Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""MULTIDRUG resistance"" wg kryterium: Temat


Tytuł :
Polysaccharides of vinegar-baked radix bupleuri promote the hepatic targeting effect of oxymatrine by regulating the protein expression of HNF4α, Mrp2, and OCT1.
Autorzy :
Wu Y; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Liu L; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Zhao Y; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Zhao R; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113471. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cooking*
ATP-Binding Cassette Transporters/*metabolism
Acetic Acid/*chemistry
Alkaloids/*pharmacokinetics
Alkaloids/*pharmacology
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Hepatocyte Nuclear Factor 4/*metabolism
Liver/*drug effects
Multidrug Resistance-Associated Proteins/*metabolism
Plant Extracts/*pharmacology
Polysaccharides/*pharmacology
Quinolizines/*pharmacokinetics
Quinolizines/*pharmacology
ATP-Binding Cassette Transporters/genetics ; Animals ; Bupleurum/chemistry ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Gene Expression Regulation ; Hep G2 Cells ; Hepatocyte Nuclear Factor 4/genetics ; Hot Temperature ; Humans ; Liver/metabolism ; Male ; Multidrug Resistance-Associated Proteins/genetics ; Plant Extracts/chemistry ; Polysaccharides/chemistry ; Rats, Sprague-Dawley ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead.
Autorzy :
Lu X; Key Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.; Department of Genetics, Wuhan University, Wuhan 430071, China.
Long Y; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Li X; Department of Genetics, Wuhan University, Wuhan 430071, China.; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Zhang L; Department of Genetics, Wuhan University, Wuhan 430071, China.
Li Q; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Wen H; Key Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Zhong S; Department of Genetics, Wuhan University, Wuhan 430071, China.; Hubei Provincial Key Laboratory of Allergy and Immunology, Wuhan 430071, China.
Cui Z; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 19; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Knockout Techniques*
Lead/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Zebrafish/*genetics
Zebrafish Proteins/*metabolism
Animals ; Animals, Genetically Modified ; Base Sequence ; Biological Transport ; Gene Expression Regulation, Developmental ; Inactivation, Metabolic ; LLC-PK1 Cells ; Multidrug Resistance-Associated Proteins/genetics ; Mutation/genetics ; Swine ; Zebrafish/embryology ; Zebrafish Proteins/genetics
Czasopismo naukowe
Tytuł :
In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus.
Autorzy :
Muniz DF; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Dos Santos Barbosa CR; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
de Menezes IRA; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry/CCBS/URCA, Brazil.
de Sousa EO; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Pereira RLS; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Júnior JTC; Laboratory of Studies of the Regional Flora of the Cariri (LEFLORE), Regional University of Cariri, Brazil.
Pereira PS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry/CCBS/URCA, Brazil.
de Matos YMLS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry/CCBS/URCA, Brazil.
da Costa RHS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry/CCBS/URCA, Brazil.
de Morais Oliveira-Tintino CD; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Coutinho HDM; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: .
Filho JMB; Laboratory of Phamaceutical Tecnology Federal, University of João Pessoa (UFPB), CCBS/URCA, Brazil.
Ribeiro de Sousa G; Laboratory of Phamaceutical Tecnology Federal, University of João Pessoa (UFPB), CCBS/URCA, Brazil.
Filho JR; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Brazil.
Siqueira-Junior JP; Laboratory of Phamaceutical Tecnology Federal, University of João Pessoa (UFPB), CCBS/URCA, Brazil.
Tintino SR; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Pokaż więcej
Źródło :
Food chemistry [Food Chem] 2021 Feb 01; Vol. 337, pp. 127776. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins/*metabolism
Eugenol/*analogs & derivatives
Multidrug Resistance-Associated Proteins/*metabolism
Staphylococcus aureus/*metabolism
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/antagonists & inhibitors ; Binding Sites ; Ethidium/pharmacology ; Eugenol/metabolism ; Eugenol/pharmacology ; Hydrogen Bonding ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Multidrug Resistance-Associated Proteins/antagonists & inhibitors ; Norfloxacin/pharmacology ; Staphylococcus aureus/drug effects
Czasopismo naukowe
Tytuł :
Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.
Autorzy :
Reading E; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK. .
Ahdash Z; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Fais C; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy.
Ricci V; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Wang-Kan X; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Grimsey E; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Stone J; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Malloci G; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy.
Lau AM; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Findlay H; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Konijnenberg A; Thermo Fisher Scientific, Zwaanstraat 31G/H, 5651 CA, Eindhoven, The Netherlands.
