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Title:
Melittin Inducing the Apoptosis of Renal Tubule Epithelial Cells through Upregulation of Bax/Bcl-2 Expression and Activation of TNF- α Signaling Pathway.
Authors:
Shu Y; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.; Division of Nephrology, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, China.
Yang Y; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Zhao Y; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Ma L; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Fu P; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Wei T; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Zhang L; Kidney Research Institute, Division of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
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Source:
BioMed research international [Biomed Res Int] 2019 May 29; Vol. 2019, pp. 9450368. Date of Electronic Publication: 2019 May 29 (Print Publication: 2019).
Publication Type:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Epithelial Cells/*drug effects
Kidney Tubules, Proximal/*drug effects
Melitten/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*metabolism
Signal Transduction/*drug effects
Tumor Necrosis Factor-alpha/*metabolism
bcl-2-Associated X Protein/*metabolism
Acute Kidney Injury/pathology ; Animals ; Cell Line ; Disease Models, Animal ; Epithelial Cells/pathology ; Humans ; In Situ Nick-End Labeling ; Kidney Tubules, Proximal/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Up-Regulation
Academic Journal
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Title:
Arenobufagin Induces Apoptotic Cell Death in Human Non-Small-Cell Lung Cancer Cells via the Noxa-Related Pathway.
Authors:
Ma L; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Zhu Y; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Fang S; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Long H; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Liu X; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
Liu Z; Department of Chemical Biology and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan 243002, Anhui, China. .
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Source:
Molecules (Basel, Switzerland) [Molecules] 2017 Sep 11; Vol. 22 (9). Date of Electronic Publication: 2017 Sep 11.
Publication Type:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Bufanolides/*chemistry
Bufanolides/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*genetics
A549 Cells ; Amino Acid Chloromethyl Ketones/pharmacology ; Amphibian Venoms/chemistry ; Antineoplastic Agents/isolation & purification ; Apoptosis/genetics ; Bufanolides/isolation & purification ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 9/genetics ; Caspase 9/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Medicine, Chinese Traditional ; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Poly(ADP-ribose) Polymerases/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Signal Transduction ; Tumor Suppressor Protein p53/agonists ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Academic Journal
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Showing 1-20 from 89 results

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