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Tytuł:
Design, synthesis, biological assessment and molecular modeling studies of novel imidazothiazole-thiazolidinone hybrids as potential anticancer and anti-inflammatory agents.
Autorzy:
Kamboj P; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Anjali; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Imtiyaz K; Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
Rizvi MA; Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
Nath V; Department of Pharmacy, Central University of Rajasthan, Ajmer, India.
Kumar V; Department of Pharmacy, Central University of Rajasthan, Ajmer, India.
Husain A; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.
Amir M; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. .
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Źródło:
Scientific reports [Sci Rep] 2024 Apr 11; Vol. 14 (1), pp. 8457. Date of Electronic Publication: 2024 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Cardiomyopathies*
Chemical and Drug Induced Liver Injury*
Humans ; Rats ; Animals ; Structure-Activity Relationship ; Cell Line, Tumor ; Molecular Docking Simulation ; HEK293 Cells ; Anti-Inflammatory Agents/pharmacology ; ErbB Receptors/metabolism ; Molecular Structure ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Protein Kinase Inhibitors/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
1,2,3-triazole and chiral Schiff base hybrids as potential anticancer agents: DFT, molecular docking and ADME studies.
Autorzy:
Belay Y; Department of Chemical Sciences, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa. .
Muller A; Department of Chemical Sciences, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa.
Mokoena FS; Department of Chemical Sciences, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa.
Adeyinka AS; Department of Chemical Sciences, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa.
Motadi LR; Department of Biochemistry, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa.
Oyebamiji AK; Industrial Chemistry Programme, Bowen University, PMB 284, Iwo, Osun State, Nigeria.
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 23; Vol. 14 (1), pp. 6951. Date of Electronic Publication: 2024 Mar 23.
Typ publikacji:
Journal Article
MeSH Terms:
Schiff Bases*/pharmacology
Schiff Bases*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Humans ; Molecular Docking Simulation ; Triazoles/pharmacology ; Triazoles/chemistry ; Structure-Activity Relationship ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis and in vitro anticancer activity of some new lomefloxacin derivatives.
Autorzy:
Adly ME; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt. .
Gedawy EM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University in Cairo, Cairo, 11829, Egypt.
El-Malah AA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt.
Khalil OM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 33 Kasr El-Aini Street, Cairo, 11562, Egypt.
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 14; Vol. 14 (1), pp. 6175. Date of Electronic Publication: 2024 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Fluoroquinolones*
Humans ; Molecular Structure ; Structure-Activity Relationship ; Cell Line, Tumor ; DNA Topoisomerases, Type II/metabolism ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Dose-Response Relationship, Drug
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-Inflammatory and Cytotoxic Compounds Isolated from Plants of Euphorbia Genus.
Autorzy:
Rojas-Jiménez S; Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Ciudad de México 04960, Mexico.
Valladares-Cisneros MG; Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico.
Salinas-Sánchez DO; Centro de Investigación en Biodiversidad y Conservación, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico.
Pérez-Ramos J; Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Ciudad de México 04960, Mexico.
Sánchez-Pérez L; Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Ciudad de México 04960, Mexico.
Pérez-Gutiérrez S; Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Ciudad de México 04960, Mexico.
Campos-Xolalpa N; Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Ciudad de México 04960, Mexico.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Euphorbia*/chemistry
Diterpenes*/chemistry
Antineoplastic Agents*
Triterpenes*/chemistry
Abietanes ; Molecular Structure ; Anti-Inflammatory Agents
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Designing Potent Anti-Cancer Agents: Synthesis and Molecular Docking Studies of Thieno[2,3- d ][1,2,4]triazolo[1,5- a ]pyrimidine Derivatives.
Autorzy:
Elsenbawy ESM; Department of Chemistry, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
Alshehri ZS; Department of Medical Laboratories, College of Applied Medical Sciences, Shaqra University, Dawadmi 19257, Saudi Arabia.
