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    Wyświetlanie 1-14 z 14
    Tytuł:
    ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas.
    Autorzy:
    Nguyen V; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.; Curriculum in Toxicology and Environmental Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America.
    Schrank TP; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.; Department of Otolaryngology, University of North Carolina, Chapel Hill, North Carolina, United States of America.
    Major MB; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, United States of America.
    Weissman BE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.; Curriculum in Toxicology and Environmental Medicine, University of North Carolina, Chapel Hill, North Carolina, United States of America.; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, United States of America.
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    Źródło:
    PloS one [PLoS One] 2024 Feb 15; Vol. 19 (2), pp. e0297741. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    DNA-Binding Proteins*/genetics
    DNA-Binding Proteins*/metabolism
    Head and Neck Neoplasms*/genetics
    NF-E2-Related Factor 2*/genetics
    NF-E2-Related Factor 2*/metabolism
    Transcription Factors*/genetics
    Transcription Factors*/metabolism
    Humans ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Mutation ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Signal Transduction/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma.
    Autorzy:
    Sheth S; Division of Hematology and Oncology, Department of Medicine The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Farquhar DR; Department of Otolaryngology-Head and Neck Surgery The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Schrank TP; Department of Otolaryngology-Head and Neck Surgery The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.; Department of Cell Biology and Physiology The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Stepp W; Department of Otolaryngology-Head and Neck Surgery The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Mazul A; Department of Otolaryngology Washington University in Saint Louis, School of Medicine St. Louis Missouri USA.
    Hayward M; Division of Hematology and Oncology, Department of Medicine The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Lenze N; Department of Otolaryngology-Head and Neck Surgery The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Little P; Division of Hematology and Oncology, Department of Medicine The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Jo H; Division of Hematology-Oncology, Department of Medicine University of Tennessee Health Science Center Memphis Tennessee USA.
    Major MB; Department of Cell Biology and Physiology The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Chera BS; Department of Radiation Oncology The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA.
    Zevallos JP; Department of Otolaryngology Washington University in Saint Louis, School of Medicine St. Louis Missouri USA.
    Hayes DN; Division of Hematology-Oncology, Department of Medicine University of Tennessee Health Science Center Memphis Tennessee USA.
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    Źródło:
    Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2021 Jun 03; Vol. 6 (4), pp. 699-707. Date of Electronic Publication: 2021 Jun 03 (Print Publication: 2021).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.
    Autorzy:
    Franks JL; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Martinez-Chacin RC; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Wang X; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Tiedemann RL; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan, United States of America.
    Bonacci T; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Choudhury R; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Bolhuis DL; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Enrico TP; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Mouery RD; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Damrauer JS; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Yan F; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Harrison JS; Department of Chemistry, University of the Pacific, Stockton, California, United States of America.
    Major MB; Department of Cell Biology and Physiology, Department of Otolaryngology, Washington University in St. Louis, St. Louis, Missouri, United States of America.
    Hoadley KA; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Suzuki A; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, Wisconsin, United States of America.
    Rothbart SB; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan, United States of America.
    Brown NG; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Emanuele MJ; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
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    Źródło:
    PLoS biology [PLoS Biol] 2020 Dec 11; Vol. 18 (12), pp. e3000975. Date of Electronic Publication: 2020 Dec 11 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Anaphase-Promoting Complex-Cyclosome/*metabolism
    CCAAT-Enhancer-Binding Proteins/*metabolism
    Chromatin/*metabolism
    Ubiquitin-Protein Ligases/*metabolism
    Anaphase-Promoting Complex-Cyclosome/physiology ; CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/physiology ; Cell Cycle/physiology ; Cell Cycle Proteins/metabolism ; Cell Line ; Chromatin/genetics ; Computer Simulation ; HEK293 Cells ; HeLa Cells ; Humans ; Protein Processing, Post-Translational ; Transcription Factors/metabolism ; Ubiquitin-Protein Ligases/physiology ; Ubiquitination
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor.
    Autorzy:
    Tamir TY; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Wells C; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Major MB; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, MO, USA.
    Axtman AD; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. .
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    Źródło:
    Scientific reports [Sci Rep] 2020 Sep 28; Vol. 10 (1), pp. 15826. Date of Electronic Publication: 2020 Sep 28.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genomic Library*
    Small Molecule Libraries*
    Protein Kinase Inhibitors/*pharmacology
    Protein Serine-Threonine Kinases/*antagonists & inhibitors
    Drug Evaluation, Preclinical/methods ; HEK293 Cells ; Humans ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/metabolism ; Structure-Activity Relationship
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target.
    Autorzy:
    Ma S; Department of Thoracic Surgery, Peking University Third Hospital, Beijing, China.; Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina.
