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Wyszukujesz frazę ""Macaca fascicularis"" wg kryterium: Temat


Tytuł :
Biological implications and limitations of a cynomolgus monkey with naturally occurring Parkinson's disease.
Autorzy :
Li H; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; National Resource Center for Non-Human Primates, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China.
Yao YG; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; National Resource Center for Non-Human Primates, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China.; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China. E-mail: .
Hu XT; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China.; National Resource Center for Non-Human Primates, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China.; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China. E-mail:.
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Źródło :
Zoological research [Zool Res] 2021 Mar 18; Vol. 42 (2), pp. 138-140.
Typ publikacji :
Editorial
MeSH Terms :
Macaca fascicularis*
Monkey Diseases/*pathology
Parkinson Disease/*veterinary
Animals ; Humans ; Male ; Monkey Diseases/genetics ; Mutation ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Species Specificity
Opinia redakcyjna
Tytuł :
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.
Autorzy :
Brouwer PJM; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Brinkkemper M; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Maisonnasse P; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Dereuddre-Bosquet N; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Grobben M; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Claireaux M; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
de Gast M; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Marlin R; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Chesnais V; Life and Soft, 92350 Le Plessis-Robinson, France.
Diry S; Life and Soft, 92350 Le Plessis-Robinson, France.
Allen JD; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Watanabe Y; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK; Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.
Giezen JM; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Kerster G; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
van der Straten K; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
van der Linden CA; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Aldon Y; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Naninck T; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Bontjer I; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Burger JA; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Poniman M; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Mykytyn AZ; Department of Viroscience, Erasmus Medical Center, 3015 GD Rotterdam, the Netherlands.
Okba NMA; Department of Viroscience, Erasmus Medical Center, 3015 GD Rotterdam, the Netherlands.
Schermer EE; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
van Breemen MJ; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Ravichandran R; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Caniels TG; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
van Schooten J; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Kahlaoui N; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Contreras V; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Lemaître J; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Chapon C; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Fang RHT; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France.
Villaudy J; AIMM Therapeutics BV, 1105 BA Amsterdam, the Netherlands.
Sliepen K; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
van der Velden YU; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Haagmans BL; Department of Viroscience, Erasmus Medical Center, 3015 GD Rotterdam, the Netherlands.
de Bree GJ; Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ Amsterdam, the Netherlands.
Ginoux E; Life and Soft, 92350 Le Plessis-Robinson, France.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Crispin M; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.
King NP; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
van der Werf S; Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, CNRS UMR 3569, Université de Paris, Paris, France; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France.
van Gils MJ; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands.
Le Grand R; Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France. Electronic address: .
Sanders RW; Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, the Netherlands. Electronic address: .
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Źródło :
Cell [Cell] 2021 Mar 04; Vol. 184 (5), pp. 1188-1200.e19. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Macaca fascicularis*
COVID-19 Vaccines/*administration & dosage
COVID-19 Vaccines/*immunology
Spike Glycoprotein, Coronavirus/*chemistry
Animals ; Antibodies, Neutralizing ; B-Lymphocytes/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; Mice ; Mice, Inbred BALB C ; Models, Animal ; Nanoparticles/administration & dosage ; Rabbits ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/blood ; T-Lymphocytes/immunology ; Viral Load
Czasopismo naukowe
Tytuł :
Evolutionary pattern of Macaca fascicularis in Southeast Asia inferred using Y-chromosomal gene.
Autorzy :
Rovie-Ryan JJ; National Wildlife Forensic Laboratory, Ex-Situ Conservation Division, Department of Wildlife and National Parks (DWNP) Peninsular Malaysia, KM 10 Cheras Road, 56100, Kuala Lumpur, Malaysia.; Faculty of Resource Science and Technology (FRST), Universiti Malaysia Sarawak (UNIMAS), 94300, Kota Samarahan, Sarawak, Malaysia.
Khan FAA; Faculty of Resource Science and Technology (FRST), Universiti Malaysia Sarawak (UNIMAS), 94300, Kota Samarahan, Sarawak, Malaysia. .
Abdullah MT; Institute of Tropical Biodiversity and Sustainable Development (ITBSD), Universiti Malaysia Terengganu (UMT), 21030, Kuala Nerus, Terengganu, Malaysia.; Fellow Academy of Sciences Malaysia, Level 20, West Wing, Tingkat 20, Menara MATRADE, Jalan Sultan Haji Ahmad Shah, 50480, Kuala Lumpur, Malaysia.
