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Tytuł:
Combined sedation in pediatric magnetic resonance imaging: determination of median effective dose of intranasal dexmedetomidine combined with oral midazolam.
Autorzy:
Xie H; Department of Anesthesiology, Children's Hospital, School of Medicine, Zhejiang University, 3333 Binsheng Rd, Hangzhou, Zhejiang, 310052, P.R. China.
Zhao J; Department of Anesthesiology, Children's Hospital, School of Medicine, Zhejiang University, 3333 Binsheng Rd, Hangzhou, Zhejiang, 310052, P.R. China.
Tu H; Department of Anesthesiology, Children's Hospital, School of Medicine, Zhejiang University, 3333 Binsheng Rd, Hangzhou, Zhejiang, 310052, P.R. China.
Wang W; Department of Anesthesiology, Children's Hospital, School of Medicine, Zhejiang University, 3333 Binsheng Rd, Hangzhou, Zhejiang, 310052, P.R. China.
Hu Y; Department of Anesthesiology, Children's Hospital, School of Medicine, Zhejiang University, 3333 Binsheng Rd, Hangzhou, Zhejiang, 310052, P.R. China. .
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Źródło:
BMC anesthesiology [BMC Anesthesiol] 2024 Mar 23; Vol. 24 (1), pp. 112. Date of Electronic Publication: 2024 Mar 23.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Dexmedetomidine*
Midazolam*
Child ; Humans ; Administration, Intranasal ; Hypnotics and Sedatives/therapeutic use ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Prospective Studies ; Infant ; Child, Preschool
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Distribution and elimination kinetics of midazolam and metabolites after post-resuscitation care: a prospective observational study.
Autorzy:
Jeong W; Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.; Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Sunwoo J; Clinical Trials Center, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.
You Y; Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.; Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Park JS; Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.; Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Min JH; Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.; Department of Emergency Medicine, Sejong Chungnam National University Hospital, Sejong, 30099, Republic of Korea.
In YN; Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.; Department of Emergency Medicine, Sejong Chungnam National University Hospital, Sejong, 30099, Republic of Korea.
Ahn HJ; Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.; Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Jeon SY; Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.; Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Hong JH; Clinical Trials Center, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.; Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Song JH; Clinical Trials Center, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea.; Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Kang H; Department of Food and Nutrition, Chungnam National University, Daejeon, 34134, Republic of Korea.
Nguyen MTT; Department of Food and Nutrition, Chungnam National University, Daejeon, 34134, Republic of Korea.; Department of Food Technology, Can Tho University, Can Tho City, 90000, Vietnam.
Kim J; Department of Food and Nutrition, Chungnam National University, Daejeon, 34134, Republic of Korea.
Kang C; Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, 35015, Republic of Korea. .; Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 25; Vol. 14 (1), pp. 4574. Date of Electronic Publication: 2024 Feb 25.
Typ publikacji:
Observational Study; Journal Article
MeSH Terms:
Midazolam*
Hypnotics and Sedatives*
Humans ; Prospective Studies ; Chromatography, Liquid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Treatment of agitation in terminally ill patients with intranasal midazolam versus subcutaneous midazolam: study protocol for a randomised controlled open-label monocentric trial (MinTU Study).
Autorzy:
Hirschinger H; 3rd Department of Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. .; Pharmacy, Mannheim University Hospital, Theodor-Kutzer- Ufer 1-3, 68167, Mannheim, Germany. .
Jaeger E; Institute for Clinical Chemistry, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Nittka S; Institute for Clinical Chemistry, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Hetjens S; Department of Medical Statistics, Biomathematics and Information Processing, University Medical Center, Heidelberg University, Mannheim, Heidelberg, Germany.
Lorenz C; Pharmacy, Mannheim University Hospital, Theodor-Kutzer- Ufer 1-3, 68167, Mannheim, Germany.
Remi C; Hospital Pharmacy, Department of Palliative Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Saussele S; 3rd Department of Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Hofmann WK; 3rd Department of Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Gencer D; Centre for Integrative Oncology, Pain and Palliative Medicine, Oeschelbronn Clinic, 75223, Niefern-Oeschelbronn, Germany.
