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Wyszukujesz frazę ""Macrophage Colony-Stimulating Factor"" wg kryterium: Temat


Tytuł :
Macrophage colony-stimulating factor could evaluate both disease activity and renal involvement in systemic lupus erythematosus.
Autorzy :
Wang R; Department of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Zhao H; Basic Medical College, Henan University of Science and Technology, Luoyang, China.
Liu Y; Department of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Li Y; Department of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China. .
Cai J; Department of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China. .
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Źródło :
Annals of palliative medicine [Ann Palliat Med] 2021 Feb; Vol. 10 (2), pp. 2098-2107. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article
MeSH Terms :
Lupus Erythematosus, Systemic*
Macrophage Colony-Stimulating Factor*
Cytokines ; Granulocyte-Macrophage Colony-Stimulating Factor ; Humans ; Interferon-gamma ; Monocytes
Czasopismo naukowe
Tytuł :
Association of miltefosine with granulocyte and macrophage colony-stimulating factor (GM-CSF) in the treatment of cutaneous leishmaniasis in the Amazon region: A randomized and controlled trial.
Autorzy :
Mendes L; Programa de Pós graduação em Medicina Tropical da Universidade do Estado do Amazonas/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-UEA/FMTHVD, Manaus, Amazonas, Brazil; Universidade Federal do Amazonas, Brazil.
Guerra JO; Programa de Pós graduação em Medicina Tropical da Universidade do Estado do Amazonas/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-UEA/FMTHVD, Manaus, Amazonas, Brazil.
Costa B; Universidade Federal do Amazonas, Brazil.
Silva ASD; Programa de Pós graduação em Medicina Tropical da Universidade do Estado do Amazonas/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-UEA/FMTHVD, Manaus, Amazonas, Brazil.
Guerra MDGB; Programa de Pós graduação em Medicina Tropical da Universidade do Estado do Amazonas/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-UEA/FMTHVD, Manaus, Amazonas, Brazil.
Ortiz J; Programa de Pós graduação em Medicina Tropical da Universidade do Estado do Amazonas/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-UEA/FMTHVD, Manaus, Amazonas, Brazil.
Doria SS; Programa de Pós graduação em Medicina Tropical da Universidade do Estado do Amazonas/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-UEA/FMTHVD, Manaus, Amazonas, Brazil.
Silva GVD; Programa de Pós graduação em Medicina Tropical da Universidade do Estado do Amazonas/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-UEA/FMTHVD, Manaus, Amazonas, Brazil.
de Jesus DV; Programa de Pós graduação em Medicina Tropical da Universidade do Estado do Amazonas/Fundação de Medicina Tropical Dr. Heitor Vieira Dourado-UEA/FMTHVD, Manaus, Amazonas, Brazil.
Barral-Netto M; Instituto Gonçalo Moniz (IGM), FIOCRUZ, Bahia, Brazil.
Penna G; Núcleo de Medicina Tropical, Universidade de Brasília (UnB), Brasília-DF, e Escola Fiocruz de Governo, Fundação Oswaldo Cruz Brasília, Brazil.
Carvalho EM; Instituto Gonçalo Moniz (IGM), FIOCRUZ, Bahia, Brazil; Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Ministério da Ciência, Tecnologia, Inovações e Comunicações, CNPq, Brasília, DF, Brazil.
Machado PRL; Instituto Gonçalo Moniz (IGM), FIOCRUZ, Bahia, Brazil; Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Ministério da Ciência, Tecnologia, Inovações e Comunicações, CNPq, Brasília, DF, Brazil. Electronic address: .
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Źródło :
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Feb; Vol. 103, pp. 358-363. Date of Electronic Publication: 2020 Nov 27.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Antiprotozoal Agents/*therapeutic use
Granulocyte-Macrophage Colony-Stimulating Factor/*therapeutic use
Leishmaniasis, Cutaneous/*drug therapy
Meglumine Antimoniate/*therapeutic use
Phosphorylcholine/*analogs & derivatives
Administration, Oral ; Administration, Topical ; Adolescent ; Adult ; Antiprotozoal Agents/administration & dosage ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/administration & dosage ; Humans ; Macrophage Colony-Stimulating Factor/administration & dosage ; Macrophage Colony-Stimulating Factor/therapeutic use ; Male ; Meglumine Antimoniate/administration & dosage ; Middle Aged ; Phosphorylcholine/administration & dosage ; Phosphorylcholine/therapeutic use ; Young Adult
Czasopismo naukowe
Tytuł :
Abnormal expression of colony stimulating factor 1 receptor (CSF1R) and transcription factor PU.1 (SPI1) in the spleen from patients with major psychiatric disorders: A role of brain-spleen axis.
