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    Tytuł:
    Differing natural killer cell, T cell and antibody profiles in antiretroviral-naive HIV-1 viraemic controllers with and without protective HLA alleles.
    Autorzy:
    Moyano A; Africa Health Research Institute, KwaZulu-Natal, South Africa, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
    Ndlovu B; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
    Mbele M; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
    Naidoo K; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
    Khan N; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
    Mann JK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
    Ndung'u T; Africa Health Research Institute, KwaZulu-Natal, South Africa, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Division of Infection and Immunity, University College London, London, United Kingdom.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, United States of America.
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    Źródło:
    PloS one [PLoS One] 2023 Jun 02; Vol. 18 (6), pp. e0286507. Date of Electronic Publication: 2023 Jun 02 (Print Publication: 2023).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    HIV-1*
    HIV Infections*
    Humans ; HIV Non-Progressors ; Alleles ; CD8-Positive T-Lymphocytes ; Killer Cells, Natural ; HLA-DR Antigens/metabolism ; Cytokines/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    HIV-1 subtype C Nef-mediated SERINC5 down-regulation significantly contributes to overall Nef activity.
    Autorzy:
    Naicker D; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, 4001, South Africa.
    Sonela N; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, 4001, South Africa.; Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management (CIRCB), P.O. Box 3077, Yaoundé, Cameroon.
    Jin SW; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
    Mulaudzi T; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, 4001, South Africa.
    Ojwach D; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, 4001, South Africa.
    Reddy T; Medical Research Council, Biostatistics Unit, Durban, 4001, South Africa.
    Brockman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.; Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, V6Z 1Y6, Canada.
    Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, V6Z 1Y6, Canada.
    Ndung'u T; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, 4001, South Africa.; Africa Health Research Institute, Durban, 4001, South Africa.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Division of Infection and Immunity, University College London, London, WC1E 6BT, UK.
    Mann JK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, 4001, South Africa. .
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    Źródło:
    Retrovirology [Retrovirology] 2023 Mar 31; Vol. 20 (1), pp. 3. Date of Electronic Publication: 2023 Mar 31.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    HIV-1*/physiology
    HIV Infections*
    Humans ; Down-Regulation ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; nef Gene Products, Human Immunodeficiency Virus/genetics ; nef Gene Products, Human Immunodeficiency Virus/metabolism ; T-Lymphocytes
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Results of a clinician questionnaire assessing the design and feasibility of the SeCondary intention vs. grAfts for heaLing scalP wounds (SCALP) study.
    Autorzy:
    Hunt WTN; Dermatology Surgery Unit, Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Plymouth, UK.
    Mann JK; Department of Dermatology, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
    Ashraf I; Department of Dermatology, Warwick Hospital, South Warwickshire University NHS Foundation Trust, Warwick, UK.
    Gnanappiragasam D; Department of Dermatology, University Hospitals of Leicester NHS Trust, Leicester, UK.
    Barlow R; Department of Dermatology, Birmingham City Hospital Dudley Road, Birmingham B18 7QH, UK.
    DeGiovanni C; Department of Dermatology, Brighton General Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
    Abbott R; Welsh Institute of Dermatology, Cardiff and Vale University Local Health Board, Cardiff, UK.
    Wernham AGH; Department of Dermatology, Walsall Manor Hospital, Walsall Healthcare NHS Trust, Walsall, UK.
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    Źródło:
    Clinical and experimental dermatology [Clin Exp Dermatol] 2023 Mar 01; Vol. 48 (3), pp. 235-265.
    Typ publikacji:
    Letter
    MeSH Terms:
    Scalp*/surgery
    Intention*
    Humans ; Feasibility Studies ; Wound Healing ; Skin Transplantation
    Opinia redakcyjna
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A review of Mohs micrographic surgery for skin cancer. Part 1: Melanoma and rare skin cancers.
    Autorzy:
    Charalambides M; Department of Dermatology, City Hospital, Sandwell and West Birmingham NHS Trust, Birmingham, UK.
    Yannoulias B; Department of Dermatology, New Cross Hospital, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.
    Malik N; Watford General Hospital, West Hertfordshire Hospitals NHS Trust, Watford, UK.
    Mann JK; Department of Dermatology, Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
    Celebi P; Department of Dermatology, Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, UK.
    Veitch D; Department of Dermatology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK.
    Wernham A; Department of Dermatology, Manor Hospital, Walsall Healthcare NHS Trust, Walsall, UK.
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    Źródło:
    Clinical and experimental dermatology [Clin Exp Dermatol] 2022 May; Vol. 47 (5), pp. 833-849. Date of Electronic Publication: 2022 Feb 22.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Dermatofibrosarcoma*/pathology
    Dermatofibrosarcoma*/surgery
    Hutchinson's Melanotic Freckle*/surgery
    Melanoma*/pathology
    Melanoma*/surgery
    Skin Neoplasms*/pathology
    Skin Neoplasms*/surgery
    Humans ; Mohs Surgery/methods ; Neoplasm Recurrence, Local ; Neoplasms, Adnexal and Skin Appendage ; Systematic Reviews as Topic
    SCR Disease Name:
    Microcystic adnexal carcinoma
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa.
    Autorzy:
    Farinre O; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
    Gounder K; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute, Durban, 4001, South Africa.
    Reddy T; Biostatistics Research Unit, South African Medical Research Council, Durban, South Africa.
    Tongo M; Centre of Research for Emerging and Re-Emerging Diseases (CREMER), Yaoundé, Cameroon.
    Hare J; International AIDS Vaccine Initiative (IAVI) Human Immunology Laboratory (HIL), Imperial College, London, UK.; IAVI Global Headquarters, 125 Broad Street, 9th Floor,, New York, NY, USA.
    Chaplin B; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
    Gilmour J; International AIDS Vaccine Initiative (IAVI) Human Immunology Laboratory (HIL), Imperial College, London, UK.; IAVI Global Headquarters, 125 Broad Street, 9th Floor,, New York, NY, USA.
    Kanki P; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
    Mann JK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
    Ndung'u T; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. .; Africa Health Research Institute, Durban, 4001, South Africa. .; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. .; Max Planck Institute for Infection Biology, Berlin, Germany. .; Division of Infection and Immunity, University College London, London, UK. .
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    Źródło:
    Retrovirology [Retrovirology] 2021 May 05; Vol. 18 (1), pp. 11. Date of Electronic Publication: 2021 May 05.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    HIV Protease/*genetics
    HIV-1/*genetics
    HIV-1/*physiology
    Virus Replication/*genetics
    gag Gene Products, Human Immunodeficiency Virus/*genetics
    Adult ; Africa, Eastern ; Africa, Western ; Cross-Sectional Studies ; Female ; Genotype ; HIV Infections/virology ; HIV Protease/classification ; HIV-1/classification ; HIV-1/enzymology ; Humans ; Male ; Phylogeny ; Recombination, Genetic ; Retrospective Studies ; Virus Replication/physiology ; Young Adult ; gag Gene Products, Human Immunodeficiency Virus/classification
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5.
    Autorzy:
    Jin SW; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
    Mwimanzi FM; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
    Mann JK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
    Bwana MB; Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
    Lee GQ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
    Brumme CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada.
    Hunt PW; School of Medicine, University of California, San Francisco, United States of America.
    Martin JN; School of Medicine, University of California, San Francisco, United States of America.
    Bangsberg DR; School of Public Health, Oregon Health Science University, Portland, United States of America.
    Ndung'u T; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute, Durban, South Africa.; Ragon Institute of MGH, MIT, and Harvard University, Cambridge, United States of America.; Max Planck Institute for Infection Biology, Berlin, Germany.; Division of Infection and Immunity, University College London, London, United Kingdom.
    Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
    Brockman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2020 Sep 14; Vol. 16 (9), pp. e1008813. Date of Electronic Publication: 2020 Sep 14 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Polymorphism, Genetic*
    Virus Replication*
    HIV Infections/*virology
    HIV-1/*physiology
    Membrane Glycoproteins/*antagonists & inhibitors
    Membrane Proteins/*antagonists & inhibitors
    nef Gene Products, Human Immunodeficiency Virus/*metabolism
    HIV Infections/genetics ; HIV Infections/metabolism ; HIV Seropositivity ; Host-Pathogen Interactions ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/virology ; Tumor Cells, Cultured ; nef Gene Products, Human Immunodeficiency Virus/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection.
    Autorzy:
    Muema DM; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
    Akilimali NA; Africa Health Research Institute, Durban, South Africa.
    Ndumnego OC; Africa Health Research Institute, Durban, South Africa.
    Rasehlo SS; Africa Health Research Institute, Durban, South Africa.
    Durgiah R; Africa Health Research Institute, Durban, South Africa.
    Ojwach DBA; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
    Ismail N; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
    Dong M; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
    Moodley A; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
    Dong KL; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA.
    Ndhlovu ZM; Africa Health Research Institute, Durban, South Africa.; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA.
    Mabuka JM; Africa Health Research Institute, Durban, South Africa.
    Walker BD; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA.
    Mann JK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
    Ndung'u T; Africa Health Research Institute, Durban, South Africa. .; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. .; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA. .; Max Planck Institute for Infection Biology, Berlin, Germany. .; Division of Infection and Immunity, University College London, London, UK. .
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    Źródło:
    BMC medicine [BMC Med] 2020 Mar 25; Vol. 18 (1), pp. 81. Date of Electronic Publication: 2020 Mar 25.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cytokines/*therapeutic use
    HIV Infections/*immunology
    Viral Load/*methods
    Viremia/*immunology
    Adolescent ; Adult ; Cytokines/pharmacology ; Female ; HIV Infections/drug therapy ; Humans ; Male ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C.
    Autorzy:
    Mann JK; HIV Pathogenesis Programme, University of KwaZulu-Natal, 719 Umbilo Road, Durban, 4013, South Africa. .; KwaZulu-Natal Research Institute for Tuberculosis and HIV, University of KwaZulu-Natal, Durban, 4001, South Africa. .
    Omarjee S; HIV Pathogenesis Programme, University of KwaZulu-Natal, 719 Umbilo Road, Durban, 4013, South Africa. .; KwaZulu-Natal Research Institute for Tuberculosis and HIV, University of KwaZulu-Natal, Durban, 4001, South Africa. .
    Khumalo P; HIV Pathogenesis Programme, University of KwaZulu-Natal, 719 Umbilo Road, Durban, 4013, South Africa. .; KwaZulu-Natal Research Institute for Tuberculosis and HIV, University of KwaZulu-Natal, Durban, 4001, South Africa. .
    Ndung'u T; HIV Pathogenesis Programme, University of KwaZulu-Natal, 719 Umbilo Road, Durban, 4013, South Africa. .; KwaZulu-Natal Research Institute for Tuberculosis and HIV, University of KwaZulu-Natal, Durban, 4001, South Africa. .; Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, 02139, USA. .; Max Planck Institute for Infection Biology, Chariteplatz, D-10117, Berlin, Germany. .
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    Źródło:
    Virology journal [Virol J] 2015 Nov 25; Vol. 12, pp. 200. Date of Electronic Publication: 2015 Nov 25.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genotype*
    Host-Pathogen Interactions*
    CD4 Antigens/*analysis
    CD4-Positive T-Lymphocytes/*virology
    HIV-1/*physiology
    Histocompatibility Antigens Class I/*analysis
    nef Gene Products, Human Immunodeficiency Virus/*metabolism
    Amino Acid Substitution ; CD4-Positive T-Lymphocytes/chemistry ; Cell Line ; DNA Mutational Analysis ; Down-Regulation ; Flow Cytometry ; HIV-1/classification ; HIV-1/genetics ; Humans ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; RNA, Viral/genetics ; Sequence Analysis, DNA
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
    Autorzy:
    Hölzemer A; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Heinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany.; First Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Thobakgale CF; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Jimenez Cruz CA; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, United States of America.
    Garcia-Beltran WF; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Carlson JM; Microsoft Research, Los Angeles, California, United States of America.
    van Teijlingen NH; Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
    Mann JK; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Jaggernath M; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Kang SG; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, United States of America.
    Körner C; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Heinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany.
    Chung AW; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Schafer JL; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Microbiology, New England Primate Research Center, Southborough, Massachusetts, United States of America.
    Evans DT; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Microbiology, New England Primate Research Center, Southborough, Massachusetts, United States of America.; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Madison, Wisconsin, United States of America.
    Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Goulder PJ; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
    Carrington M; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
    Hartmann P; First Department of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
    Pertel T; Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
    Zhou R; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, United States of America.
    Ndung'u T; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany.; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Altfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Heinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany.
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    Źródło:
    PLoS medicine [PLoS Med] 2015 Nov 17; Vol. 12 (11), pp. e1001900; discussion e1001900. Date of Electronic Publication: 2015 Nov 17 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Variation*
    Immune Evasion*
    HIV Core Protein p24/*genetics
    HIV-1/*genetics
    HLA-C Antigens/*genetics
    Killer Cells, Natural/*immunology
    gag Gene Products, Human Immunodeficiency Virus/*genetics
    Cohort Studies ; Epitopes ; Female ; Genotype ; HIV Infections/immunology ; HIV-1/immunology ; HLA-C Antigens/immunology ; Humans ; Male ; RNA, Viral/genetics ; Receptors, KIR2DL3/immunology ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Analysis, RNA ; South Africa
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    High frequency of transmitted HIV-1 Gag HLA class I-driven immune escape variants but minimal immune selection over the first year of clade C infection.
    Autorzy:
    Gounder K; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    Padayachi N; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    Mann JK; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    Radebe M; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    Mokgoro M; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    van der Stok M; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    Mkhize L; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    Mncube Z; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    Jaggernath M; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa.
    Reddy T; Biostatistics Unit, Medical Research Council, 491 Peter Mokaba Road, Overport, Durban, South Africa.
    Walker BD; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, Boston, Massachusetts, United States of America; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD, United States of America.
    Ndung'u T; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, 719 Umbilo Road, Durban, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, 400 Technology Square, Cambridge, Boston, Massachusetts, United States of America; Max Planck Institute for Infection Biology, Charitestraße 1, Berlin, Germany.
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2015 Mar 17; Vol. 10 (3), pp. e0119886. Date of Electronic Publication: 2015 Mar 17 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Polymorphism, Genetic*
    Selection, Genetic*
    HIV-1/*genetics
    gag Gene Products, Human Immunodeficiency Virus/*genetics
    Adolescent ; Adult ; Base Sequence ; Female ; Gene Frequency ; HIV Infections/virology ; HLA Antigens/immunology ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; gag Gene Products, Human Immunodeficiency Virus/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    HIV-1 vaccine immunogen design strategies.
    Autorzy:
    Mann JK
    Ndung'u T; HIV Pathogenesis Programme, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa. .
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    Źródło:
    Virology journal [Virol J] 2015 Jan 24; Vol. 12, pp. 3. Date of Electronic Publication: 2015 Jan 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    AIDS Vaccines/*immunology
    HIV Infections/*prevention & control
    HIV-1/*immunology
    Antibodies, Neutralizing ; HIV Infections/virology ; Humans ; T-Lymphocytes, Cytotoxic/immunology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells.
    Autorzy:
    Hew KM; Department of Pediatric Allergy and Immunology, Stanford University, Stanford, CA, USA.
    Walker AI
    Kohli A
    Garcia M
    Syed A
    McDonald-Hyman C
    Noth EM
    Mann JK
    Pratt B
    Balmes J
    Hammond SK
    Eisen EA
    Nadeau KC
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    Źródło:
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2015 Jan; Vol. 45 (1), pp. 238-48.
    Typ publikacji:
    Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Asthma*/chemically induced
    Asthma*/immunology
    Rhinitis, Allergic*/chemically induced
    Rhinitis, Allergic*/immunology
    Air Pollution/*adverse effects
    Environmental Exposure/*adverse effects
    Epigenesis, Genetic/*drug effects
    Immunity, Cellular/*drug effects
    Polycyclic Aromatic Hydrocarbons/*toxicity
    T-Lymphocytes, Regulatory/*immunology
    Child ; Child, Preschool ; DNA Methylation/drug effects ; DNA Methylation/immunology ; Epigenesis, Genetic/immunology ; Female ; Forkhead Transcription Factors/immunology ; Humans ; Immunoglobulin E/immunology ; Infant ; Interferon-gamma/immunology ; Interleukin-10/immunology ; Male
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.
    Autorzy:
    Mann JK; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Barton JP; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, United States of America.
    Ferguson AL; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
    Omarjee S; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
    Walker BD; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, United States of America; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.
    Chakraborty A; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, United States of America; Departments of Chemistry and Physics, Massachusetts Institute of Technology, Boston, Massachusetts, United States of America.
    Ndung'u T; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, United States of America; Max Planck Institute for Infection Biology, Berlin, Germany.
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    Źródło:
    PLoS computational biology [PLoS Comput Biol] 2014 Aug 07; Vol. 10 (8), pp. e1003776. Date of Electronic Publication: 2014 Aug 07 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genes, gag/*genetics
    Genetic Fitness/*genetics
    HIV-1/*genetics
    HIV-1/*physiology
    Immune Evasion/*genetics
    Computer Simulation ; HIV Infections/virology ; Humans ; Models, Biological ; Mutation ; RNA, Viral
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.
    Autorzy:
    Mann JK; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada. mark_.
    Byakwaga H
    Kuang XT
    Le AQ
    Brumme CJ
    Mwimanzi P
    Omarjee S
    Martin E
    Lee GQ
    Baraki B
    Danroth R
    McCloskey R
    Muzoora C
    Bangsberg DR
    Hunt PW
    Goulder PJ
    Walker BD
    Harrigan PR
    Martin JN
    Ndung'u T
    Brockman MA
    Brumme ZL
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    Źródło:
    Retrovirology [Retrovirology] 2013 Sep 16; Vol. 10, pp. 100. Date of Electronic Publication: 2013 Sep 16.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Host-Pathogen Interactions*
    CD4 Antigens/*biosynthesis
    HIV-1/*physiology
    Histocompatibility Antigens Class I/*biosynthesis
    nef Gene Products, Human Immunodeficiency Virus/*metabolism
    Adult ; Africa ; CD4-Positive T-Lymphocytes/virology ; Cell Line ; Down-Regulation ; Female ; Genotype ; HIV Infections/virology ; HIV-1/classification ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Male ; North America
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.
    Autorzy:
    Chopera DR; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa ; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa ; Institute of Infectious Disease and Molecular Medicine, and the Division of Medical Virology, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa ; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
    Mann JK
    Mwimanzi P
    Omarjee S
    Kuang XT
    Ndabambi N
    Goodier S
    Martin E
    Naranbhai V
    Karim SA
    Karim QA
    Brumme ZL
    Ndung'u T
    Williamson C
    Brockman MA
    Pokaż więcej
    Corporate Authors:
    CAPRISA 004 TRAPS Team
    Źródło:
    PloS one [PLoS One] 2013 Aug 28; Vol. 8 (8), pp. e71758. Date of Electronic Publication: 2013 Aug 28 (Print Publication: 2013).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Adenine/*analogs & derivatives
    Anti-HIV Agents/*pharmacology
    HIV Infections/*virology
    HIV-1/*genetics
    Organophosphonates/*pharmacology
    Vaginal Creams, Foams, and Jellies/*pharmacology
    Adenine/administration & dosage ; Adenine/pharmacology ; Anti-HIV Agents/administration & dosage ; Clinical Trials as Topic ; Female ; HIV Infections/prevention & control ; HIV Infections/transmission ; HIV-1/drug effects ; HIV-1/enzymology ; Humans ; Organophosphonates/administration & dosage ; Phylogeny ; Sequence Analysis, DNA ; Tenofovir ; Vaginal Creams, Foams, and Jellies/administration & dosage ; Virus Replication ; gag Gene Products, Human Immunodeficiency Virus/genetics ; nef Gene Products, Human Immunodeficiency Virus/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Evaluation of a heat vulnerability index on abnormally hot days: an environmental public health tracking study.
    Autorzy:
    Reid CE; Environmental Health Sciences, School of Public Health, University of California-Berkeley, Berkeley, California 94720-7360, USA. />Mann JK
    Alfasso R
    English PB
    King GC
    Lincoln RA
    Margolis HG
    Rubado DJ
    Sabato JE
    West NL
    Woods B
    Navarro KM
    Balmes JR
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    Źródło:
    Environmental health perspectives [Environ Health Perspect] 2012 May; Vol. 120 (5), pp. 715-20. Date of Electronic Publication: 2012 Jan 31.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
    MeSH Terms:
    Climate*
    Environmental Health*
    Hot Temperature*
    Public Health*
    Heat Exhaustion/*epidemiology
    Disease Susceptibility ; Humans ; United States/epidemiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Altered pulmonary function in children with asthma associated with highway traffic near residence.
    Autorzy:
    Margolis HG; Division of General Medicine, Department of Internal Medicine, School of Medicine, University of California, Davis, CA, USA.
    Mann JK
    Lurmann FW
    Mortimer KM
    Balmes JR
    Hammond SK
    Tager IB
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    Źródło:
    International journal of environmental health research [Int J Environ Health Res] 2009 Apr; Vol. 19 (2), pp. 139-55.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Environmental Exposure*
    Asthma/*physiopathology
    Lung/*physiopathology
    Vehicle Emissions/*toxicity
    Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Regression Analysis ; Residence Characteristics ; Respiratory Function Tests
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Hin-mediated DNA knotting and recombining promote replicon dysfunction and mutation.
    Autorzy:
    Deibler RW; Interdepartmental Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030-3411, USA. richard_
    Mann JK
    Sumners de WL
    Zechiedrich L
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    Źródło:
    BMC molecular biology [BMC Mol Biol] 2007 May 25; Vol. 8, pp. 44. Date of Electronic Publication: 2007 May 25.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Mutation*
    Nucleic Acid Conformation*
    Recombination, Genetic*
    Replicon*/genetics
    DNA/*chemistry
    DNA/*metabolism
    DNA Nucleotidyltransferases/*metabolism
    DNA/genetics ; DNA Nucleotidyltransferases/genetics ; DNA Replication ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Genes, Reporter ; Plasmids/genetics ; Plasmids/metabolism ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia.
    Autorzy:
    Mann JK; Department of Epidemiology, University of California, Berkeley, 94720, USA.
    Tager IB
    Lurmann F
    Segal M
    Quesenberry CP Jr
    Lugg MM
    Shan J
    Van Den Eeden SK
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    Źródło:
    Environmental health perspectives [Environ Health Perspect] 2002 Dec; Vol. 110 (12), pp. 1247-52.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Air Pollutants/*adverse effects
    Arrhythmias, Cardiac/*complications
    Carbon Monoxide/*adverse effects
    Heart Failure/*complications
    Myocardial Ischemia/*epidemiology
    Myocardial Ischemia/*etiology
    Nitrogen Dioxide/*adverse effects
    Oxidants, Photochemical/*adverse effects
    Ozone/*adverse effects
    Patient Admission/*statistics & numerical data
    Aged ; Epidemiologic Studies ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Myocardial Ischemia/therapy ; Particle Size ; Risk Factors ; Vehicle Emissions/adverse effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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