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Źródło :
BMC ecology and evolution [BMC Ecol Evol] 2021 Feb 15; Vol. 21 (1), pp. 26. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Macaca fascicularis*
Phylogeny*
Animals ; Asia, Southeastern ; Bayes Theorem ; Borneo ; Indonesia ; Malaysia ; Male ; Philippines ; Thailand
Czasopismo naukowe
Tytuł :
Aerosolized pH1N1 influenza infection induces less systemic and local immune activation in the lung than combined intrabronchial, nasal and oral exposure in cynomolgus macaques.
Autorzy :
Mooij P; Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.
Mortier D; Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.
Stammes M; Department of Parasitology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.
Fagrouch Z; Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.
Verschoor EJ; Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.
Bogers WMJM; Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.
Koopman G; Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands.
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Źródło :
The Journal of general virology [J Gen Virol] 2020 Dec; Vol. 101 (12), pp. 1229-1241. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Influenza A Virus, H1N1 Subtype*/immunology
Influenza A Virus, H1N1 Subtype*/physiology
Macaca fascicularis*
Lung/*immunology
Orthomyxoviridae Infections/*immunology
Orthomyxoviridae Infections/*virology
Animals ; Bronchi/virology ; Bronchoalveolar Lavage Fluid/immunology ; Bronchoalveolar Lavage Fluid/virology ; Cytokines/blood ; Cytokines/metabolism ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Influenza, Human/immunology ; Influenza, Human/virology ; Lung/virology ; Lymphopenia ; Male ; Mouth/virology ; Nose/virology ; Orthomyxoviridae Infections/pathology ; Virus Replication ; Virus Shedding
Czasopismo naukowe
Tytuł :
Interstitial pneumonitis related to trastuzumab deruxtecan, a human epidermal growth factor receptor 2-targeting Ab-drug conjugate, in monkeys.
Autorzy :
Kumagai K; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Aida T; Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc, Tokyo, Japan.
Tsuchiya Y; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Kishino Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Kai K; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Mori K; Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
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Źródło :
Cancer science [Cancer Sci] 2020 Dec; Vol. 111 (12), pp. 4636-4645. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Macaca fascicularis*
Camptothecin/*analogs & derivatives
Immunoconjugates/*adverse effects
Immunoconjugates/*metabolism
Lung Diseases, Interstitial/*chemically induced
Trastuzumab/*adverse effects
Trastuzumab/*metabolism
Animals ; Camptothecin/administration & dosage ; Camptothecin/adverse effects ; Camptothecin/metabolism ; Cathepsin B/analysis ; Drug Administration Schedule ; Female ; Immunoconjugates/administration & dosage ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Lung Diseases, Interstitial/metabolism ; Lung Diseases, Interstitial/pathology ; Male ; Receptor, ErbB-2/metabolism ; Time Factors ; Trastuzumab/administration & dosage
Czasopismo naukowe
Tytuł :
Cryopreservation of Mauritian Cynomolgus Macaque ( Macaca fascicularis ) Sperm in Chemically Defined Medium.
Autorzy :
Strelchenko NS; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin.
Schmidt JK; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin.
Mean KD; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin.
Schotzko ML; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin.
Golos TG; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Slukvin II; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin; Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin;, Email: .
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Źródło :
Journal of the American Association for Laboratory Animal Science : JAALAS [J Am Assoc Lab Anim Sci] 2020 Nov 01; Vol. 59 (6), pp. 681-686. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Macaca fascicularis*
Semen Preservation/*veterinary
Animals ; Cryopreservation/methods ; Cryoprotective Agents/chemistry ; Ethylene Glycol/chemistry ; Female ; Fertilization in Vitro/veterinary ; Glycerol/chemistry ; Male ; Semen Preservation/methods ; Spermatozoa/cytology
Czasopismo naukowe
Tytuł :
Comparison of nonhuman primates identified the suitable model for COVID-19.