Booth PJ; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Ruggerone P; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy.
Vargiu AV; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy.
Piddock LJV; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Politis A; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Nov 04; Vol. 11 (1), pp. 5565. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Ciprofloxacin/*pharmacology
Dipeptides/*pharmacology
Drug Resistance, Multiple, Bacterial/*genetics
Escherichia coli/*metabolism
Escherichia coli Proteins/*chemistry
Membrane Proteins/*chemistry
Multidrug Resistance-Associated Proteins/*chemistry
Protein Kinases/*chemistry
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Binding Sites/genetics ; Biological Transport, Active/drug effects ; Biological Transport, Active/genetics ; Ciprofloxacin/chemistry ; Circular Dichroism ; Deuterium/chemistry ; Dipeptides/chemistry ; Drug Resistance, Multiple, Bacterial/drug effects ; Escherichia coli/genetics ; Escherichia coli Proteins/antagonists & inhibitors ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Ligands ; Mass Spectrometry/methods ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Microbial Sensitivity Tests ; Molecular Dynamics Simulation ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Mutation ; Protein Kinases/genetics ; Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Mesothelioma Biomarkers: Discovery in Search of Validation.
Autorzy :
Pass HI; Research, Department of Cardiothoracic Surgery, General Thoracic Surgery, NYU Langone Medical Center, 530 First Avenue, 9V, New York, NY 10016, USA. Electronic address: .
Alimi M; Department of Cardiothoracic Surgery, NYU Langone Medical Center, 530 First Avenue, 9V, New York, NY 10016, USA.
Carbone M; Department of Thoracic Oncology, John A. Burns School of Medicine, University of Hawaii Cancer Center, 701 Ilalo Street, Room 437, Honolulu, HI 96813, USA.
Yang H; Department of Thoracic Oncology, John A. Burns School of Medicine, University of Hawaii Cancer Center, 701 Ilalo Street, Room 437, Honolulu, HI 96813, USA.
Goparaju CM; Department of Cardiothoracic Surgery, NYU Langone Medical Center, 530 First Avenue, 9V, New York, NY 10016, USA.
Pokaż więcej
Źródło :
Thoracic surgery clinics [Thorac Surg Clin] 2020 Nov; Vol. 30 (4), pp. 395-423. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biomarkers, Tumor*/analysis
Biomarkers, Tumor*/blood
Biomarkers, Tumor*/genetics
Biomarkers, Tumor*/metabolism
Mesothelioma, Malignant/*blood
Multidrug Resistance-Associated Proteins/*blood
Asbestos/adverse effects ; Calbindin 2/analysis ; Calbindin 2/blood ; Calbindin 2/genetics ; Calbindin 2/metabolism ; Extracellular Matrix Proteins/analysis ; Extracellular Matrix Proteins/blood ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; HMGB1 Protein/analysis ; HMGB1 Protein/blood ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; Humans ; Mesothelioma, Malignant/chemistry ; Mesothelioma, Malignant/genetics ; Mesothelioma, Malignant/metabolism ; Multidrug Resistance-Associated Proteins/analysis ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Pleural Neoplasms/blood ; Pleural Neoplasms/chemistry ; Pleural Neoplasms/genetics ; Pleural Neoplasms/metabolism ; Prognosis ; Proteomics
Czasopismo naukowe
Tytuł :
Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
Autorzy :
Chatterjee S; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.) .
Mukherjee S; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Sankara Sivaprasad LVJ; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Naik T; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Gautam SS; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Murali BV; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Hadambar AA; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Gunti GR; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Kuchibhotla V; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Deyati A; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Basavanthappa S; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Ramarao M; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Mariappan TT; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Zinker BA; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Zhang Y; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Sinz M; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Shen H; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Pokaż więcej
Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Jan; Vol. 376 (1), pp. 29-39. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coproporphyrins/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Non-alcoholic Fatty Liver Disease/*metabolism
Angiogenic Proteins/genetics ; Angiogenic Proteins/metabolism ; Animals ; Coproporphyrins/blood ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Multidrug Resistance-Associated Proteins/genetics ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; Sf9 Cells ; Spodoptera
Czasopismo naukowe
Tytuł :
C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors.
Autorzy :
Felicetti T; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Mangiaterra G; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.
Cannalire R; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Cedraro N; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.
Pietrella D; Department of Pharmaceutical Sciences, Biochemical Sciences and Health Section, Università degli Studi di Perugia, Perugia, Italy.
