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Tytuł :
Multi-center real-world comparison of the fully automated Idylla™ microsatellite instability assay with routine molecular methods and immunohistochemistry on formalin-fixed paraffin-embedded tissue of colorectal cancer.
Autorzy :
Velasco A; Departments of Pathology and Molecular Genetics, Hospital U Arnau de Vilanova and Hospital U de Bellvitge, University of Lleida, IRBLLEIDA, IDIBELL, CIBERONC, Av. Alcalde Rovira Roure, 80 25198, Lleida, Spain. .
Tokat F; Department of Pathology, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Turkey.
Bonde J; Molecular Pathology Laboratory, Department of Pathology, afs. 134, Hvidovre Hospital, Hvidovre, Denmark.
Trim N; Molecular Pathology Diagnostic Service, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Bauer E; Städtisches Klinikum Karlsruhe gGmbH, Institut für Pathologie, Karlsruhe, Germany.
Meeney A; Ophthalmic Pathology Laboratory Histopathology, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK.
de Leng W; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Chong G; Molecular Pathology Centre, Jewish General Hospital-McGill University, Montreal, Quebec, Canada.
Dalstein V; Laboratoire de Biopathologie, Unité INSERM UMR-S 1250, CHU Reims, Reims, France.
Kis LL; Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
Lorentzen JA; Molecular Pathology Unit, Department of Pathology, Oslo University Hospital, Oslo, Norway.
Tomić S; Department of Pathology, Forensic Medicine and Cytology, University Hospital Split, Split, Croatia.
Thwaites K; Histopathology Department, Barking, Havering and Redbridge University Hospitals NHS Trust, Queen's Hospital, Romford, UK.
Putzová M; Bioptická laboratoř s.r.o., Laboratory of Molecular Genetics, Plzeň, Czech Republic.; ÚBLG FN Motol, Praha, Czech Republic.; LF UK, Plzeň, Czech Republic.
Birnbaum A; Institute of Pathology, Dessau, Germany.
Qazi R; Department of Pathology, Shaukat Khanum Memorial Cancer Hospital & Research Centre, Johr Town, Lahore, Pakistan.
Primmer V; Pathologisch-Bakteriologisches Institut Kaiser-Franz-Josef-Spital, Vienna, Austria.
Dockhorn-Dworniczak B; Zentrum für Pathologie Kempten-Allgäu (MVZ), Kempten, Germany.
Hernández-Losa J; Department of Pathology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Spanish Biomedical Research Network Centre in Oncology (CIBERONC), Madrid, Spain.
Soares FA; Anatomia Patológica Rede D'Or, São Paulo, SP, Brazil.
Gertler AA; Department of Pathology, Hadassah Medical Center, Jerusalem, Israel.
Kalman M; Department of Pathologic Anatomy, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovak Republic.; Martin's Biopsy Center Ltd., Martin, Slovak Republic.
Wong C; Hong Kong Molecular Pathology Diagnostic Centre, Hong Kong Special Administrative Region of the People's Republic of China, Hong Kong, People's Republic of China.
Carraro DM; Genomics and Molecular Biology Group, International Research Center/CIPE, A. C. Camargo Cancer Center, São Paulo, SP, Brazil.
Sousa AC; GenoMed, Diagnósticos de Medicina Molecular, SA, Lisbon, Portugal.
Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Fox SB; Pathology, Peter MacCallum Cancer Centre and University of Melbourne, Vic, Australia.
Fassan M; Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Brevet M; Department of Pathology, Hospices Civils de Lyon, Université Lyon 1, Bron, France & Cypath, Villeurbanne, France.
Merkelbach-Bruse S; Institute of Pathology, University Hospital Cologne, Cologne, Germany.
Colling R; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Soilleux E; Department of Pathology, University of Cambridge, Cambridge, UK.
Teo RYW; Department of Pathology, Tan Tock Seng Hospital, Novena, Republic of Singapore.
D'Haene N; Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Nolet S; Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montreal, Québec, Canada.
Ristimäki A; Department of Pathology, Research Programs Unit and HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Väisänen T; Oulu University Hospital and Department of Pathology, Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.