Autorzy :
Lu S; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
Zhao Y; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Yu W; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Yang Y; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Gao J; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Wang J; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Kuang D; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Yang M; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Yang J; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Ma C; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Xu J; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Qian X; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Li H; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Zhao S; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Li J; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Wang H; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Long H; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Zhou J; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Luo F; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Ding K; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Wu D; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Zhang Y; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Dong Y; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Liu Y; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
Zheng Y; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Lin X; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Jiao L; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Zheng H; Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Dai Q; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Sun Q; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Hu Y; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
Ke C; Medical Key Laboratory for Repository and Application of Pathogenic Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. .
Liu H; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China. .
Peng X; National Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China. .; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2020 Oct 19; Vol. 5 (1), pp. 157. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Pandemics*
Betacoronavirus/*pathogenicity
Callithrix/*virology
Coronavirus Infections/*epidemiology
Macaca fascicularis/*virology
Macaca mulatta/*virology
Pneumonia, Viral/*epidemiology
Animals ; Antibodies, Viral/biosynthesis ; Betacoronavirus/immunology ; Body Temperature ; Body Weight ; COVID-19 ; Callithrix/immunology ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Cytokines/biosynthesis ; Cytokines/classification ; Cytokines/immunology ; Disease Susceptibility ; Female ; Humans ; Lung/diagnostic imaging ; Lung/immunology ; Lung/pathology ; Lung/virology ; Macaca fascicularis/immunology ; Macaca mulatta/immunology ; Male ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Species Specificity ; Tomography, X-Ray Computed ; Viral Load ; Virus Replication
Czasopismo naukowe
Tytuł :
SARS-CoV-2 causes COVID-19-like disease in cynomolgus macaques.
Autorzy :
Le Bras A; Lab Animal, . .
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Źródło :
Lab animal [Lab Anim (NY)] 2020 Jun; Vol. 49 (6), pp. 174.
Typ publikacji :
Journal Article
MeSH Terms :
Disease Models, Animal*
Macaca fascicularis*
Betacoronavirus/*physiology
Coronavirus Infections/*pathology
Pneumonia, Viral/*pathology
Animals ; COVID-19 ; Coronavirus Infections/virology ; Pandemics ; Pneumonia, Viral/virology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Nonhuman primate models for SARS-CoV-2 research: Consider alternatives to macaques.
Autorzy :
Chang MC; Office of Research Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, Maryland, USA. .
Hild S; Office of Research Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, Maryland, USA.
Grieder F; Office of Research Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło :
Lab animal [Lab Anim (NY)] 2021 May; Vol. 50 (5), pp. 113-114.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*
SARS-CoV-2*
Animals ; Disease Models, Animal ; Humans ; Macaca fascicularis ; Macaca mulatta
Czasopismo naukowe
Tytuł :
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C -Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
Autorzy :
Mackman RL; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Hui HC; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Perron M; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Murakami E; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Palmiotti C; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Lee G; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Stray K; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Zhang L; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Goyal B; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Chun K; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Byun D; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Siegel D; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Simonovich S; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Du Pont V; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Pitts J; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Babusis D; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Vijjapurapu A; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Lu X; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Kim C; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Zhao X; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Chan J; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Ma B; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Lye D; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Vandersteen A; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Wortman S; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Barrett KT; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Toteva M; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Jordan R; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Subramanian R; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Bilello JP; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Cihlar T; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 5001-5017. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antiviral Agents/*pharmacology
Prodrugs/*pharmacology
Respiratory Syncytial Virus Infections/*drug therapy
Respiratory Syncytial Virus, Human/*drug effects
Adenosine Monophosphate/pharmacology ; Alanine/pharmacology ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Caco-2 Cells ; Cells, Cultured ; Chlorocebus aethiops ; Disease Models, Animal ; Dogs ; Drug Evaluation, Preclinical/methods ; Epithelial Cells/virology ; Humans ; Macaca fascicularis ; Male ; Prodrugs/chemistry ; Prodrugs/pharmacokinetics ; Rats, Sprague-Dawley ; Respiratory Syncytial Virus Infections/virology ; Structure-Activity Relationship ; Tissue Distribution ; Tubercidin/analogs & derivatives ; Tubercidin/chemistry ; Viral Load
Czasopismo naukowe
Tytuł :
AAV2/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1 A.
Autorzy :
Gautier B; INM, Univ. Montpellier, INSERM, Montpellier, France. .
Hajjar H; INM, Univ. Montpellier, INSERM, Montpellier, France.; Institute of Regenerative Medicine and Biotherapies (IRMB), University of Montpellier, INSERM, Montpellier, France.
