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Tytuł :
Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD.
Autorzy :
Mepham JR; Graduate Program in Neuroscience, Western University, London, Ontario, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
MacFabe DF; Department of Psychology, Western University, London, Ontario, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
Boon FH; Department of Psychology, Western University, London, Ontario, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
Foley KA; Graduate Program in Neuroscience, Western University, London, Ontario, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
Cain DP; Graduate Program in Neuroscience, Western University, London, Ontario, Canada; Department of Psychology, Western University, London, Ontario, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
Ossenkopp KP; Graduate Program in Neuroscience, Western University, London, Ontario, Canada; Department of Psychology, Western University, London, Ontario, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada. Electronic address: .
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Źródło :
Behavioural brain research [Behav Brain Res] 2021 Apr 09; Vol. 403, pp. 113140. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Enteric short-chain fatty acids promote proliferation of human neural progenitor cells.
Autorzy :
Yang LL; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Millischer V; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Rodin S; Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
MacFabe DF; The Kilee Patchell-Evans Autism Research Group, London, Canada.; Center for Healthy Eating and Food Innovation, Faculty of Medicine, Maastricht University, Maastricht, Netherlands.
Villaescusa JC; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Lavebratt C; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
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Źródło :
Journal of neurochemistry [J Neurochem] 2020 Sep; Vol. 154 (6), pp. 635-646. Date of Electronic Publication: 2019 Dec 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Acids, Volatile/*pharmacology
Neural Stem Cells/*drug effects
Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Cell Division/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Gastrointestinal Microbiome ; Humans ; Neurogenesis/drug effects ; Neurogenesis/genetics
Czasopismo naukowe
Tytuł :
Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats.
Autorzy :
Meeking MM; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Ontario, Canada; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada.
MacFabe DF; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Ontario, Canada; Department of Psychology, University of Western Ontario, London, Ontario, Canada.
Mepham JR; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Ontario, Canada; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada.
Foley KA; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Ontario, Canada; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada.
Tichenoff LJ; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Ontario, Canada.
Boon FH; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Ontario, Canada.
Kavaliers M; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Ontario, Canada; Department of Psychology, University of Western Ontario, London, Ontario, Canada; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada.
Ossenkopp KP; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, Ontario, Canada; Department of Psychology, University of Western Ontario, London, Ontario, Canada; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada. Electronic address: .
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Źródło :
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2020 Mar 08; Vol. 97, pp. 109794. Date of Electronic Publication: 2019 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autism Spectrum Disorder/*psychology
Behavior, Animal/*drug effects
Exploratory Behavior/*drug effects
Locomotion/*drug effects
Propionates/*pharmacology
Stereotyped Behavior/*drug effects
Animals ; Dose-Response Relationship, Drug ; Infusions, Intraventricular ; Male ; Propionates/administration & dosage ; Rats ; Time Factors
Czasopismo naukowe
Tytuł :
Effect of propionic acid on the morphology of the amygdala in adolescent male rats and their behavior.
Autorzy :
Lobzhanidze G; School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili venue, 0162 Tbilisi, Georgia; Department of Brain Ultrastructure and Nanoarchitecture. I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, 0160 Tbilisi, Georgia.
Lordkipanidze T; School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili venue, 0162 Tbilisi, Georgia; Department of Brain Ultrastructure and Nanoarchitecture. I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, 0160 Tbilisi, Georgia.
Zhvania M; School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili venue, 0162 Tbilisi, Georgia; Department of Brain Ultrastructure and Nanoarchitecture. I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, 0160 Tbilisi, Georgia. Electronic address: .
Japaridze N; Department of Brain Ultrastructure and Nanoarchitecture. I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, 0160 Tbilisi, Georgia; New Vision University, 1A EvgeniMikeladze Street, 0159 Tbilisi, Georgia.
MacFabe DF; Kilee Patchell-Evans Autism Research Group, London, Canada; Maastricht University, Netherlands.