Chapusot C; Platform of Somatic Oncology of Burgundy, CHU, Dijon, France.
Soruri A; Institut für Pathologie und Molekularpathologie, Pforzheim, Germany.
Unger T; Institut für Pathologie, University of Leipzig, Leipzig, Germany.
Wecgowiec J; Institut für Pathologie, Evangelisches Krankenhaus BETHESDA Zu Duisburg GmbH, Duisburg, Germany.
Biscuola M; Department of Pathology, Molecular Pathology Laboratory, Hospital Universitario Virgen del Rocío-IBIS, Seville, Spain.
Frattini M; Laboratory of Molecular Pathology, Institute of Pathology, Locarno, Switzerland.
Long A; Cellular Pathology, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Campregher PV; Hospital Israelita Albert Einstein, São Paulo, Brazil.
Matias-Guiu X; Departments of Pathology and Molecular Genetics, Hospital U Arnau de Vilanova and Hospital U de Bellvitge, University of Lleida, IRBLLEIDA, IDIBELL, CIBERONC, Av. Alcalde Rovira Roure, 80 25198, Lleida, Spain.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 May; Vol. 478 (5), pp. 851-863. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study
MeSH Terms :
Biomarkers, Tumor*/analysis
Biomarkers, Tumor*/genetics
DNA Mutational Analysis*
Immunohistochemistry*
Microsatellite Instability*
Mutation*
Paraffin Embedding*
Tissue Fixation*
Colorectal Neoplasms/*chemistry
Colorectal Neoplasms/*genetics
Automation, Laboratory ; Colorectal Neoplasms/pathology ; Fixatives ; Formaldehyde ; Humans ; Predictive Value of Tests ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
MSIFinder: a python package for detecting MSI status using random forest classifier.
Autorzy :
Zhou T; AcornMed Biotechnology Co., Ltd., Floor 18, Block 5, Yard 18, Kechuang 13 RD, Beijing, 100176, China.
Chen L; AcornMed Biotechnology Co., Ltd., Floor 18, Block 5, Yard 18, Kechuang 13 RD, Beijing, 100176, China.
Guo J; AcornMed Biotechnology Co., Ltd., Floor 18, Block 5, Yard 18, Kechuang 13 RD, Beijing, 100176, China.
Zhang M; AcornMed Biotechnology Co., Ltd., Floor 18, Block 5, Yard 18, Kechuang 13 RD, Beijing, 100176, China.
Zhang Y; AcornMed Biotechnology Co., Ltd., Floor 18, Block 5, Yard 18, Kechuang 13 RD, Beijing, 100176, China.
Cao S; AcornMed Biotechnology Co., Ltd., Floor 18, Block 5, Yard 18, Kechuang 13 RD, Beijing, 100176, China.
Lou F; AcornMed Biotechnology Co., Ltd., Floor 18, Block 5, Yard 18, Kechuang 13 RD, Beijing, 100176, China. .
Wang H; Department of Pathology, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou, 310009, Zhejiang, China. .
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Źródło :
BMC bioinformatics [BMC Bioinformatics] 2021 Apr 12; Vol. 22 (1), pp. 185. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms*/genetics
Microsatellite Instability*
DNA Mismatch Repair ; Humans ; Microsatellite Repeats ; Prospective Studies
Czasopismo naukowe
Tytuł :
Microsatellite instability in Gastric Cancer: Between lights and shadows.
Autorzy :
Puliga E; Department of Oncology, University of Torino, Candiolo, Italy; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy. Electronic address: .
Corso S; Department of Oncology, University of Torino, Candiolo, Italy; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.
Pietrantonio F; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Giordano S; Department of Oncology, University of Torino, Candiolo, Italy; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy. Electronic address: .
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Źródło :
Cancer treatment reviews [Cancer Treat Rev] 2021 Apr; Vol. 95, pp. 102175. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Microsatellite Instability*
Antineoplastic Agents/*therapeutic use
Stomach Neoplasms/*drug therapy
Animals ; Humans ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Multi-omics characterization and validation of MSI-related molecular features across multiple malignancies.
Autorzy :
Zheng Y; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Huang Y; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Bi G; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Du Y; Center for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, Shanghai, People's Republic of China.
