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Tytuł:
Hierarchical Clustering and Trajectory Analyses Reveal Viremia-Independent B-Cell Perturbations in HIV-2 Infection.
Autorzy:
Johansson E; Department of Laboratory Medicine, Lund University, 22184 Lund, Sweden.
Kerkman PF; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.; Department of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Scharf L; Department of Laboratory Medicine, Karolinska Institutet, 14152 Huddinge, Sweden.
Lindman J; Department of Clinical Sciences Lund, Lund University, 22184 Lund, Sweden.
Szojka ZI; Department of Laboratory Medicine, Lund University, 22184 Lund, Sweden.
Månsson F; Department of Translational Medicine, Lund University, 20502 Malmö, Sweden.
Biague A; National Laboratory for Public Health, Bissau 1041, Guinea-Bissau.
Medstrand P; Department of Translational Medicine, Lund University, 20502 Malmö, Sweden.
Norrgren H; Department of Clinical Sciences Lund, Lund University, 22184 Lund, Sweden.
Buggert M; Department of Medicine Huddinge, Karolinska Institutet, 14186 Stockholm, Sweden.
Karlsson AC; Department of Laboratory Medicine, Karolinska Institutet, 14152 Huddinge, Sweden.
Forsell MNE; Department of Clinical Microbiology, Umeå University, 90185 Umeå, Sweden.
Esbjörnsson J; Department of Translational Medicine, Lund University, 20502 Malmö, Sweden.; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Jansson M; Department of Laboratory Medicine, Lund University, 22184 Lund, Sweden.
The Swegub Core Group
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Źródło:
Cells [Cells] 2022 Oct 06; Vol. 11 (19). Date of Electronic Publication: 2022 Oct 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections*
HIV Seropositivity*
HIV-1*/physiology
Cluster Analysis ; HIV-2 ; Humans ; Viremia
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells.
Autorzy:
Fittje P; Leibniz Institute of Virology (LIV), Hamburg, Germany.
Hœlzemer A; Leibniz Institute of Virology (LIV), Hamburg, Germany.; First Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Garcia-Beltran WF; Leibniz Institute of Virology (LIV), Hamburg, Germany.; Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America.
Vollmers S; Leibniz Institute of Virology (LIV), Hamburg, Germany.
Niehrs A; Leibniz Institute of Virology (LIV), Hamburg, Germany.
Hagemann K; Leibniz Institute of Virology (LIV), Hamburg, Germany.
Martrus G; Leibniz Institute of Virology (LIV), Hamburg, Germany.
Körner C; Leibniz Institute of Virology (LIV), Hamburg, Germany.
Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Sauter D; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
Altfeld M; Leibniz Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
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Źródło:
PLoS pathogens [PLoS Pathog] 2022 Jun 24; Vol. 18 (6), pp. e1010572. Date of Electronic Publication: 2022 Jun 24 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections*
HIV Seropositivity*
HIV-1*
Antiviral Agents/metabolism ; Down-Regulation ; Humans ; Killer Cells, Natural ; Ligands ; Receptors, Natural Killer Cell/metabolism ; Receptors, Virus ; nef Gene Products, Human Immunodeficiency Virus/genetics ; nef Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Systems Biology Analysis of the Antagonizing Effects of HIV-1 Tat Expression in the Brain over Transcriptional Changes Caused by Methamphetamine Sensitization.
Autorzy:
Basova LV; San Diego Biomedical Research Institute, San Diego, CA 92121, USA.
Kesby JP; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.; Queensland Brain Institute, The University of Queensland, St. Lucia, Qld 4072, Australia.; Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Qld 4029, Australia.
Kaul M; School of Medicine, Department of Biomedical Sciences, University of California Riverside, Riverside, CA 92521, USA.
Semenova S; Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.; Parexel International, Glendale, CA 91206, USA.
Marcondes MCG; San Diego Biomedical Research Institute, San Diego, CA 92121, USA.