Soares S; Sorbonne Université, CNRS, INSERM, IBPS, Neuroscience Paris Seine, Paris, France.
Berthelot J; INM, Univ. Montpellier, INSERM, Montpellier, France.
Deck M; INM, Univ. Montpellier, INSERM, Montpellier, France.
Abbou S; INM, Univ. Montpellier, INSERM, Montpellier, France.
Campbell G; INM, Univ. Montpellier, INSERM, Montpellier, France.
Ceprian M; INM, Univ. Montpellier, INSERM, Montpellier, France.; Laboratory of Pathogen-Host Interactions (LPHI), University of Montpellier, Montpellier, France.
Gonzalez S; INM, Univ. Montpellier, INSERM, Montpellier, France.; Laboratory of Pathogen-Host Interactions (LPHI), University of Montpellier, Montpellier, France.
Fovet CM; INSERM U1184, Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (ImVA-HB), IDMIT Department, CEA, Fontenay-Aux-Roses, France.
Schütza V; Institute of Anatomy, Leipzig University, Leipzig, Germany.
Jouvenel A; INM, Univ. Montpellier, INSERM, Montpellier, France.
Rivat C; INM, Univ. Montpellier, INSERM, Montpellier, France.
Zerah M; Paediatric Neurosurgery Department, Université Paris Descartes and Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Necker, Paris, France.
François V; INSERM UMR 1089, Université de Nantes, CHU de Nantes, Nantes, France.
Le Guiner C; INSERM UMR 1089, Université de Nantes, CHU de Nantes, Nantes, France.
Aubourg P; Department of Paediatric Neurology, Centre Hospitalier Universitaire de Bicêtre, Le Kremlin-Bicètre, France.; INSERM U1169, Université Paris-Sud, Orsay, France.
Fledrich R; Institute of Anatomy, Leipzig University, Leipzig, Germany. .
Tricaud N; INM, Univ. Montpellier, INSERM, Montpellier, France. .; I-Stem, UEVE/UPS U861, INSERM U861, AFM, Corbeil-Essonnes, France. .; Laboratory of Pathogen-Host Interactions (LPHI), University of Montpellier, Montpellier, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 21; Vol. 12 (1), pp. 2356. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Charcot-Marie-Tooth Disease/*genetics
Charcot-Marie-Tooth Disease/*therapy
Myelin Proteins/*antagonists & inhibitors
Myelin Proteins/*genetics
Animals ; Charcot-Marie-Tooth Disease/pathology ; Dependovirus/genetics ; Disease Models, Animal ; Female ; Gene Silencing ; Genetic Therapy/methods ; Genetic Vectors ; Humans ; Macaca fascicularis ; Male ; Mice ; Mice, Inbred C57BL ; RNA, Small Interfering/genetics ; Rats ; Rats, Mutant Strains ; Schwann Cells/metabolism ; Schwann Cells/pathology ; Sciatic Nerve/metabolism ; Sciatic Nerve/pathology
Czasopismo naukowe
Tytuł :
Paraquat pharmacokinetics in primates and extrapolation to humans.
Autorzy :
Stevens AJ; Syngenta Ltd, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK. Electronic address: .
Campbell JL Jr; Ramboll Environment and Health Consulting, 3214 Charles B. Root Wynd Suite 130, Raleigh, NC 27612, USA. Electronic address: .
Travis KZ; Syngenta Ltd, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK. Electronic address: .
Clewell HJ 3rd; Ramboll Environment and Health Consulting, 3214 Charles B. Root Wynd Suite 130, Raleigh, NC 27612, USA. Electronic address: .
Hinderliter PM; Syngenta Crop Protection LLC, P.O. Box 18300, Greensboro, NC, USA.
Botham PA; Syngenta Ltd, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK. Electronic address: .
Cook AR; Syngenta Ltd, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK. Electronic address: .
Minnema DJ; Syngenta Crop Protection LLC, P.O. Box 18300, Greensboro, NC, USA. Electronic address: .