Autorzy :
Zhang J; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan; Department of Critical Care Medicine (Dr. Zhang), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, P.R. China.
Chang L; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Pu Y; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Hashimoto K; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan. Electronic address: .
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Źródło :
Journal of affective disorders [J Affect Disord] 2020 Jul 01; Vol. 272, pp. 110-115. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Depressive Disorder, Major*/genetics
Macrophage Colony-Stimulating Factor*/metabolism
Brain/metabolism ; Humans ; Proto-Oncogene Proteins ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Spleen/metabolism ; Trans-Activators
Czasopismo naukowe
Tytuł :
The Presence of Colony-Stimulating Factor-1 and Its Receptor in Different Cells of the Testis; It Involved in the Development of Spermatogenesis In Vitro.
Autorzy :
Sawaied A; The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.; The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Arazi E; The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.; The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
AbuElhija A; The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Lunenfeld E; The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.; Department of OB/GYN, Soroka Medical Center, Beer Sheva 8410501, Israel.; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
Huleihel M; The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.; The Center of Advanced Research and Education in Reproduction (CARER), Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8410501, Israel.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 26; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Spermatogenesis*
Macrophage Colony-Stimulating Factor/*metabolism
Testis/*metabolism
Animals ; Humans ; Male ; Mice ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Testis/cytology
Czasopismo naukowe
Tytuł :
An Early Microglial Response Is Needed To Efficiently Control Herpes Simplex Virus Encephalitis.
Autorzy :
Uyar O; Research Center in Infectious Diseases, CHU de Québec-Laval University Research Center and Department of Microbiology, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
Laflamme N; Neuroscience Laboratory, CHU de Québec-Laval University Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
Piret J; Research Center in Infectious Diseases, CHU de Québec-Laval University Research Center and Department of Microbiology, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
Venable MC; Research Center in Infectious Diseases, CHU de Québec-Laval University Research Center and Department of Microbiology, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
Carbonneau J; Research Center in Infectious Diseases, CHU de Québec-Laval University Research Center and Department of Microbiology, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
Zarrouk K; Research Center in Infectious Diseases, CHU de Québec-Laval University Research Center and Department of Microbiology, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
Rivest S; Neuroscience Laboratory, CHU de Québec-Laval University Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.
Boivin G; Research Center in Infectious Diseases, CHU de Québec-Laval University Research Center and Department of Microbiology, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada .
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Źródło :
Journal of virology [J Virol] 2020 Nov 09; Vol. 94 (23). Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Encephalitis, Herpes Simplex/*metabolism
Herpesvirus 1, Human/*metabolism
Macrophage Colony-Stimulating Factor/*metabolism
Macrophage Colony-Stimulating Factor/*pharmacology
Microglia/*metabolism
Microglia/*virology
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*metabolism
Animals ; Brain/virology ; Central Nervous System/metabolism ; Chemokines/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Macrophage Colony-Stimulating Factor/genetics ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/metabolism ; Phagocytosis ; Receptor, Macrophage Colony-Stimulating Factor/genetics ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Viral Load
Czasopismo naukowe
Tytuł :
A Transgenic Line That Reports CSF1R Protein Expression Provides a Definitive Marker for the Mouse Mononuclear Phagocyte System.
Autorzy :
Grabert K; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH259RG, United Kingdom.
Sehgal A; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Queensland 4102, Australia.
Irvine KM; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Queensland 4102, Australia.
Wollscheid-Lengeling E; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH259RG, United Kingdom.
Ozdemir DD; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH259RG, United Kingdom.
Stables J; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Queensland 4102, Australia.
Luke GA; School of Biology, University of St Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom.
Ryan MD; School of Biology, University of St Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom.
Adamson A; Faculty of Biology, Medicine and Health, School of Biological Sciences, Manchester M13 9PT, United Kingdom.
Humphreys NE; Faculty of Biology, Medicine and Health, School of Biological Sciences, Manchester M13 9PT, United Kingdom.