Boch T; 3rd Department of Medicine, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
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Źródło:
BMC palliative care [BMC Palliat Care] 2024 Jan 03; Vol. 23 (1), pp. 8. Date of Electronic Publication: 2024 Jan 03.
Typ publikacji:
Clinical Trial Protocol; Journal Article
MeSH Terms:
Midazolam*/therapeutic use
Terminally Ill*
Humans ; Palliative Care ; Treatment Outcome ; Anxiety ; Hypnotics and Sedatives/therapeutic use ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Study of the ketohexokinase inhibitor PF-06835919 as a clinical cytochrome P450 3A inducer: Integrated use of oral midazolam and liquid biopsy.
Autorzy:
Qiu R; Pfizer Inc, Cambridge, Massachusetts, USA.
Fonseca K; Pfizer Inc, Cambridge, Massachusetts, USA.
Bergman A; Pfizer Inc, Cambridge, Massachusetts, USA.
Lin J; Pfizer Inc, Groton, Connecticut, USA.
Tess D; Pfizer Inc, Cambridge, Massachusetts, USA.
Newman L; Flinders University, Adelaide, South Australia, Australia.
Fahmy A; Flinders University, Adelaide, South Australia, Australia.
Useckaite Z; Flinders University, Adelaide, South Australia, Australia.
Rowland A; Flinders University, Adelaide, South Australia, Australia.
Vourvahis M; Pfizer Inc, New York, New York, USA.
Rodrigues D; Pfizer Inc, Groton, Connecticut, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2024 Jan; Vol. 17 (1), pp. e13644. Date of Electronic Publication: 2023 Dec 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Midazolam*/pharmacokinetics
Cytochrome P-450 CYP3A*/metabolism
Humans ; Proteomics ; Pharmaceutical Preparations ; Liquid Biopsy ; Drug Interactions ; Administration, Oral
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Safety and efficacy of remimazolam compared with midazolam during bronchoscopy: a single-center, randomized controlled study.
Autorzy:
Kim SH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Cho JY; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Kim M; Academic Cooperation Foundation, Chungbuk National University Industry, Cheongju, Korea.
Chung JM; Red Cross College of Nursing, Chung-Ang University, Seoul, Korea.
Yang J; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Seong C; Department of Clinical Pharmacology & Therapeutics, Chungbuk National University Hospital, Cheongju, Korea.
Kim EG; Department of Biochemistry, Chungbuk National University College of Medicine, Cheongju, Korea.
Seok JW; Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Shin YM; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Lee KM; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Choe KH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Han JH; Division of Gastroenterology, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea. .
Yang B; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea. .
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Źródło:
Scientific reports [Sci Rep] 2023 Nov 22; Vol. 13 (1), pp. 20498. Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Midazolam*/adverse effects
Drug-Related Side Effects and Adverse Reactions*
Humans ; Hypnotics and Sedatives/adverse effects ; Bronchoscopy/adverse effects ; Bronchoscopy/methods ; Prospective Studies ; Double-Blind Method ; Benzodiazepines/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differences of Atomic-Level Interactions between Midazolam and Two CYP Isoforms 3A4 and 3A5.
Autorzy:
Liu S; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.; School and Hospital of Stomatology, Jilin University, Changchun 130023, China.
Zheng Q; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.
Bai F; Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130023, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Oct 01; Vol. 28 (19). Date of Electronic Publication: 2023 Oct 01.
Typ publikacji:
Journal Article
MeSH Terms:
Midazolam*/chemistry
Cytochrome P-450 CYP3A*/metabolism
Humans ; Cytochrome P-450 Enzyme System/metabolism ; Catalytic Domain ; Protein Isoforms/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of nivasorexant (ACT-539313), a selective orexin-1-receptor antagonist, on multiple cytochrome P450 probe substrates in vitro and in vivo using a cocktail approach in healthy subjects.
Autorzy:
Berger B; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Kaufmann P; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Berse M; CRS Berlin GmbH, Berlin, Germany.
Treiber A; Department of Preclinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Grignaschi N; Department of Preclinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Dingemanse J; Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2023 Oct; Vol. 11 (5), pp. e01143.