Wolf DC; Syngenta Crop Protection LLC, Research Triangle Park, NC 27709, USA. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Apr 15; Vol. 417, pp. 115463. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Herbicides/*pharmacokinetics
Paraquat/*pharmacokinetics
Animals ; Computer Simulation ; Herbicides/administration & dosage ; Herbicides/blood ; Herbicides/toxicity ; Humans ; Infusions, Intravenous ; Intestinal Elimination ; Macaca fascicularis ; Paraquat/administration & dosage ; Paraquat/blood ; Paraquat/toxicity ; Rats ; Renal Elimination ; Risk Assessment ; Skin Absorption ; Species Specificity ; Tissue Distribution ; Toxicokinetics
Czasopismo naukowe
Tytuł :
Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice.
Autorzy :
Sun S; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
He L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Zhao Z; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Gu H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Fang X; National Institutes for Food and Drug Control, Beijing, China.
Wang T; Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun, China.
Yang X; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Chen S; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Deng Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Li J; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Zhao J; JOINN Biologics, Beijing, China.
Li L; Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun, China.
Li X; ZHONGYIANKE Biotech Co., LTD, Tianjin, China.
He P; National Institutes for Food and Drug Control, Beijing, China.
Li G; Beijing Institute of Basic Medical Sciences, Beijing, China.
Li H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Zhao Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Gao C; ZHONGYIANKE Biotech Co., LTD, Tianjin, China.
Lang X; JOINN Biologics, Beijing, China.
Wang X; ZHONGYIANKE Biotech Co., LTD, Tianjin, China.
Fei G; ZHONGYIANKE Biotech Co., LTD, Tianjin, China.
Li Y; Beijing Institute of Basic Medical Sciences, Beijing, China.
Geng S; JOINN Biologics, Beijing, China.
Gao Y; Institute of Military Veterinary, Academic of Military Medical Sciences, Changchun, China. .
Wei W; ZHONGYIANKE Biotech Co., LTD, Tianjin, China. .
Hu Z; National Institutes for Food and Drug Control, Beijing, China. .
Han G; Beijing Institute of Basic Medical Sciences, Beijing, China. .
Sun Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. .
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Źródło :
Cellular & molecular immunology [Cell Mol Immunol] 2021 Apr; Vol. 18 (4), pp. 1070-1073. Date of Electronic Publication: 2021 Mar 17.
Typ publikacji :
Letter
MeSH Terms :
COVID-19/*prevention & control
COVID-19 Vaccines/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Angiotensin-Converting Enzyme 2/chemistry ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; CHO Cells ; COVID-19/immunology ; COVID-19 Vaccines/genetics ; Cricetulus ; Immunoglobulin Fc Fragments/genetics ; Macaca fascicularis ; Mice ; Mice, Inbred BALB C ; Molecular Docking Simulation ; Protein Domains/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/immunology
Opinia redakcyjna
Tytuł :
Single-cell transcriptomic atlas of primate cardiopulmonary aging.
Autorzy :
Ma S; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
Sun S; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Li J; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.; China National Center for Bioinformation, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Fan Y; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.; China National Center for Bioinformation, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Qu J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Sun L; The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, 100730, China.; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, Yunnan, 650223, China.
Wang S; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.; Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
Zhang Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Yang S; Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
Liu Z; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Wu Z; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zhang S; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Wang Q; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.; China National Center for Bioinformation, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Zheng A; University of Chinese Academy of Sciences, Beijing, 100049, China.; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Duo S; Laboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Yu Y; Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, 100191, China.; Stem Cell Research Center, Peking University Third Hospital, Beijing, 100191, China.
Belmonte JCI; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.
Chan P; Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
Zhou Q; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.
Song M; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. .; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
Zhang W; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. .; China National Center for Bioinformation, Beijing, 100101, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .
Liu GH; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. .; Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. .; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. .; University of Chinese Academy of Sciences, Beijing, 100049, China. .; Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. .
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Źródło :
Cell research [Cell Res] 2021 Apr; Vol. 31 (4), pp. 415-432. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
Aging*
Transcriptome*/drug effects
SARS-CoV-2/*physiology
Alveolar Epithelial Cells/cytology ; Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/virology ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Ascorbic Acid/pharmacology ; COVID-19/pathology ; COVID-19/virology ; Cell Line ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Endothelial Cells/virology ; Humans ; Interleukin-7/metabolism ; Interleukin-7/pharmacology ; Macaca fascicularis ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/virology ; RNA-Seq ; SARS-CoV-2/isolation & purification ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Comparative Pharmacokinetics of Puerarin Alone and in Pueraria mirifica Extract in Female Cynomolgus Monkeys.