Sandrock CJ; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Queensland 4102, Australia.
Rojo R; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, 64710 Monterrey, Mexico; and.
Verkasalo VA; Centre for Inflammation Research, University of Edinburgh, Little France, Edinburgh EH16 4TJ, United Kingdom.
Mueller W; Faculty of Biology, Medicine and Health, School of Biological Sciences, Manchester M13 9PT, United Kingdom.
Hohenstein P; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH259RG, United Kingdom.
Pettit AR; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Queensland 4102, Australia.
Pridans C; Centre for Inflammation Research, University of Edinburgh, Little France, Edinburgh EH16 4TJ, United Kingdom.
Hume DA; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Brisbane, Queensland 4102, Australia; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2020 Dec 01; Vol. 205 (11), pp. 3154-3166. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers/*metabolism
Mononuclear Phagocyte System/*metabolism
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*metabolism
Animals ; Cell Differentiation/physiology ; Dendritic Cells/metabolism ; Hematopoietic Stem Cells/metabolism ; Macrophage Colony-Stimulating Factor/metabolism ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Monocytes/metabolism ; Muscle, Skeletal/metabolism ; RNA, Messenger/metabolism ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Tendons/metabolism
Czasopismo naukowe
Tytuł :
Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE.
Autorzy :
Hu X; Department of Neurology, Guizhou Provincial People's Hospital, Guiyang 550002, China.; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.
Li S; Department of Neurology, Guizhou Provincial People's Hospital, Guiyang 550002, China.; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.
Doycheva DM; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.
Huang L; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.; Department of Neurosurgery, Loma Linda University, Loma Linda, CA 92350, USA.
Lenahan C; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.; Burrell College of Osteopathic Medicine, Las Cruces, NM 88003, USA.
Liu R; Department of Neurology, Guizhou Provincial People's Hospital, Guiyang 550002, China.; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.
Huang J; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.; Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China.
Gao L; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.; Department of Neurosurgery, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, Hainan 570208, China.
Tang J; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.
Zuo G; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.; Department of Neurosurgery, Taicang Hospital Affiliated to Soochow University, Taicang, Suzhou, Jiangsu 215400, China.
Zhang JH; Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USA.; Department of Neurosurgery, Loma Linda University, Loma Linda, CA 92350, USA.; Department of Anesthesiology, Loma Linda University, Loma Linda, CA 92350, USA.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Oct 07; Vol. 2020, pp. 6801587. Date of Electronic Publication: 2020 Oct 07 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Hypoxia-Ischemia, Brain/*pathology
Macrophage Colony-Stimulating Factor/*pharmacology
Neuroprotective Agents/*pharmacology
Oxidative Stress/*drug effects
Signal Transduction/*drug effects
Animals ; Benzothiazoles/pharmacology ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Disease Models, Animal ; Humans ; Macrophage Colony-Stimulating Factor/genetics ; Macrophage Colony-Stimulating Factor/metabolism ; Neurons/cytology ; Neurons/metabolism ; Phospholipase C gamma/antagonists & inhibitors ; Phospholipase C gamma/metabolism ; Picolinic Acids/pharmacology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/pharmacology ; Uncoupling Protein 2/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages.
Autorzy :
Joshi N; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; These authors contributed equally to this work.
Watanabe S; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Dept of Respiratory Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.; These authors contributed equally to this work.
Verma R; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; These authors contributed equally to this work.
Jablonski RP; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Dept of Medicine, Section of Pulmonary and Critical Care, The University of Chicago, Chicago, IL, USA.
Chen CI; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Cheresh P; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Dept of Medicine, Division of Pulmonary and Critical Care Medicine, Jesse Brown VA Medical Center, Chicago, IL, USA.
Markov NS; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Reyfman PA; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
McQuattie-Pimentel AC; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Sichizya L; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lu Z; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Piseaux-Aillon R; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kirchenbuechler D; Center for Advanced Microscopy, Robert H. Lurie Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Flozak AS; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Gottardi CJ; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Cuda CM; Division of Rheumatology, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Perlman H; Division of Rheumatology, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jain M; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Dept of Medicine, Division of Pulmonary and Critical Care Medicine, Jesse Brown VA Medical Center, Chicago, IL, USA.