    Paiboonrungruan C; Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina.
    Yan T; Department of Thoracic Surgery, Peking University Third Hospital, Beijing, China.
    Williams KP; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, North Carolina.
    Major MB; Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
    Chen XL; Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina.; Center for Esophageal Disease and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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    Źródło:
    Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2018 Dec; Vol. 1434 (1), pp. 164-172. Date of Electronic Publication: 2018 May 11.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Esophageal Neoplasms*/genetics
    Esophageal Neoplasms*/metabolism
    Esophageal Neoplasms*/pathology
    Esophageal Neoplasms*/therapy
    Esophageal Squamous Cell Carcinoma*/genetics
    Esophageal Squamous Cell Carcinoma*/metabolism
    Esophageal Squamous Cell Carcinoma*/pathology
    Esophageal Squamous Cell Carcinoma*/therapy
    Esophagus*/metabolism
    Esophagus*/pathology
    Gene Expression Regulation, Neoplastic*
    NF-E2-Related Factor 2*/biosynthesis
    NF-E2-Related Factor 2*/genetics
    Neoplasm Proteins*/biosynthesis
    Neoplasm Proteins*/genetics
    Signal Transduction*
    Animals ; Humans
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.
    Autorzy:
    Gao Y; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA.
    Kardos J; Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.
    Yang Y; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA.
    Tamir TY; Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
    Mutter-Rottmayer E; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA.
    Weissman B; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA.; Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.
    Major MB; Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
    Kim WY; Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.
    Vaziri C; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA. cyrus_.; Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA. cyrus_.
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    Źródło:
    Scientific reports [Sci Rep] 2018 Oct 17; Vol. 8 (1), pp. 15304. Date of Electronic Publication: 2018 Oct 17.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Radiation, Ionizing*
    Recombinational DNA Repair*
    Adenocarcinoma of Lung/*metabolism
    Cell Cycle Proteins/*metabolism
    Lung Neoplasms/*metabolism
    Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/radiotherapy ; Antineoplastic Agents/therapeutic use ; Camptothecin/therapeutic use ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cisplatin/therapeutic use ; DNA End-Joining Repair ; Drug Resistance, Neoplasm ; Etoposide/therapeutic use ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/radiotherapy
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.
    Autorzy:
    Kahremany S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Babaev I; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Hasin P; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Tamir TY; Department of Pharmacology, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
    Ben-Zur T; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv University, Rabin Medical Center-Beilinson Campus, Petah Tikva, 49100, Israel.
    Cohen G; The Skin Research Institute, The Dead Sea & Arava Science Center, Tamar Regional Council, Dead Sea Mobile Post, 86910, Israel.
    Jiang Z; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University Nanjing, Jiangsu, 210008, P. R. China.
    Weintraub S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Offen D; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv University, Rabin Medical Center-Beilinson Campus, Petah Tikva, 49100, Israel.
    Rahimipour S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Major MB; Department of Pharmacology, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
    Senderowitz H; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Gruzman A; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
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    Źródło:
    ChemPlusChem [Chempluschem] 2018 May; Vol. 83 (5), pp. 320-333. Date of Electronic Publication: 2018 Mar 08.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}-5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.
    Autorzy:
    Kahremany S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Babaev I; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Hasin P; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Tamir TY; Department of Pharmacology, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
    Ben-Zur T; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv University, Rabin Medical Center-Beilinson Campus, Petah Tikva, 49100, Israel.
    Cohen G; The Skin Research Institute, The Dead Sea & Arava Science Center, Tamar Regional Council, Dead Sea Mobile Post, 86910, Israel.
    Jiang Z; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University Nanjing, Jiangsu, 210008, P. R. China.
    Weintraub S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Offen D; Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel-Aviv University, Rabin Medical Center-Beilinson Campus, Petah Tikva, 49100, Israel.
    Rahimipour S; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Major MB; Department of Pharmacology, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
    Senderowitz H; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
    Gruzman A; Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, 5290002, Israel.
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    Źródło:
    ChemPlusChem [Chempluschem] 2018 May; Vol. 83 (5), pp. 318. Date of Electronic Publication: 2018 Apr 06.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.
    Autorzy:
    Stratford JK; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Yan F; Department of Cell Biology and Physiology University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Hill RA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Major MB; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Cell Biology and Physiology University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Graves LM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Der CJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
    Yeh JJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
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    Źródło:
    PloS one [PLoS One] 2017 Apr 05; Vol. 12 (4), pp. e0174863. Date of Electronic Publication: 2017 Apr 05 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Carcinoma, Pancreatic Ductal/*physiopathology
    Cell Cycle Proteins/*physiology
    Chromosomal Instability/*drug effects
    Pancreatic Neoplasms/*physiopathology
    Protein Serine-Threonine Kinases/*physiology
    Protein-Tyrosine Kinases/*physiology
    Aneuploidy ; Apoptosis ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Cycle/physiology ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Flow Cytometry ; Gene Expression Profiling ; Humans ; Immunoblotting ; Immunoprecipitation ; M Phase Cell Cycle Checkpoints ; Oligonucleotide Array Sequence Analysis ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/metabolism ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/genetics ; RNA, Small Interfering/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Weight loss reduces basal-like breast cancer through kinome reprogramming.
