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You search for a phrase ""MONOAMINE oxidase inhibitors"" according to the criterion: Subject Terms


Title:
Molecular Investigation of the Antitumor Effects of Monoamine Oxidase Inhibitors in Breast Cancer Cells.
Authors:
Alkhawaldeh A; Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Queen Rania Street, Amman 11942, Jordan.
Bardaweel S; Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan, Queen Rania Street, Amman 11942, Jordan.
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Source:
BioMed research international [Biomed Res Int] 2023 Oct 05; Vol. 2023, pp. 2592691. Date of Electronic Publication: 2023 Oct 05 (Print Publication: 2023).
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase Inhibitors*/pharmacology
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Male ; Humans ; Monoamine Oxidase/genetics ; Monoamine Oxidase/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism
Academic Journal
Title:
Rethinking, reducing, and refining the classical oral tyramine challenge test of monoamine oxidase (MAO) inhibitors.
Authors:
van Hoogdalem EJ; Drug Development Solutions - Clinical Pharmacology, ICON, Groningen, The Netherlands.
Smith KL; Biostatistics Consulting, ICON, Reading, UK.
Hartstra J; Drug Development Solutions - Pharmacokinetics, ICON, Groningen, The Netherlands.
Constant J; Scientific Affairs, ICON, Victoria, British Columbia, Canada.
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Source:
Clinical and translational science [Clin Transl Sci] 2023 Oct; Vol. 16 (10), pp. 2058-2069. Date of Electronic Publication: 2023 Aug 21.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Monoamine Oxidase Inhibitors*/adverse effects
Tyramine*/pharmacology
Humans ; Monoamine Oxidase/pharmacology ; Blood Pressure
Academic Journal
Title:
Microbial Metabolites of 3- n -butylphthalide as Monoamine Oxidase A Inhibitors.
Authors:
Gach J; Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
Grzelczyk J; Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 2/22, 90-924 Łódź, Poland.
Strzała T; Department of Genetics, Wrocław University of Environmental and Life Sciences, Kożuchowska 7, 51-631 Wrocław, Poland.
Boratyński F; Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
Olejniczak T; Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 25; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 25.
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase Inhibitors*/pharmacology
Monoamine Oxidase Inhibitors*/chemistry
Monoamine Oxidase*/metabolism
Antidepressive Agents ; Lactones
Academic Journal
Title:
Structure-Based Design of Novel MAO-B Inhibitors: A Review.
Authors:
Mateev E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria.
Georgieva M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria.
Mateeva A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria.
Zlatkov A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria.
Ahmad S; Department of Computer Science, Jamia Millia Islamia, New Delhi 110025, India.
Raza K; Department of Computer Science, Jamia Millia Islamia, New Delhi 110025, India.
Azevedo V; Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Barh D; Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.; Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur 721172, India.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2023 Jun 16; Vol. 28 (12). Date of Electronic Publication: 2023 Jun 16.
Publication Type:
Journal Article; Review
MeSH Terms:
Monoamine Oxidase Inhibitors*/pharmacology
Monoamine Oxidase Inhibitors*/chemistry
Monoamine Oxidase*/metabolism
Humans ; Molecular Docking Simulation ; Drug Discovery ; Drug Design ; Structure-Activity Relationship
Academic Journal
Title:
New Insights on the Activity and Selectivity of MAO-B Inhibitors through In Silico Methods.
Authors:
Pacureanu L; 'Coriolan Dragulescu' Institute of Chemistry, 24 Mihai Viteazu Ave., 300223 Timisoara, Romania.
Bora A; 'Coriolan Dragulescu' Institute of Chemistry, 24 Mihai Viteazu Ave., 300223 Timisoara, Romania.
Crisan L; 'Coriolan Dragulescu' Institute of Chemistry, 24 Mihai Viteazu Ave., 300223 Timisoara, Romania.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 May 31; Vol. 24 (11). Date of Electronic Publication: 2023 May 31.
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase Inhibitors*/pharmacology
Monoamine Oxidase Inhibitors*/chemistry
Monoamine Oxidase*/metabolism
Molecular Docking Simulation ; Quantitative Structure-Activity Relationship ; Pharmacophore ; Structure-Activity Relationship
Academic Journal
Title:
Chemical and Biological Evaluation of Novel 1 H -Chromeno[3,2- c ]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity.
Authors:
Kulikova LN; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.
Purgatorio R; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Beloglazkin AA; A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 29 Leninskiy Prosp., 119991 Moscow, Russia.
