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Tytuł :
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration.
Autorzy :
Wang B; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Ke W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang K; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li G; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Ma L; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Lu S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Xiang Q; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Liao Z; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Luo R; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Song Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Hua W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wu X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhang Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zeng X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yang C; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Feb 10; Vol. 2021, pp. 8884922. Date of Electronic Publication: 2021 Feb 10 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cellular Senescence*
Mechanotransduction, Cellular*
Oxidative Stress*
Extracellular Matrix/*metabolism
Intervertebral Disc Degeneration/*pathology
Ion Channels/*metabolism
Adolescent ; Adult ; Aged ; Animals ; Biomechanical Phenomena ; Disease Progression ; Endoplasmic Reticulum Stress ; Female ; Gene Knockdown Techniques ; Humans ; Male ; Middle Aged ; Models, Biological ; Nucleus Pulposus/pathology ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Up-Regulation ; Young Adult
Czasopismo naukowe
Tytuł :
Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells.
Autorzy :
Xiang Q; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Cheng Z; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang J; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Feng X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Hua W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Luo R; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang B; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Liao Z; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Ma L; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li G; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Lu S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang K; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Song Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wu X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yang C; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhang Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Dec 14; Vol. 2020, pp. 6685043. Date of Electronic Publication: 2020 Dec 14 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Disulfides/*pharmacology
Nucleus Pulposus/*drug effects
Oxidative Stress/*drug effects
Sulfinic Acids/*pharmacology
Adolescent ; Adult ; Advanced Oxidation Protein Products/adverse effects ; Advanced Oxidation Protein Products/metabolism ; Aged ; Cells, Cultured ; Down-Regulation/drug effects ; Female ; Humans ; Intervertebral Disc Degeneration/metabolism ; Intervertebral Disc Degeneration/pathology ; Intervertebral Disc Degeneration/prevention & control ; Male ; Membrane Potential, Mitochondrial/drug effects ; Middle Aged ; Mitochondria/drug effects ; Mitochondria/physiology ; Nucleus Pulposus/pathology ; Nucleus Pulposus/physiology ; Oxidation-Reduction/drug effects ; Reactive Oxygen Species/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Activation of GPR120 by TUG891 ameliorated cisplatin-induced acute kidney injury via repressing ER stress and apoptosis.
Autorzy :
Huang Z; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China; Division of Pathology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Guo F; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Xia Z; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Liang Y; Division of Pathology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Lei S; Division of Pathology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Tan Z; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Ma L; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address: .
Fu P; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Jun; Vol. 126, pp. 110056. Date of Electronic Publication: 2020 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*prevention & control
Apoptosis/*drug effects
Biphenyl Compounds/*pharmacology
Cisplatin/*toxicity
Endoplasmic Reticulum Stress/*drug effects
Phenylpropionates/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Animals ; Disease Models, Animal ; Male ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
High expression of the CKIP-1 gene might promote apoptosis through downregulation of the Ras/ERK signalling pathway in the intestinal type of gastric cancer.
Autorzy :
Ma L; Guizhou University School of Medicine, Guiyang, Guizhou Province, China.
Cao Y; Department of Pathology, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China.
Hu J; Department of Pathology, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China.
Chu M; Department of Pathology, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China.
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Źródło :
The Journal of international medical research [J Int Med Res] 2020 Mar; Vol. 48 (3), pp. 300060520909025.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
MAP Kinase Signaling System*
Apoptosis/*genetics
Down-Regulation/*genetics
Intestines/*pathology
Intracellular Signaling Peptides and Proteins/*genetics
Stomach Neoplasms/*genetics
ras Proteins/*metabolism
Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Line, Tumor ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Middle Aged ; Stomach Neoplasms/pathology ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.
