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Wyszukujesz frazę ""MLL"" wg kryterium: Temat


Tytuł:
Role of the MOZ/MLL-mediated transcriptional activation system for self-renewal in normal hematopoiesis and leukemogenesis.
Autorzy:
Yokoyama A; Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.; National Cancer Center Research Institute, Tokyo, Japan.
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Źródło:
The FEBS journal [FEBS J] 2022 Dec; Vol. 289 (24), pp. 7987-8002. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Leukemia*/genetics
Leukemia*/metabolism
Humans ; Transcriptional Activation ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Hematopoietic Stem Cells/metabolism ; Carcinogenesis/metabolism ; Hematopoiesis/genetics
Czasopismo naukowe
Tytuł:
Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia.
Autorzy:
Brzezinka K; Pharmaceuticals, Research & Development, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany.
Nevedomskaya E; Pharmaceuticals, Research & Development, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany.
Lesche R; Pharmaceuticals, Research & Development, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany.
Steckel M; Pharmaceuticals, Research & Development, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany.
Eheim AL; Pharmaceuticals, Research & Development, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany.
Haegebarth A; Pharmaceuticals, Research & Development, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany.
Stresemann C; Pharmaceuticals, Research & Development, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany. .
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2019 Jun 28; Vol. 12 (1), pp. 66. Date of Electronic Publication: 2019 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Histone-Lysine N-Methyltransferase/*genetics
Leukemia/*drug therapy
Myeloid-Lymphoid Leukemia Protein/*genetics
Cell Line, Tumor ; Cell Proliferation/drug effects ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation, Leukemic/drug effects ; Gene Rearrangement/drug effects ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Leukemia/genetics ; Leukemia/metabolism ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Protein Interaction Maps/drug effects ; Proto-Oncogene Proteins/metabolism
Czasopismo naukowe
Tytuł:
Direct targeted therapy for MLL-fusion-driven high-risk acute leukaemias.
Autorzy:
Cantilena S; Cancer Section, Development Biology and Cancer Programme, UCL GOS Institute of Child Health, London, UK.
Gasparoli L; Cancer Section, Development Biology and Cancer Programme, UCL GOS Institute of Child Health, London, UK.
Pal D; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Heidenreich O; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Klusmann JH; Department of Pediatrics I, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Martens JHA; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.
Faille A; Cambridge Institute for Medical Research, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
Warren AJ; Cambridge Institute for Medical Research, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.
Karsa M; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, New South Wales, Australia.
Pandher R; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, New South Wales, Australia.
Somers K; Children's Cancer Institute, Lowy Cancer Research Institute, University of New South Wales, Randwick, New South Wales, Australia.; School of Women's and Children's Health, University of New South Wales, Randwick, New South Wales, Australia.
Williams O; Cancer Section, Development Biology and Cancer Programme, UCL GOS Institute of Child Health, London, UK.
de Boer J; Cancer Section, Development Biology and Cancer Programme, UCL GOS Institute of Child Health, London, UK.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2022 Jun; Vol. 12 (6), pp. e933.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Leukemia*/genetics
Oncogene Proteins, Fusion*/genetics
Oncogene Proteins, Fusion*/metabolism
Acute Disease ; Apoptosis ; Cell Proliferation ; Child ; Epigenesis, Genetic ; Humans ; Infant
Czasopismo naukowe
Tytuł:
Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias.
Autorzy:
Yi Y; Departments of Hematology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
Ge S; Departments of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Street, Changsha, 410011, Hunan, People's Republic of China. .
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2022 Mar 24; Vol. 15 (1), pp. 35. Date of Electronic Publication: 2022 Mar 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Histones*
Leukemia*/drug therapy
Leukemia*/genetics
Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Lysine ; Methyltransferases/metabolism ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism
Czasopismo naukowe
Tytuł:
SET-NUP214 and MLL cooperatively regulate the promoter activity of the HoxA10 gene.
Autorzy:
Cigdem S; Laboratory of Biochemistry, School of Pharmacy, Kitasato University, Minato-ku, Japan.; Department of Infection Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Saito S; Laboratory of Biochemistry, School of Pharmacy, Kitasato University, Minato-ku, Japan.
