Temat: "MULTIDRUG resistance" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Polysaccharides of vinegar-baked radix bupleuri promote the hepatic targeting effect of oxymatrine by regulating the protein expression of HNF4α, Mrp2, and OCT1.
Autorzy :: Wu Y; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Liu L; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Zhao Y; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Zhao R; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, China. Electronic address: .; Pokaż więcej
Źródło :: Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113471. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :: Journal Article
MeSH Terms :: Cooking*
ATP-Binding Cassette Transporters/*metabolism
Acetic Acid/*chemistry
Alkaloids/*pharmacokinetics
Alkaloids/*pharmacology
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Hepatocyte Nuclear Factor 4/*metabolism
Liver/*drug effects
Multidrug Resistance-Associated Proteins/*metabolism
Plant Extracts/*pharmacology
Polysaccharides/*pharmacology
Quinolizines/*pharmacokinetics
Quinolizines/*pharmacology
ATP-Binding Cassette Transporters/genetics ; Animals ; Bupleurum/chemistry ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Gene Expression Regulation ; Hep G2 Cells ; Hepatocyte Nuclear Factor 4/genetics ; Hot Temperature ; Humans ; Liver/metabolism ; Male ; Multidrug Resistance-Associated Proteins/genetics ; Plant Extracts/chemistry ; Polysaccharides/chemistry ; Rats, Sprague-Dawley ; Tissue Distribution
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Generation of Knockout and Transgenic Zebrafish to Characterize Abcc4 Functions in Detoxification and Efflux of Lead.
Autorzy :: Lu X; Key Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.; Department of Genetics, Wuhan University, Wuhan 430071, China.
Long Y; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Li X; Department of Genetics, Wuhan University, Wuhan 430071, China.; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.
Zhang L; Department of Genetics, Wuhan University, Wuhan 430071, China.
Li Q; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.
Wen H; Key Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture and Rural Affairs, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Zhong S; Department of Genetics, Wuhan University, Wuhan 430071, China.; Hubei Provincial Key Laboratory of Allergy and Immunology, Wuhan 430071, China.
Cui Z; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 19; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :: Journal Article
MeSH Terms :: Gene Knockout Techniques*
Lead/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Zebrafish/*genetics
Zebrafish Proteins/*metabolism
Animals ; Animals, Genetically Modified ; Base Sequence ; Biological Transport ; Gene Expression Regulation, Developmental ; Inactivation, Metabolic ; LLC-PK1 Cells ; Multidrug Resistance-Associated Proteins/genetics ; Mutation/genetics ; Swine ; Zebrafish/embryology ; Zebrafish Proteins/genetics
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 3 3.