Autorzy :
Li G; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Song Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Liao Z; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang K; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Luo R; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Lu S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhao K; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Feng X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Liang H; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Ma L; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang B; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Ke W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yin H; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhan S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wu X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhang Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yang C; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2020 Feb 06; Vol. 11 (2), pp. 103. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Autophagy*
Adenosine/*analogs & derivatives
Mesenchymal Stem Cells/*metabolism
Nucleus Pulposus/*metabolism
RNA, Messenger/*metabolism
Spinal Cord Compression/*metabolism
Adenosine/metabolism ; Adolescent ; AlkB Homolog 5, RNA Demethylase/genetics ; AlkB Homolog 5, RNA Demethylase/metabolism ; Autophagy-Related Protein-1 Homolog/genetics ; Autophagy-Related Protein-1 Homolog/metabolism ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Cells, Cultured ; Coculture Techniques ; Demethylation ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Nucleus Pulposus/ultrastructure ; Paracrine Communication ; RNA Stability ; RNA, Messenger/genetics ; Signal Transduction ; Spinal Cord Compression/genetics ; Spinal Cord Compression/pathology
Czasopismo naukowe
Tytuł :
Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice.
Autorzy :
Ren Q; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Guo F; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Tao S; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Huang R; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Ma L; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address: .
Fu P; Division of Nephrology and National Clinical Research Center for Geriatrics, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Feb; Vol. 122, pp. 109772. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Kidney Injury/*drug therapy
Apoptosis/*drug effects
Flavonoids/*pharmacology
Inflammation/*drug therapy
Sepsis/*drug therapy
Signal Transduction/*drug effects
Acute Kidney Injury/metabolism ; Animals ; Genes, src/drug effects ; Inflammation/metabolism ; Kidney/drug effects ; Lipopolysaccharides/pharmacology ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Sepsis/metabolism ; Transcription Factor RelA/metabolism
Czasopismo naukowe
Tytuł :
Anti-cancer effects of Polyphyllin I: An update in 5 years.
Autorzy :
Tian Y; Department of Nephrology and Endocrinology, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, 710038, China. Electronic address: .
Gong GY; The Institute for Translational Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Ma LL; Department of Hematology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116021, China.
Wang ZQ; Department of Oncology, Central Hospital of Zibo, Zibo, 255036, China.
Song D; Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116021, China.
Fang MY; Department of Hematology, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Jan 25; Vol. 316, pp. 108936. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Diosgenin/*analogs & derivatives
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Cycle Checkpoints/drug effects ; Diosgenin/chemistry ; Diosgenin/pharmacology ; Diosgenin/therapeutic use ; Drug Resistance, Neoplasm/drug effects ; Humans ; Medicine, Chinese Traditional ; Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Preliminary study on the anti-apoptotic mechanism of Astragaloside IV on radiation-induced brain cells.
Autorzy :
Liu X; School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
Chu W; School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
Shang S; School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
Ma L; School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
Jiang C; School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
Ding Y; School wof Life Sciences, Northwest Normal University, Lanzhou, Gansu Province, China.
Wang J; School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
Zhang S; School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
Shao B; School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, China.
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Źródło :
International journal of immunopathology and pharmacology [Int J Immunopathol Pharmacol] 2020 Jan-Dec; Vol. 34, pp. 2058738420954594.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Brain/*drug effects
Neurons/*drug effects
Neuroprotective Agents/*pharmacology
Radiation-Protective Agents/*pharmacology
Saponins/*pharmacology
Triterpenes/*pharmacology
Animals ; Apoptosis/radiation effects ; Apoptosis Regulatory Proteins/metabolism ; Brain/metabolism ; Brain/pathology ; Brain/radiation effects ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Mice ; Neurons/metabolism ; Neurons/pathology ; Neurons/radiation effects ; PC12 Cells ; Phosphorylation ; Rats ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Berberine ameliorates oxidative stress-induced apoptosis by modulating ER stress and autophagy in human nucleus pulposus cells.