Tafeenko VA; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, 119234 Moscow, Russia.
Reza RG; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.
Levickaya DD; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.
Sblano S; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Boccarelli A; Department of Precision and Regenerative Medicine and Ionian Area, School of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124 Bari, Italy.
de Candia M; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Catto M; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Voskressensky LG; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.
Altomare CD; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 23; Vol. 24 (9). Date of Electronic Publication: 2023 Apr 23.
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase Inhibitors*/chemistry
Monoamine Oxidase*/metabolism
Humans ; Structure-Activity Relationship ; Pyridines/pharmacology ; Cholinesterase Inhibitors/chemistry
Academic Journal
Title:
Effect of Hydroxytyrosol Derivatives of Donepezil on the Activity of Enzymes Involved in Neurodegenerative Diseases and Oxidative Damage.
Authors:
D'Errico A; Department of Medical, Movement and Well-Being Sciences, University of Naples 'Parthenope', Via Medina, 40, 80133 Napoli, Italy.
Nasso R; Department of Medical, Movement and Well-Being Sciences, University of Naples 'Parthenope', Via Medina, 40, 80133 Napoli, Italy.
Rullo R; Institute for the Animal Production Systems in the Mediterranean Environment, Consiglio Nazionale delle Ricerche Piazzale Enrico Fermi 1, 80055 Portici, Italy.
Maiuolo J; Department of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), University Magna Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Costanzo P; Department of Chemistry and Chemical Technologies, University of Calabria, Via P. Bucci, Cubo 12C, 87036 Rende, Italy.
Bonacci S; Department of Health Sciences, University Magna Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Oliverio M; Department of Health Sciences, University Magna Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
De Vendittis E; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Napoli, Italy.
Masullo M; Department of Medical, Movement and Well-Being Sciences, University of Naples 'Parthenope', Via Medina, 40, 80133 Napoli, Italy.
Arcone R; Department of Medical, Movement and Well-Being Sciences, University of Naples 'Parthenope', Via Medina, 40, 80133 Napoli, Italy.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2024 Jan 22; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 22.
Publication Type:
Journal Article
MeSH Terms:
Neurodegenerative Diseases*/drug therapy
Phenylethyl Alcohol/*analogs & derivatives
Humans ; Donepezil/pharmacology ; Donepezil/therapeutic use ; Xanthine Oxidase ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/therapeutic use ; Monoamine Oxidase/metabolism ; Oxidative Stress ; Structure-Activity Relationship
Academic Journal
Title:
Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect.
Authors:
Kumar S; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India.
Oh JM; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, 57922, Republic of Korea.
Prabhakaran P; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, 570015, India.
Awasti A; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, 570015, India.
Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, 57922, Republic of Korea. .
Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India. .
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Source:
Scientific reports [Sci Rep] 2024 Jan 13; Vol. 14 (1), pp. 1264. Date of Electronic Publication: 2024 Jan 13.
Publication Type:
Journal Article
MeSH Terms:
Isatin*/pharmacology
Neuroprotective Agents*/pharmacology
Neuroblastoma*
Humans ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/chemistry ; Molecular Docking Simulation ; Lipopolysaccharides ; Structure-Activity Relationship ; Monoamine Oxidase/metabolism ; Coloring Agents/pharmacology
Academic Journal
Title:
Machine learning driven web-based app platform for the discovery of monoamine oxidase B inhibitors.
Authors:
Kumar, Sunil (AUTHOR)
Bhowmik, Ratul (AUTHOR)
Oh, Jong Min (AUTHOR)
Abdelgawad, Mohamed A. (AUTHOR)
Ghoneim, Mohammed M. (AUTHOR)
Al‑Serwi, Rasha Hamed (AUTHOR)
Kim, Hoon (AUTHOR)
Mathew, Bijo (AUTHOR)
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Source:
Scientific Reports. 2/28/2024, Vol. 14 Issue 1, p1-20. 20p.
Academic Journal
Title:
Potential of Tryptamine Derivatives as Multi-Target Directed Ligands for Alzheimer's Disease: AChE, MAO-B, and COX-2 as Molecular Targets.
Authors:
Asghar S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi 74600, Pakistan.
Mushtaq N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan.
Ahmed A; Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi 75510, Pakistan.
Anwar L; Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Karachi 74600, Pakistan.
Munawar R; Department of Pharmaceutical Chemistry, Dow College of Pharmacy, Dow University of Health Sciences, Karachi 74200, Pakistan.