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Źródło:
Viruses [Viruses] 2020 Apr 09; Vol. 12 (4). Date of Electronic Publication: 2020 Apr 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Systems Biology*/methods
Brain/*metabolism
Gene Expression Regulation/*drug effects
HIV Infections/*virology
HIV-1/*drug effects
HIV-1/*genetics
Methamphetamine/*pharmacology
tat Gene Products, Human Immunodeficiency Virus/*genetics
Animals ; Binding Sites ; Brain/virology ; Gene Expression Profiling ; Humans ; Male ; Mice ; Mice, Transgenic ; Mitochondria/metabolism ; Protein Binding ; Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis.
Autorzy:
Claiborne DT; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Scully EP; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Palmer CD; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Prince JL; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.
Macharia GN; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.
Kopycinski J; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.
Michelo CM; Zambia-Emory HIV Research Project, Lusaka, Zambia.
Wiener HW; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Parker R; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Nganou-Makamdop K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Douek D; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Altfeld M; Virus Immunology Unit, Heinrich-Pette-Institut, Hamburg, Germany.
Gilmour J; Human Immunology Laboratory, International AIDS Vaccine Initiative, London, United Kingdom.
Price MA; International AIDS Vaccine Initiative, New York, New York, United States of America.; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California, United States of America.
Tang J; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
Kilembe W; Zambia-Emory HIV Research Project, Lusaka, Zambia.
Allen SA; Zambia-Emory HIV Research Project, Lusaka, Zambia.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
Hunter E; Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2019 Aug 26; Vol. 15 (8), pp. e1007981. Date of Electronic Publication: 2019 Aug 26 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
CD4-Positive T-Lymphocytes/*immunology
Genes, MHC Class I/*genetics
HIV Infections/*immunology
HIV-1/*immunology
HIV-1/*pathogenicity
Lipopolysaccharides/*deficiency
Virus Replication/*immunology
Alleles ; Cohort Studies ; Female ; HIV Infections/genetics ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Male ; T-Lymphocytes, Cytotoxic/immunology ; Viral Load ; Virus Replication/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.
Autorzy:
Buggert M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.; Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Nguyen S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
McLane LM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Steblyanko M; Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States of America.
Anikeeva N; Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States of America.
Paquin-Proulx D; Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Del Rio Estrada PM; Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
Ablanedo-Terrazas Y; Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
Noyan K; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Reuter MA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Demers K; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Sandberg JK; Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Eller MA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Streeck H; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.; Institute for HIV Research, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Jansson M; Department of Laboratory Medicine, Lund University, Lund, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Nowak P; Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Sönnerborg A; Center for Infection Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Canaday DH; Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH, United States of America.; Geriatric Research, Education and Clinical Center, Louis Stokes VA Medical Center, Cleveland, OH, United States of America.
Naji A; Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Wherry EJ; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Robb ML; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States of America.
Deeks SG; Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA, United States of America.
Reyes-Teran G; Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
Sykulev Y; Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States of America.; Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States of America.
Karlsson AC; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2018 Apr 13; Vol. 14 (4), pp. e1006973. Date of Electronic Publication: 2018 Apr 13 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunologic Surveillance*
CD4-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Lymph Nodes/*immunology
Lymphoid Tissue/*immunology
CD4-Positive T-Lymphocytes/virology ; Case-Control Studies ; HIV Infections/virology ; Humans ; Lymph Nodes/virology ; Lymphoid Tissue/virology ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health.
Autorzy:
Altfeld M; Department of Virus Immunology, Heinrich-Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Bunders MJ; Department of Virus Immunology, Heinrich-Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany. m..; Department of Experimental Immunology, University of Amsterdam (UvA), Academic Medical Center (AMC), Amsterdam, The Netherlands. m..; Emma Childrens Hospital,UvA, AMC, Amsterdam, The Netherlands. m..
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Źródło:
Seminars in immunopathology [Semin Immunopathol] 2016 Nov; Vol. 38 (6), pp. 727-738. Date of Electronic Publication: 2016 Jul 08.