Tytuł :: In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus.
Autorzy :: Muniz DF; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Dos Santos Barbosa CR; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
de Menezes IRA; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry/CCBS/URCA, Brazil.
de Sousa EO; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Pereira RLS; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Júnior JTC; Laboratory of Studies of the Regional Flora of the Cariri (LEFLORE), Regional University of Cariri, Brazil.
Pereira PS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry/CCBS/URCA, Brazil.
de Matos YMLS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry/CCBS/URCA, Brazil.
da Costa RHS; Laboratory of Pharmacology and Molecular Chemistry (LFQM), Department of Biological Chemistry/CCBS/URCA, Brazil.
de Morais Oliveira-Tintino CD; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
Coutinho HDM; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil. Electronic address: .
Filho JMB; Laboratory of Phamaceutical Tecnology Federal, University of João Pessoa (UFPB), CCBS/URCA, Brazil.
Ribeiro de Sousa G; Laboratory of Phamaceutical Tecnology Federal, University of João Pessoa (UFPB), CCBS/URCA, Brazil.
Filho JR; Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, Brazil.
Siqueira-Junior JP; Laboratory of Phamaceutical Tecnology Federal, University of João Pessoa (UFPB), CCBS/URCA, Brazil.
Tintino SR; Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.; Pokaż więcej
Źródło :: Food chemistry [Food Chem] 2021 Feb 01; Vol. 337, pp. 127776. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :: Journal Article
MeSH Terms :: Bacterial Proteins/*metabolism
Eugenol/*analogs & derivatives
Multidrug Resistance-Associated Proteins/*metabolism
Staphylococcus aureus/*metabolism
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/antagonists & inhibitors ; Binding Sites ; Ethidium/pharmacology ; Eugenol/metabolism ; Eugenol/pharmacology ; Hydrogen Bonding ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Multidrug Resistance-Associated Proteins/antagonists & inhibitors ; Norfloxacin/pharmacology ; Staphylococcus aureus/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB.
Autorzy :: Reading E; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK. .
Ahdash Z; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Fais C; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy.
Ricci V; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Wang-Kan X; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Grimsey E; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Stone J; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Malloci G; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy.
Lau AM; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Findlay H; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Konijnenberg A; Thermo Fisher Scientific, Zwaanstraat 31G/H, 5651 CA, Eindhoven, The Netherlands.
Booth PJ; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.
Ruggerone P; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy.
Vargiu AV; Department of Physics, University of Cagliari, Cittadella Universitaria, S.P. Monserrato-Sestu, 09042, Monserrato, (CA), Italy.
Piddock LJV; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, B15 2TT, UK.
Politis A; Department of Chemistry, King's College London, Britannia House, 7 Trinity Street, London, SE1 1DB, UK. .; Pokaż więcej
Źródło :: Nature communications [Nat Commun] 2020 Nov 04; Vol. 11 (1), pp. 5565. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Ciprofloxacin/*pharmacology
Dipeptides/*pharmacology
Drug Resistance, Multiple, Bacterial/*genetics
Escherichia coli/*metabolism
Escherichia coli Proteins/*chemistry
Membrane Proteins/*chemistry
Multidrug Resistance-Associated Proteins/*chemistry
Protein Kinases/*chemistry
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Binding Sites/genetics ; Biological Transport, Active/drug effects ; Biological Transport, Active/genetics ; Ciprofloxacin/chemistry ; Circular Dichroism ; Deuterium/chemistry ; Dipeptides/chemistry ; Drug Resistance, Multiple, Bacterial/drug effects ; Escherichia coli/genetics ; Escherichia coli Proteins/antagonists & inhibitors ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Ligands ; Mass Spectrometry/methods ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Microbial Sensitivity Tests ; Molecular Dynamics Simulation ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Mutation ; Protein Kinases/genetics ; Protein Kinases/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Mesothelioma Biomarkers: Discovery in Search of Validation.
Autorzy :: Pass HI; Research, Department of Cardiothoracic Surgery, General Thoracic Surgery, NYU Langone Medical Center, 530 First Avenue, 9V, New York, NY 10016, USA. Electronic address: .
Alimi M; Department of Cardiothoracic Surgery, NYU Langone Medical Center, 530 First Avenue, 9V, New York, NY 10016, USA.
Carbone M; Department of Thoracic Oncology, John A. Burns School of Medicine, University of Hawaii Cancer Center, 701 Ilalo Street, Room 437, Honolulu, HI 96813, USA.
Yang H; Department of Thoracic Oncology, John A. Burns School of Medicine, University of Hawaii Cancer Center, 701 Ilalo Street, Room 437, Honolulu, HI 96813, USA.
Goparaju CM; Department of Cardiothoracic Surgery, NYU Langone Medical Center, 530 First Avenue, 9V, New York, NY 10016, USA.; Pokaż więcej
Źródło :: Thoracic surgery clinics [Thorac Surg Clin] 2020 Nov; Vol. 30 (4), pp. 395-423. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Biomarkers, Tumor*/analysis
Biomarkers, Tumor*/blood
Biomarkers, Tumor*/genetics
Biomarkers, Tumor*/metabolism
Mesothelioma, Malignant/*blood
Multidrug Resistance-Associated Proteins/*blood
Asbestos/adverse effects ; Calbindin 2/analysis ; Calbindin 2/blood ; Calbindin 2/genetics ; Calbindin 2/metabolism ; Extracellular Matrix Proteins/analysis ; Extracellular Matrix Proteins/blood ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; HMGB1 Protein/analysis ; HMGB1 Protein/blood ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; Humans ; Mesothelioma, Malignant/chemistry ; Mesothelioma, Malignant/genetics ; Mesothelioma, Malignant/metabolism ; Multidrug Resistance-Associated Proteins/analysis ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Pleural Neoplasms/blood ; Pleural Neoplasms/chemistry ; Pleural Neoplasms/genetics ; Pleural Neoplasms/metabolism ; Prognosis ; Proteomics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 6 6.