Liang J; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Zhao M; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Chen Z; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Zhan C; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. Electronic address: .
Xi J; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. Electronic address: .
Wang Q; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
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Źródło :
Life sciences [Life Sci] 2021 Apr 01; Vol. 270, pp. 119081. Date of Electronic Publication: 2021 Jan 28.
Typ publikacji :
Journal Article
MeSH Terms :
Microsatellite Instability*
Microsatellite Repeats/*genetics
Neoplasms/*genetics
Cholestanetriol 26-Monooxygenase ; DNA Methylation ; Databases, Genetic ; Gene Expression/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Genomics/methods ; Humans ; Intercellular Signaling Peptides and Proteins ; MicroRNAs ; Microsatellite Repeats/physiology ; Models, Theoretical ; Mutation ; Neoplasms/metabolism ; Proteomics/methods ; Ribosomal Proteins ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations.
Autorzy :
Willvonseder B; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.
Stögbauer F; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.
Steiger K; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
Jesinghaus M; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Institute for Translational Cancer Research, Munich, Germany.
Kuhn PH; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.
Brambs C; Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany.
Engel J; Munich Cancer Registry, Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Ludwig-Maximilians-University (LMU), Munich, Germany.
Bronger H; Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany.
Schmidt GP; Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany.
Haller B; Institute for Epidemiology and Statistics, Technical University Munich, Munich, Germany.
Weichert W; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany.
Keller G; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.
Noske A; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.
Pfarr N; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany.
Boxberg M; Institute of Pathology, Technical University Munich, Trogerstrasse 18, 81675, Munich, Germany. .; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Jun; Vol. 70 (6), pp. 1679-1689. Date of Electronic Publication: 2020 Dec 19.
Typ publikacji :
Journal Article
MeSH Terms :
Microsatellite Instability*
Mutation*
Biomarkers, Tumor/*genetics
Carcinoma, Endometrioid/*pathology
Endometrial Neoplasms/*pathology
Lymphocytes, Tumor-Infiltrating/*immunology
Tumor Microenvironment/*immunology
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Endometrioid/genetics ; Carcinoma, Endometrioid/immunology ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/immunology ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate
Czasopismo naukowe
Tytuł :
[Analysis of microsatellite instability in endometroid carcinoma with deficient mismatch repair].
Autorzy :
Zhang YH; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China.
Wu HW; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China.
Wang J; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China.
Liang ZY; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China.
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Źródło :
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2021 May 08; Vol. 50 (5), pp. 470-475.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Endometrioid*
Microsatellite Instability*
DNA Mismatch Repair/genetics ; Female ; Humans ; Immunohistochemistry ; Mismatch Repair Endonuclease PMS2/genetics ; Mismatch Repair Endonuclease PMS2/metabolism ; MutL Protein Homolog 1/genetics ; MutL Protein Homolog 1/metabolism ; MutS Homolog 2 Protein/genetics ; MutS Homolog 2 Protein/metabolism
Czasopismo naukowe
Tytuł :
Health-related quality of life in patients with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer treated with first-line pembrolizumab versus chemotherapy (KEYNOTE-177): an open-label, randomised, phase 3 trial.
Autorzy :
Andre T; Sorbonne Université and Hõpital Saint-Antoine, Paris, France. Electronic address: .
Amonkar M; Merck & Co, Kenilworth, NJ, USA.
Norquist JM; Merck & Co, Kenilworth, NJ, USA.
Shiu KK; University College Hospital, NHS Foundation Trust, London, UK.
Kim TW; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Jensen BV; Herlev og Gentofte Hospital, Herlev, Denmark.
Jensen LH; University Hospital of Southern Denmark, Vejle, Denmark.
Punt CJA; Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands; Julius Center, University Medical Center Utrecht, Utrecht University, Netherlands.
Smith D; Hopital Haut Leveque, Pessac, France.
Garcia-Carbonero R; Hospital Universitario 12 de Octubre, Imas12, UCM, Madrid, Spain.
Sevilla I; Investigación Clínica y Traslacional en Cáncer, Instituto de Investigaciones Biomédicas de Málaga, Hospitales Universitarios Regional y Virgen de la Victoria de Málaga, Malaga, Spain.
