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Tytuł:
The Role of the Dysregulated JNK Signaling Pathway in the Pathogenesis of Human Diseases and Its Potential Therapeutic Strategies: A Comprehensive Review.
Autorzy:
Yan H; Department of Ultrasound, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
He L; Department of Ultrasound, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Lv; Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Yang J; Cancer Center and State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Yuan Z; Cancer Center and State Key Laboratory of Biotherapy, Department of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 19; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 19.
Typ publikacji:
Journal Article; Review
MeSH Terms:
MAP Kinase Signaling System*
Mitogen-Activated Protein Kinases*/metabolism
Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Cell Differentiation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Conditional Ablation of Spred1 and Spred2 in the Eye Lens Negatively Impacts Its Development and Growth.
Autorzy:
Wazin F; Molecular and Cellular Biomedicine, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Lovicu FJ; Molecular and Cellular Biomedicine, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
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Źródło:
Cells [Cells] 2024 Feb 06; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
MAP Kinase Signaling System*/physiology
Lens, Crystalline*/metabolism
Humans ; Cell Differentiation/physiology ; Signal Transduction/physiology ; Cell Proliferation/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Asynchronous Pattern of MAPKs' Activity during Aging of Different Tissues and of Distinct Types of Skeletal Muscle.
Autorzy:
Gilad N; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.; Singapore-HUJ Alliance for Research and Enterprise, Mechanisms of Liver Inflammatory Diseases Program, National University of Singapore, Singapore 138602, Singapore.
Mohanam MP; Singapore-HUJ Alliance for Research and Enterprise, Mechanisms of Liver Inflammatory Diseases Program, National University of Singapore, Singapore 138602, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.
Darlyuk-Saadon I; Singapore-HUJ Alliance for Research and Enterprise, Mechanisms of Liver Inflammatory Diseases Program, National University of Singapore, Singapore 138602, Singapore.
Heng CKM; Singapore-HUJ Alliance for Research and Enterprise, Mechanisms of Liver Inflammatory Diseases Program, National University of Singapore, Singapore 138602, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.
Plaschkes I; Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Benyamini H; Info-CORE, Bioinformatics Unit of the I-CORE, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Berezhnoy NV; Singapore-HUJ Alliance for Research and Enterprise, Mechanisms of Liver Inflammatory Diseases Program, National University of Singapore, Singapore 138602, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.
Engelberg D; Department of Biological Chemistry, The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.; Singapore-HUJ Alliance for Research and Enterprise, Mechanisms of Liver Inflammatory Diseases Program, National University of Singapore, Singapore 138602, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 30; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Muscle, Skeletal*
MAP Kinase Signaling System*/physiology
Mice ; Animals ; Phosphorylation ; Signal Transduction ; Aging/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Porcine Placenta Peptide Inhibits UVB-Induced Skin Wrinkle Formation and Dehydration: Insights into MAPK Signaling Pathways from In Vitro and In Vivo Studies.
Autorzy:
Sim WJ; Department of Food Science & Biotechnology, Sejong University, Seoul 05006, Republic of Korea.
Kim J; R&D Division, Daehan Chemtech Co., Ltd., Gwacheon-si 13840, Republic of Korea.
Baek KS; R&D Division, Daehan Chemtech Co., Ltd., Gwacheon-si 13840, Republic of Korea.
Lim W; Department of Food Science & Biotechnology, Sejong University, Seoul 05006, Republic of Korea.; Carbohydrate Bioproduct Research Center, Sejong University, Seoul 05006, Republic of Korea.
Lim TG; Department of Food Science & Biotechnology, Sejong University, Seoul 05006, Republic of Korea.; Carbohydrate Bioproduct Research Center, Sejong University, Seoul 05006, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 20; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
MAP Kinase Signaling System*
Skin Aging*
Female ; Pregnancy ; Mice ; Swine ; Animals ; Antioxidants/pharmacology ; Dehydration ; Placenta ; Signal Transduction ; Mice, Hairless ; Peptides/pharmacology ; Collagen
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis.
Autorzy:
Kirkbride JA; Department of Molecular Physiology and Biophysics, and Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.
Nilsson GY; Department of Molecular Physiology and Biophysics, and Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.
Kim JI; Department of Molecular Physiology and Biophysics, and Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.; Department of Molecular Medicine, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.
Takeya K; Department of Veterinary Medicine, Faculty of Veterinary Medicine, Okayama University of Science, Imabari 794-8555, Ehime, Japan.
Tanaka Y; Department of Veterinary Medicine, Faculty of Veterinary Medicine, Okayama University of Science, Imabari 794-8555, Ehime, Japan.