Autorzy :
Namken S; Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
Songvut P; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.; Translational Research Unit, Chulabhorn Research Institute, Bangkok, Thailand.
Nuengchamnong N; Science Laboratory Centre, Faculty of Science, Naresuan University, Phitsanulok, Thailand.
Kemthong T; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.
Khemawoot P; Preclinical Pharmacokinetics and Interspecies Scaling for Drug Development Research Unit, Chulalongkorn University, Bangkok, Thailand.; Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samutprakarn, Thailand.
Malaivijitnond S; Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.; National Primate Research Center of Thailand-Chulalongkorn University, Saraburi, Thailand.; Preclinical Pharmacokinetics and Interspecies Scaling for Drug Development Research Unit, Chulalongkorn University, Bangkok, Thailand.
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Źródło :
Planta medica [Planta Med] 2021 Apr; Vol. 87 (5), pp. 395-403. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Isoflavones*
Pueraria*
Animals ; Female ; Macaca fascicularis ; Phytoestrogens ; Plant Extracts ; Thailand
Czasopismo naukowe
Tytuł :
A ROCK Inhibitor Promotes Graft Survival during Transplantation of iPS-Cell-Derived Retinal Cells.
Autorzy :
Ishida M; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.; Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Sugita S; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.; Vison Care Inc, Kobe 650-0047, Japan.
Makabe K; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.
Fujii S; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.
Futatsugi Y; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.
Kamao H; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.; Department of Ophthalmology, Kawasaki Medical School, Okayama 701-0114, Japan.
Yamasaki S; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.; Regenerative and Cellular Medicine Kobe Center, Sumitomo Dainippon Pharma Co., Ltd., Kobe 650-0047, Japan.
Sakai N; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.; Vison Care Inc, Kobe 650-0047, Japan.
Maeda A; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.
Mandai M; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.
Takahashi M; RIKEN Center for Biosystems Dynamics Research, Laboratory for Retinal Regeneration, Kobe 650-0047, Japan.; Vison Care Inc, Kobe 650-0047, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 22; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article
MeSH Terms :
Stem Cell Transplantation*
Graft Survival/*drug effects
Induced Pluripotent Stem Cells/*cytology
Protein Kinase Inhibitors/*pharmacology
rho-Associated Kinases/*antagonists & inhibitors
Amides/pharmacology ; Animals ; Apoptosis/drug effects ; Biomarkers ; Cell Adhesion/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Cytokines/metabolism ; Humans ; Immunohistochemistry ; Inflammation Mediators/metabolism ; Macaca fascicularis ; Pyridines/pharmacology ; Retinal Pigment Epithelium/drug effects ; Retinal Pigment Epithelium/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2 viral dynamics in non-human primates.
Autorzy :
Gonçalves A; Université de Paris, IAME, INSERM, Paris, France.
Maisonnasse P; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Donati F; Unité de Génétique Moléculaire des Virus à ARN, GMVR: Institut Pasteur, UMR CNRS 3569, Université de Paris, Paris, France.; Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut Pasteur, Paris, France.
Albert M; Unité de Génétique Moléculaire des Virus à ARN, GMVR: Institut Pasteur, UMR CNRS 3569, Université de Paris, Paris, France.; Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut Pasteur, Paris, France.
Behillil S; Unité de Génétique Moléculaire des Virus à ARN, GMVR: Institut Pasteur, UMR CNRS 3569, Université de Paris, Paris, France.; Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut Pasteur, Paris, France.
Contreras V; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Naninck T; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Marlin R; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Solas C; Aix-Marseille Univ, APHM, Unité des Virus Emergents (UVE) IRD 190, INSERM 1207, Laboratoire de Pharmacocinétique et Toxicologie, Hôpital La Timone, Marseille, France.
Pizzorno A; CIRI, Centre International de Recherche en Infectiologie, (Team VirPath), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Lemaitre J; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Kahlaoui N; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Terrier O; CIRI, Centre International de Recherche en Infectiologie, (Team VirPath), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Ho Tsong Fang R; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Enouf V; Unité de Génétique Moléculaire des Virus à ARN, GMVR: Institut Pasteur, UMR CNRS 3569, Université de Paris, Paris, France.; Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut Pasteur, Paris, France.; Plate-forme de microbiologie mutualisée (P2M), Pasteur International Bioresources Network (PIBnet), Institut Pasteur, Paris, France.