Typ publikacji:
Journal Article
MeSH Terms:
Midazolam*
Flurbiprofen*
Adult ; Humans ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C9 ; Orexins ; Cytochrome P-450 CYP3A Inhibitors ; Healthy Volunteers ; Drug Interactions ; Cytochrome P-450 Enzyme System/genetics ; Omeprazole/pharmacokinetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neurosteroids Mediate Neuroprotection in an In Vitro Model of Hypoxic/Hypoglycaemic Excitotoxicity via δ-GABA A Receptors without Affecting Synaptic Plasticity.
Autorzy:
Puig-Bosch X; Department of Anaesthesiology and Intensive Care Medicine, Medical School, Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, Germany.; BCN-AIM Lab, Departament de Matemàtiques i Informàtica, Universitat de Barcelona, 08007 Barcelona, Spain.
Ballmann M; Department of Anaesthesiology and Intensive Care Medicine, Medical School, Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, Germany.
Bieletzki S; Department of Anaesthesiology and Intensive Care Medicine, Experimental Anaesthesiology Section, Eberhard Karls University, 72072 Tübingen, Germany.
Antkowiak B; Department of Anaesthesiology and Intensive Care Medicine, Experimental Anaesthesiology Section, Eberhard Karls University, 72072 Tübingen, Germany.
Rudolph U; Department of Comparative Biosciences, and Carl R. Woese Institute for Genomic Biology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Zeilhofer HU; Institute of Pharmacology and Toxicology, University of Zürich, 8057 Zürich, Switzerland.; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zürich, 8092 Zürich, Switzerland.
Rammes G; Department of Anaesthesiology and Intensive Care Medicine, Medical School, Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 21; Vol. 24 (10). Date of Electronic Publication: 2023 May 21.
Typ publikacji:
Journal Article
MeSH Terms:
Midazolam*/pharmacology
Neurosteroids*/pharmacology
Mice ; Animals ; Neuroprotection ; Hypoglycemic Agents/pharmacology ; Receptors, GABA-A/metabolism ; Benzodiazepines/pharmacology ; Carrier Proteins ; Ligands ; Long-Term Potentiation ; gamma-Aminobutyric Acid/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of YWHAH as a Novel Brain-Derived Extracellular Vesicle Marker Post Long-Term Midazolam Exposure during Early Development.
Autorzy:
Nguyen NM; Department of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Meyer D; Department of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Meyer L; Department of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Chand S; Department of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Jagadesan S; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Miravite M; Department of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Guda C; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Yelamanchili SV; Department of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
Pendyala G; Department of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.; Child Health Research Institute, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.; National Strategic Research Institute, University of Nebraska Medical Center (UNMC), Omaha, NE 68198, USA.
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Źródło:
Cells [Cells] 2023 Mar 22; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
14-3-3 Proteins*
Extracellular Vesicles*/metabolism
Midazolam*/adverse effects
Midazolam*/pharmacology
Animals ; Rats ; Biomarkers ; Brain ; Hypnotics and Sedatives/adverse effects ; Models, Biological ; Proteome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Safety and efficacy of a low-dose combination of midazolam, alfentanil, and propofol for deep sedation of elderly patients undergoing ERCP.
Autorzy:
Zhang Y; Department of Anesthesiology, Cheeloo College of Medicine, Shandong Provincial Third Hospital, Shandong University, No.12 Wuyingshan Middle Road, Jinan, Shandong, 250000, China.
Zhang N; Department of Cardiopulmonary rehabilitation, Cheeloo College of Medicine, Shandong Provincial Third Hospital, Shandong University, No.12 Wuyingshan Middle Road, Jinan, Shandong, 250000, China.
Hu J; Department of Anesthesiology, Cheeloo College of Medicine, Shandong Provincial Third Hospital, Shandong University, No.12 Wuyingshan Middle Road, Jinan, Shandong, 250000, China.
Liu C; Department of Anesthesiology, Cheeloo College of Medicine, Shandong Provincial Third Hospital, Shandong University, No.12 Wuyingshan Middle Road, Jinan, Shandong, 250000, China.
Li G; Department of Anesthesiology, Cheeloo College of Medicine, Shandong Provincial Third Hospital, Shandong University, No.12 Wuyingshan Middle Road, Jinan, Shandong, 250000, China. .