De La Fouchardiere C; Centre Leon Berard, Lyon, France.
Rivera F; Hospital Universitario M de Valdecilla, IDIVAL, Santander, Spain.
Elez E; Vall d'Hebron Barcelona Hospital Campus, Vall d'Hebron Institute of Oncology, Universitat Autonoma de Barcelona, Barcelona, Spain.
Diaz LA Jr; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yoshino T; National Cancer Center Hospital East, Kashiwa, Japan.
Van Cutsem E; University Hospitals Gasthuisberg/Leuven and KU Leuven, Leuven, Belgium.
Yang P; MSD China, Shanghai, China.
Farooqui M; Merck & Co, Kenilworth, NJ, USA.
Le DT; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
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Źródło :
The Lancet. Oncology [Lancet Oncol] 2021 May; Vol. 22 (5), pp. 665-677. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Microsatellite Instability*
Quality of Life*
Antibodies, Monoclonal, Humanized/*therapeutic use
Brain Neoplasms/*drug therapy
Colorectal Neoplasms/*drug therapy
Neoplastic Syndromes, Hereditary/*drug therapy
Adult ; Aged ; Brain Neoplasms/genetics ; Brain Neoplasms/mortality ; Brain Neoplasms/psychology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/psychology ; DNA Mismatch Repair ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplastic Syndromes, Hereditary/genetics ; Neoplastic Syndromes, Hereditary/mortality ; Neoplastic Syndromes, Hereditary/psychology
SCR Disease Name :
Turcot syndrome
Czasopismo naukowe
Tytuł :
Colorectal cancer under 20 years old: a retrospective analysis from three tertiary hospitals.
Autorzy :
Zhou C; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.
Xiao W; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.
Wang X; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.
Chen H; Department of Radiation Oncology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655, China.
Niu S; Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Wang Q; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.
Chang H; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.
Wu X; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Ding P; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Pan Z; Department of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Wan X; Department of Radiation Oncology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655, China.
Bao Y; Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
Gao Y; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Apr; Vol. 147 (4), pp. 1145-1155. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Microsatellite Instability*
Adenocarcinoma/*pathology
Biomarkers, Tumor/*metabolism
Colorectal Neoplasms/*pathology
Tertiary Care Centers/*statistics & numerical data
Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma/therapy ; Adolescent ; Adult ; Biomarkers, Tumor/genetics ; Child ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/therapy ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Prognosis ; Retrospective Studies ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
A greater lymph node yield is required during pathological examination in microsatellite instability-high gastric cancer.
Autorzy :
Cai Z; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China.; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China.
Song H; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China.; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China.
Fingerhut A; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China.; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China.; Section for Surgical Research, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29, 8036, Graz, Austria.
Sun J; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China.; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China.
Ma J; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China.; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China.
Zhang L; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China.; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China.
Li S; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China.; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China.
Yu C; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China.; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China.
Zheng M; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China. .; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China. .
Zang L; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin Er Road, Shanghai, 200025, P. R. China. .; Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Mar 25; Vol. 21 (1), pp. 319. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Microsatellite Instability*
Lymph Nodes/*pathology
Lymphatic Metastasis/*diagnosis
Stomach Neoplasms/*diagnosis
Adult ; Aged ; Aged, 80 and over ; Female ; Gastrectomy/methods ; Gastrectomy/statistics & numerical data ; Humans ; Lymph Node Excision/statistics & numerical data ; Lymph Nodes/surgery ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Young Adult
Czasopismo naukowe
Tytuł :
A next-generation sequencing-based strategy combining microsatellite instability and tumor mutation burden for comprehensive molecular diagnosis of advanced colorectal cancer.
Autorzy :
Xiao J; Department of Medical Oncology, The Sixth Affiliated hospital of Sun Yat-sen University, Guangzhou, China.
Li W; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Huang Y; Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Huang M; The Medical Department, 3D Medicines Inc., Shanghai, China.
Li S; Department of Medical Oncology, The Sixth Affiliated hospital of Sun Yat-sen University, Guangzhou, China.