Astolfi A; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Massari S; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Tabarrini O; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Manfroni G; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Barreca ML; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Cecchetti V; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Biavasco F; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.
Sabatini S; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Pokaż więcej
Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 584-597.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Multidrug Resistance-Associated Proteins/*antagonists & inhibitors
Quinolines/*pharmacology
Staphylococcus aureus/*drug effects
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Bacterial Proteins/metabolism ; Microbial Sensitivity Tests ; Molecular Structure ; Multidrug Resistance-Associated Proteins/metabolism ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Staphylococcus aureus/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters.
Autorzy :
Sudhakaran M; Physiology Graduate Program, Michigan State University, East Lansing, MI 48824, United States.
Parra MR; Department of Physiology, Michigan State University, East Lansing, MI 48824, United States.
Stoub H; Physiology Graduate Program, Michigan State University, East Lansing, MI 48824, United States.
Gallo KA; Department of Physiology, Michigan State University, East Lansing, MI 48824, United States. Electronic address: .
Doseff AI; Department of Physiology, Michigan State University, East Lansing, MI 48824, United States; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, United States. Electronic address: .
Pokaż więcej
Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114259. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily G, Member 2/*biosynthesis
Apigenin/*metabolism
Doxorubicin/*metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group A-B/*deficiency
Multidrug Resistance-Associated Proteins/*biosynthesis
Neoplasm Proteins/*biosynthesis
Triple Negative Breast Neoplasms/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/metabolism ; Apigenin/administration & dosage ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Doxorubicin/administration & dosage ; Drug Delivery Systems/methods ; Female ; Gene Expression Regulation, Neoplastic ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Humans ; Mice ; Multidrug Resistance-Associated Proteins/genetics ; Neoplasm Proteins/genetics ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/metabolism ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Synthesis, biological evaluation and computational studies of acrylohydrazide derivatives as potential Staphylococcus aureus NorA efflux pump inhibitors.
Autorzy :
Kumar G; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India.
Goutami Godavari A; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India.
Tambat R; CSIR-Institute of Microbial Technology, Sector-39A, Chandigarh 160036, India.
Kumar S; Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India.
Nandanwar H; CSIR-Institute of Microbial Technology, Sector-39A, Chandigarh 160036, India.
Elizabeth Sobhia M; Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India.
Jachak SM; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104225. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Density Functional Theory*
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Hydrazines/*pharmacology
Multidrug Resistance-Associated Proteins/*antagonists & inhibitors
Staphylococcus aureus/*drug effects
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Bacterial Proteins/metabolism ; Dose-Response Relationship, Drug ; Hydrazines/chemical synthesis ; Hydrazines/chemistry ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Multidrug Resistance-Associated Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
P-glycoprotein and multidrug resistance-associated protein-1 expression in acute myeloid leukemia: Biological and prognosis implications.
Autorzy :
da Silveira Júnior LS; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Soares VL; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Jardim da Silva AS; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.; Faculdade de Ciências da Saúde do Trairi/UFRN, Santa Cruz, Brazil.
Gil EA; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Pereira de Araújo MDG; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.; Laboratório de Citometria de Fluxo, Hemocentro Dalton Cunha, Natal, Brazil.
Merces Gonçalves CA; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.; Laboratório de Citometria de Fluxo, Hemocentro Dalton Cunha, Natal, Brazil.
Paiva AS; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Moura de Oliveira TM; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Oliveira GHM; Laboratório de Citometria de Fluxo, Hemocentro Dalton Cunha, Natal, Brazil.
Kramer Cavacanti E Silva DG; Faculdade de Ciências da Saúde do Trairi/UFRN, Santa Cruz, Brazil.
de Araújo Moura Lemos TM; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Moretti Rebecchi IM; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
de Farias Sales VS; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Luchessi AD; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Cavalcanti Júnior GB; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.; Laboratório de Citometria de Fluxo, Hemocentro Dalton Cunha, Natal, Brazil.
Pokaż więcej
Źródło :
International journal of laboratory hematology [Int J Lab Hematol] 2020 Oct; Vol. 42 (5), pp. 594-603. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics
Leukemia, Myeloid, Acute/*diagnosis
Leukemia, Myeloid, Acute/*genetics
Multidrug Resistance-Associated Proteins/*genetics
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Biomarkers, Tumor ; Child ; Child, Preschool ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Infant ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/mortality ; Male ; Middle Aged ; Multidrug Resistance-Associated Proteins/metabolism ; Phenotype ; Prognosis ; Symptom Assessment ; Young Adult
Czasopismo naukowe
Tytuł :
Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines.