Pochkidze N; School of Natural Sciences and Medicine, Ilia State University, 3/5 K. Cholokashvili venue, 0162 Tbilisi, Georgia; Department of Brain Ultrastructure and Nanoarchitecture. I. Beritashvili Center of Experimental Biomedicine. 14 Gotua Street, 0160 Tbilisi, Georgia.
Gasimov E; Azerbaijan Medical University, 23 Bakikhanov Street, 1022 Baku, Azerbaijan.
Rzaev F; Azerbaijan Medical University, 23 Bakikhanov Street, 1022 Baku, Azerbaijan.
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Źródło :
Micron (Oxford, England : 1993) [Micron] 2019 Oct; Vol. 125, pp. 102732. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Czasopismo naukowe
Tytuł :
Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder.
Autorzy :
Shams S; Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Foley KA; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada.
Kavaliers M; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada.; Department of Psychology, University of Western Ontario, London, Ontario, Canada.
MacFabe DF; Department of Psychology, University of Western Ontario, London, Ontario, Canada.
Ossenkopp KP; Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada.; Department of Psychology, University of Western Ontario, London, Ontario, Canada.
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Źródło :
Developmental psychobiology [Dev Psychobiol] 2019 Jul; Vol. 61 (5), pp. 688-699. Date of Electronic Publication: 2019 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autism Spectrum Disorder*
Social Behavior*
Behavior, Animal/*drug effects
Propionates/*pharmacology
Animals ; Anxiety ; Disease Models, Animal ; Male ; Motor Activity/drug effects ; Rats ; Rats, Long-Evans
Czasopismo naukowe
Tytuł :
Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD.
Autorzy :
Mepham JR; Graduate Program in Neuroscience, Western University, London, Ontario, Canada.; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
Boon FH; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.; Department of Psychology, Western University, London, Ontario, N6A 5C2, Canada.
Foley KA; Graduate Program in Neuroscience, Western University, London, Ontario, Canada.; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.
Cain DP; Graduate Program in Neuroscience, Western University, London, Ontario, Canada.; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.; Department of Psychology, Western University, London, Ontario, N6A 5C2, Canada.
MacFabe DF; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada.; Department of Psychology, Western University, London, Ontario, N6A 5C2, Canada.
Ossenkopp KP; Graduate Program in Neuroscience, Western University, London, Ontario, Canada. .; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Western University, London, Ontario, Canada. .; Department of Psychology, Western University, London, Ontario, N6A 5C2, Canada. .
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Źródło :
Neurotoxicity research [Neurotox Res] 2019 May; Vol. 35 (4), pp. 823-837. Date of Electronic Publication: 2019 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Autism Spectrum Disorder/*psychology
Propionates/*administration & dosage
Spatial Learning/*drug effects
Animals ; Autism Spectrum Disorder/chemically induced ; Autism Spectrum Disorder/microbiology ; Behavior, Animal/drug effects ; Gastrointestinal Microbiome ; Infusions, Intraventricular ; Male ; Motor Activity ; Rats, Long-Evans
Czasopismo naukowe
Tytuł :
Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.
Autorzy :
Rose S; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
Bennuri SC; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
Davis JE; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
Wynne R; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
Slattery JC; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
Tippett M; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
Delhey L; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
Melnyk S; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
Kahler SG; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA.
MacFabe DF; Kilee Patchell-Evans Autism Research Group, Alberta Children's Hospital Research Institute, Calgary, AB, Canada.
Frye RE; Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, AR, USA. .; Division of Neurodevelopmental Disorders, Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA. .
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Źródło :
Translational psychiatry [Transl Psychiatry] 2018 Feb 02; Vol. 8 (1), pp. 42. Date of Electronic Publication: 2018 Feb 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastrointestinal Microbiome*
Oxidative Stress*
Autism Spectrum Disorder/*metabolism
Butyrates/*metabolism
Butyrates/*pharmacology
Lymphocytes/*metabolism
Mitochondria/*metabolism
Mitochondrial Diseases/*metabolism
Reactive Oxygen Species/*metabolism
Cell Line ; Child ; Humans ; Male
Czasopismo naukowe
Tytuł :
Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid.