Tokumitsu H; Applied Cell Biology, Graduate School of Interdisciplinary Science & Engineering in Health Systems, Okayama University, Okayama 700-8530, Okayama, Japan.
Suizu F; Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kita-gun 761-0793, Kagawa, Japan.
Eto M; Department of Molecular Physiology and Biophysics, and Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.; Department of Veterinary Medicine, Faculty of Veterinary Medicine, Okayama University of Science, Imabari 794-8555, Ehime, Japan.
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Źródło:
Biomolecules [Biomolecules] 2023 Dec 04; Vol. 13 (12). Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
MAP Kinase Signaling System*/physiology
Neoplasms*
Humans ; Protein Phosphatase 1 ; Proteostasis ; HEK293 Cells ; Mitogen-Activated Protein Kinase Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Navigating the ERK1/2 MAPK Cascade.
Autorzy:
Martin-Vega A; Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Rd., Dallas, TX 75390, USA.
Cobb MH; Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Rd., Dallas, TX 75390, USA.; Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 6001 Forest Park Rd., Dallas, TX 75390, USA.
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Źródło:
Biomolecules [Biomolecules] 2023 Oct 20; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
MAP Kinase Signaling System*
Neoplasms*/metabolism
Humans ; Signal Transduction/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis.
Autorzy:
Nguyen L; Institute of Stem Cell Research and Regenerative Medicine, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Thewes L; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Westerhoff M; Institute of Biochemistry and Molecular Biology I, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Wruck W; Institute of Stem Cell Research and Regenerative Medicine, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Reichert AS; Institute of Biochemistry and Molecular Biology I, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Berndt C; Department of Neurology, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Adjaye J; Institute of Stem Cell Research and Regenerative Medicine, University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.; EGA Institute for Women's Health, Zayed Centre for Research into Rare Diseases in Children (ZCR), University College London (UCL), 20 Guilford Street, London WC1N 1DZ, UK.
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Źródło:
Cells [Cells] 2023 Sep 02; Vol. 12 (17). Date of Electronic Publication: 2023 Sep 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ferroptosis*
Renal Insufficiency, Chronic*
MAP Kinase Signaling System*
Humans ; Kidney ; Renal Dialysis ; Stem Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
JNK Cascade-Induced Apoptosis-A Unique Role in GqPCR Signaling.
Autorzy:
Nadel G; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Maik-Rachline G; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Seger R; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 31; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 31.
Typ publikacji:
Journal Article; Review
MeSH Terms:
MAP Kinase Signaling System*
Signal Transduction*
Apoptosis ; Cell Differentiation ; GTP-Binding Protein alpha Subunits, Gq-G11 ; JNK Mitogen-Activated Protein Kinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ERK1/2-Dependent Phosphorylation of GABA B1 (S867/T872), Controlled by CaMKIIβ, Is Required for GABA B Receptor Degradation under Physiological and Pathological Conditions.
Autorzy:
Bhat MA; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland.
Grampp T; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland.
Benke D; Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 30; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 30.
Typ publikacji:
Journal Article
MeSH Terms:
MAP Kinase Signaling System*
Receptors, GABA-B*/genetics
Phosphorylation ; Down-Regulation ; Cell Movement ; gamma-Aminobutyric Acid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibitory Effects of Simvastatin on IL-33-Induced MCP-1 via the Suppression of the JNK Pathway in Human Vascular Endothelial Cells.
Autorzy:
Umebashi K; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Yamamoto M; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Tokito A; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Sudou K; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Takenoshita Y; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
Jougasaki M; Institute for Clinical Research, National Hospital Organization Kagoshima Medical Center, Kagoshima 892-0853, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 21; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 21.
Typ publikacji:
Journal Article
MeSH Terms:
Simvastatin*/pharmacology
MAP Kinase Signaling System*
Humans ; Interleukin-33 ; Human Umbilical Vein Endothelial Cells ; Inflammation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Role of Activation of PI3K/AKT/mTOR and RAF/MEK/ERK Pathways in Aggressive Pituitary Adenomas-New Potential Therapeutic Approach-A Systematic Review.
Autorzy:
Derwich A; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.; Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Sykutera M; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Bromińska B; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Rubiś B; Department of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Ruchała M; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Sawicka-Gutaj N; Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 30; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 30.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
MAP Kinase Signaling System*
Pituitary Neoplasms*/drug therapy
Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Carcinogenesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively.