Autorzy :
Low FG; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Shabir K; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Brown JE; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Bill RM; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Rothnie AJ; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 16; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :
Journal Article
MeSH Terms :
Multidrug Resistance-Associated Proteins/*metabolism
Triple Negative Breast Neoplasms/*metabolism
Cell Movement ; Cell Proliferation ; Cyclic AMP/metabolism ; Humans ; Lysophospholipids/metabolism ; MCF-7 Cells ; Multidrug Resistance-Associated Proteins/antagonists & inhibitors ; Multidrug Resistance-Associated Proteins/genetics ; Receptor, ErbB-2/genetics ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Triple Negative Breast Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Genetic analysis of the orthologous crt and mdr1 genes in Plasmodium malariae from Thailand and Myanmar.
Autorzy :
Pimpat Y; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Saralamba N; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. .; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. .
Boonyuen U; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pukrittayakamee S; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Nosten F; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Smithuis F; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Medical Action Myanmar, Yangon, Myanmar.
Day NPJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Churchill Hospital, University of Oxford, Oxford, UK.
Dondorp AM; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Churchill Hospital, University of Oxford, Oxford, UK.
Imwong M; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pokaż więcej
Źródło :
Malaria journal [Malar J] 2020 Aug 31; Vol. 19 (1), pp. 315. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Genetic*
Drug Resistance/*genetics
Insecticides/*pharmacology
Membrane Transport Proteins/*genetics
Multidrug Resistance-Associated Proteins/*genetics
Plasmodium malariae/*genetics
Protozoan Proteins/*genetics
Chloroquine/pharmacology ; Mefloquine/pharmacology ; Membrane Transport Proteins/metabolism ; Multidrug Resistance-Associated Proteins/metabolism ; Myanmar ; Plasmodium malariae/drug effects ; Protozoan Proteins/metabolism ; Thailand
Czasopismo naukowe
Tytuł :
Peptide-Based Approach to Inhibition of the Multidrug Resistance Efflux Pump AcrB.
Autorzy :
Jesin JA; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
Stone TA; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
Mitchell CJ; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
Reading E; Department of Chemistry, Britannia House, King's College London, 7 Trinity Street, London SE1 1DB, United Kingdom.
Deber CM; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
Pokaż więcej
Źródło :
Biochemistry [Biochemistry] 2020 Oct 20; Vol. 59 (41), pp. 3973-3981. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Escherichia coli/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Binding Sites ; Drug Resistance, Multiple, Bacterial/genetics ; Drug Resistance, Multiple, Bacterial/physiology ; Escherichia coli/chemistry ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Fluorescence Resonance Energy Transfer ; Membrane Transport Proteins/chemistry ; Membrane Transport Proteins/metabolism ; Multidrug Resistance-Associated Proteins/chemistry ; Peptides/chemistry ; Peptides/metabolism ; Protein Conformation
Czasopismo naukowe
Tytuł :
Interplay of drug transporters P-glycoprotein (MDR1), MRP1, OATP1A2 and OATP1B3 in passage of maraviroc across human placenta.
Autorzy :
Tupova L; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic.
Hirschmugl B; Medical University of Graz, Department of Obstetrics and Gynecology, 8036, Graz, Austria.
Sucha S; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic.
Pilarova V; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Analytical Chemistry, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic.
Székely V; Membrane Protein Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Magyar tudósok krt. 2., H-1117, Budapest, Hungary.
Bakos É; Membrane Protein Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Magyar tudósok krt. 2., H-1117, Budapest, Hungary.
Novakova L; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Analytical Chemistry, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic.
Özvegy-Laczka C; Membrane Protein Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Magyar tudósok krt. 2., H-1117, Budapest, Hungary.
Wadsack C; Medical University of Graz, Department of Obstetrics and Gynecology, 8036, Graz, Austria.
Ceckova M; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic. Electronic address: .
Pokaż więcej
Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Sep; Vol. 129, pp. 110506. Date of Electronic Publication: 2020 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-HIV Agents/*metabolism
Maraviroc/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Organic Anion Transporters/*metabolism
Placenta/*metabolism
Solute Carrier Organic Anion Transporter Family Member 1B3/*metabolism
ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Acridines/pharmacology ; Animals ; Anti-HIV Agents/blood ; Anti-HIV Agents/pharmacology ; Cell Line, Tumor ; Dogs ; Drug Interactions ; Female ; Gene Expression Regulation ; Humans ; Madin Darby Canine Kidney Cells ; Maraviroc/blood ; Multidrug Resistance-Associated Proteins/genetics ; Organic Anion Transporters/antagonists & inhibitors ; Organic Anion Transporters/genetics ; Perfusion ; Placenta/drug effects ; Placental Circulation ; Pregnancy ; Ritonavir/pharmacology ; Solute Carrier Organic Anion Transporter Family Member 1B3/antagonists & inhibitors ; Solute Carrier Organic Anion Transporter Family Member 1B3/genetics ; Tetrahydroisoquinolines/pharmacology
Czasopismo naukowe
Tytuł :
Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity.