Babteen NA; Department of Biochemistry, College of Sciences, University of Jeddah, Jeddah 21577, Saudi Arabia.
Abdel-Rahman AA; Department of Chemistry, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt.
El-Manawaty MA; Department of Pharmacognosy, Pharmaceutical Science Division, National Research Centre, Cairo 12622, Egypt.
Nossier ES; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.
Arafa RK; Drug Design and Discovery Laboratory, Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Ahmed Zewail Road, October Gardens, Cairo 12578, Egypt.
Hassan NA; Synthetic Unit, Department of Photochemistry, Chemical Industries Research Institute, National Research Centre, Cairo 12622, Egypt.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 29; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 29.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Humans ; Molecular Structure ; Structure-Activity Relationship ; Molecular Docking Simulation ; Pyrimidines/pharmacology ; Triazoles/pharmacology ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Cell Line, Tumor ; Drug Design
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cytotoxic naphtho- and benzofurans from an endophytic fungus Epicoccum nigrum Ann-B-2 associated with Annona squamosa fruits.
Autorzy:
Elnaggar MS; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt. .
Fayez S; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt. shaimaa_.
Anwar A; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Ebada SS; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt. .
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 28; Vol. 14 (1), pp. 4940. Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Annona*/chemistry
Benzofurans*/pharmacology
Ascomycota*/chemistry
Antineoplastic Agents*/chemistry
Fruit ; Molecular Structure
SCR Organism:
Epicoccum nigrum
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Recent Trends in the Synthesis and Bioactivity of Coumarin, Coumarin-Chalcone, and Coumarin-Triazole Molecular Hybrids.
Autorzy:
Rohman N; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia.
Ardiansah B; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia.
Wukirsari T; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia.
Judeh Z; School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 62 Nanyang Drive, N1.2-B1-14, Singapore 637459, Singapore.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 27; Vol. 29 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Chalcone*
Chalcones*
Antineoplastic Agents*/pharmacology
Structure-Activity Relationship ; Triazoles/chemistry ; Coumarins/chemistry ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Conjugates of Indolo[2,3- b ]quinoline as Anti-Pancreatic Cancer Agents: Design, Synthesis, Molecular Docking and Biological Evaluations.
Autorzy:
Cybulski M; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
Sidoryk K; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
Zaremba-Czogalla M; Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, Poland.
Trzaskowski B; Chemical and Biological Systems Simulation Lab, Center of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.
Kubiszewski M; Pharmaceutical Analysis Laboratory, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
Tobiasz J; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
Jaromin A; Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, Poland.
Michalak O; Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 01-793 Warsaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 22; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Pancreatic Neoplasms*
Quinolines*
Antineoplastic Agents*
Humans ; Molecular Docking Simulation ; Pancreatic Hormones ; Coumaric Acids ; Multienzyme Complexes ; DNA ; Structure-Activity Relationship ; Molecular Structure ; Cell Line, Tumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Biological Evaluation of Novel Amino and Amido Substituted Pentacyclic Benzimidazole Derivatives as Antiproliferative Agents.
Autorzy:
Perin N; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Gulin M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Kos M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
Persoons L; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, 3000 Leuven, Belgium.
Daelemans D; KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, 3000 Leuven, Belgium.
Fabijanić I; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Stojković MR; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Bijenička cesta 54, HR-10000 Zagreb, Croatia.
Hranjec M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 14; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Humans ; Structure-Activity Relationship ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Benzimidazoles/chemistry ; Cell Proliferation ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Antitumor Activity Evaluation of Novel Echinatin Derivatives with a 1,3,4-Oxadiazole Moiety.
Autorzy:
Tian X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Sun Z; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhong Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yang H; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 13; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Neoplasms*
Oxadiazoles*
Chalcones*
Humans ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Cell Proliferation ; Molecular Structure ; Cell Line, Tumor ; Dose-Response Relationship, Drug
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of A Novel Series of Quinazoline-Thiazole Hybrids as Potential Antiproliferative and Anti-Angiogenic Agents.