    Autorzy:
    Qin Y; CB 7461, Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2203 McGavran Greenberg Hall, Chapel Hill, NC 27599-7461 USA.
    Sundaram S; CB 7461, Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2203 McGavran Greenberg Hall, Chapel Hill, NC 27599-7461 USA.
    Essaid L; CB 7461, Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2203 McGavran Greenberg Hall, Chapel Hill, NC 27599-7461 USA.
    Chen X; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Miller SM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Yan F; Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Darr DB; Mouse Phase I Unit, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Galanko JA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Montgomery SA; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Major MB; Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Johnson GL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC USA ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Troester MA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC USA ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
    Makowski L; CB 7461, Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2203 McGavran Greenberg Hall, Chapel Hill, NC 27599-7461 USA ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
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    Źródło:
    Cancer cell international [Cancer Cell Int] 2016 Apr 01; Vol. 16, pp. 26. Date of Electronic Publication: 2016 Apr 01 (Print Publication: 2016).
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma.
    Autorzy:
    Arensman MD; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
    Kovochich AN; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
    Kulikauskas RM; Howard Hughes Medical Institute, Department of Pharmacology, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA.
    Lay AR; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
    Yang PT; Howard Hughes Medical Institute, Department of Pharmacology, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA.
    Li X; 1] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA [2] Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
    Donahue T; 1] Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA [2] Department of Surgery, Division of General Surgery, Institute for Molecular Medicine and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
    Major MB; Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
    Moon RT; Howard Hughes Medical Institute, Department of Pharmacology, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA.
    Chien AJ; 1] Howard Hughes Medical Institute, Department of Pharmacology, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA [2] Department of Medicine, Division of Dermatology, University of Washington School of Medicine, Seattle, WA, USA.
    Dawson DW; 1] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA [2] Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
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    Źródło:
    Oncogene [Oncogene] 2014 Feb 13; Vol. 33 (7), pp. 899-908. Date of Electronic Publication: 2013 Feb 18.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cell Proliferation*
    Wnt Signaling Pathway*
    Carcinoma, Pancreatic Ductal/*metabolism
    Pancreatic Neoplasms/*metabolism
    Wnt Proteins/*physiology
    Aged ; Autocrine Communication ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/pathology ; Cell Adhesion ; Cell Line, Tumor ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Prognosis ; Proportional Hazards Models ; Transcription, Genetic ; Transcriptome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
    Autorzy:
    James RG; Department of Pharmacology, Seattle, Washington, United States of America ; Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America.
    Davidson KC
    Bosch KA
    Biechele TL
    Robin NC
    Taylor RJ
    Major MB
    Camp ND
    Fowler K
    Martins TJ
    Moon RT
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (12), pp. e50457. Date of Electronic Publication: 2012 Dec 05.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Enzyme Inhibitors/*pharmacology
    Naphthalimides/*pharmacology
    Signal Transduction/*drug effects
    Tankyrases/*antagonists & inhibitors
    Triazoles/*pharmacology
    Wnt Proteins/*antagonists & inhibitors
    beta Catenin/*antagonists & inhibitors
    Cell Line ; High-Throughput Screening Assays ; Humans ; Ubiquitination ; Wnt Proteins/metabolism ; beta Catenin/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.
    Autorzy:
    Sorrells S; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America.
    Carbonneau S
    Harrington E
    Chen AT
    Hast B
    Milash B
    Pyati U
    Major MB
    Zhou Y
    Zon LI
    Stewart RA
    Look AT
    Jette C
    Pokaż więcej
    Źródło:
    PLoS genetics [PLoS Genet] 2012; Vol. 8 (8), pp. e1002922. Date of Electronic Publication: 2012 Aug 30.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Zebrafish*/embryology
    Zebrafish*/genetics
    DNA Breaks, Double-Stranded/*radiation effects
    Radiation Tolerance/*genetics
    Tumor Suppressor Protein p53/*genetics
    Zebrafish Proteins/*genetics
    Animals ; Apoptosis/radiation effects ; Embryonic Development/radiation effects ; Gene Expression Regulation ; Genes, Recessive ; Mutation ; Neurons/radiation effects ; Radiation, Ionizing ; Tumor Suppressor Protein p53/metabolism ; Zebrafish Proteins/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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