Zhai X; Department of Medical Oncology, The Sixth Affiliated hospital of Sun Yat-sen University, Guangzhou, China.
Zhao J; The Medical Department, 3D Medicines Inc., Shanghai, China.
Gao C; The Medical Department, 3D Medicines Inc., Shanghai, China.
Xie W; The Medical Department, 3D Medicines Inc., Shanghai, China.
Qin H; Research and Development Institute of Precision Medicine, 3D Medicines Inc., Shanghai, China.
Cai S; The Medical Department, 3D Medicines Inc., Shanghai, China.
Bai Y; The Medical Department, 3D Medicines Inc., Shanghai, China.
Lan P; Department of Colorectal Surgery, The Sixth Affiliated hospital of Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangzhou, 510655, Guangdong, China. .
Zou Y; Department of Colorectal Surgery, The Sixth Affiliated hospital of Sun Yat-sen University, 26 Yuancun Er Heng Road, Guangzhou, 510655, Guangdong, China. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Mar 16; Vol. 21 (1), pp. 282. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Evaluation Study; Journal Article
MeSH Terms :
Microsatellite Instability*
Biomarkers, Tumor/*genetics
Colorectal Neoplasms/*diagnosis
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Colon/pathology ; Colon/surgery ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; DNA Mutational Analysis ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Staging ; Rectum/pathology ; Rectum/surgery ; Retrospective Studies ; Tumor Microenvironment/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Real-world data on microsatellite instability status in various unresectable or metastatic solid tumors.
Autorzy :
Akagi K; Department of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Saitama, Japan.
Oki E; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Taniguchi H; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Nakatani K; Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Tsu, Japan.
Aoki D; Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Kuwata T; Department of Genetic Medicine and Services, National Cancer Center Hospital East, Kashiwa, Japan.
Yoshino T; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Mar; Vol. 112 (3), pp. 1105-1113. Date of Electronic Publication: 2021 Feb 07.
Typ publikacji :
Journal Article
MeSH Terms :
Microsatellite Instability*
Drug Resistance, Neoplasm/*genetics
Immune Checkpoint Inhibitors/*pharmacology
Neoplasms/*genetics
Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized ; Child ; Child, Preschool ; Cohort Studies ; DNA Mismatch Repair ; Female ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Middle Aged ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/pathology ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Risk Factors ; Sex Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Expression of Thomsen-Friedenreich Antigen in Colorectal Cancer and Association with Microsatellite Instability.
Autorzy :
Leão B; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
Wen X; Department of Pathology, Centro Hospitalar Vila Nova de Gaia/Espinho, 4434-502 Vila Nova de Gaia, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
Duarte HO; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
Gullo I; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.; Department of Pathology, Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal.; Department of Pathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Gonçalves G; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
Pontes P; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.; Department of Pathology, Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal.
Castelli C; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
Diniz F; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
Mereiter S; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
Gomes J; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.
Carneiro F; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.; Department of Pathology, Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal.; Department of Pathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Reis CA; Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; IPATIMUP-Institute of Molecular Pathology and Immunology, University of Porto, 4200-135 Porto, Portugal.; Department of Pathology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 29; Vol. 22 (3). Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Microsatellite Instability*
Antigens, Tumor-Associated, Carbohydrate/*analysis
Colorectal Neoplasms/*pathology
Colon/pathology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prognosis ; Rectum/pathology ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Clinical responses to PD-1 inhibition and their molecular characterization in six patients with mismatch repair-deficient metastatic cancer of the digestive system.
Autorzy :
Hirsch D; Institute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. .
Gaiser T; Institute of Pathology, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Merx K; Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Weingaertner S; Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Forster M; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.
Hendricks A; Department of Surgery, University Medical Center Rostock, Rostock, Germany.
Woenckhaus M; Institute of Pathology, Caritas-Hospital Bad Mergentheim, Bad Mergentheim, Germany.
Schubert T; Institute of Applied Pathology, Speyer, Germany.
Hofheinz RD; Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Gencer D; Department of Medicine III, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Jan; Vol. 147 (1), pp. 263-273. Date of Electronic Publication: 2020 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
Microsatellite Instability*
Antineoplastic Agents, Immunological/*therapeutic use
DNA Repair Enzymes/*genetics
Gastrointestinal Neoplasms/*pathology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Adult ; Female ; Follow-Up Studies ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/metabolism ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Survival Rate
Czasopismo naukowe
Tytuł :
NGS-based identification and tracing of microsatellite instability from minute amounts DNA using inter-Alu-PCR.