Autorzy:
Șandor A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 Victor Babes, Street, 400010 Cluj-Napoca, Romania.
Fizeșan I; Department of Toxicology, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
Ionuț I; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 Victor Babes, Street, 400010 Cluj-Napoca, Romania.
Marc G; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 Victor Babes, Street, 400010 Cluj-Napoca, Romania.
Moldovan C; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 Victor Babes, Street, 400010 Cluj-Napoca, Romania.
Oniga I; Department of Pharmacognosy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010 Cluj-Napoca, Romania.
Pîrnău A; National Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath Street, 400293 Cluj-Napoca, Romania.
Vlase L; Department of Pharmaceutical Technology and Biopharmaceutics, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 Victor Babeș, Street, 400012 Cluj-Napoca, Romania.
Petru AE; Department of Toxicology, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
Macasoi I; Department of Toxicology, Faculty of Pharmacy, 'Victor Babeș' University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.; Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, 'Victor Babes' University of Medicine and Pharmacy Timișoara, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
Oniga O; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 41 Victor Babes, Street, 400010 Cluj-Napoca, Romania.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 12; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Sorafenib/pharmacology ; Molecular Docking Simulation ; Quinazolines/pharmacology ; Quinazolines/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology ; Cell Proliferation ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis, Characterization, Antioxidant, and Anticancer Activity against Colon Cancer Cells of Some Cinnamaldehyde-Based Chalcone Derivatives.
Autorzy:
El-Atawy MA; Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu 46423, Saudi Arabia.; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426 Ibrahemia, Alexandria 21321, Egypt.
Hanna DH; Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Bashal AH; Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu 46423, Saudi Arabia.
Ahmed HA; Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu 46423, Saudi Arabia.; Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
Alshammari EM; Department of Chemistry, College of Sciences, University of Ha'il, Ha'il 55473, Saudi Arabia.
Hamed EA; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426 Ibrahemia, Alexandria 21321, Egypt.
Aljohani AR; Chemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu 46423, Saudi Arabia.; Saudi Irrigation Organization (SIO), Al-Hassa 31982, Saudi Arabia.
Omar AZ; Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426 Ibrahemia, Alexandria 21321, Egypt.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 12; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Chalcones*/pharmacology
Chalcone*/pharmacology
Chalcone*/chemistry
Antineoplastic Agents*/chemistry
Colonic Neoplasms*/drug therapy
Acrolein/*analogs & derivatives
Humans ; Structure-Activity Relationship ; Antioxidants/pharmacology ; Cell Line, Tumor ; Caco-2 Cells ; Cell Proliferation ; Apoptosis ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and molecular docking simulations of novel azepines based on quinazolinone moiety as prospective antimicrobial and antitumor hedgehog signaling inhibitors.
Autorzy:
Noser AA; Organic Chemistry, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt. .
El-Barbary AA; Organic Chemistry, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Salem MM; Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
El Salam HAA; Green Chemistry Department, National Research Centre, Dokki, GizaCairo, 12622, Egypt.
Shahien M; Organic Chemistry, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 12; Vol. 14 (1), pp. 3530. Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article
MeSH Terms:
Oxazepines*/pharmacology
Anti-Infective Agents*/pharmacology
Antineoplastic Agents*/chemistry
Structure-Activity Relationship ; Molecular Docking Simulation ; Hedgehog Proteins ; Quinazolinones/pharmacology ; Cell Proliferation ; Escherichia coli/metabolism ; Staphylococcus aureus/metabolism ; Glucan 1,3-beta-Glucosidase ; Prospective Studies ; Molecular Structure ; Drug Screening Assays, Antitumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Novel pyridine bearing pentose moiety-based anticancer agents: design, synthesis, radioiodination and bioassessments.
Autorzy:
Mehany MM; Laboratory Department, Chemistry Unit, Police Hospital, Agouza, Cairo, Egypt.