Autorzy :
Frye RE; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.; Autism Research Program, Arkansas Children's Research Institute, Little Rock, AR, United States.
Nankova B; New York Medical College, Valhalla, NY, United States.
Bhattacharyya S; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.; Autism Research Program, Arkansas Children's Research Institute, Little Rock, AR, United States.
Rose S; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.; Autism Research Program, Arkansas Children's Research Institute, Little Rock, AR, United States.
Bennuri SC; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.; Autism Research Program, Arkansas Children's Research Institute, Little Rock, AR, United States.
MacFabe DF; Kilee Patchell-Evans Autism Research Group, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
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Źródło :
Frontiers in immunology [Front Immunol] 2017 Dec 22; Vol. 8, pp. 1670. Date of Electronic Publication: 2017 Dec 22 (Print Publication: 2017).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines.
Autorzy :
Frye RE; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
Rose S; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
Chacko J; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Wynne R; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
Bennuri SC; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
Slattery JC; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
Tippett M; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
Delhey L; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
Melnyk S; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
Kahler SG; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Arkansas Children's Research Institute, Little Rock, AR, USA.
MacFabe DF; Kilee Patchell-Evans Autism Research Group, Division of Developmental Disabilities, Department of Psychology/Psychiatry, University of Western Ontario, London, ON, Canada.
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Źródło :
Translational psychiatry [Transl Psychiatry] 2016 Oct 25; Vol. 6 (10), pp. e927. Date of Electronic Publication: 2016 Oct 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autism Spectrum Disorder/*physiopathology
Gastrointestinal Microbiome/*physiology
Mitochondria/*physiology
Mitochondrial Diseases/*physiopathology
Propionates/*metabolism
Propionic Acidemia/*physiopathology
Case-Control Studies ; Cell Line ; Child ; Humans ; Male
Czasopismo naukowe
Tytuł :
The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.
Autorzy :
Slattery J; Arkansas Children's Research Institute, Little Rock, AR, USA.; Division of Neurology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
MacFabe DF; The Kilee Patchell-Evans Autism Research Group, Departments of Psychology (Neuroscience) and Psychiatry, Division of Developmental Disabilities, University of Western Ontario, London, ON, Canada.
Frye RE; Arkansas Children's Research Institute, Little Rock, AR, USA.; Division of Neurology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
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Źródło :
Clinical medicine insights. Pediatrics [Clin Med Insights Pediatr] 2016 Oct 09; Vol. 10, pp. 91-107. Date of Electronic Publication: 2016 Oct 09 (Print Publication: 2016).
Typ publikacji :
Review; Journal Article
Czasopismo naukowe
Tytuł :
Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored?
Autorzy :
Slattery J
MacFabe DF
Kahler SG
Frye RE; Slot 512-41B, Room R4041, 13 Children's Way, Little Rock, AR 72202, USA.
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Źródło :
Current pharmaceutical design [Curr Pharm Des] 2016; Vol. 22 (40), pp. 6107-6121.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Autism Spectrum Disorder/*immunology
Autism Spectrum Disorder/*metabolism
Microbiota/*immunology
Animals ; Autism Spectrum Disorder/drug therapy ; Humans
Czasopismo naukowe
Tytuł :
Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders.
Autorzy :
MacFabe DF; The Kilee Patchell-Evans Autism Research Group, Departments of Psychology (Neuroscience) and Psychiatry, Division of Developmental Disabilities, University of Western Ontario, Ontario, Canada; .
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Źródło :
Microbial ecology in health and disease [Microb Ecol Health Dis] 2015 May 29; Vol. 26, pp. 28177. Date of Electronic Publication: 2015 May 29 (Print Publication: 2015).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms.