Dereuddre-Bosquet N; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Brisebarre A; Unité de Génétique Moléculaire des Virus à ARN, GMVR: Institut Pasteur, UMR CNRS 3569, Université de Paris, Paris, France.; Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut Pasteur, Paris, France.
Touret F; Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, France.
Chapon C; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Hoen B; Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.
Lina B; CIRI, Centre International de Recherche en Infectiologie, (Team VirPath), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.; Laboratoire de Virologie, Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut des Agents Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France.
Rosa Calatrava M; CIRI, Centre International de Recherche en Infectiologie, (Team VirPath), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
de Lamballerie X; Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, France.
Mentré F; Université de Paris, IAME, INSERM, Paris, France.
Le Grand R; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
van der Werf S; Unité de Génétique Moléculaire des Virus à ARN, GMVR: Institut Pasteur, UMR CNRS 3569, Université de Paris, Paris, France.; Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut Pasteur, Paris, France.
Guedj J; Université de Paris, IAME, INSERM, Paris, France.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2021 Mar 17; Vol. 17 (3), pp. e1008785. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*virology
Macaca fascicularis/*virology
SARS-CoV-2/*physiology
Animals ; Antiviral Agents/pharmacology ; Basic Reproduction Number ; COVID-19/blood ; COVID-19/prevention & control ; Cytokines/blood ; Disease Models, Animal ; Nasopharynx/virology ; SARS-CoV-2/drug effects ; Trachea/virology ; Viral Load ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody.
Autorzy :
Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121; .
Cross RW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Geisbert JB; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Borisevich V; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Agans KN; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Prasad AN; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Enterlein S; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878.
Aman MJ; Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878.
Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Brennan MB; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Campbell L; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Kim D; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Mlakar N; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Moyer CL; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Pauly MH; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Shestowsky W; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Whaley KJ; Mapp Biopharmaceutical, Inc., San Diego, CA 92121.
Fenton KA; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
Geisbert TW; Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 16; Vol. 118 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Monoclonal, Humanized/*pharmacology
Antibodies, Viral/*pharmacology
Hemorrhagic Fever, American/*prevention & control
Junin virus/*metabolism
Animals ; Disease Models, Animal ; Female ; Guinea Pigs ; Hemorrhagic Fever, American/blood ; Humans ; Macaca fascicularis
Czasopismo naukowe
Tytuł :
Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates.
Autorzy :
Darricarrère N; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.
Qiu Y; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.
Kanekiyo M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Creanga A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Gillespie RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Moin SM; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Saleh J; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.
Sancho J; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.
Chou TH; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.
Zhou Y; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.
Zhang R; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.
Dai S; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA.
Moody A; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Saunders KO; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
Crank MC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Mascola JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Graham BS; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Wei CJ; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA. .
Nabel GJ; Sanofi, 640 Memorial Drive, Cambridge, MA 02139, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2021 Mar 03; Vol. 13 (583).
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hemagglutinin Glycoproteins, Influenza Virus/*immunology
Influenza Vaccines/*immunology
Primates/*immunology
Animals ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/chemistry ; Antigen-Antibody Complex/chemistry ; Broadly Neutralizing Antibodies/biosynthesis ; Broadly Neutralizing Antibodies/chemistry ; COVID-19 ; Ferritins/chemistry ; Ferritins/immunology ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Humans ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/chemistry ; Influenza, Human/immunology ; Influenza, Human/virology ; Macaca fascicularis ; Models, Molecular ; Nanoparticles/chemistry ; Pandemics ; Primates/virology ; Protein Structure, Quaternary ; SARS-CoV-2 ; Translational Medical Research
Czasopismo naukowe
Tytuł :
The geometry of neuronal representations during rule learning reveals complementary roles of cingulate cortex and putamen.
Autorzy :
Cohen Y; Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
Schneidman E; Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
Paz R; Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Mar 03; Vol. 109 (5), pp. 839-851.e9. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Decision Making/*physiology
Gyrus Cinguli/*physiology
Learning/*physiology
Neurons/*physiology
Putamen/*physiology
Animals ; Behavior, Animal ; Macaca fascicularis ; Male ; Psychomotor Performance/physiology
Czasopismo naukowe

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