Kamp DW; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Dept of Medicine, Division of Pulmonary and Critical Care Medicine, Jesse Brown VA Medical Center, Chicago, IL, USA.
Budinger GRS; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Dept of Medicine, Division of Pulmonary and Critical Care Medicine, Jesse Brown VA Medical Center, Chicago, IL, USA.; These authors contributed equally to this work.
Misharin AV; Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA .; These authors contributed equally to this work.
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Źródło :
The European respiratory journal [Eur Respir J] 2020 Jan 16; Vol. 55 (1). Date of Electronic Publication: 2020 Jan 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Macrophage Colony-Stimulating Factor*
Pulmonary Fibrosis*/chemically induced
Pulmonary Fibrosis*/pathology
Animals ; Fibrosis ; Macrophages/pathology ; Macrophages, Alveolar ; Mice ; Monocytes ; Receptor, Macrophage Colony-Stimulating Factor
Czasopismo naukowe
Tytuł :
Possible inhibition of GM-CSF production by SARS-CoV-2 spike-based vaccines.
Autorzy :
Li J; The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.
Wang P; The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, NY, 11549, USA.
Tracey KJ; The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, NY, 11549, USA.
Wang H; The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA. .; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, NY, 11549, USA. .
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Źródło :
Molecular medicine (Cambridge, Mass.) [Mol Med] 2021 May 22; Vol. 27 (1), pp. 49. Date of Electronic Publication: 2021 May 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Antibodies, Neutralizing/*metabolism
COVID-19/*prevention & control
COVID-19 Vaccines/*therapeutic use
Granulocyte-Macrophage Colony-Stimulating Factor/*antagonists & inhibitors
Spike Glycoprotein, Coronavirus/*metabolism
Antibodies, Neutralizing/immunology ; COVID-19/metabolism ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Host-Pathogen Interactions/drug effects ; Humans ; Protein Binding/drug effects ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/immunology ; Virus Internalization/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Granulocyte-macrophage colony-stimulating factor mRNA and Neuroprotective Immunity in Parkinson's disease.
Autorzy :
Olson KE; Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Namminga KL; Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Lu Y; Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Thurston MJ; Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Schwab AD; Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
de Picciotto S; Moderna, Inc., Cambridge, MA, 02139, USA.
Tse SW; Moderna, Inc., Cambridge, MA, 02139, USA.
Walker W; Moderna, Inc., Cambridge, MA, 02139, USA.
Iacovelli J; Moderna, Inc., Cambridge, MA, 02139, USA.
Small C; Moderna, Inc., Cambridge, MA, 02139, USA.
Wipke BT; Moderna, Inc., Cambridge, MA, 02139, USA.
Mosley RL; Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: .
Huang E; Moderna, Inc., Cambridge, MA, 02139, USA.
Gendelman HE; Department of Pharmacology and Experimental Neuroscience, Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: .
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Źródło :
Biomaterials [Biomaterials] 2021 May; Vol. 272, pp. 120786. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Granulocyte-Macrophage Colony-Stimulating Factor*/genetics
Parkinson Disease*/genetics
Parkinson Disease*/therapy
Animals ; Mice ; Mice, Inbred C57BL ; Neuroprotection ; RNA, Messenger/genetics ; Rats
Czasopismo naukowe
Tytuł :
Discovery of potent colony-stimulating factor 1 receptor inhibitors by replacement of hinge-binder moieties.
Autorzy :
Lee JW; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea.
Park J; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea.
Kim J; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea.
Kim J; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea.
Choi C; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea.
Min KH; College of Pharmacy, Chung-Ang University, Seoul, 06974, Republic of Korea; Department of Global Innovative Drugs, Graduate School of Chung-Ang University, Seoul, 06974, Republic of Korea. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113298. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Protein Kinase Inhibitors/*chemistry
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*antagonists & inhibitors
Animals ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/chemistry ; Pyrazoles/metabolism ; Pyrazoles/pharmacology ; Pyridines/chemistry ; Pyridines/metabolism ; Pyridines/pharmacology ; RAW 264.7 Cells ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Targeting colony stimulating factor-1 receptor signalling to treat ectopic pregnancy.
Autorzy :
Ahmad SF; MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK.
Duncan WC; MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK.
Campbell LL; MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK.
Beaty RE; Edinburgh Medical School, University of Edinburgh, Edinburgh, EH16 4SA, UK.