Autorzy :
Frye RE; Division of Neurology, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; .
Slattery J; Division of Neurology, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
MacFabe DF; Department of Psychology and Psychiatry, Western University, London, ON, Canada.
Allen-Vercoe E; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Parker W; Department of Surgery, Duke University, Durham, NC USA.
Rodakis J; N of One: Autism Research Foundation, Dallas, TX, USA.
Adams JB; School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ, USA.
Krajmalnik-Brown R; Swette Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Bolte E; N of One: Autism Research Foundation, Dallas, TX, USA.
Kahler S; Division of Neurology, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jennings J; Private Practice, Benton, AR, USA.
James J; Department of Developmental Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Cerniglia CE; National Center for Toxicological Research, Jefferson, AR, USA.
Midtvedt T; MTC, Karolinska Institutet, Stockholm, Sweden.
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Źródło :
Microbial ecology in health and disease [Microb Ecol Health Dis] 2015 May 07; Vol. 26, pp. 26878. Date of Electronic Publication: 2015 May 07 (Print Publication: 2015).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.
Autorzy :
Frye RE; Autism Research Program, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA; .
Rose S; Autism Research Program, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Slattery J; Autism Research Program, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
MacFabe DF; Kilee Patchell-Evans Autism Research Group, Division of Developmental Disabilities, Departments of Psychology and Psychiatry, University of Western Ontario, London, ON, Canada.
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Źródło :
Microbial ecology in health and disease [Microb Ecol Health Dis] 2015 May 07; Vol. 26, pp. 27458. Date of Electronic Publication: 2015 May 07 (Print Publication: 2015).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats.
Autorzy :
Shultz SR; Melbourne Brain Centre, Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia. Electronic address: .
Aziz NA; Melbourne Brain Centre, Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.
Yang L; Melbourne Brain Centre, Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia; Department of Histology and Embryology, Kunming Medical University, Kunming, Yunnan, China.
Sun M; Melbourne Brain Centre, Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.
MacFabe DF; The Kilee Patchell-Evans Autism Research Group, Department of Psychology and Psychiatry, University of Western Ontario, London, ON, Canada.
O'Brien TJ; Melbourne Brain Centre, Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.
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Źródło :
Behavioural brain research [Behav Brain Res] 2015 Feb 01; Vol. 278, pp. 542-8. Date of Electronic Publication: 2014 Nov 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Propionates/*toxicity
Seizures/*chemically induced
Seizures/*physiopathology
Social Behavior Disorders/*chemically induced
Analysis of Variance ; Animals ; Astrocytes/drug effects ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Corpus Callosum/drug effects ; Corpus Callosum/metabolism ; Exploratory Behavior/drug effects ; Glial Fibrillary Acidic Protein/metabolism ; Injections, Intraventricular ; Locomotion/drug effects ; Male ; Rats
Czasopismo naukowe
Tytuł :
Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: relevance to autism spectrum disorders.
Autorzy :
Foley KA; Graduate Program in Neuroscience, Department of Psychology, University of Western Ontario, London, ON, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, ON, Canada.
MacFabe DF; The Kilee Patchell-Evans Autism Research Group, Department of Psychology and Psychiatry, Division of Developmental Disabilities, University of Western Ontario, London, ON, Canada.
Kavaliers M; Graduate Program in Neuroscience, Department of Psychology, University of Western Ontario, London, ON, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, ON, Canada.
Ossenkopp KP; Graduate Program in Neuroscience, Department of Psychology, University of Western Ontario, London, ON, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, ON, Canada. Electronic address: .