Autorzy :
Yu F; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Leong KW; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Makrigiorgos A; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Adalsteinsson VA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ladas I; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ng K; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medicine School, Boston, MA, USA.
Mamon H; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Makrigiorgos GM; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. e24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Microsatellite Instability*
High-Throughput Nucleotide Sequencing/*methods
Multiplex Polymerase Chain Reaction/*methods
Sequence Analysis, DNA/*methods
Alu Elements ; Cell Line ; Humans ; Limit of Detection
Czasopismo naukowe
Tytuł :
Low level of microsatellite instability correlates with short disease-free survival of gastric cancer patients undergoing neoadjuvant chemotherapy.
Autorzy :
Jiang D; Department of Pathology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, Sichuan, China. .
Shu C; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China.
Zhang W; Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Sun L; Department of Pathology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Zhang M; Department of Pathology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
He Y; Department of Pathology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Owen G; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Jin W; West China College of Clinical Medicine, Sichuan University, Chengdu, China.
He D; Department of Pathology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Deng X; Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Liu X; Department of Pathology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Feb; Vol. 478 (2), pp. 231-240. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Gastrectomy*/adverse effects
Gastrectomy*/mortality
Lymph Node Excision*/adverse effects
Lymph Node Excision*/mortality
Microsatellite Instability*
Neoadjuvant Therapy*/adverse effects
Neoadjuvant Therapy*/mortality
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Biomarkers, Tumor/*genetics
Capecitabine/*therapeutic use
Oxaloacetates/*therapeutic use
Stomach Neoplasms/*therapy
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Capecitabine/adverse effects ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Oxaloacetates/adverse effects ; Prospective Studies ; Risk Assessment ; Risk Factors ; Stomach Neoplasms/genetics ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Time Factors
SCR Protocol :
XELOX
Czasopismo naukowe
Tytuł :
Molecular Biomarkers according to Primary Tumor Location in Colorectal Cancer: Current Standard and New Insights.
Autorzy :
De Renzi G; Department of Molecular Medicine, Cancer Liquid Biopsy Unit, Sapienza University of Rome, Rome, Italy.
Gaballo G; Department of Molecular Medicine, Cancer Liquid Biopsy Unit, Sapienza University of Rome, Rome, Italy.
Gazzaniga P; Department of Molecular Medicine, Cancer Liquid Biopsy Unit, Sapienza University of Rome, Rome, Italy.
Nicolazzo C; Department of Molecular Medicine, Cancer Liquid Biopsy Unit, Sapienza University of Rome, Rome, Italy, .
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Źródło :
Oncology [Oncology] 2021; Vol. 99 (3), pp. 135-143. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Microsatellite Instability*
Colonic Neoplasms/*diagnosis
Colonic Neoplasms/*genetics
Proto-Oncogene Proteins B-raf/*genetics
ras Proteins/*genetics
Biomarkers, Tumor/genetics ; Colonic Neoplasms/pathology ; Humans ; Liquid Biopsy ; Prognosis
Czasopismo naukowe
Tytuł :
Accumulation of Mitochondrial DNA Microsatellite Instability in Malaysian Patients with Primary Central Nervous System Tumors.
Autorzy :
Radzak S; Sains Malaysia University, School of Medical Sciences, Health Campus, Department of Neurosciences, 16150 Kubang Kerian, Kelantan, Malaysia.
Khair Z
Ahmad F
Idris Z
Yusoff A
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Źródło :
Turkish neurosurgery [Turk Neurosurg] 2021; Vol. 31 (1), pp. 99-106.
Typ publikacji :
Journal Article
MeSH Terms :
Microsatellite Instability*
Brain Neoplasms/*epidemiology
Brain Neoplasms/*genetics
DNA, Mitochondrial/*genetics
Adolescent ; Adult ; Aged ; Brain Neoplasms/diagnosis ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/epidemiology ; Central Nervous System Neoplasms/genetics ; Child ; Child, Preschool ; Female ; Humans ; Malaysia/epidemiology ; Male ; Microsatellite Repeats/genetics ; Middle Aged ; Mitochondria/genetics ; Polymerase Chain Reaction/trends ; Young Adult
Czasopismo naukowe
Tytuł :
Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA.