Tytuł :: Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
Autorzy :: Chatterjee S; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.) .
Mukherjee S; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Sankara Sivaprasad LVJ; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Naik T; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Gautam SS; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Murali BV; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Hadambar AA; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Gunti GR; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Kuchibhotla V; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Deyati A; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Basavanthappa S; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Ramarao M; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Mariappan TT; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Zinker BA; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Zhang Y; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Sinz M; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).
Shen H; Pharmaceutical Candidate Optimization (S.C., S.S.L.V.J., T.N., S.S.G., B.V.M.) and Discovery and Translational Medicine (S.M., A.A.H., G.R.G., V.K., A.D., S.B.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Syngene International Ltd., Bangalore, India; Pharmaceutical Candidate Optimization (T.T.M.) and Discovery and Translational Medicine, Bristol-Myers Squibb India Pvt. Ltd. (M.R.), Biocon Bristol-Myers Squibb R&D Center (BBRC), Bangalore, India; BMS Fibrosis Drug Discovery, Research and Early Development, Princeton, New Jersey (B.A.Z.); and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey (Y.Z., M.S., H.S.).; Pokaż więcej
Źródło :: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Jan; Vol. 376 (1), pp. 29-39. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Coproporphyrins/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Non-alcoholic Fatty Liver Disease/*metabolism
Angiogenic Proteins/genetics ; Angiogenic Proteins/metabolism ; Animals ; Coproporphyrins/blood ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Multidrug Resistance-Associated Proteins/genetics ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; Sf9 Cells ; Spodoptera
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors.
Autorzy :: Felicetti T; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Mangiaterra G; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.
Cannalire R; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Cedraro N; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.
Pietrella D; Department of Pharmaceutical Sciences, Biochemical Sciences and Health Section, Università degli Studi di Perugia, Perugia, Italy.
Astolfi A; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Massari S; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Tabarrini O; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Manfroni G; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Barreca ML; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Cecchetti V; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.
Biavasco F; Department of Life and Environmental Sciences, Università Politecnica delle Marche, Ancona, Italy.
Sabatini S; Department of Pharmaceutical Sciences, Chemistry and Technology of the Drug Section, Università degli Studi di Perugia, Perugia, Italy.; Pokaż więcej
Źródło :: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 584-597.
Typ publikacji :: Journal Article
MeSH Terms :: Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Multidrug Resistance-Associated Proteins/*antagonists & inhibitors
Quinolines/*pharmacology
Staphylococcus aureus/*drug effects
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Bacterial Proteins/metabolism ; Microbial Sensitivity Tests ; Molecular Structure ; Multidrug Resistance-Associated Proteins/metabolism ; Quinolines/chemical synthesis ; Quinolines/chemistry ; Staphylococcus aureus/metabolism ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 8 8.

Tytuł :: Apigenin by targeting hnRNPA2 sensitizes triple-negative breast cancer spheroids to doxorubicin-induced apoptosis and regulates expression of ABCC4 and ABCG2 drug efflux transporters.
Autorzy :: Sudhakaran M; Physiology Graduate Program, Michigan State University, East Lansing, MI 48824, United States.
Parra MR; Department of Physiology, Michigan State University, East Lansing, MI 48824, United States.
Stoub H; Physiology Graduate Program, Michigan State University, East Lansing, MI 48824, United States.
Gallo KA; Department of Physiology, Michigan State University, East Lansing, MI 48824, United States. Electronic address: .
Doseff AI; Department of Physiology, Michigan State University, East Lansing, MI 48824, United States; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, United States. Electronic address: .; Pokaż więcej
Źródło :: Biochemical pharmacology [Biochem Pharmacol] 2020 Dec; Vol. 182, pp. 114259. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :: ATP Binding Cassette Transporter, Subfamily G, Member 2/*biosynthesis
Apigenin/*metabolism
Doxorubicin/*metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group A-B/*deficiency
Multidrug Resistance-Associated Proteins/*biosynthesis
Neoplasm Proteins/*biosynthesis
Triple Negative Breast Neoplasms/*metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/metabolism ; Apigenin/administration & dosage ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Doxorubicin/administration & dosage ; Drug Delivery Systems/methods ; Female ; Gene Expression Regulation, Neoplastic ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Humans ; Mice ; Multidrug Resistance-Associated Proteins/genetics ; Neoplasm Proteins/genetics ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/metabolism ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Xenograft Model Antitumor Assays/methods
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Synthesis, biological evaluation and computational studies of acrylohydrazide derivatives as potential Staphylococcus aureus NorA efflux pump inhibitors.
Autorzy :: Kumar G; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India.
Goutami Godavari A; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India.
Tambat R; CSIR-Institute of Microbial Technology, Sector-39A, Chandigarh 160036, India.
Kumar S; Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India.
Nandanwar H; CSIR-Institute of Microbial Technology, Sector-39A, Chandigarh 160036, India.
Elizabeth Sobhia M; Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India.
Jachak SM; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S Nagar, Punjab 160062, India. Electronic address: .; Pokaż więcej
Źródło :: Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104225. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :: Journal Article
MeSH Terms :: Density Functional Theory*
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Hydrazines/*pharmacology
Multidrug Resistance-Associated Proteins/*antagonists & inhibitors
Staphylococcus aureus/*drug effects
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Bacterial Proteins/metabolism ; Dose-Response Relationship, Drug ; Hydrazines/chemical synthesis ; Hydrazines/chemistry ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Structure ; Multidrug Resistance-Associated Proteins/metabolism ; Structure-Activity Relationship
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: Spread of Multidrug-Resistant Rhodococcus equi, United States.
Autorzy :: Álvarez-Narváez, Sonsiray
Giguère, Steeve
Cohen, Noah
Slovis, Nathan
Vázquez-Boland, José A.; Pokaż więcej
Temat :: RHODOCOCCUS
MULTIDRUG resistance
MACROLIDE antibiotics
RIFAMPIN
TETRACYCLINES
Źródło :: Emerging Infectious Diseases. Feb2021, Vol. 27 Issue 2, p529-537. 9p.
Terminy geograficzne :: UNITED States
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 11 11.