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Źródło :
Behavioural brain research [Behav Brain Res] 2015 Feb 01; Vol. 278, pp. 244-56. Date of Electronic Publication: 2014 Oct 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Child Development Disorders, Pervasive/*psychology
Lipopolysaccharides/*pharmacology
Prenatal Exposure Delayed Effects/*psychology
Prepulse Inhibition/*drug effects
Propionates/*pharmacology
Reflex, Startle/*drug effects
Age Factors ; Animals ; Auditory Perception/drug effects ; Child Development Disorders, Pervasive/chemically induced ; Female ; Lipopolysaccharides/administration & dosage ; Male ; Pregnancy ; Propionates/administration & dosage ; Rats ; Rats, Long-Evans ; Risk Factors ; Sex Factors ; Time Factors
Czasopismo naukowe
Tytuł :
Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: implications for autism spectrum disorders.
Autorzy :
Foley KA; Graduate Program in Neuroscience, The University of Western Ontario, London, ON N6A 5B7, Canada; Department of Psychology, The University of Western Ontario, London, ON N6A 5C2, Canada. Electronic address: .
MacFabe DF; Department of Psychology, The University of Western Ontario, London, ON N6A 5C2, Canada; The Kilee Patchell-Evans Autism Research Group, Departments of Psychology and Psychiatry, Division of Developmental Disabilities, The University of Western Ontario, London, ON N6A 5C2, Canada. Electronic address: .
Vaz A; Department of Psychology, The University of Western Ontario, London, ON N6A 5C2, Canada. Electronic address: .
Ossenkopp KP; Graduate Program in Neuroscience, The University of Western Ontario, London, ON N6A 5B7, Canada; Department of Psychology, The University of Western Ontario, London, ON N6A 5C2, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, The University of Western Ontario, London, ON N6A 5C2, Canada. Electronic address: .
Kavaliers M; Graduate Program in Neuroscience, The University of Western Ontario, London, ON N6A 5B7, Canada; Department of Psychology, The University of Western Ontario, London, ON N6A 5C2, Canada; The Kilee Patchell-Evans Autism Research Group, Department of Psychology, The University of Western Ontario, London, ON N6A 5C2, Canada. Electronic address: .
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Źródło :
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2014 Dec; Vol. 39, pp. 68-78. Date of Electronic Publication: 2014 Apr 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
Sex Characteristics*
Social Behavior*
Lipopolysaccharides/*toxicity
Prenatal Exposure Delayed Effects/*physiopathology
Propionates/*toxicity
Age Factors ; Animals ; Choice Behavior/drug effects ; Discrimination, Psychological/drug effects ; Disease Models, Animal ; Exploratory Behavior/drug effects ; Female ; Male ; Pregnancy ; Rats ; Rats, Long-Evans ; Recognition, Psychology ; Smell/drug effects
Czasopismo naukowe
Tytuł :
Enteric bacterial metabolites propionic and butyric acid modulate gene expression, including CREB-dependent catecholaminergic neurotransmission, in PC12 cells--possible relevance to autism spectrum disorders.
Autorzy :
Nankova BB; New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America.
Agarwal R; New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America.
MacFabe DF; The Kilee Patchell-Evans Autism Research Group, Departments of Psychology (Neuroscience) and Psychiatry, Division of Developmental Disabilities, The University of Western Ontario, London, Ontario, Canada.
La Gamma EF; New York Medical College, Department of Pediatrics/Maria Fareri Children's Hospital, Valhalla, New York, United States of America.
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Źródło :
PloS one [PLoS One] 2014 Aug 29; Vol. 9 (8), pp. e103740. Date of Electronic Publication: 2014 Aug 29 (Print Publication: 2014).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Host-Pathogen Interactions*
Butyric Acid/*metabolism
Cyclic AMP Response Element-Binding Protein/*metabolism
Enterobacteriaceae/*physiology
PC12 Cells/*microbiology
Propionates/*metabolism
Animals ; Child Development Disorders, Pervasive/microbiology ; Gene Expression Regulation ; Gene Regulatory Networks ; PC12 Cells/metabolism ; Rats ; Synaptic Transmission ; Transcriptional Activation ; Tyrosine 3-Monooxygenase/genetics
Czasopismo naukowe

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