Autorzy :
Luo R; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Liao Z; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Song Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yin H; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhan S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li G; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Ma L; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Lu S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang K; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Li S; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhang Y; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yang C; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2019 Jul 01; Vol. 228, pp. 85-97. Date of Electronic Publication: 2019 Apr 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*pharmacology
Apoptosis/*drug effects
Berberine/*pharmacology
Endoplasmic Reticulum Stress/*drug effects
Intervertebral Disc Degeneration/*drug therapy
Nucleus Pulposus/*drug effects
Oxidative Stress/*drug effects
Animals ; Antioxidants/therapeutic use ; Autophagy/drug effects ; Berberine/therapeutic use ; Cells, Cultured ; Female ; Humans ; Intervertebral Disc Degeneration/metabolism ; Intervertebral Disc Degeneration/pathology ; Nucleus Pulposus/cytology ; Nucleus Pulposus/metabolism ; Nucleus Pulposus/pathology ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Melittin Inducing the Apoptosis of Renal Tubule Epithelial Cells through Upregulation of Bax/Bcl-2 Expression and Activation of TNF- α Signaling Pathway.
Autorzy :
Shu Y; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; Division of Nephrology, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, China.
Yang Y; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Zhao Y; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Ma L; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Fu P; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Wei T; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Zhang L; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
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Źródło :
BioMed research international [Biomed Res Int] 2019 May 29; Vol. 2019, pp. 9450368. Date of Electronic Publication: 2019 May 29 (Print Publication: 2019).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Epithelial Cells/*drug effects
Kidney Tubules, Proximal/*drug effects
Melitten/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*metabolism
Signal Transduction/*drug effects
Tumor Necrosis Factor-alpha/*metabolism
bcl-2-Associated X Protein/*metabolism
Acute Kidney Injury/pathology ; Animals ; Cell Line ; Disease Models, Animal ; Epithelial Cells/pathology ; Humans ; In Situ Nick-End Labeling ; Kidney Tubules, Proximal/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Up-Regulation
Czasopismo naukowe
Tytuł :
Activated mitochondrial apoptosis in hESCs after dissociation involving the PKA/p-p53/Bax signaling pathway.
Autorzy :
Zhang L; Biochemical Engineering Research Center, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
Ma L; Biochemical Engineering Research Center, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China; School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China.
Yan T; Biochemical Engineering Research Center, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China; School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China.
Han X; School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China.
Xu J; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
Xu J; Biochemical Engineering Research Center, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China; School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China.
Xu X; Biochemical Engineering Research Center, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China; School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui 243002, PR China; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
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Źródło :
Experimental cell research [Exp Cell Res] 2018 Aug 15; Vol. 369 (2), pp. 226-233. Date of Electronic Publication: 2018 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Human Embryonic Stem Cells/*cytology
Human Embryonic Stem Cells/*metabolism
Mitochondria/*metabolism
Apoptosis/drug effects ; Caspases/metabolism ; Cell Line ; Cell Survival/drug effects ; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Human Embryonic Stem Cells/drug effects ; Humans ; Isoquinolines/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction/physiology ; Sulfonamides/pharmacology ; Tumor Suppressor Protein p53/chemistry ; Tumor Suppressor Protein p53/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Metformin and FTY720 Synergistically Induce Apoptosis in Multiple Myeloma Cells.
Autorzy :
Zhao Y; Bone Marrow Transplantation Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Zhang E; Bone Marrow Transplantation Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Lv N; Department of Pharmacy, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Ma L; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School, Ningbo University, Ningbo, China.
Yao S; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School, Ningbo University, Ningbo, China.
Yan M; Department of General Surgery, No. 7 Hospital of Ningbo, Ningbo, China.
Zi F; Bone Marrow Transplantation Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Deng G; Ningbo Central Blood Station, Ningbo, China.
Liu X; Bone Marrow Transplantation Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
He J; Bone Marrow Transplantation Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Wu W; Bone Marrow Transplantation Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Cai Z; Bone Marrow Transplantation Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Yu R; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School, Ningbo University, Ningbo, China.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2018; Vol. 48 (2), pp. 785-800. Date of Electronic Publication: 2018 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Fingolimod Hydrochloride/*pharmacology
Metformin/*pharmacology
Caspase 3/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Synergism ; Endoplasmic Reticulum Stress/drug effects ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
[Dynamic changes of pH2AX expression in the reversibility of mouse testicular reproductive function impaired by single heat stress].