Akhtar S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, Karachi 74600, Pakistan.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2024 Jan 19; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 19.
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase*/metabolism
Alzheimer Disease*/metabolism
Humans ; Monoamine Oxidase Inhibitors/chemistry ; Cyclooxygenase 2/metabolism ; Molecular Docking Simulation ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Cholinesterase Inhibitors/chemistry ; Structure-Activity Relationship ; Tryptamines/pharmacology ; Acetylcholinesterase/metabolism ; Ligands
Academic Journal
Title:
Synthesis of Novel Benzo[ b ][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors.
Authors:
Kulikova LN; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya St. 6., 117198 Moscow, Russia.
Raesi GR; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya St. 6., 117198 Moscow, Russia.
Levickaya DD; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya St. 6., 117198 Moscow, Russia.
Purgatorio R; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Spada G; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Catto M; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Altomare CD; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.
Voskressensky LG; Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya St. 6., 117198 Moscow, Russia.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 09; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 09.
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase Inhibitors*/pharmacology
Pargyline*
Monoamine Oxidase/metabolism ; Naphthyridines ; Structure-Activity Relationship
Academic Journal
Title:
Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer's disease.
Authors:
Hafez DE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Dubiel M; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Duesseldorf, Germany.
La Spada G; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Bari, Italy.
Catto M; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Bari, Italy.
Reiner-Link D; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Duesseldorf, Germany.
Syu YT; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Research Center for Chinese Herbal Medicine, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan.
Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Duesseldorf, Germany.
Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
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Source:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2175821.
Publication Type:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Humans ; Structure-Activity Relationship ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Acetylcholinesterase/metabolism ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/chemistry ; Benzothiazoles/pharmacology ; Ligands
Academic Journal
Title:
Positional scanning of natural product hispidol's ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases.
Authors:
Hassan AHE; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.; Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
Kim HJ; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Gee MS; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Park JH; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Jeon HR; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Lee CJ; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Choi Y; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Moon S; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.
Lee D; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Lee JK; Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Park KD; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
Lee YS; Medicinal Chemistry Laboratory, Department of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.; Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
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Source:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 768-780.
Publication Type:
Journal Article
MeSH Terms:
Benzofurans/*pharmacology
Benzylidene Compounds/*pharmacology
Biological Products/*pharmacology
Inflammation/*drug therapy
Monoamine Oxidase/*metabolism
Monoamine Oxidase Inhibitors/*pharmacology
Neurodegenerative Diseases/*drug therapy
Benzofurans/chemical synthesis ; Benzofurans/chemistry ; Benzylidene Compounds/chemical synthesis ; Benzylidene Compounds/chemistry ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Drug Discovery ; Humans ; Inflammation/metabolism ; Molecular Structure ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Neurodegenerative Diseases/metabolism ; Structure-Activity Relationship
Academic Journal
Title:
Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease.
Authors:
Sang Z; College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, China.; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Song Q; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Cao Z; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Deng Y; Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Zhang L; Department of Elderly Digestive, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China.
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Source:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 69-85.
Publication Type:
Journal Article
MeSH Terms:
Drug Design*
Alzheimer Disease/*drug therapy
Antioxidants/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Monoamine Oxidase Inhibitors/*pharmacology
Neuroprotective Agents/*pharmacology
Acetylcholinesterase/metabolism ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Chalcone/chemistry ; Chalcone/pharmacology ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Electrophorus ; Humans ; Ligands ; Molecular Structure ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/chemistry ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; PC12 Cells ; Protein Aggregates/drug effects ; Rats ; Structure-Activity Relationship ; Vitamin E/chemistry ; Vitamin E/pharmacology
Academic Journal
Title:
Discovery of MAO-B Inhibitor with Machine Learning, Topomer CoMFA, Molecular Docking and Multi-Spectroscopy Approaches.
Authors:
Zheng L; School of Life Science, Shanghai University, Shanghai 200444, China.; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
Qin X; Department of Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 710032, China.
Wang J; School of Life Science, Shanghai University, Shanghai 200444, China.
Zhang M; School of Life Science, Shanghai University, Shanghai 200444, China.
An Q; Institute of Clinical Science, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200444, China.
Xu J; Institute of Clinical Science, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200444, China.
Qu X; National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Cao X; Institute of Clinical Science, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200444, China.
Niu B; School of Life Science, Shanghai University, Shanghai 200444, China.