Autorzy:
Bui DV; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.; Allergy and Clinical Immunology Department, Hanoi Medical University, Hanoi 115000, Vietnam.; Allergy, Immunology and Dermatology Department, E Hospital, Hanoi 122000, Vietnam.
Nguyen LM; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.
Kanda A; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.; Laboratory Medicine Center, Kansai Medical University Hospital, Osaka 573-1010, Japan.; Allergy Center, Kansai Medical University Hospital, Osaka 573-1010, Japan.
Chu HH; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.; Allergy, Immunology and Rheumatology Department, National Children Hospital, Hanoi 115000, Vietnam.
Thi Le NK; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.
Yun Y; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.
Kobayashi Y; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.; Allergy Center, Kansai Medical University Hospital, Osaka 573-1010, Japan.
Suzuki K; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.
Mitani A; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.
Shimamura A; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.
Fukui K; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.
Sawada S; Dentistry and Oral Surgery and Care Center, Kansai Medical University Hospital, Osaka 573-1010, Japan.
Dombrowicz D; University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, 59000 Lille, France.
Iwai H; Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka 573-1010, Japan.
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Źródło:
Biomolecules [Biomolecules] 2024 Mar 18; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 18.
Typ publikacji:
Journal Article
MeSH Terms:
Asthma*/metabolism
Eosinophils*/metabolism
Animals ; Humans ; Mice ; Antigens, CD/metabolism ; Apoptosis ; Interleukin-10/genetics ; Interleukin-10/metabolism ; MAP Kinase Signaling System
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Review.
Autorzy:
Fonseca J; UCIBIO-Applied Molecular Biosciences Unit, Toxicologic Pathology Research Laboratory, University Institute of Health Sciences (UCIBIO-IUCS-CESPU), 4585-116 Gandra, Portugal.; Associate Laboratory i4HB-Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal.; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
Vaz JA; Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
Ricardo S; Associate Laboratory i4HB-Institute for Health and Bioeconomy, University Institute of Health Sciences-CESPU, 4585-116 Gandra, Portugal.; Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.; Differentiation and Cancer Group, Institute for Research and Innovation in Health (i3S), University of Porto, 4099-002 Porto, Portugal.
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Źródło:
Cells [Cells] 2024 Mar 14; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 14.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Agaricales*
Neoplasms*/drug therapy
MicroRNAs*/therapeutic use
MAP Kinase Signaling System
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Emerging Roles of Mitogen-Activated Protein Kinase Signaling Pathways in the Regulation of Fruit Ripening and Postharvest Quality.
Autorzy:
Jin J; Institute of Horticulture Crops, Xinjiang Academy of Agricultural Sciences, Urumqi 830000, China.
Wang W; College of Horticulture, China Agricultural University, Beijing 100193, China.
Fan D; Institute of Horticulture Crops, Xinjiang Academy of Agricultural Sciences, Urumqi 830000, China.
Hao Q; Institute of Horticulture Crops, Xinjiang Academy of Agricultural Sciences, Urumqi 830000, China.
Jia W; Institute of Horticulture Crops, Xinjiang Academy of Agricultural Sciences, Urumqi 830000, China.; College of Horticulture, China Agricultural University, Beijing 100193, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 29; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Fruit*/metabolism
Plant Development*
Signal Transduction ; MAP Kinase Signaling System ; Mitogen-Activated Protein Kinases/metabolism ; Gene Expression Regulation, Plant ; Plant Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MiR-290 Family Maintains Pluripotency and Self-Renewal by Regulating MAPK Signaling Pathway in Intermediate Pluripotent Stem Cells.
Autorzy:
Liu Y; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (RRBGL), Inner Mongolia University, Hohhot 010070, China.
Li X; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (RRBGL), Inner Mongolia University, Hohhot 010070, China.
Ma X; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (RRBGL), Inner Mongolia University, Hohhot 010070, China.
Du Q; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (RRBGL), Inner Mongolia University, Hohhot 010070, China.
Wang J; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (RRBGL), Inner Mongolia University, Hohhot 010070, China.
Yu H; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (RRBGL), Inner Mongolia University, Hohhot 010070, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 26; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:
Journal Article
MeSH Terms:
Pluripotent Stem Cells*/metabolism
MicroRNAs*/metabolism
Animals ; Mice ; Female ; Cell Differentiation/genetics ; Signal Transduction ; MAP Kinase Signaling System ; Germ Layers/metabolism ; MAP Kinase Kinase 6
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
H9N2 Avian Influenza Virus Downregulates FcRY Expression in Chicken Macrophage Cell Line HD11 by Activating the JNK MAPK Pathway.
Autorzy:
Sun Z; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan 430070, China.