Autorzy :
Tian HC; Department of Reproductive Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256600, China.
Xu YQ; Department of Reproductive Medicine, Weihai Maternity and Child Care Hospital, Weihai, Shandong 264200, China.
Ma H; Department of Reproductive Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256600, China.
Wang HJ; Department of Reproductive Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256600, China.
Li XF; Department of Reproductive Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256600, China.
Wang XH; Department of Reproductive Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256600, China.
Ma LH; Department of Urology ,General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.
Li QC; Department of Reproductive Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256600, China.
Zhang DM; Department of Reproductive Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256600, China.
Wang YL; Department of Reproductive Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256600, China.
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Źródło :
Zhonghua nan ke xue = National journal of andrology [Zhonghua Nan Ke Xue] 2017 Oct; Vol. 23 (10), pp. 873-877.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Heat Stress Disorders/*complications
Histones/*metabolism
Spermatozoa/*metabolism
Animals ; Blotting, Western ; Hot Temperature ; Immunohistochemistry ; In Situ Nick-End Labeling ; Male ; Mice ; Mice, Inbred C57BL ; Random Allocation ; Seminiferous Tubules/cytology ; Spermatozoa/cytology ; Testis ; Time Factors
Czasopismo naukowe
Tytuł :
Arenobufagin Induces Apoptotic Cell Death in Human Non-Small-Cell Lung Cancer Cells via the Noxa-Related Pathway.
Autorzy :
Ma L; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Zhu Y; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Fang S; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Long H; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Liu X; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Liu Z; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2017 Sep 11; Vol. 22 (9). Date of Electronic Publication: 2017 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Bufanolides/*chemistry
Bufanolides/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*genetics
A549 Cells ; Amino Acid Chloromethyl Ketones/pharmacology ; Amphibian Venoms/chemistry ; Antineoplastic Agents/isolation & purification ; Apoptosis/genetics ; Bufanolides/isolation & purification ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Medicine, Chinese Traditional ; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Signal Transduction ; Tumor Suppressor Protein p53/agonists ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis.
Autorzy :
Chen JF; Translational Research Laboratory for Urology, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Yu BX; Translational Research Laboratory for Urology, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Yu R; Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315212, P.R. China.
Ma L; Translational Research Laboratory for Urology, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Lv XY; Translational Research Laboratory for Urology, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Cheng Y; Translational Research Laboratory for Urology, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
Ma Q; Translational Research Laboratory for Urology, Ningbo First Hospital, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China.
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Źródło :
Oncology reports [Oncol Rep] 2017 Feb; Vol. 37 (2), pp. 721-728. Date of Electronic Publication: 2017 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal/*pharmacology
Apoptosis/*drug effects
Drug Resistance, Neoplasm/*drug effects
Epirubicin/*pharmacology
G1 Phase/*drug effects
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
S Phase/*drug effects
Urinary Bladder Neoplasms/*pathology
Antibiotics, Antineoplastic/pharmacology ; Blotting, Western ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Humans ; Receptor Protein-Tyrosine Kinases/immunology ; Tumor Cells, Cultured ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
[Effect of BRD4 Inhibitor JQ1 on Proliferation Inhibition and Apotosis Induction in Jurkat Cells].
Autorzy :
Sun XX; Graduate School of Shanxi Medical University,Taiyuan 030001, Shanxi Province, China.
Ma LM; Department of Hematology, Shanxi Da Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.E-mail:.
Wang T; Department of Hematology, Shanxi Da Hospital Affiliated to Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2016 Aug; Vol. 24 (4), pp. 1019-23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Proliferation*
Azepines ; Cell Cycle Proteins ; Flow Cytometry ; Genes, myc ; Humans ; Jurkat Cells ; Nuclear Proteins ; Transcription Factors ; Triazoles
Czasopismo naukowe
Tytuł :
[Evaluation of nephrotoxicity induced by total terpenoids from Alismatis Rhizoma on HK-2 cells in vitro and its induction of apoptosis].