Typ publikacji:
Journal Article; Review
MeSH Terms:
HIV-1*/immunology
Infant Health*
Pregnancy Complications, Infectious*
Pregnancy Outcome*
HIV Infections/*epidemiology
Antiretroviral Therapy, Highly Active/adverse effects ; Antiretroviral Therapy, Highly Active/methods ; Female ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Immune System/cytology ; Immune System/drug effects ; Immune System/immunology ; Immune System/metabolism ; Immunomodulation/drug effects ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Maternal Exposure/adverse effects ; Pregnancy ; Premature Birth/immunology ; Prenatal Exposure Delayed Effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.
Autorzy:
Tully DC; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Ogilvie CB; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Batorsky RE; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Bean DJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Power KA; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Ghebremichael M; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Bedard HE; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Gladden AD; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Seese AM; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Amero MA; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Lane K; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
McGrath G; Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Bazner SB; Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Tinsley J; The Fenway Institute, Fenway Health, Boston, Massachusetts, United States of America.
Lennon NJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Henn MR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.
Norris PJ; Blood Systems Research Institute, San Francisco, California, United States of America.
Rosenberg ES; Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Mayer KH; The Fenway Institute, Fenway Health, Boston, Massachusetts, United States of America.
Jessen H; HIV Clinic Praxis, Jessen, Berlin, Germany.
Kosakovsky Pond SL; Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.
Altfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Heinrich-Pette-Institut, Hamburg, Germany.
Carlson JM; Microsoft Research, Redmond, Washington, United States of America.
Allen TM; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2016 May 10; Vol. 12 (5), pp. e1005619. Date of Electronic Publication: 2016 May 10 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
HIV Infections/*transmission
HIV-1/*genetics
Evolution, Molecular ; Genetic Variation ; Genome, Viral ; HIV Envelope Protein gp120/genetics ; Humans ; Male ; Models, Theoretical ; Polymerase Chain Reaction ; Selection, Genetic/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
Autorzy:
Hölzemer A; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Heinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany.; First Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thobakgale CF; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Jimenez Cruz CA; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, United States of America.
Garcia-Beltran WF; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Carlson JM; Microsoft Research, Los Angeles, California, United States of America.
van Teijlingen NH; Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands.
Mann JK; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Jaggernath M; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Kang SG; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, United States of America.
Körner C; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Heinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Chung AW; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Schafer JL; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Microbiology, New England Primate Research Center, Southborough, Massachusetts, United States of America.
Evans DT; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Microbiology, New England Primate Research Center, Southborough, Massachusetts, United States of America.; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Madison, Wisconsin, United States of America.
Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Walker BD; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.
Goulder PJ; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
Carrington M; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.
Hartmann P; First Department of Internal Medicine, Division of Infectious Diseases, University of Cologne, Cologne, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
Pertel T; Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Zhou R; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, United States of America.
Ndung'u T; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; Max Planck Institute for Infection Biology, Berlin, Germany.; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Altfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America.; Heinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany.
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Źródło:
PLoS medicine [PLoS Med] 2015 Nov 17; Vol. 12 (11), pp. e1001900; discussion e1001900. Date of Electronic Publication: 2015 Nov 17 (Print Publication: 2015).
Typ publikacji:
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Variation*
Immune Evasion*
HIV Core Protein p24/*genetics
HIV-1/*genetics
HLA-C Antigens/*genetics
Killer Cells, Natural/*immunology
gag Gene Products, Human Immunodeficiency Virus/*genetics
Cohort Studies ; Epitopes ; Female ; Genotype ; HIV Infections/immunology ; HIV-1/immunology ; HLA-C Antigens/immunology ; Humans ; Male ; RNA, Viral/genetics ; Receptors, KIR2DL3/immunology ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Analysis, RNA ; South Africa
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Multidimensional Clusters of CD4+ T Cell Dysfunction Are Primarily Associated with the CD4/CD8 Ratio in Chronic HIV Infection.