Hammam OA; Pathology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Selim AA; Labeled Compounds Department, Hot Laboratories Centre, Egyptian Atomic Energy Authority (EAEA), Cairo, 13759, Egypt. adli_a_.
Sayed GH; Heterocyclic Synthesis Lab., Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
Anwer KE; Heterocyclic Synthesis Lab., Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo, 11566, Egypt.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 01; Vol. 14 (1), pp. 2738. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Iodine Radioisotopes*/pharmacology
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Humans ; Animals ; Mice ; MCF-7 Cells ; Caco-2 Cells ; Cell Proliferation ; Pyridines/pharmacology ; Pyridines/chemistry ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Drug Design ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis of 2-Amino- N '-aroyl(het)arylhydrazides, DNA Photocleavage, Molecular Docking and Cytotoxicity Studies against Melanoma CarB Cell Lines.
Autorzy:
Mitrakas A; Laboratory of Cellular Biology, Molecular Biology and Genetics Department, Democritus University of Thrace, University Campus, 68100 Alexandroupolis, Greece.
Stathopoulou MK; Laboratory of Organic, Bioorganic and Natural Product Chemistry, Molecular Biology and Genetics Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Mikra C; Laboratory of Organic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Konstantinou C; Laboratory of Organic, Bioorganic and Natural Product Chemistry, Molecular Biology and Genetics Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Rizos S; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA 02138, USA.
Malichetoudi S; Laboratory of Cellular Biology, Molecular Biology and Genetics Department, Democritus University of Thrace, University Campus, 68100 Alexandroupolis, Greece.
Koumbis AE; Laboratory of Organic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Koffa M; Laboratory of Cellular Biology, Molecular Biology and Genetics Department, Democritus University of Thrace, University Campus, 68100 Alexandroupolis, Greece.
Fylaktakidou KC; Laboratory of Organic, Bioorganic and Natural Product Chemistry, Molecular Biology and Genetics Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.; Laboratory of Organic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Jan 30; Vol. 29 (3). Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article
MeSH Terms:
Melanoma*/drug therapy
Antineoplastic Agents*/pharmacology
Humans ; Molecular Docking Simulation ; DNA/metabolism ; Cell Line, Tumor ; Quinazolinones ; Structure-Activity Relationship ; Molecular Structure ; Drug Screening Assays, Antitumor
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Thymoquinone-protoflavone hybrid molecules as potential antitumor agents.
Autorzy:
Ahmed SHH; Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Tayeb BA; Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Gonda T; Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Girst G; Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Szőri K; Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.
Berkecz R; Institute of Pharmaceutical Analysis, University of Szeged, Szeged, Hungary.
Zupkó I; Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Minorics R; Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
Hunyadi A; Institute of Pharmacognosy, University of Szeged, Szeged, Hungary.; HUN-REN-SZTE Biologically Active Natural Products Research Group, Szeged, Hungary.; Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, Hungary.
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Źródło:
PloS one [PLoS One] 2024 Jan 25; Vol. 19 (1), pp. e0291567. Date of Electronic Publication: 2024 Jan 25 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Antineoplastic Agents*/pharmacology
Humans ; Drug Screening Assays, Antitumor ; Benzoquinones/pharmacology ; Cell Proliferation ; Cell Line, Tumor ; Structure-Activity Relationship ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Self-Assembled Molecular Complexes of 1,10-Phenanthroline and 2-Aminobenzimidazoles: Synthesis, Structure Investigations, and Cytotoxic Properties.
Autorzy:
Anichina K; Department of Organic Synthesis, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.
Kaloyanov N; Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.
Zasheva D; Laboratory of Reproductive OMICs Technologies, Acad. Kiril Bratanov Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, 73A Tsarigradsko Shosse Blvd., 1113 Sofia, Bulgaria.
Rusew R; Department of Structural Crystallography and Materials Science, Acad. Ivan Kostov Institute of Mineralogy and Crystallography, Bulgarian Academy of Sciences, Acad G. Bonchev Str., Build. 107, 1113 Sofia, Bulgaria.