Nishikata D; Laboratory of Biochemistry, School of Pharmacy, Kitasato University, Minato-ku, Japan.
Nagata K; University of Tsukuba, Tsukuba, Japan.
Okuwaki M; Laboratory of Biochemistry, School of Pharmacy, Kitasato University, Minato-ku, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2021 Oct; Vol. 26 (10), pp. 830-837. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji:
Journal Article
MeSH Terms:
Leukemia*
Nuclear Pore Complex Proteins*/metabolism
DNA-Binding Proteins/*metabolism
Histone Chaperones/*metabolism
Histone-Lysine N-Methyltransferase/*metabolism
Myeloid-Lymphoid Leukemia Protein/*metabolism
DNA-Binding Proteins/genetics ; Gene Expression ; Histone Chaperones/genetics ; Homeobox A10 Proteins ; Humans ; Promoter Regions, Genetic
Czasopismo naukowe
Tytuł:
Editorial: Harnessing chemotherapy resistance and development of novel therapeutic strategies for acute leukemia with KMT2A (MLL)-gene rearrangements
Autorzy:
Maria Teresa Esposito
Anna Hagström-Andersson
Ronald W. Stam
Stefania Bortoluzzi
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Temat:
KMT2A
MLL
ALL
AML
Leukemia
drug repositioining
Therapeutics. Pharmacology
RM1-950
Źródło:
Frontiers in Pharmacology, Vol 13 (2022)
Opis pliku:
electronic resource
Relacje:
https://www.frontiersin.org/articles/10.3389/fphar.2022.977741/full; https://doaj.org/toc/1663-9812
Dostęp URL:
https://doaj.org/article/8c8c757410ac4f75863a23266d6d4775  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Drug Repurposing for Targeting Acute Leukemia With KMT2A (MLL)—Gene Rearrangements
Autorzy:
Alexia Tsakaneli
Owen Williams
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Temat:
MLL-rearrangements
leukemia
drug repurposing
AML
ALL
Therapeutics. Pharmacology
RM1-950
Źródło:
Frontiers in Pharmacology, Vol 12 (2021)
Opis pliku:
electronic resource
Relacje:
https://www.frontiersin.org/articles/10.3389/fphar.2021.741413/full; https://doaj.org/toc/1663-9812
Dostęp URL:
https://doaj.org/article/0bee4060574a4917831393a258862d28  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia
Autorzy:
William F Richter
Rohan N Shah
Alexander J Ruthenburg
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Temat:
chromatin
leukemia
MLL-rearranged
H3K79me2
MV4
11
FLT3
Medicine
Science
Biology (General)
QH301-705.5
Źródło:
eLife, Vol 10 (2021)
Opis pliku:
electronic resource
Relacje:
https://elifesciences.org/articles/64960; https://doaj.org/toc/2050-084X
Dostęp URL:
https://doaj.org/article/e5b40cfc226c4f88af0da6f8ae7c2097  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation
Autorzy:
Fioretti, Tiziana
Cevenini, ArmandoAff2, Aff3
Zanobio, Mariateresa
Raia, Maddalena
Sarnataro, DanielaAff2, Aff3
Salvatore, FrancescoAff1, Aff3
Esposito, GabriellaAff1, Aff2
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Źródło:
Cellular Oncology: The official journal of the International Society for Cellular Oncology. 42(6):829-845
Czasopismo naukowe
Tytuł:
MEIS1 in Hematopoiesis and Cancer. How MEIS1-PBX Interaction Can Be Used in Therapy
Autorzy:
Francesco Blasi
Chiara Bruckmann
Pokaż więcej
Temat:
MEIS1
PBX1
MLL-r
leukemia
interaction surface
Biology (General)
QH301-705.5
Źródło:
Journal of Developmental Biology, Vol 9, Iss 4, p 44 (2021)
Opis pliku:
electronic resource
Relacje:
https://www.mdpi.com/2221-3759/9/4/44; https://doaj.org/toc/2221-3759
Dostęp URL:
https://doaj.org/article/7d8dcc5c4e3046dca1fe6c294a3aa6e3  Link otwiera się w nowym oknie
Czasopismo naukowe

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