03; Vol. 15 (9), pp. e0235824. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Hypertension, Pulmonary/*physiopathology
Matrix Metalloproteinase 9/*metabolism
Pulmonary Veins/*physiopathology
Transforming Growth Factor beta1/*metabolism
Ventricular Dysfunction, Left/*physiopathology
Animals ; Biomechanical Phenomena ; Disease Models, Animal ; Enzyme Activation ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/metabolism ; Male ; Pulmonary Veins/metabolism ; Rats ; Rats, Sprague-Dawley ; Stress, Mechanical ; Vascular Remodeling ; Ventricular Dysfunction, Left/complications ; Ventricular Dysfunction, Left/metabolism
Czasopismo naukowe
Tytuł :
Inhibitors of BRAF dimers using an allosteric site.
Autorzy :
Cotto-Rios XM; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Agianian B; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA. .; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA. .
Gitego N; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Zacharioudakis E; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Giricz O; Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Wu Y; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Zou Y; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
Verma A; Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.; Department of Developmental & Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA.; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Poulikakos PI; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, USA.
Gavathiotis E; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA. .; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA. .; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Sep 01; Vol. 11 (1), pp. 4370. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
MAP Kinase Signaling System/*drug effects
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins B-raf/*antagonists & inhibitors
Allosteric Site/drug effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cell Line, Tumor ; Crystallography, X-Ray ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; MAP Kinase Signaling System/genetics ; Molecular Docking Simulation ; Mutation ; Neoplasms/genetics ; Neoplasms/pathology ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/therapeutic use ; Protein Multimerization/drug effects ; Protein Subunits/antagonists & inhibitors ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Proto-Oncogene Proteins B-raf/ultrastructure ; Pyridazines/pharmacology ; Pyridazines/therapeutic use ; Small Molecule Libraries ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The Ras-ERK1/2 signaling pathway regulates H3K9ac through PCAF to promote the development of pancreatic cancer.
Autorzy :
Li YH; Department of Pathology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.
Li YX; Department of Pathology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.
Li M; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Song SW; Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Ge Y; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Jin JY; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Li XY; Department of General Surgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Tan XD; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Ye J; Department of Pathology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117936. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System*
Carcinogenesis/*pathology
Histones/*metabolism
Lysine/*metabolism
Pancreatic Neoplasms/*metabolism
Pancreatic Neoplasms/*pathology
p300-CBP Transcription Factors/*metabolism
ras Proteins/*metabolism
Acetylation ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Histone Deacetylase 1/metabolism ; Humans ; Pancreatic Neoplasms/genetics ; Phenotype ; Proteolysis ; Proto-Oncogene Proteins c-mdm2/metabolism ; Signal Transduction ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway.
Autorzy :
Hsieh YH; Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Clinical laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.
Syu RJ; Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
Lee CC; Department of Medicine Research, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan.
Lin SH; Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.
Lee CH; Division of Pediatric Surgery, Department of Surgery, Children's Hospital of China Medical University, Taichung, Taiwan.; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Cheng CW; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.; Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan.
Tsai JP; Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan.
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Źródło :
Environmental toxicology [Environ Toxicol] 2020 Sep; Vol. 35 (9), pp. 1007-1014. Date of Electronic Publication: 2020 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Areca/*toxicity
Arecoline/*toxicity
Epithelial-Mesenchymal Transition/*drug effects
Kidney Tubules/*drug effects
MAP Kinase Signaling System/*drug effects
Actins/genetics ; Actins/metabolism ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Areca/chemistry ; Cadherins/genetics ; Cadherins/metabolism ; Cell Cycle/drug effects ; Cell Line ; Cell Movement/drug effects ; Dose-Response Relationship, Drug ; Epithelial-Mesenchymal Transition/genetics ; Fibrosis ; Humans ; Kidney Tubules/metabolism ; Kidney Tubules/pathology ; MAP Kinase Signaling System/genetics ; Phosphorylation ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/pathology ; Up-Regulation
Czasopismo naukowe
Tytuł :
MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.
Autorzy :
Sangokoya C; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, CA 94143.; Department of Pathology, University of California, San Francisco, CA 94143.
Blelloch R; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences, University of California, San Francisco, CA 94143; .; Department of Pathology, University of California, San Francisco, CA 94143.; Department of Urology, University of California, San Francisco, CA 94143.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 25; Vol. 117 (34), pp. 20625-20635. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
MAP Kinase Signaling System*
Embryonic Stem Cells/*metabolism
MicroRNAs/*metabolism
Pluripotent Stem Cells/*metabolism
Profilins/*metabolism
3' Untranslated Regions ; Animals ; Cell Differentiation/genetics ; Cell Line ; Embryonic Stem Cells/cytology ; Endocytosis/physiology ; Humans ; Mice ; Mice, Knockout ; MicroRNAs/genetics ; Pluripotent Stem Cells/cytology ; Profilins/genetics ; Signal Transduction/genetics
Czasopismo naukowe

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