Tytuł :: P-glycoprotein and multidrug resistance-associated protein-1 expression in acute myeloid leukemia: Biological and prognosis implications.
Autorzy :: da Silveira Júnior LS; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Soares VL; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Jardim da Silva AS; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.; Faculdade de Ciências da Saúde do Trairi/UFRN, Santa Cruz, Brazil.
Gil EA; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Pereira de Araújo MDG; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.; Laboratório de Citometria de Fluxo, Hemocentro Dalton Cunha, Natal, Brazil.
Merces Gonçalves CA; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.; Laboratório de Citometria de Fluxo, Hemocentro Dalton Cunha, Natal, Brazil.
Paiva AS; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Moura de Oliveira TM; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Oliveira GHM; Laboratório de Citometria de Fluxo, Hemocentro Dalton Cunha, Natal, Brazil.
Kramer Cavacanti E Silva DG; Faculdade de Ciências da Saúde do Trairi/UFRN, Santa Cruz, Brazil.
de Araújo Moura Lemos TM; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Moretti Rebecchi IM; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
de Farias Sales VS; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Luchessi AD; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.
Cavalcanti Júnior GB; Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.; Laboratório de Citometria de Fluxo, Hemocentro Dalton Cunha, Natal, Brazil.; Pokaż więcej
Źródło :: International journal of laboratory hematology [Int J Lab Hematol] 2020 Oct; Vol. 42 (5), pp. 594-603. Date of Electronic Publication: 2020 May 26.
Typ publikacji :: Journal Article
MeSH Terms :: ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics
Leukemia, Myeloid, Acute/*diagnosis
Leukemia, Myeloid, Acute/*genetics
Multidrug Resistance-Associated Proteins/*genetics
ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Biomarkers, Tumor ; Child ; Child, Preschool ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Female ; Flow Cytometry ; Humans ; Immunophenotyping ; Infant ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/mortality ; Male ; Middle Aged ; Multidrug Resistance-Associated Proteins/metabolism ; Phenotype ; Prognosis ; Symptom Assessment ; Young Adult
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines.
Autorzy :: Low FG; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Shabir K; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Brown JE; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Bill RM; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Rothnie AJ; College of Health & Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2020 Oct 16; Vol. 21 (20). Date of Electronic Publication: 2020 Oct 16.
Typ publikacji :: Journal Article
MeSH Terms :: Multidrug Resistance-Associated Proteins/*metabolism
Triple Negative Breast Neoplasms/*metabolism
Cell Movement ; Cell Proliferation ; Cyclic AMP/metabolism ; Humans ; Lysophospholipids/metabolism ; MCF-7 Cells ; Multidrug Resistance-Associated Proteins/antagonists & inhibitors ; Multidrug Resistance-Associated Proteins/genetics ; Receptor, ErbB-2/genetics ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Triple Negative Breast Neoplasms/genetics
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 13 13.