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Source:
Biomolecules [Biomolecules] 2022 Oct 13; Vol. 12 (10). Date of Electronic Publication: 2022 Oct 13.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Monoamine Oxidase Inhibitors*/pharmacology
Monoamine Oxidase Inhibitors*/chemistry
Alzheimer Disease*/drug therapy
Humans ; Molecular Docking Simulation ; Monoamine Oxidase/chemistry ; Spectrum Analysis ; Machine Learning
Academic Journal
Title:
Computational Insights into β-Carboline Inhibition of Monoamine Oxidase A.
Authors:
Prah A; National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.; Jožef Stefan Institute, SI-1000 Ljubljana, Slovenia.
Gavranić T; National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.; Faculty of Pharmacy, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Perdih A; National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.; Faculty of Pharmacy, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Sollner Dolenc M; Faculty of Pharmacy, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Mavri J; National Institute of Chemistry, SI-1000 Ljubljana, Slovenia.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2022 Oct 09; Vol. 27 (19). Date of Electronic Publication: 2022 Oct 09.
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase Inhibitors*/chemistry
Monoamine Oxidase Inhibitors*/pharmacology
Tobacco Smoke Pollution*
Carbolines/pharmacology ; Coffee ; Humans ; Molecular Docking Simulation ; Monoamine Oxidase/metabolism ; Structure-Activity Relationship
Academic Journal
Title:
Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer's disease.
Authors:
Zhang C; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.
Zhang Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.
Lv Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.
Guo J; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.
Gao B; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.
Lu Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.
Zang A; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.
Zhu X; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.
Zhou T; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, P. R. China.
Xie Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, P. R. China.; Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, P. R. China.
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Source:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 100-117.
Publication Type:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Animals ; Mice ; Chromones/pharmacology ; Prospective Studies ; Drug Design ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/chemistry ; Monoamine Oxidase/metabolism ; Iron Chelating Agents/pharmacology ; Cholinesterase Inhibitors/pharmacology ; Structure-Activity Relationship ; Molecular Docking Simulation
Academic Journal
Title:
Latest advances in dual inhibitors of acetylcholinesterase and monoamine oxidase B against Alzheimer's disease.
Authors:
Zou D; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Liu R; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Lv Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Guo J; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Zhang C; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Xie Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.; Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceutical, Zhejiang University of Technology, Hangzhou, China.; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Hangzhou, China.
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Source:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2270781. Date of Electronic Publication: 2023 Nov 13.
Publication Type:
Journal Article; Review
MeSH Terms:
Monoamine Oxidase*/metabolism
Alzheimer Disease*/drug therapy
Humans ; Acetylcholinesterase/metabolism ; Monoamine Oxidase Inhibitors/pharmacology ; Monoamine Oxidase Inhibitors/chemistry ; Molecular Docking Simulation ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Structure-Activity Relationship
Academic Journal
Title:
Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B.
Authors:
Oh JM; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
Jang HJ; Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea.
Kang MG; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Mun SK; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
Park D; Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Hong SJ; Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea.
Kim MH; National Institute of Biological Resources, Environmental Research Complex, Incheon 22689, Republic of Korea.
Kim SY; National Institute of Biological Resources, Environmental Research Complex, Incheon 22689, Republic of Korea.
Yee ST; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
Kim H; Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 28; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 28.
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase Inhibitors*/chemistry
Neuroblastoma*
Humans ; Canavalia ; Molecular Docking Simulation ; Monoamine Oxidase/metabolism ; Structure-Activity Relationship
Academic Journal
Title:
Synthesis, Characterization and Biological Evaluation of Benzothiazole-Isoquinoline Derivative.
Authors:
Liu W; Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China.
Zhao D; Pharmacy College, Jilin Medical University, Jilin 132013, China.
He Z; Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China.
Hu Y; Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China.
Zhu Y; Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China.
Zhang L; Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China.
Jin L; Pharmacy College, Jilin Medical University, Jilin 132013, China.
Guan L; Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China.
Wang S; Key Laboratory of Natural Resource of the Changbai Mountain and Functiaonal Molecules, Ministry of Education, Yanbian University, Yanji 133000, China.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 19; Vol. 27 (24). Date of Electronic Publication: 2022 Dec 19.
Publication Type:
Journal Article
MeSH Terms:
Monoamine Oxidase Inhibitors*/pharmacology
Butyrylcholinesterase*/metabolism
Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Monoamine Oxidase/metabolism ; Benzothiazoles/pharmacology ; Isoquinolines ; Cholinesterase Inhibitors/pharmacology ; Molecular Structure
Academic Journal

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