Koscielniak M; MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK.
Collins F; Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK.
Saunders PTK; Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK.
Horne AW; MRC Centre for Reproductive Health, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK. .
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 24; Vol. 10 (1), pp. 15638. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Targeted Therapy*
Pregnancy, Ectopic/*drug therapy
Pregnancy, Ectopic/*pathology
Receptor, Macrophage Colony-Stimulating Factor/*metabolism
Signal Transduction/*drug effects
Cell Death/drug effects ; Cell Line ; Cell Movement/drug effects ; Female ; Gene Expression Regulation/drug effects ; Humans ; Macrophage Colony-Stimulating Factor/metabolism ; Pregnancy ; Pregnancy, Ectopic/metabolism ; Receptor, Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Trophoblasts/drug effects ; Trophoblasts/pathology
Czasopismo naukowe
Tytuł :
Microglia: Same same, but different.
Autorzy :
Kierdorf K; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany .; Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Prinz M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany .; Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
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Źródło :
The Journal of experimental medicine [J Exp Med] 2019 Oct 07; Vol. 216 (10), pp. 2223-2225. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Macrophage Colony-Stimulating Factor*
Microglia*
Animals ; Interpersonal Relations ; Mice ; Receptor, Macrophage Colony-Stimulating Factor ; Signal Transduction
Czasopismo naukowe
Tytuł :
Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis.
Autorzy :
Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; Center for Data Sciences, Harvard Medical School, Boston, USA.; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, USA.
Yamaguchi E; Division of Respiratory Medicine and Allergology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Aichi, Japan.
Inoue Y; Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan.
Takahashi M; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hirata J; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Pharmaceutical Discovery Research Laboratories, TEIJIN PHARMA LIMITED, Hino, Japan.
Suzuki K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Ito S; Division of Respiratory Medicine and Allergology, Department of Internal Medicine, School of Medicine, Aichi Medical University, Aichi, Japan.
Arai T; Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan.
Hirose M; Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan.
Tanino Y; Department of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.
Nikaido T; Department of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.
Ichiwata T; Department Respiratory Medicine, Tokyo Medical University, Tokyo, Japan.
Ohkouchi S; Occupational Health, Graduate School of Medicine, Tohoku University, Miyagi, Japan.
Hirano T; Respiratory Medicine, School of Medicine, Tohoku University, Miyagi, Japan.
Takada T; Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.
Miyawaki S; Department of Neurosurgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan.
Dofuku S; Department of Neurosurgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan.
Maeda Y; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Immune Regulation, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Nii T; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Immune Regulation, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Kishikawa T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Ogawa K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Masuda T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan.
Yamamoto K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.
Sonehara K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Tazawa R; Student Support and Health Administration Organization, Tokyo Medical and Dental University, Tokyo, Japan.
Morimoto K; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Takaki M; Department of Infectious Diseases, Nagasaki University Hospital, Nagasaki University, Nagasaki, Japan.
Konno S; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Suzuki M; Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Tomii K; Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
Nakagawa A; Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
Handa T; Department of Advanced Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tanizawa K; Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ishii H; Department of Respiratory Medicine, Kyorin University, Mitaka, Japan.
Ishida M; Department of Respiratory Medicine, Kyorin University, Mitaka, Japan.
Kato T; Department of Respiratory Medicine and Allergology, Kariya Toyota General Hospital, Kariya, Japan.
Takeda N; Department of Respiratory Medicine and Allergology, Kariya Toyota General Hospital, Kariya, Japan.
Yokomura K; Department of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
Matsui T; Department of Respiratory Medicine, Respiratory Disease Center, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
Watanabe M; Department of Pulmonary Medicine, Graduate School of Medical & Dental Sciences, Kagoshima University, Kagoshima, Japan.
Inoue H; Department of Pulmonary Medicine, Graduate School of Medical & Dental Sciences, Kagoshima University, Kagoshima, Japan.
Imaizumi K; Department of Respiratory Medicine, Fujita Health University School of Medicine, Aichi, Japan.
Goto Y; Department of Respiratory Medicine, Fujita Health University School of Medicine, Aichi, Japan.
Kida H; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Toyonaka, Japan.
Fujisawa T; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Suda T; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yamada T; Department of Respiratory Medicine, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.