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Źródło:
BMC gastroenterology [BMC Gastroenterol] 2024 Apr 02; Vol. 24 (1), pp. 124. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Propofol*/adverse effects
Deep Sedation*/adverse effects
Deep Sedation*/methods
Aged ; Middle Aged ; Humans ; Midazolam/adverse effects ; Alfentanil/adverse effects ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Hypnotics and Sedatives/adverse effects ; Retrospective Studies ; Conscious Sedation/adverse effects ; Conscious Sedation/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Residual unabsorbed midazolam: a case report.
Autorzy:
Baboolal HA; Department of Anesthesiology, University of North Carolina Hospital, 101 Manning Drive, Chapel Hill, NC, 27514, USA. Hemanth_.
Gulati A; Department of Pediatrics, University of North Carolina, Chapel Hill, USA.
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Źródło:
Journal of medical case reports [J Med Case Rep] 2023 Mar 25; Vol. 17 (1), pp. 118. Date of Electronic Publication: 2023 Mar 25.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Midazolam*/therapeutic use
Preanesthetic Medication*/methods
Child ; Male ; Humans ; Child, Preschool ; Hypnotics and Sedatives/therapeutic use ; Anxiety ; Anxiety Disorders/drug therapy ; Administration, Oral
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism.
Autorzy:
Li R; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Wang Q; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Liu Z; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Xie L; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Diao Z; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Peng Y; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Wang G; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Sun J; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 184-192. Date of Electronic Publication: 2023 Apr 27.
Typ publikacji:
Journal Article
MeSH Terms:
Midazolam*/pharmacokinetics
Liver*/metabolism
Rats ; Animals ; Rats, Sprague-Dawley ; Intestines ; Biological Availability ; Administration, Oral ; Area Under Curve
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of oral triclofos and intranasal midazolam and dexmedetomidine for sedation in children undergoing magnetic resonance imaging (MRI): an open-label, three-arm, randomized trial.
Autorzy:
Chandrasekar S; Department of Pediatrics, Pharmacology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, 751019, India.
Dwibedi B; Department of Pediatrics, Pharmacology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, 751019, India. .
Das RR; Department of Pediatrics, Pharmacology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, 751019, India.
Padhy BM; Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, 751019, India.
Behera BK; Department of Anesthesia & Critical Care, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, 751019, India.
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Źródło:
European journal of pediatrics [Eur J Pediatr] 2023 Mar; Vol. 182 (3), pp. 1385-1391. Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Midazolam*
Dexmedetomidine*/adverse effects
Child ; Humans ; Hypnotics and Sedatives ; Chloral Hydrate ; Administration, Intranasal ; Magnetic Resonance Imaging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mechanism-based inactivation of cytochrome P450 3A by evodol.
Autorzy:
Zhao J; Pharmaceutical Animal Experimental Center, China Pharmaceutical University, Nanjing, China.
He J; R&D Institute, Chia Tai Tianqing Pharmaceutical Group Co., LTD, Nanjing, China.
Xu J; Department of Phase I Clinical Trial Research, Nanjing Gaoxin Hospital, Nanjing, China.
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Źródło:
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2023 Mar; Vol. 53 (3), pp. 129-139. Date of Electronic Publication: 2023 May 02.
Typ publikacji:
Journal Article
MeSH Terms:
Cytochrome P-450 CYP3A*
Midazolam*/pharmacology
Humans ; Microsomes, Liver ; Ketoconazole/pharmacology ; Testosterone
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A "middle-out approach" for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models.
Autorzy:
Yau E; Centre for Applied Pharmacokinetic Research, The University of Manchester, Manchester, UK.; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Gertz M; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Ogungbenro K; Centre for Applied Pharmacokinetic Research, The University of Manchester, Manchester, UK.
Aarons L; Centre for Applied Pharmacokinetic Research, The University of Manchester, Manchester, UK.
Olivares-Morales A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Mar; Vol. 12 (3), pp. 346-359. Date of Electronic Publication: 2023 Jan 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Midazolam*/pharmacokinetics
Diazepam*/pharmacokinetics
Humans ; Rats ; Animals ; Kinetics ; Models, Biological ; Haplorhini
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Effect of Rectal Midazolam on Pain, Stress, and Cooperation of Patient during Urodynamic Test in Women: A Randomized Clinical Trial.