Nikolova R; Department of Structural Crystallography and Materials Science, Acad. Ivan Kostov Institute of Mineralogy and Crystallography, Bulgarian Academy of Sciences, Acad G. Bonchev Str., Build. 107, 1113 Sofia, Bulgaria.
Yancheva D; Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Build. 9, 1113 Sofia, Bulgaria.
Bakov V; Department of Organic Synthesis, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.
Georgiev N; Department of Organic Synthesis, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Jan 24; Vol. 29 (3). Date of Electronic Publication: 2024 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemistry
Coordination Complexes*/chemistry
Humans ; Phenanthrolines/chemistry ; Benzimidazoles/pharmacology ; Crystallography, X-Ray ; DNA/chemistry ; Copper/chemistry ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antiproliferative Activities and SwissADME Predictions of Physicochemical Properties of Carbonyl Group-Modified Rotenone Analogues.
Autorzy:
Hernandez RD; Institute of Chemistry, University of the Philippines Diliman, Quezon City, Philippines, 1101.
Genio FAF; Institute of Chemistry, University of the Philippines Diliman, Quezon City, Philippines, 1101.
Casanova JR; Institute of Chemistry, University of the Philippines Diliman, Quezon City, Philippines, 1101.
Conato MT; Institute of Chemistry, University of the Philippines Diliman, Quezon City, Philippines, 1101.
Paderes MC; Institute of Chemistry, University of the Philippines Diliman, Quezon City, Philippines, 1101.
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Źródło:
ChemistryOpen [ChemistryOpen] 2024 Jan; Vol. 13 (1), pp. e202300087. Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Rotenone*/pharmacology
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Humans ; Molecular Structure ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; MCF-7 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluation of anticancer potential of tetracene-5,12-dione (A01) and pyrimidine-2,4-dione (A02) via caspase 3 and lactate dehydrogenase cytotoxicity investigations.
Autorzy:
Aziz M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Sarfraz M; College of Pharmacy, Al Ain University, Al Ain, United Arab Emirates.
Khurrum Ibrahim M; Baqai Medical University, Karachi, Pakistan.
Ejaz SA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Zehra T; Department of Basic Science & Humanities, Dawood University of Engineering & Technology, Karachi, Pakistan.
Ogaly HA; Chemistry Department, College of Science, King Khalid University, Abha, Saudi Arabia.
Arafat M; College of Pharmacy, Al Ain University, Al Ain, United Arab Emirates.
Al-Zahrani FAM; Chemistry Department, College of Science, King Khalid University, Abha, Saudi Arabia.
Li C; Department of Biology, Chemistry, Pharmacy, Free University of Berlin, Berlin, Germany.
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Źródło:
PloS one [PLoS One] 2023 Dec 21; Vol. 18 (12), pp. e0292455. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/chemistry
Neoplasms*
Humans ; Caspase 3 ; Molecular Docking Simulation ; L-Lactate Dehydrogenase ; Pyrimidines/pharmacology ; DNA ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Thiophene derivative inflicts cytotoxicity via an intrinsic apoptotic pathway on human acute lymphoblastic leukemia cells.
Autorzy:
Swain RM; Department of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas, United States of America.; Department of Molecular and Translational Medicine, Center of Emphasis in Cancer, Paul Foster School of Medicine, Texas Tech University Health Science Center El Paso, El Paso, Texas, United States of America.
Sanchez A; Department of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas, United States of America.
Gutierrez DA; Department of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas, United States of America.
Varela-Ramirez A; Department of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas, United States of America.
Aguilera RJ; Department of Biological Sciences, The Border Biomedical Research Center, The University of Texas at El Paso, El Paso, Texas, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Dec 21; Vol. 18 (12), pp. e0295441. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Lymphoma*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Humans ; Cell Line, Tumor ; Thiophenes/pharmacology ; Cell Proliferation ; Apoptosis ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship ; Molecular Structure
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 3836

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