Satake Y; Department of Respiratory Medicine, Shizuoka City Shizuoka Hospital, Shizuoka, Japan.
Ibata H; Department of Respiratory Medicine, National Hospital Organization Mie Chuo Medical Center, Tsu, Japan.
Hizawa N; Department of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Mochizuki H; Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.
Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nakata K; Division of Advanced Medical Development, Niigata University Medical and Dental Hospital, Niigata, Japan.
Hirota T; Division of Molecular Genetics, the Jikei University School of Medicine, Research Center for Medical Science, Tokyo, Japan.
Tamari M; Division of Molecular Genetics, the Jikei University School of Medicine, Research Center for Medical Science, Tokyo, Japan.
Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. .; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan. .; Laboratory of Statistical Immunology, World Premier International Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 15; Vol. 12 (1), pp. 1032. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Predisposition to Disease*
Autoantibodies/*genetics
Autoimmune Diseases/*genetics
Granulocyte-Macrophage Colony-Stimulating Factor/*genetics
HLA-DRB1 Chains/*genetics
Pulmonary Alveolar Proteinosis/*genetics
Adult ; Aged ; Alleles ; Asian Continental Ancestry Group ; Autoantibodies/biosynthesis ; Autoimmune Diseases/ethnology ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Case-Control Studies ; Chromosomes, Human, Pair 6 ; Female ; Gene Expression ; Gene Frequency ; Genome-Wide Association Study ; Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & inhibitors ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; HLA-DRB1 Chains/immunology ; Humans ; Japan ; Male ; Middle Aged ; Odds Ratio ; Protein Isoforms/genetics ; Pulmonary Alveolar Proteinosis/ethnology ; Pulmonary Alveolar Proteinosis/immunology ; Pulmonary Alveolar Proteinosis/pathology ; Pulmonary Surfactants/immunology ; Pulmonary Surfactants/metabolism ; Risk
Czasopismo naukowe
Tytuł :
Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis.
Autorzy :
Sinha SK; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA (S.K.S., T.B.R.).
Miikeda A; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Fouladian Z; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Mehrabian M; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Edillor C; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Shih D; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Zhou Z; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Paul MK; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Charugundla S; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Davis RC; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
Rajavashisth TB; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA (S.K.S., T.B.R.).; Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India (T.B.R.).
Lusis AJ; Department of Microbiology, Immunology, and Molecular Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Medicine (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.; Department of Human Genetics (S.K.S., A.M., Z.F., M.M., C.E., D.S., Z.Z., M.K.P., S.C., R.C.D., T.B.R., A.J.L.), University of California, Los Angeles.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Jan; Vol. 41 (1), pp. 220-233. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Cell Proliferation*
Atherosclerosis/*metabolism
Endothelial Cells/*metabolism
Macrophage Colony-Stimulating Factor/*metabolism
Macrophages/*metabolism
Muscle, Smooth, Vascular/*metabolism
Myocytes, Smooth Muscle/*metabolism
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Aorta/metabolism ; Aorta/pathology ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Atherosclerosis/prevention & control ; Cadherins/genetics ; Cadherins/metabolism ; Disease Models, Animal ; Endothelial Cells/pathology ; Female ; Macrophage Colony-Stimulating Factor/deficiency ; Macrophage Colony-Stimulating Factor/genetics ; Macrophages/pathology ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/pathology ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE.
Autorzy :
Hu X; Department of Neurology, Guizhou Provincial People's Hospital, Guiyang, 550002, China.; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.
Li S; Department of Neurology, Guizhou Provincial People's Hospital, Guiyang, 550002, China.; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.
Doycheva DM; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.
Huang L; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.; Department of Neurosurgery, Loma Linda University, Loma Linda, CA, 92350, USA.
Lenahan C; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.; Bvrrell College of Osteopathic Medicine, Las Cruces, NM, 88003, USA.
Liu R; Department of Neurology, Guizhou Provincial People's Hospital, Guiyang, 550002, China.; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.
Huang J; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.; Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Xie S; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.; Department of Hepatobiliary Surgery, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, 570208, Hainan, China.
Tang J; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA.
Zuo G; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA. .; Department of Neurosurgery, Taicang Hospital Affiliated to Soochow University, Taicang, Suzhou, 215400, Jiangsu, China. .