Autorzy:
Saberi N; Department of Urology, School of Medicine Nour and Ali-Asghar Hospital Isfahan University of Medical Sciences, Isfahan, Iran. .
Hayrabedian A; Instructor of Operating Room Department, School of Nursing and Midwifery Isfahan University of Medical Sciences. .
Mazdak H; Department of Urology, School of Medicine Al-Zahra Hospital Isfahan University of Medical Sciences. .
Hassannejad R; Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. .
Zargham M; Department of Urology, School of Medicine Al-Zahra Hospital Isfahan University of Medical Sciences . mah_.
Mohammadi Sichani M; Department of Urology, School of Medicine Al-Zahra Hospital Isfahan University of Medical Sciences. M_.
Mirzaei M; Department of Urology, Kerman University of Medical Sciences, Kerman, Iran. .
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Źródło:
Urology journal [Urol J] 2023 Feb 27; Vol. 20 (2), pp. 129-134. Date of Electronic Publication: 2023 Feb 27.
Typ publikacji:
Randomized Controlled Trial; Journal Article
MeSH Terms:
Midazolam*/pharmacology
Urodynamics*
Adult ; Female ; Humans ; Blood Pressure ; Heart Rate ; Pain ; Stress, Physiological
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A comparative evaluation of intranasal α2-adrenoceptor agonists and intranasal midazolam as premedication in pediatric sedation: A meta-analysis of randomized controlled trials.
Autorzy:
Fu Y; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.
Zhang Q; Department of Anesthesiology, Chengdu Women and Children's Central Hospital, Chengdu, China.
Jiang Y; Department of Pharmacy, Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, China.
Lang B; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.
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Źródło:
PloS one [PLoS One] 2023 Feb 14; Vol. 18 (2), pp. e0281751. Date of Electronic Publication: 2023 Feb 14 (Print Publication: 2023).
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
Midazolam*/therapeutic use
Dexmedetomidine*/adverse effects
Child ; Humans ; Clonidine ; Randomized Controlled Trials as Topic ; Hypnotics and Sedatives/therapeutic use ; Premedication ; Anesthesia, General ; Receptors, Adrenergic ; Administration, Intranasal
Czasopismo naukowe
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Tytuł:
Formation of CYP3A-specific metabolites of ibrutinib in vitro is correlated with hepatic CYP3A activity and 4β-hydroxycholesterol/cholesterol ratio.
Autorzy:
Lee J; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Fallon JK; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Smith PC; Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Jackson KD; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Feb; Vol. 16 (2), pp. 279-291. Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cytochrome P-450 CYP3A*/metabolism
Midazolam*
Humans ; Infant ; Cholesterol ; Biomarkers ; Liver/metabolism
Czasopismo naukowe
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Tytuł:
Tolerance to remimazolam at a high effect-site concentration.
Autorzy:
Kida K; Department of Anesthesiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Taguchi M; Department of Anesthesiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Uchiyama K; Department of Anesthesiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Fujioka S; Department of Anesthesiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Tsubokawa T; Department of Anesthesiology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan. .
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Źródło:
Journal of anesthesia [J Anesth] 2023 Feb; Vol. 37 (1), pp. 168-169. Date of Electronic Publication: 2022 Nov 30.
Typ publikacji:
Letter
MeSH Terms:
Benzodiazepines*
Midazolam*
Hypnotics and Sedatives
Opinia redakcyjna
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Tytuł:
An Open-Label Study to Evaluate the Effect of Eluxadoline on the Single-Dose Pharmacokinetics of Midazolam in Healthy Participants.
Autorzy:
Boinpally R; AbbVie Inc, Madison, New Jersey, USA.
McGeeney D; AbbVie Inc, North Chicago, Illinois, USA.
Kaczynski E; AbbVie Inc, Madison, New Jersey, USA.
Weissman D; AbbVie Inc, Madison, New Jersey, USA.
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Źródło:
Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Nov; Vol. 11 (11), pp. 1341-1348. Date of Electronic Publication: 2022 Aug 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Midazolam*/adverse effects
Midazolam*/pharmacokinetics
Cytochrome P-450 CYP3A*
Adult ; Humans ; Healthy Volunteers ; Phenylalanine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 1211

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