Zhang W; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan 430070, China.
Li J; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan 430070, China.
Yang K; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan 430070, China.
Zhang Y; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan 430070, China.
Li Z; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan 430070, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 24; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Influenza A Virus, H9N2 Subtype*/physiology
Influenza in Birds*
Animals ; Chickens/metabolism ; MAP Kinase Signaling System ; Cell Line ; Macrophages/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
ERK1/2-CEBPB Axis-Regulated hBD1 Enhances Anti-Tuberculosis Capacity in Alveolar Type II Epithelial Cells.
Autorzy:
Chen Y; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Han Z; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Zhang S; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Liu H; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Wang K; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Liu J; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Liu F; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Yu S; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Sai N; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Mai H; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Zhou X; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Zhou C; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Wen Q; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
Ma L; Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.; Key Laboratory of Infectious Diseases Research in South China (Southern Medical University), Ministry of Education, Guangzhou 510515, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 18; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 18.
Typ publikacji:
Journal Article
MeSH Terms:
beta-Defensins*/genetics
beta-Defensins*/pharmacology
Mycobacterium tuberculosis*
Tuberculosis*/metabolism
Animals ; Humans ; Mice ; Alveolar Epithelial Cells ; CCAAT-Enhancer-Binding Protein-beta/genetics ; Epithelial Cells ; MAP Kinase Signaling System
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer.
Autorzy:
Morgos DT; Discipline of Anatomy, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Stefani C; Department I of Family Medicine and Clinical Base, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Miricescu D; Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Greabu M; Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Stanciu S; Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy, Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Nica S; Emergency Discipline, University Hospital of Bucharest, 050098 Bucharest, Romania.
Stanescu-Spinu II; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Balan DG; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Balcangiu-Stroescu AE; Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Coculescu EC; Discipline of Oral Pathology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Georgescu DE; Department of General Surgery, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 50474 Bucharest, Romania.; Department of General Surgery, 'Dr. Ion Cantacuzino' Clinical Hospital, 020475 Bucharest, Romania.
Nica RI; Central Military Emergency University Hospital 'Dr. Carol Davila', 010825 Bucharest, Romania.; Discipline of General Surgery, Faculty of Midwifery and Nursing, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 03; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Proto-Oncogene Proteins c-akt*/metabolism
Stomach Neoplasms*/etiology
Stomach Neoplasms*/genetics
Humans ; Phosphatidylinositol 3-Kinase/metabolism ; Sirolimus ; Phosphatidylinositol 3-Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism ; MAP Kinase Signaling System
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Endothelin-1 Induces Cell Proliferation and Myofibroblast Differentiation through the ET A R/G αq /ERK Signaling Pathway in Human Cardiac Fibroblasts.
Autorzy:
Duangrat R; Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.; Molecular Medicine Graduate Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Parichatikanond W; Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.; Centre of Biopharmaceutical Science for Healthy Ageing (BSHA), Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Likitnukul S; Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Mangmool S; Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 24; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
MAP Kinase Signaling System*
Myofibroblasts*/metabolism
Humans ; Endothelin-1/metabolism ; Bosentan/pharmacology ; Signal Transduction ; Fibroblasts/metabolism ; Cell Differentiation ; Cell Proliferation ; Collagen Type I/metabolism ; GTP-Binding Proteins/metabolism ; Collagen/metabolism ; Fibrosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of New Heterocyclic/Benzofuran Hybrids as Potential Anti-Inflammatory Agents: Design, Synthesis, and Evaluation of the Inhibitory Activity of Their Related Inflammatory Factors Based on NF-κB and MAPK Signaling Pathways.
Autorzy:
Chen Y; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.
Chen R; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.
Yuan R; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.
Huo L; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.; Guangxi Key Laboratory of Zhuang and Yao Medicine, Guangxi University of Chinese Medicine, Nanning 530222, China.
Gao H; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.
Zhuo Y; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.
Chen X; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.
Zhang C; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.
Yang S; College of pharmacy, Guangxi University of Chinese Medicine, Nanning 530222, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 10; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Inflammatory Agents*/chemistry
Anti-Inflammatory Agents*/pharmacology
Benzofurans*/chemistry
Benzofurans*/pharmacology
MAP Kinase Signaling System*/drug effects
NF-kappa B*/drug effects
NF-kappa B*/metabolism
Animals ; Mice ; Inflammation/metabolism ; Interleukin-6/metabolism ; Lipopolysaccharides/pharmacology ; RAW 264.7 Cells ; Signal Transduction ; Tumor Necrosis Factor-alpha/metabolism ; Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1010

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