Zhang JH; Department of Physiology and Pharmacology, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92350, USA. .; Department of Neurosurgery, Loma Linda University, Loma Linda, CA, 92350, USA. .; Department of Anesthesiology, Loma Linda University, Loma Linda, CA, 92350, USA. .
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Źródło :
Journal of neuroinflammation [J Neuroinflammation] 2020 Jun 10; Vol. 17 (1), pp. 182. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia-Ischemia, Brain/*metabolism
Inflammation/*metabolism
Macrophage Colony-Stimulating Factor/*pharmacology
Neuroprotective Agents/*pharmacology
Signal Transduction/*drug effects
Animals ; Animals, Newborn ; Humans ; Hypoxia-Ischemia, Brain/physiopathology ; Macrophage Colony-Stimulating Factor/metabolism ; Neuroprotective Agents/metabolism ; Phospholipase C gamma/metabolism ; Protein Kinase C-epsilon/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system.
Autorzy :
Wu Z; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Harne R; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Chintoan-Uta C; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Hu TJ; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Wallace R; The Department of Orthopedic Surgery, University of Edinburgh, Chancellor's Building, Edinburgh BioQuarter, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.
MacCallum A; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Stevens MP; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Kaiser P; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Balic A; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK. Electronic address: .
Hume DA; Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD, 4104, Australia. Electronic address: .
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Źródło :
Developmental and comparative immunology [Dev Comp Immunol] 2020 Apr; Vol. 105, pp. 103586. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*isolation & purification
Antibodies, Blocking/*isolation & purification
Avian Proteins/*genetics
Bursa of Fabricius/*metabolism
Chickens/*immunology
Macrophage Colony-Stimulating Factor/*genetics
Macrophages/*physiology
Animals ; Avian Proteins/metabolism ; Cell Differentiation ; Cells, Cultured ; Chick Embryo ; Gene Expression Regulation, Developmental ; Immunoglobulin Fc Fragments/genetics ; Macrophage Colony-Stimulating Factor/immunology ; Macrophage Colony-Stimulating Factor/metabolism ; Receptor, Macrophage Colony-Stimulating Factor/genetics ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Recombinant Fusion Proteins/genetics
Czasopismo naukowe
Tytuł :
Severe COVID-19 infection in a child receiving immunotherapy for cancer.
Autorzy :
Smith VR; Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Whittle SB; Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Coleman RD; Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.; Section of Pulmonary Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Munoz FM; Section of Infectious Disease, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
De Guzman MM; Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Foster JH; Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Navai SA; Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Pokaż więcej
Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2021 Mar; Vol. 68 (3), pp. e28710. Date of Electronic Publication: 2020 Sep 15.
Typ publikacji :
Case Reports; Letter; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19/*therapy
Granulocyte-Macrophage Colony-Stimulating Factor/*adverse effects
Immunologic Factors/*adverse effects
Immunotherapy/*adverse effects
Neuroblastoma/*drug therapy
Child ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use ; Humans ; Immunologic Factors/therapeutic use ; Immunotherapy/methods ; Infant ; SARS-CoV-2/drug effects
Raport
Tytuł :
Small-molecule CSF1R kinase inhibitors; review of patents 2015-present.
Autorzy :
Denny WA; Auckland Cancer Society Research Centre, School of Medical Sciences and Maurice Wilkins Centre, University of Auckland , Auckland, New Zealand.
Flanagan JU; Auckland Cancer Society Research Centre, School of Medical Sciences and Maurice Wilkins Centre, University of Auckland , Auckland, New Zealand.; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, University of Auckland , Auckland, New Zealand.
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Źródło :
Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2021 Feb; Vol. 31 (2), pp. 107-117. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Receptor, Macrophage Colony-Stimulating Factor/*antagonists & inhibitors
Animals ; Disease Progression ; Humans ; Neoplasm Metastasis ; Neoplasms/pathology ; Patents as Topic ; Receptor, Macrophage Colony-Stimulating Factor/metabolism ; Tumor-Associated Macrophages/metabolism
Czasopismo naukowe
Tytuł :
Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622.
Autorzy :
Lei F; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
Cui N; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.
Zhou C; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
Chodosh J; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
Vavvas DG; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114.
Paschalis EI; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).
Typ publikacji :
Letter; Comment
MeSH Terms :
Microglia*
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor*
Hematopoiesis ; Macrophages ; Organic Chemicals
Opinia redakcyjna

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