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Tytuł :
Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress.
Autorzy :
Amano R; Department of Microbiology, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
Yamashita A; Department of Microbiology, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
Kasai H; Department of Microbiology, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
Hori T; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Miyasato S; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Saito S; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Yokoe H; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Takahashi K; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Tanaka T; Department of Microbiology, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
Otoguro T; Department of Microbiology, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
Maekawa S; The First Department of Internal Medicine, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
Enomoto N; The First Department of Internal Medicine, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.
Tsubuki M; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Moriishi K; Department of Microbiology, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan. Electronic address: .
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Źródło :
Antiviral research [Antiviral Res] 2017 Sep; Vol. 145, pp. 123-130. Date of Electronic Publication: 2017 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Oxidative Stress*
Antiviral Agents/*pharmacology
Cinnamates/*pharmacology
Hepacivirus/*drug effects
Virus Replication/*drug effects
Antiviral Agents/chemical synthesis ; Cell Line ; Cinnamates/chemical synthesis ; Cinnamates/chemistry ; DNA Replication/drug effects ; Hepacivirus/physiology ; Hepatitis C/virology ; High-Throughput Screening Assays ; Humans ; RNA, Viral ; Reactive Oxygen Species/metabolism ; Replicon/drug effects ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Involvement of FKBP6 in hepatitis C virus replication.
Autorzy :
Kasai H; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Kawakami K; Faculty of Life and Environmental Sciences, University of Yamanashi, Kofu-shi, Yamanashi 400-8510, Japan.
Yokoe H; Institute of Medical Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Yoshimura K; Department of Anatomy and Cell Biology, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Matsuda M; Department of First Surgery, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Yasumoto J; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Maekawa S; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Yamashita A; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Tanaka T; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Ikeda M; Department of Tumor Virology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Okayama 700-8530, Japan.
Kato N; Department of Tumor Virology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Okayama 700-8530, Japan.
Okamoto T; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Matsuura Y; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
Sakamoto N; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan.
Enomoto N; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Takeda S; Department of Anatomy and Cell Biology, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Fujii H; Department of First Surgery, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
Tsubuki M; Institute of Medical Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Kusunoki M; Faculty of Life and Environmental Sciences, University of Yamanashi, Kofu-shi, Yamanashi 400-8510, Japan.
Moriishi K; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Chuo-shi, Yamanashi 409-3898, Japan.
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Źródło :
Scientific reports [Sci Rep] 2015 Nov 16; Vol. 5, pp. 16699. Date of Electronic Publication: 2015 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*
Hepacivirus/*physiology
Tacrolimus Binding Proteins/*metabolism
Viral Nonstructural Proteins/*metabolism
CRISPR-Cas Systems/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cycloheximide/analogs & derivatives ; Cycloheximide/pharmacology ; HEK293 Cells ; Humans ; Microscopy, Fluorescence ; Protein Interaction Domains and Motifs ; Protein Multimerization/drug effects ; RNA Interference ; RNA, Double-Stranded/metabolism ; RNA, Small Interfering/metabolism ; Tacrolimus Binding Proteins/antagonists & inhibitors ; Tacrolimus Binding Proteins/genetics ; Viral Nonstructural Proteins/chemistry
Czasopismo naukowe
Tytuł :
Resistance-Associated NS5A Variants of Hepatitis C Virus Are Susceptible to Interferon-Based Therapy.
Autorzy :
Itakura J; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Kurosaki M; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Higuchi M; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Takada H; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Nakakuki N; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Itakura Y; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Tamaki N; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Yasui Y; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Suzuki S; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Tsuchiya K; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Nakanishi H; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Takahashi Y; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
Maekawa S; First Department of Internal Medicine, University of Yamanashi, Chuou Yamanashi, Japan.
Enomoto N; First Department of Internal Medicine, University of Yamanashi, Chuou Yamanashi, Japan.
Izumi N; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino, Tokyo, Japan.
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Źródło :
PloS one [PLoS One] 2015 Sep 14; Vol. 10 (9), pp. e0138060. Date of Electronic Publication: 2015 Sep 14 (Print Publication: 2015).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation, Missense*
Antiviral Agents/*administration & dosage
Drug Resistance, Viral/*genetics
Hepacivirus/*genetics
Hepatitis C/*genetics
Interferons/*administration & dosage
Viral Nonstructural Proteins/*genetics
Amino Acid Substitution ; Drug Resistance, Viral/drug effects ; Drug Therapy, Combination/methods ; Female ; Hepacivirus/enzymology ; Hepatitis C/drug therapy ; Hepatitis C/enzymology ; Humans ; Male ; Ribavirin/administration & dosage ; Simeprevir/administration & dosage ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Deep sequencing and phylogenetic analysis of variants resistant to interferon-based protease inhibitor therapy in chronic hepatitis induced by genotype 1b hepatitis C virus.
Autorzy :
Sato M; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Maekawa S; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan maekawa@yamanashi.ac.jp.
Komatsu N; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Tatsumi A; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Miura M; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Muraoka M; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Suzuki Y; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Amemiya F; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Takano S; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Fukasawa M; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Nakayama Y; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Yamaguchi T; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Uetake T; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Inoue T; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Sato T; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Sakamoto M; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Yamashita A; Department of Microbiology, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Moriishi K; Department of Microbiology, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Enomoto N; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
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Źródło :
Journal of virology [J Virol] 2015 Jun; Vol. 89 (11), pp. 6105-16. Date of Electronic Publication: 2015 Mar 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Viral*
Phylogeny*
Antiviral Agents/*therapeutic use
Hepacivirus/*classification
Hepatitis C, Chronic/*virology
Protease Inhibitors/*therapeutic use
Adult ; Aged ; Base Sequence ; Female ; Genotype ; Hepacivirus/genetics ; Hepacivirus/isolation & purification ; Hepatitis C, Chronic/drug therapy ; High-Throughput Nucleotide Sequencing ; Humans ; Interferon-alpha/therapeutic use ; Male ; Middle Aged ; Molecular Sequence Data ; Oligopeptides/therapeutic use ; Ribavirin/therapeutic use ; Sequence Alignment ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Hallmarks of hepatitis C virus in equine hepacivirus.
Autorzy :
Tanaka T; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Kasai H; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Yamashita A; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Okuyama-Dobashi K; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Yasumoto J; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Maekawa S; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Enomoto N; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Okamoto T; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Matsuura Y; Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Morimatsu M; Laboratory of Laboratory Animal Science and Medicine, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Manabe N; Animal Resource Science Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Kasama, Japan.
Ochiai K; Department of Basic Science, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan.
Yamashita K; Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Moriishi K; Department of Microbiology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan .
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Źródło :
Journal of virology [J Virol] 2014 Nov; Vol. 88 (22), pp. 13352-66. Date of Electronic Publication: 2014 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
Hepacivirus/*isolation & purification
Hepatitis C/*veterinary
Horse Diseases/*virology
RNA, Viral/*genetics
Animals ; Conserved Sequence ; Gene Order ; Hepacivirus/genetics ; Hepacivirus/immunology ; Hepatitis C/virology ; Hepatitis C Antibodies/blood ; Horses ; Japan ; Molecular Sequence Data ; RNA, Viral/blood ; Sequence Analysis, DNA ; Sequence Homology
Czasopismo naukowe
Tytuł :
Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus.
Autorzy :
Shen H; Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
Yamashita A; Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
Nakakoshi M; Faculty of Pharmaceutical Sciences, Toho University, Chiba, Japan.
Yokoe H; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Sudo M; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Kasai H; Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
Tanaka T; Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
Fujimoto Y; Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
Ikeda M; Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Kato N; Department of Tumor Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Sakamoto N; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Shindo H; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Maekawa S; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Enomoto N; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Tsubuki M; Institute of Medical Chemistry, Hoshi University, Tokyo, Japan.
Moriishi K; Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
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Źródło :
PloS one [PLoS One] 2013 Dec 17; Vol. 8 (12), pp. e82299. Date of Electronic Publication: 2013 Dec 17 (Print Publication: 2013).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Caffeic Acids/*pharmacology
Hepacivirus/*physiology
Phenylethyl Alcohol/*analogs & derivatives
Virus Replication/*drug effects
Hepacivirus/genetics ; Phenylethyl Alcohol/pharmacology ; RNA, Viral/genetics ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Deep-sequencing analysis of the association between the quasispecies nature of the hepatitis C virus core region and disease progression.
Autorzy :
Miura M; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.
Maekawa S
Takano S
Komatsu N
Tatsumi A
Asakawa Y
Shindo K
Amemiya F
Nakayama Y
Inoue T
Sakamoto M
Yamashita A
Moriishi K
Enomoto N
Pokaż więcej
Źródło :
Journal of virology [J Virol] 2013 Dec; Vol. 87 (23), pp. 12541-51. Date of Electronic Publication: 2013 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*virology
Hepacivirus/*genetics
Hepacivirus/*isolation & purification
Hepatitis C, Chronic/*virology
Liver Cirrhosis/*virology
Liver Neoplasms/*virology
Viral Core Proteins/*genetics
Adult ; Aged ; Aged, 80 and over ; Amino Acid Sequence ; Carcinoma, Hepatocellular/pathology ; Disease Progression ; Female ; Genotype ; Hepacivirus/chemistry ; Hepacivirus/classification ; Hepatitis C, Chronic/pathology ; High-Throughput Nucleotide Sequencing ; Humans ; Liver Cirrhosis/pathology ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Molecular Sequence Data ; Mutation, Missense ; Phylogeny ; Sequence Alignment ; Viral Core Proteins/chemistry ; Young Adult
Czasopismo naukowe
Tytuł :
IL-28B (IFN-λ3) and IFN-α synergistically inhibit HCV replication.
Autorzy :
Shindo H; First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan.
Maekawa S
Komase K
Miura M
Kadokura M
Sueki R
Komatsu N
Shindo K
Amemiya F
Nakayama Y
Inoue T
Sakamoto M
Yamashita A
Moriishi K
Enomoto N
Pokaż więcej
Źródło :
Journal of viral hepatitis [J Viral Hepat] 2013 Apr; Vol. 20 (4), pp. 281-9. Date of Electronic Publication: 2012 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Biological Products/*pharmacology
Hepacivirus/*drug effects
Hepacivirus/*physiology
Interferon-alpha/*pharmacology
Interleukins/*pharmacology
Virus Replication/*drug effects
Cell Line ; Drug Synergism ; Gene Expression Profiling ; Hepatocytes/immunology ; Hepatocytes/virology ; Humans ; Interferons ; Microarray Analysis
Czasopismo naukowe
Tytuł :
Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection.
Autorzy :
Maekawa S; Department of Advanced Medicine for Liver Diseases, University of Yamanashi, Yamanashi, Japan. maekawa@yamanashi.ac.jp
Sakamoto M
Miura M
Kadokura M
Sueki R
Komase K
Shindo H
Komatsu N
Shindo K
Kanayama A
Ohmori T
Amemiya F
Takano S
Yamaguchi T
Nakayama Y
Kitamura T
Inoue T
Okada S
Enomoto N
Pokaż więcej
Źródło :
Hepatology (Baltimore, Md.) [Hepatology] 2012 Nov; Vol. 56 (5), pp. 1611-21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*therapeutic use
Drug Resistance, Viral/*genetics
Hepacivirus/*genetics
Hepatitis C, Chronic/*drug therapy
Hepatitis C, Chronic/*genetics
Interleukins/*genetics
Viral Nonstructural Proteins/*genetics
Adolescent ; Adult ; Aged ; Alleles ; Female ; Genotype ; Humans ; Interferons/therapeutic use ; Japan ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Open Reading Frames ; Polyethylene Glycols/therapeutic use ; Polymorphism, Single Nucleotide ; Recurrence ; Retrospective Studies ; Ribavirin/therapeutic use ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia.
Autorzy :
Yamashita A; Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan. />Salam KA
Furuta A
Matsuda Y
Fujita O
Tani H
Fujita Y
Fujimoto Y
Ikeda M
Kato N
Sakamoto N
Maekawa S
Enomoto N
Nakakoshi M
Tsubuki M
Sekiguchi Y
Tsuneda S
Akimitsu N
Noda N
Tanaka J
Moriishi K
Pokaż więcej
Źródło :
Marine drugs [Mar Drugs] 2012 Apr; Vol. 10 (4), pp. 744-61. Date of Electronic Publication: 2012 Mar 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Aquatic Organisms/*chemistry
Echinodermata/*chemistry
Hepacivirus/*physiology
RNA Helicases/*antagonists & inhibitors
Virus Replication/*drug effects
Acetates/chemistry ; Adenosine Triphosphatases/metabolism ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/isolation & purification ; DNA Replication/drug effects ; Hepacivirus/drug effects ; Hepacivirus/enzymology ; Interferons/metabolism ; RNA Helicases/metabolism ; RNA, Viral/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp.
Autorzy :
Fujimoto Y; Department of Microbiology, Division of Medicine, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
Salam KA
Furuta A
Matsuda Y
Fujita O
Tani H
Ikeda M
Kato N
Sakamoto N
Maekawa S
Enomoto N
de Voogd NJ
Nakakoshi M
Tsubuki M
Sekiguchi Y
Tsuneda S
Akimitsu N
Noda N
Yamashita A
Tanaka J
Moriishi K
Pokaż więcej
Źródło :
PloS one [PLoS One] 2012; Vol. 7 (11), pp. e48685. Date of Electronic Publication: 2012 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Hepacivirus/*drug effects
Porifera/*chemistry
Protease Inhibitors/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Acetates ; Animals ; Antiviral Agents/isolation & purification ; Cell Line ; Complex Mixtures/chemistry ; Hepacivirus/enzymology ; Hepacivirus/genetics ; Interferon-alpha/metabolism ; Protease Inhibitors/isolation & purification ; Signal Transduction/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors.
Autorzy :
Kurosaki M; Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino-shi, Tokyo, Japan.
Tanaka Y
Nishida N
Sakamoto N
Enomoto N
Honda M
Sugiyama M
Matsuura K
Sugauchi F
Asahina Y
Nakagawa M
Watanabe M
Sakamoto M
Maekawa S
Sakai A
Kaneko S
Ito K
Masaki N
Tokunaga K
Izumi N
Mizokami M
Pokaż więcej
Źródło :
Journal of hepatology [J Hepatol] 2011 Mar; Vol. 54 (3), pp. 439-48. Date of Electronic Publication: 2010 Sep 19.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Study
MeSH Terms :
Polymorphism, Single Nucleotide*
Hepacivirus/*genetics
Hepatitis C, Chronic/*drug therapy
Hepatitis C, Chronic/*genetics
Interferon Type I/*therapeutic use
Interleukins/*genetics
Ribavirin/*therapeutic use
Aged ; Alleles ; Antiviral Agents/therapeutic use ; Data Mining ; Decision Trees ; Drug Resistance, Viral/genetics ; Female ; Genes, Viral ; Genotype ; Hepacivirus/drug effects ; Hepatitis C, Chronic/immunology ; Hepatitis C, Chronic/virology ; Humans ; Interferons ; Japan ; Logistic Models ; Male ; Middle Aged ; Models, Biological ; Mutation ; Prognosis ; RNA, Viral/blood ; RNA, Viral/genetics ; Recombinant Proteins ; Retrospective Studies ; Treatment Outcome ; Viral Core Proteins/genetics ; Viral Load
Czasopismo naukowe
Tytuł :
Analysis of the complete open reading frame of genotype 2b hepatitis C virus in association with the response to peginterferon and ribavirin therapy.
Autorzy :
Kadokura M; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Maekawa S
Sueki R
Miura M
Komase K
Shindo H
Amemiya F
Uetake T
Inoue T
Sakamoto M
Nakagawa M
Sakamoto N
Watanabe M
Enomoto N
Pokaż więcej
Źródło :
PloS one [PLoS One] 2011; Vol. 6 (9), pp. e24514. Date of Electronic Publication: 2011 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Hepacivirus/*genetics
Hepacivirus/*pathogenicity
Interferon-alpha/*pharmacology
Open Reading Frames/*genetics
Ribavirin/*pharmacology
Adult ; Aged ; Aged, 80 and over ; Female ; Genotype ; Hepacivirus/classification ; Hepacivirus/drug effects ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Phylogeny ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
HCV genetic elements determining the early response to peginterferon and ribavirin therapy.
Autorzy :
Enomoto N; First Department of Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan. />Maekawa S
Pokaż więcej
Źródło :
Intervirology [Intervirology] 2010; Vol. 53 (1), pp. 66-9. Date of Electronic Publication: 2010 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*therapeutic use
Hepacivirus/*genetics
Hepacivirus/*pathogenicity
Hepatitis C, Chronic/*drug therapy
Interferons/*therapeutic use
Ribavirin/*therapeutic use
Genome, Viral ; Humans ; Mutation, Missense ; RNA, Viral/genetics ; Treatment Outcome ; Viral Core Proteins/genetics ; Viral Nonstructural Proteins/genetics
Czasopismo naukowe
Tytuł :
Viral factors influencing the response to the combination therapy of peginterferon plus ribavirin in chronic hepatitis C.
Autorzy :
Maekawa S; First Department of Internal Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan. maekawa@yamanashi.ac.jp
Enomoto N
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Źródło :
Journal of gastroenterology [J Gastroenterol] 2009; Vol. 44 (10), pp. 1009-15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*therapeutic use
Hepacivirus/*genetics
Hepatitis C, Chronic/*drug therapy
Hepatitis C, Chronic/*virology
Interferon-alpha/*therapeutic use
Ribavirin/*therapeutic use
Drug Therapy, Combination ; Genetic Variation ; Genotype ; Hepacivirus/pathogenicity ; Humans ; Interferon alpha-2 ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/therapeutic use ; Recombinant Proteins ; Treatment Outcome ; Viral Load ; Virulence Factors
Czasopismo naukowe
Tytuł :
Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.
Autorzy :
Sakamoto N; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan. />Tanabe Y
Yokota T
Satoh K
Sekine-Osajima Y
Nakagawa M
Itsui Y
Tasaka M
Sakurai Y
Cheng-Hsin C
Yano M
Ohkoshi S
Aoyagi Y
Maekawa S
Enomoto N
Kohara M
Watanabe M
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Źródło :
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2008 Sep; Vol. 23 (9), pp. 1437-47. Date of Electronic Publication: 2007 Aug 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Vectors*
RNA Interference*
RNA, Viral*
Adenoviridae/*genetics
Genetic Therapy/*methods
Hepacivirus/*genetics
Hepatitis C/*prevention & control
RNA, Small Interfering/*metabolism
Animals ; Cell Line, Tumor ; Disease Models, Animal ; Feasibility Studies ; Hepacivirus/growth & development ; Hepacivirus/metabolism ; Hepatitis C/genetics ; Hepatitis C/metabolism ; Humans ; Interferon Regulatory Factors/genetics ; Liver/metabolism ; Liver/virology ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Retroviridae/genetics ; Time Factors ; Transduction, Genetic ; Transfection ; Viral Proteins/biosynthesis ; Viral Proteins/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response.
Autorzy :
Tasaka M; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Sakamoto N; Department for Hepatitis Control, Tokyo Medical and Dental University, Tokyo, Japan.; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Itakura Y; First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan.; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Nakagawa M; Department for Hepatitis Control, Tokyo Medical and Dental University, Tokyo, Japan.; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Itsui Y; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Sekine-Osajima Y; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Nishimura-Sakurai Y; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Chen CH; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Yoneyama M; Laboratory of Molecular Genetics, Department of Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Fujita T; Laboratory of Molecular Genetics, Department of Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Wakita T; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Maekawa S; First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan.
Enomoto N; First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan.
Watanabe M; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
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Źródło :
The Journal of general virology [J Gen Virol] 2007 Dec; Vol. 88 (Pt 12), pp. 3323-3333.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Hepacivirus/*physiology
Hepatitis C/*virology
Interferons/*biosynthesis
Receptors, Retinoic Acid/*metabolism
Viral Nonstructural Proteins/*physiology
Cell Line ; Dimerization ; Down-Regulation ; Genome, Viral ; Hepacivirus/chemistry ; Hepatitis C/immunology ; Humans ; Replicon ; Virus Replication
Czasopismo naukowe
Tytuł :
Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication.
Autorzy :
Itsui Y; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Sakamoto N
Kurosaki M
Kanazawa N
Tanabe Y
Koyama T
Takeda Y
Nakagawa M
Kakinuma S
Sekine Y
Maekawa S
Enomoto N
Watanabe M
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Źródło :
Journal of viral hepatitis [J Viral Hepat] 2006 Oct; Vol. 13 (10), pp. 690-700.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Virus Replication*
Hepacivirus/*physiology
Interferon Regulatory Factors/*genetics
Interferon-alpha/*genetics
Cell Line ; Cell Line, Tumor ; Down-Regulation ; GTP-Binding Proteins/genetics ; Gene Expression Profiling ; Gene Library ; Hepacivirus/genetics ; Humans ; Liver/cytology ; Liver/virology ; Mitochondrial Proteins/genetics ; Proteins/genetics ; Replicon ; Response Elements ; Signal Transduction
Czasopismo naukowe
Tytuł :
Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication.
Autorzy :
Kohashi T; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Yushima, Bunkyo, Tokyo, Japan.
Maekawa S
Sakamoto N
Kurosaki M
Watanabe H
Tanabe Y
Chen CH
Kanazawa N
Nakagawa M
Kakinuma S
Yamashiro T
Itsui Y
Koyama T
Enomoto N
Watanabe M
Pokaż więcej
Źródło :
Journal of viral hepatitis [J Viral Hepat] 2006 Sep; Vol. 13 (9), pp. 582-90.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Hepacivirus/*genetics
Interferons/*pharmacology
Viral Nonstructural Proteins/*genetics
Virus Replication/*genetics
Amino Acid Sequence ; Amino Acid Substitution ; Cell Line, Tumor ; DNA Mutational Analysis ; Hepacivirus/physiology ; Humans ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Protein Structure, Tertiary ; Viral Nonstructural Proteins/chemistry
Czasopismo naukowe

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