Autorzy :
Pécriaux A; Department of Pathology, CHU Henri Mondor, Créteil, France.
Favre L; Department of Pathology, CHU Henri Mondor, Créteil, France.; Université Paris-Est Créteil Val de Marne Faculté de médecine, Creteil, France.
Calderaro J; Department of Pathology, CHU Henri Mondor, Créteil, France.; Université Paris-Est Créteil Val de Marne Faculté de médecine, Creteil, France.
Charpy C; Department of Pathology, CHU Henri Mondor, Créteil, France.
Derman J; Department of Pathology, CHU Henri Mondor, Créteil, France.
Pujals A; Department of Pathology, CHU Henri Mondor, Créteil, France .; Université Paris-Est Créteil Val de Marne Faculté de médecine, Creteil, France.
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Źródło :
Journal of clinical pathology [J Clin Pathol] 2021 Jan; Vol. 74 (1), pp. 36-42. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Comparative Study; Evaluation Study; Journal Article
MeSH Terms :
Microsatellite Instability*
Carcinoma/*genetics
Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics
Endometrial Neoplasms/*genetics
Ovarian Neoplasms/*genetics
Pancreatic Neoplasms/*genetics
Stomach Neoplasms/*genetics
Adult ; DNA, Neoplasm/analysis ; Female ; Humans ; Immunohistochemistry ; Phenotype ; Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Evaluating Mismatch Repair/Microsatellite Instability Status Using Cytology Effusion Specimens to Determine Eligibility for Immunotherapy.
Autorzy :
Jacobi EM; The Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston.; Jacobi is currently in the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas.
Landon G; The Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston.
Broaddus RR; The Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston.; Broaddus is currently in the Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Roy-Chowdhuri S; The Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston.
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Źródło :
Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2021 Jan 01; Vol. 145 (1), pp. 46-54.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Endometrial Neoplasms*
Microsatellite Instability*
Brain Neoplasms/*diagnosis
Colorectal Neoplasms/*diagnosis
Cytodiagnosis/*methods
Neoplastic Syndromes, Hereditary/*diagnosis
Adult ; Aged ; Aged, 80 and over ; Ascitic Fluid/pathology ; Biomarkers, Tumor/analysis ; Female ; Humans ; Immunotherapy ; Male ; Middle Aged ; Patient Selection ; Pericardial Effusion/pathology
SCR Disease Name :
Turcot syndrome
Czasopismo naukowe
Tytuł :
Deep learning model for the prediction of microsatellite instability in colorectal cancer: a diagnostic study.
Autorzy :
Yamashita R; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA; Center for Artificial Intelligence in Medicine and Imaging, Stanford University, Stanford, CA, USA.
Long J; Center for Artificial Intelligence in Medicine and Imaging, Stanford University, Stanford, CA, USA.
Longacre T; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Peng L; Department of Pathology, University of Texas, Southwestern Medical Center, Dallas, TX, USA.
Berry G; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Martin B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Higgins J; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Rubin DL; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA; Center for Artificial Intelligence in Medicine and Imaging, Stanford University, Stanford, CA, USA.
Shen J; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Center for Artificial Intelligence in Medicine and Imaging, Stanford University, Stanford, CA, USA. Electronic address: .
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Źródło :
The Lancet. Oncology [Lancet Oncol] 2021 Jan; Vol. 22 (1), pp. 132-141.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Deep Learning*
Diagnosis, Computer-Assisted*
Image Interpretation, Computer-Assisted*
Microsatellite Instability*
Microscopy*
Colorectal Neoplasms/*diagnosis
Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Coloring Agents ; Eosine Yellowish-(YS) ; Genetic Predisposition to Disease ; Hematoxylin ; Humans ; Phenotype ; Predictive Value of Tests ; Reproducibility of Results ; Staining and Labeling
Czasopismo naukowe

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