Tytuł :: Genetic analysis of the orthologous crt and mdr1 genes in Plasmodium malariae from Thailand and Myanmar.
Autorzy :: Pimpat Y; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Saralamba N; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. .; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. .
Boonyuen U; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pukrittayakamee S; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Nosten F; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand.; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Smithuis F; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.; Medical Action Myanmar, Yangon, Myanmar.
Day NPJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Churchill Hospital, University of Oxford, Oxford, UK.
Dondorp AM; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Centre for Tropical Medicine and Global Health, Churchill Hospital, University of Oxford, Oxford, UK.
Imwong M; Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.; Pokaż więcej
Źródło :: Malaria journal [Malar J] 2020 Aug 31; Vol. 19 (1), pp. 315. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :: Journal Article
MeSH Terms :: Polymorphism, Genetic*
Drug Resistance/*genetics
Insecticides/*pharmacology
Membrane Transport Proteins/*genetics
Multidrug Resistance-Associated Proteins/*genetics
Plasmodium malariae/*genetics
Protozoan Proteins/*genetics
Chloroquine/pharmacology ; Mefloquine/pharmacology ; Membrane Transport Proteins/metabolism ; Multidrug Resistance-Associated Proteins/metabolism ; Myanmar ; Plasmodium malariae/drug effects ; Protozoan Proteins/metabolism ; Thailand
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 14 14.

Tytuł :: Peptide-Based Approach to Inhibition of the Multidrug Resistance Efflux Pump AcrB.
Autorzy :: Jesin JA; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
Stone TA; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
Mitchell CJ; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Ontario, Canada.
Reading E; Department of Chemistry, Britannia House, King's College London, 7 Trinity Street, London SE1 1DB, United Kingdom.
Deber CM; Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto M5S 1A8, Ontario, Canada.; Pokaż więcej
Źródło :: Biochemistry [Biochemistry] 2020 Oct 20; Vol. 59 (41), pp. 3973-3981. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Escherichia coli/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Binding Sites ; Drug Resistance, Multiple, Bacterial/genetics ; Drug Resistance, Multiple, Bacterial/physiology ; Escherichia coli/chemistry ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Fluorescence Resonance Energy Transfer ; Membrane Transport Proteins/chemistry ; Membrane Transport Proteins/metabolism ; Multidrug Resistance-Associated Proteins/chemistry ; Peptides/chemistry ; Peptides/metabolism ; Protein Conformation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 15 15.

Tytuł :: Interplay of drug transporters P-glycoprotein (MDR1), MRP1, OATP1A2 and OATP1B3 in passage of maraviroc across human placenta.
Autorzy :: Tupova L; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic.
Hirschmugl B; Medical University of Graz, Department of Obstetrics and Gynecology, 8036, Graz, Austria.
Sucha S; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic.
Pilarova V; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Analytical Chemistry, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic.
Székely V; Membrane Protein Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Magyar tudósok krt. 2., H-1117, Budapest, Hungary.
Bakos É; Membrane Protein Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Magyar tudósok krt. 2., H-1117, Budapest, Hungary.
Novakova L; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Analytical Chemistry, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic.
Özvegy-Laczka C; Membrane Protein Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Magyar tudósok krt. 2., H-1117, Budapest, Hungary.
Wadsack C; Medical University of Graz, Department of Obstetrics and Gynecology, 8036, Graz, Austria.
Ceckova M; Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Pharmacology and Toxicology, Akademika Heyrovskeho 1203, Hradec Kralove, Czech Republic. Electronic address: .; Pokaż więcej
Źródło :: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Sep; Vol. 129, pp. 110506. Date of Electronic Publication: 2020 Jul 12.
Typ publikacji :: Journal Article
MeSH Terms :: Anti-HIV Agents/*metabolism
Maraviroc/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Organic Anion Transporters/*metabolism
Placenta/*metabolism
Solute Carrier Organic Anion Transporter Family Member 1B3/*metabolism
ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Acridines/pharmacology ; Animals ; Anti-HIV Agents/blood ; Anti-HIV Agents/pharmacology ; Cell Line, Tumor ; Dogs ; Drug Interactions ; Female ; Gene Expression Regulation ; Humans ; Madin Darby Canine Kidney Cells ; Maraviroc/blood ; Multidrug Resistance-Associated Proteins/genetics ; Organic Anion Transporters/antagonists & inhibitors ; Organic Anion Transporters/genetics ; Perfusion ; Placenta/drug effects ; Placental Circulation ; Pregnancy ; Ritonavir/pharmacology ; Solute Carrier Organic Anion Transporter Family Member 1B3/antagonists & inhibitors ; Solute Carrier Organic Anion Transporter Family Member 1B3/genetics ; Tetrahydroisoquinolines/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity.
Autorzy :: Kato M; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Tsurudome Y; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Kanemitsu T; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Yasukochi S; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Kanado Y; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Ogino T; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Matsunaga N; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.; Department of Glocal Healthcare Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Koyanagi S; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.; Department of Glocal Healthcare Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Ohdo S; Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan. .; Pokaż więcej
Źródło :: Scientific reports [Sci Rep] 2020 Aug 10; Vol. 10 (1), pp. 13484. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Circadian Rhythm/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Multidrug Resistance-Associated Proteins/*metabolism
ATP-Binding Cassette Transporters/genetics ; Animals ; Antineoplastic Agents/pharmacology ; Bone Marrow Cells/metabolism ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Gene Expression/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Male ; Mice ; Mice, Inbred ICR ; Multidrug Resistance-Associated Proteins/genetics ; Organoplatinum Compounds/pharmacology ; Oxaliplatin/pharmacology
: Czasopismo naukowe