Autorzy :
Kato M; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Tsurudome Y; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Kanemitsu T; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Yasukochi S; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Kanado Y; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Ogino T; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Matsunaga N; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.; Department of Glocal Healthcare Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Koyanagi S; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.; Department of Glocal Healthcare Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Ohdo S; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Aug 10; Vol. 10 (1), pp. 13484. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Circadian Rhythm/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Multidrug Resistance-Associated Proteins/*metabolism
ATP-Binding Cassette Transporters/genetics ; Animals ; Antineoplastic Agents/pharmacology ; Bone Marrow Cells/metabolism ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Gene Expression/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Male ; Mice ; Mice, Inbred ICR ; Multidrug Resistance-Associated Proteins/genetics ; Organoplatinum Compounds/pharmacology ; Oxaliplatin/pharmacology
Czasopismo naukowe
Tytuł :
Cryo-EM analysis of a membrane protein embedded in the liposome.
Autorzy :
Yao X; Department of Molecular Biology, Princeton University, Princeton, NJ 08544.
Fan X; Department of Molecular Biology, Princeton University, Princeton, NJ 08544 .
Yan N; Department of Molecular Biology, Princeton University, Princeton, NJ 08544 .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18497-18503. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Escherichia coli/*metabolism
Escherichia coli Proteins/*metabolism
Liposomes/*ultrastructure
Membrane Proteins/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Cryoelectron Microscopy ; Escherichia coli/ultrastructure ; Escherichia coli Proteins/ultrastructure ; Liposomes/metabolism ; Membrane Proteins/ultrastructure ; Models, Molecular ; Multidrug Resistance-Associated Proteins/ultrastructure ; Protein Conformation
Czasopismo naukowe
Tytuł :
Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses.
Autorzy :
Wang L; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, United States.
Johnson ZL; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, United States.
Wasserman MR; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, United States.
Levring J; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, United States.
Chen J; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, United States.; Howard Hughes Medical Institute, The Rockefeller University, New York, United States.
Liu S; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, United States.
Pokaż więcej
Źródło :
ELife [Elife] 2020 May 27; Vol. 9. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Multidrug Resistance-Associated Proteins/*chemistry
Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Animals ; Binding Sites ; Cattle ; Cryoelectron Microscopy ; Kinetics ; Models, Molecular ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Protein Conformation ; Spectrometry, Fluorescence
Czasopismo naukowe
Tytuł :
Substrate-dependent transport mechanism in AcrB of multidrug resistant bacteria.
Autorzy :
Jewel Y; School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington.
Van Dinh Q; School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington.
Liu J; School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington.
Dutta P; School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington.
Pokaż więcej
Źródło :
Proteins [Proteins] 2020 Jul; Vol. 88 (7), pp. 853-864. Date of Electronic Publication: 2020 Feb 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Protons*
Aspartic Acid/*chemistry
Drug Resistance, Multiple, Bacterial/*genetics
Escherichia coli/*genetics
Escherichia coli Proteins/*chemistry
Indoles/*chemistry
Multidrug Resistance-Associated Proteins/*chemistry
Anti-Bacterial Agents/pharmacology ; Aspartic Acid/metabolism ; Binding Sites ; Biological Transport ; Crystallography, X-Ray ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Indoles/metabolism ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Substrate Specificity ; Thermodynamics
Czasopismo naukowe
Tytuł :
Antibacterial Activities and Phytochemical Screening of Crude Extracts from Kenyan Macaranga Species Towards MDR Phenotypes Expressing Efflux Pumps.
Autorzy :
Hashim, Ibrahim
Omosa, Leonidah Kerubo
Nchiozem-Ngnitedem, Vaderament-Alexe
Onyari, John Mmari
Maru, Shital Mahindra
Guefack, Michel-Gael Fofack
Mbaveng, Armelle Tsafack
Kuete, Victor
Pokaż więcej
Źródło :
Pharmacognosy Communications. Apr-Jun2021, Vol. 11 Issue 2, p119-126. 8p.
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies