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    Tytuł:
    Bioengineering solutions for ureteric disorders: clinical need, challenges and opportunities.
    Autorzy:
    Kapetanos K; School of Clinical Medicine, University of Cambridge, Cambridge, UK.
    Light A; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
    Thakare N; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
    Mahbubani K; Cambridge Biorepository for Translational Medicine (CBTM), NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.
    Saeb-Parsy K; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
    Saeb-Parsy K; Department of Surgery, University of Cambridge and Cambridge NIHR Biomedical Research Centre, Cambridge, UK.
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    Źródło:
    BJU international [BJU Int] 2022 Oct; Vol. 130 (4), pp. 408-419. Date of Electronic Publication: 2022 May 15.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Ureter*/surgery
    Urologic Diseases*
    Animals ; Bioengineering ; Constriction, Pathologic ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
    Autorzy:
    Jarvis LB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Rainbow DB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
    Coppard V; Department of Medicine, University of Cambridge, Cambridge, UK.
    Howlett SK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Georgieva Z; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Davies JL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Mullay HK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Hester J; Department of Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
    Ashmore T; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.
    Van Den Bosch A; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Grist JT; Department of Radiology, University of Cambridge, Cambridge, UK.
    Coles AJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Mousa HS; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Pluchino S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Mahbubani KT; Department of Surgery, University of Cambridge, Cambridge, UK.
    Griffin JL; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.; Imperial College London Dementia Research Institute & Section of Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
    Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.
    Issa F; Department of Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
    Peruzzotti-Jametti L; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    Wicker LS; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
    Jones JL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. .
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    Źródło:
    Communications biology [Commun Biol] 2021 Oct 14; Vol. 4 (1), pp. 1186. Date of Electronic Publication: 2021 Oct 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation*
    5'-Nucleotidase/*genetics
    Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
    T-Lymphocytes, Regulatory/*metabolism
    5'-Nucleotidase/metabolism ; Female ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Male
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition.
    Autorzy:
    Nowicki-Osuch K; Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge CB2 0X2, UK.
    Zhuang L; Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge CB2 0X2, UK.
    Jammula S; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
    Bleaney CW; Faculty of Biology, Medicine and Health, Michael Smith Building, Oxford Road, University of Manchester, Manchester, UK.
    Mahbubani KT; Cambridge Biorepository for Translational Medicine (CBTM), NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.
    Devonshire G; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
    Katz-Summercorn A; Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge CB2 0X2, UK.
    Eling N; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
    Wilbrey-Clark A; Wellcome Sanger Institute, Welcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Madissoon E; Wellcome Sanger Institute, Welcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Gamble J; Cambridge Biorepository for Translational Medicine (CBTM), NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK.
    Di Pietro M; Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge CB2 0X2, UK.
    O'Donovan M; Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge CB2 0X2, UK.
    Meyer KB; Wellcome Sanger Institute, Welcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Saeb-Parsy K; Cambridge Biorepository for Translational Medicine (CBTM), NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK.
    Sharrocks AD; Faculty of Biology, Medicine and Health, Michael Smith Building, Oxford Road, University of Manchester, Manchester, UK.
    Teichmann SA; Wellcome Sanger Institute, Welcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK.
    Marioni JC; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.; Wellcome Sanger Institute, Welcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Fitzgerald RC; Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge CB2 0X2, UK. .
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    Źródło:
    Science (New York, N.Y.) [Science] 2021 Aug 13; Vol. 373 (6556), pp. 760-767.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Adenocarcinoma/*pathology
    Barrett Esophagus/*pathology
    Cardia/*cytology
    Esophageal Neoplasms/*pathology
    Esophagus/*pathology
    Barrett Esophagus/genetics ; Barrett Esophagus/metabolism ; Cardia/chemistry ; Cell Differentiation ; Cell Lineage ; Cell Transformation, Neoplastic ; Epigenesis, Genetic ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Esophagus/cytology ; Esophagus/metabolism ; Exocrine Glands/chemistry ; Exocrine Glands/cytology ; Hepatocyte Nuclear Factor 4/metabolism ; Humans ; Keratin-7/analysis ; Metaplasia ; Phenotype ; Proto-Oncogene Proteins c-myc/metabolism ; RNA-Seq ; Single-Cell Analysis ; Transcription, Genetic ; Transcriptome
    SCR Disease Name:
    Adenocarcinoma Of Esophagus
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Cholangiocyte organoids can repair bile ducts after transplantation in the human liver.
    Autorzy:
    Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK. .; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Muraro D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
    Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
    Sawiak S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK.
    Beach TE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
    Godfrey EM; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Brevini T; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
    Wesley BT; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
    Garcia-Bernardo J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.
    Mahbubani K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
    Canu G; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
    Gieseck R 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
    Berntsen NL; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
    Mulcahy VL; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK.
    Crick K; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Fear C; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Robinson S; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Swift L; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Gambardella L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
    Bargehr J; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
    Ortmann D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
    Brown SE; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
    Osnato A; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
    Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, Cambridgeshire, UK.
    Corbett G; Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Gelson WTH; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Mells GF; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK.
    Humphreys P; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.
    Davies SE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Amin I; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Gibbs P; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
    Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, Cambridgeshire, UK.
    Butler AJ; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    See TC; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Melum E; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
    Watson CJE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.; National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre and the NIHR Blood and Transplant Research Unit (BTRU), Cambridge, Cambridgeshire, UK.; University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, Cambridgeshire, UK.
    Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
    Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK. .; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.
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    Źródło:
    Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 839-846.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cell- and Tissue-Based Therapy*
    Bile Duct Diseases/*therapy
    Bile Ducts/*cytology
    Bile Ducts, Intrahepatic/*physiology
    Epithelial Cells/*cytology
    Organoids/*transplantation
    Animals ; Bile ; Bile Ducts/physiology ; Bile Ducts, Intrahepatic/cytology ; Common Bile Duct/cytology ; Epithelial Cells/physiology ; Gallbladder/cytology ; Gene Expression Regulation ; Humans ; Liver/physiology ; Liver Transplantation ; Mesenchymal Stem Cell Transplantation ; Mice ; Organoids/physiology ; RNA-Seq ; Tissue and Organ Procurement ; Transcriptome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Use of human splenocytes in an innovative humanised mouse model for prediction of immunotherapy-induced cytokine release syndrome.
    Autorzy:
    Matas-Céspedes A; Clinical Pharmacology and Safety Sciences R&D AstraZeneca Cambridge UK.; Department of Surgery University of Cambridge and NIHR Cambridge Biomedical Campus Cambridge UK.
    Brown L; Clinical Pharmacology and Safety Sciences R&D AstraZeneca Cambridge UK.
    Mahbubani KT; Department of Surgery University of Cambridge and NIHR Cambridge Biomedical Campus Cambridge UK.
    Bareham B; Department of Surgery University of Cambridge and NIHR Cambridge Biomedical Campus Cambridge UK.
    Higgins J; Department of Surgery University of Cambridge and NIHR Cambridge Biomedical Campus Cambridge UK.
    Curran M; Clinical Pharmacology and Safety Sciences R&D AstraZeneca Cambridge UK.; Department of Surgery University of Cambridge and NIHR Cambridge Biomedical Campus Cambridge UK.
    de Haan L; Clinical Pharmacology and Safety Sciences R&D AstraZeneca Cambridge UK.; Present address: ADC Therapeutics London UK.
    Lapointe JM; Clinical Pharmacology and Safety Sciences R&D AstraZeneca Cambridge UK.
    Stebbings R; Clinical Pharmacology and Safety Sciences R&D AstraZeneca Cambridge UK.
    Saeb-Parsy K; Department of Surgery University of Cambridge and NIHR Cambridge Biomedical Campus Cambridge UK.
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    Źródło:
    Clinical & translational immunology [Clin Transl Immunology] 2020 Nov 04; Vol. 9 (11), pp. e1202. Date of Electronic Publication: 2020 Nov 04 (Print Publication: 2020).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Extensive heterogeneity in somatic mutation and selection in the human bladder.
    Autorzy:
    Lawson ARJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Abascal F; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Coorens THH; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Hooks Y; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    O'Neill L; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Latimer C; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Raine K; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Sanders MA; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Department of Hematology, Erasmus University Medical Center, Rotterdam 3015 GD, Netherlands.
    Warren AY; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
    Mahbubani KTA; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
    Bareham B; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
    Butler TM; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Harvey LMR; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Cagan A; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Menzies A; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Moore L; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
    Colquhoun AJ; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Turner W; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Thomas B; The Royal Melbourne Hospital, Parkville, Victoria 3010, Australia.; Department of Surgery, The University of Melbourne, Parkville, Victoria 3010, Australia.
    Gnanapragasam V; Academic Urology Group, Department of Surgery and Oncology, University of Cambridge, Cambridge CB2 0QQ, UK.; Cambridge Urology Translational Research and Clinical Trials Office, University of Cambridge CB2 0QQ, UK.
    Williams N; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Rassl DM; Department of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge CB2 0AY, UK.
    Vöhringer H; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK.
    Zumalave S; Mobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.
    Nangalia J; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Tubío JMC; Mobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain.; The Biomedical Research Centre (CINBIO), University of Vigo, Vigo 36310, Spain.
    Gerstung M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton CB10 1SD, UK.
    Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
    Stratton MR; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
    Campbell PJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK.
    Mitchell TJ; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Martincorena I; Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK. .
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    Źródło:
    Science (New York, N.Y.) [Science] 2020 Oct 02; Vol. 370 (6512), pp. 75-82.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genes, Neoplasm*
    Mutagenesis*
    Selection, Genetic*
    Urinary Bladder/*pathology
    Urinary Bladder Neoplasms/*genetics
    Urothelium/*pathology
    APOBEC Deaminases/genetics ; Adult ; Aged ; Biopsy ; Chromatin Assembly and Disassembly/genetics ; Female ; Humans ; Male ; Middle Aged ; Mutagens/analysis ; Mutation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A cell atlas of human thymic development defines T cell repertoire formation.
    Autorzy:
    Park JE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Botting RA; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Domínguez Conde C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Popescu DM; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Lavaert M; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
    Kunz DJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
    Goh I; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Stephenson E; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Ragazzini R; Epithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK.
    Tuck E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Wilbrey-Clark A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Roberts K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Kedlian VR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Ferdinand JR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.
    He X; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK.
    Webb S; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Maunder D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Vandamme N; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
    Mahbubani KT; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Bolt L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Crossland D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
    de Rita F; Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
    Fuller A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Filby A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Reynolds G; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Dixon D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
    Lisgo S; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Henderson D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
    Vento-Tormo R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Bayraktar OA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Barker RA; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK.; WT-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre Cambridge Biomedical Campus, Cambridge CB2 0AW, UK.
    Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
    Saeys Y; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
    Bonfanti P; Epithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK.; Institute of Immunity and Transplantation, University College London, London, UK.
    Behjati S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0SP, UK.
    Clatworthy MR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
    Taghon T; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium. .; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.
    Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. .; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.
    Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. .; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2020 Feb 21; Vol. 367 (6480).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Atlases as Topic*
    Cell Differentiation*
    CD8-Positive T-Lymphocytes/*immunology
    Thymus Gland/*growth & development
    Thymus Gland/*immunology
    CD8-Positive T-Lymphocytes/cytology ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Fibroblasts/cytology ; Fibroblasts/immunology ; Humans ; RNA-Seq/methods ; Receptors, Antigen, T-Cell/metabolism ; Single-Cell Analysis/methods ; Thymus Gland/cytology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Somatic mutant clones colonize the human esophagus with age.
    Autorzy:
    Martincorena I; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK. .
    Fowler JC; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
    Wabik A; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
    Lawson ARJ; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
    Abascal F; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
    Hall MWJ; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.; MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge CB2 0XZ, UK.
    Cagan A; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
    Murai K; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
    Mahbubani K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge CB2 2QQ, UK.
    Stratton MR; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
    Fitzgerald RC; MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge CB2 0XZ, UK.
    Handford PA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
    Campbell PJ; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.; Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK.
    Saeb-Parsy K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge CB2 2QQ, UK.
    Jones PH; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK. .
    Pokaż więcej
    Źródło:
    Science (New York, N.Y.) [Science] 2018 Nov 23; Vol. 362 (6417), pp. 911-917. Date of Electronic Publication: 2018 Oct 18.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Selection, Genetic*
    Aging/*genetics
    Esophageal Neoplasms/*genetics
    Esophageal Neoplasms/*pathology
    Esophagus/*pathology
    Adult ; Aged ; Clone Cells/pathology ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Receptor, Notch1/genetics ; Tumor Suppressor Protein p53/genetics ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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