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Skocz do pozycji: 17 17.

Tytuł :: Cryo-EM analysis of a membrane protein embedded in the liposome.
Autorzy :: Yao X; Department of Molecular Biology, Princeton University, Princeton, NJ 08544.
Fan X; Department of Molecular Biology, Princeton University, Princeton, NJ 08544 .
Yan N; Department of Molecular Biology, Princeton University, Princeton, NJ 08544 .; Pokaż więcej
Źródło :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18497-18503. Date of Electronic Publication: 2020 Jul 17.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :: Escherichia coli/*metabolism
Escherichia coli Proteins/*metabolism
Liposomes/*ultrastructure
Membrane Proteins/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Cell Membrane/metabolism ; Cell Membrane/ultrastructure ; Cryoelectron Microscopy ; Escherichia coli/ultrastructure ; Escherichia coli Proteins/ultrastructure ; Liposomes/metabolism ; Membrane Proteins/ultrastructure ; Models, Molecular ; Multidrug Resistance-Associated Proteins/ultrastructure ; Protein Conformation
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses.
Autorzy :: Wang L; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, United States.
Johnson ZL; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, United States.
Wasserman MR; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, United States.
Levring J; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, United States.
Chen J; Laboratory of Membrane Biology and Biophysics, The Rockefeller University, New York, United States.; Howard Hughes Medical Institute, The Rockefeller University, New York, United States.
Liu S; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, United States.; Pokaż więcej
Źródło :: ELife [Elife] 2020 May 27; Vol. 9. Date of Electronic Publication: 2020 May 27.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Multidrug Resistance-Associated Proteins/*chemistry
Adenosine Triphosphate/chemistry ; Adenosine Triphosphate/metabolism ; Animals ; Binding Sites ; Cattle ; Cryoelectron Microscopy ; Kinetics ; Models, Molecular ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Protein Conformation ; Spectrometry, Fluorescence
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Substrate-dependent transport mechanism in AcrB of multidrug resistant bacteria.
Autorzy :: Jewel Y; School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington.
Van Dinh Q; School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington.
Liu J; School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington.
Dutta P; School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington.; Pokaż więcej
Źródło :: Proteins [Proteins] 2020 Jul; Vol. 88 (7), pp. 853-864. Date of Electronic Publication: 2020 Feb 08.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :: Protons*
Aspartic Acid/*chemistry
Drug Resistance, Multiple, Bacterial/*genetics
Escherichia coli/*genetics
Escherichia coli Proteins/*chemistry
Indoles/*chemistry
Multidrug Resistance-Associated Proteins/*chemistry
Anti-Bacterial Agents/pharmacology ; Aspartic Acid/metabolism ; Binding Sites ; Biological Transport ; Crystallography, X-Ray ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Indoles/metabolism ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Substrate Specificity ; Thermodynamics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Antibacterial Activities and Phytochemical Screening of Crude Extracts from Kenyan Macaranga Species Towards MDR Phenotypes Expressing Efflux Pumps.
Autorzy :: Hashim, Ibrahim
Omosa, Leonidah Kerubo
Nchiozem-Ngnitedem, Vaderament-Alexe
Onyari, John Mmari
Maru, Shital Mahindra
Guefack, Michel-Gael Fofack
Mbaveng, Armelle Tsafack
Kuete, Victor; Pokaż więcej
Źródło :: Pharmacognosy Communications. Apr-Jun2021, Vol. 11 Issue 2, p119-126. 8p.
: Czasopismo naukowe

Szczegóły Pełny tekst

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