Autorzy :
Wang CF; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China.; Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Ma L; Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Feng L; Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Yin MR; Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Gu JF; Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Jia XB; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230031, China.; Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
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Źródło :
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2016 Feb; Vol. 41 (3), pp. 490-497.
Typ publikacji :
Journal Article
MeSH Terms :
Alisma/*chemistry
Apoptosis/*drug effects
Drugs, Chinese Herbal/*toxicity
Kidney/*drug effects
Terpenes/*toxicity
Caspase 3/genetics ; Caspase 3/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Clusterin/genetics ; Clusterin/metabolism ; Drugs, Chinese Herbal/analysis ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Hepatitis A Virus Cellular Receptor 1/genetics ; Hepatitis A Virus Cellular Receptor 1/metabolism ; Humans ; Kidney/cytology ; Rhizome/chemistry ; Terpenes/analysis
Czasopismo naukowe
Tytuł :
[Mechanism of Notch1 Pathway in SUP-B15 Cell Apoptosis Induced by JQ1].
Autorzy :
Wang Y; Department of Hematology, Affiliated Shanxi Big Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
Ma LM; Department of Hematology, Affiliated Shanxi Big Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China. E-mail: maliangming@ medmail.com.cn.
Wang XZ; Department of Hematology, Affiliated Shanxi Big Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
Wang T; Department of Hematology, Affiliated Shanxi Big Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2015 Apr; Vol. 23 (2), pp. 364-8.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Apoptosis*
Signal Transduction*
Azepines ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Flow Cytometry ; Fusion Proteins, bcr-abl ; Humans ; Receptor, Notch1 ; Triazoles
Czasopismo naukowe
Tytuł :
[Apoptosis-inducing effect of tetrandrine and imatinib on K562/G01 cells and its related mechanism].
Autorzy :
Shi DX; Second Clinical Medical College, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
Ma LM; Department of Hematolagy, Shanxi Dayi Hospital, Shanxi Medical University, Taiyuan 030032, Shanxi Province, China. E-mail: .
Lu YJ; 2Department of Hematolagy, Shanxi Dayi Hospital, Shanxi Medical University, Taiyuan 030032, Shanxi Province, China.
Bai B; Department of Hematolagy, Shanxi Dayi Hospital, Shanxi Medical University, Taiyuan 030032, Shanxi Province, China.
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2014 Jun; Vol. 22 (3), pp. 723-8.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Apoptosis/*drug effects
Benzamides/*pharmacology
Benzylisoquinolines/*pharmacology
Piperazines/*pharmacology
Pyrimidines/*pharmacology
Caspase 3/metabolism ; Cell Proliferation/drug effects ; Gene Expression Regulation, Leukemic ; Humans ; Imatinib Mesylate ; K562 Cells ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Tytuł :
Effects of PLCE1 gene silencing by RNA interference on cell cycling and apoptosis in esophageal carcinoma cells.
Autorzy :
Zhao L; Department of Endoscopy, Peace Hospital Attached to Changzhi Medical College, Changzhi, China E-mail : .
Wei ZB
Yang CQ
Chen JJ
Li D
Ji AF
Ma L
Pokaż więcej
Źródło :
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2014; Vol. 15 (13), pp. 5437-42.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Carcinoma, Squamous Cell/*genetics
Cell Cycle Checkpoints/*genetics
Esophageal Neoplasms/*genetics
Gene Silencing/*physiology
Phosphoinositide Phospholipase C/*genetics
RNA Interference/*physiology
Caspase 3/genetics ; Cell Line, Tumor ; Cyclin D1/genetics ; Esophageal Squamous Cell Carcinoma ; G1 Phase/genetics ; Humans ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Resting Phase, Cell Cycle/genetics
Czasopismo naukowe

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