Autorzy:
Frederiksen J; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
Buggert M; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Noyan K; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Nowak P; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Sönnerborg A; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Lund O; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
Karlsson AC; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
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Źródło:
PloS one [PLoS One] 2015 Sep 24; Vol. 10 (9), pp. e0137635. Date of Electronic Publication: 2015 Sep 24 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-CD8 Ratio*
CD4-Positive T-Lymphocytes/*immunology
CD4-Positive T-Lymphocytes/*metabolism
HIV Infections/*immunology
HIV Infections/*metabolism
HIV-1/*immunology
Adult ; Case-Control Studies ; Chronic Disease ; Cluster Analysis ; Female ; Flow Cytometry ; HIV Antibodies/immunology ; HIV Infections/blood ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Antigen-specific NK cell memory in rhesus macaques.
Autorzy:
Reeves RK; 1] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. [2] Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA.
Li H; 1] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. [2] Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA.
Jost S; Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, Massachusetts, USA.
Blass E; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Li H; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Schafer JL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Varner V; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Manickam C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Eslamizar L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Altfeld M; 1] Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, Massachusetts, USA. [2] Heinrich-Pette-Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany.
von Andrian UH; 1] Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, Massachusetts, USA. [2] Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Barouch DH; 1] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. [2] Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, Massachusetts, USA.
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Źródło:
Nature immunology [Nat Immunol] 2015 Sep; Vol. 16 (9), pp. 927-32. Date of Electronic Publication: 2015 Jul 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Dendritic Cells/*immunology
HIV-1/*immunology
Killer Cells, Natural/*immunology
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*immunology
AIDS Vaccines/immunology ; Animals ; Immunologic Memory ; Killer Cells, Natural/metabolism ; Liver/cytology ; Liver/immunology ; Macaca mulatta ; Receptors, NK Cell Lectin-Like/metabolism ; Spleen/cytology ; Spleen/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.
Autorzy:
Leeansyah E; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Svärd J; Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Dias J; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Buggert M; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Nyström J; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Quigley MF; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Moll M; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Sönnerborg A; Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Nowak P; Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Sandberg JK; Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
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Źródło:
PLoS pathogens [PLoS Pathog] 2015 Aug 21; Vol. 11 (8), pp. e1005072. Date of Electronic Publication: 2015 Aug 21 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV-1*
Cytotoxicity, Immunologic/*immunology
HIV Infections/*immunology
Interleukin-7/*immunology
Natural Killer T-Cells/*immunology
Cells, Cultured ; Flow Cytometry ; Humans ; Leukocytes, Mononuclear/immunology ; Lymphocyte Activation/immunology ; Mucous Membrane/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Innate immunity against HIV-1 infection.
Autorzy:
Altfeld M; Department of Virus Immunology, Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Gale M Jr; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA.
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Źródło:
Nature immunology [Nat Immunol] 2015 Jun; Vol. 16 (6), pp. 554-62.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms:
Immunity, Innate*
HIV Infections/*immunology
HIV-1/*physiology
Receptors, Pattern Recognition/*immunology
Adaptive Immunity ; Animals ; Cytokines/metabolism ; Humans ; Immune Evasion ; Virus Replication
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.
Autorzy:
Buggert M; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Tauriainen J; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Yamamoto T; Immunology Laboratory, National Institutes of Health, Bethesda, Maryland, United States of America.
Frederiksen J; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
Ivarsson MA; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Michaëlsson J; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Lund O; Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.
Hejdeman B; Department of Infectious Diseases Venhälsan, Stockholm South General Hospital (Södersjukhuset), Stockholm, Sweden.
Jansson M; Department of Laboratory Medicine, Lund University, Lund, Sweden; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Sönnerborg A; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Koup RA; Immunology Laboratory, National Institutes of Health, Bethesda, Maryland, United States of America.
Betts MR; Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Karlsson AC; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
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Źródło:
PLoS pathogens [PLoS Pathog] 2014 Jul 17; Vol. 10 (7), pp. e1004251. Date of Electronic Publication: 2014 Jul 17 (Print Publication: 2014).
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD8-Positive T-Lymphocytes/*immunology
HIV Infections/*immunology
HIV-1/*physiology
T-Box Domain Proteins/*immunology
Virus Replication/*immunology
Adult ; Animals ; Antiretroviral Therapy, Highly Active ; CD8-Positive T-Lymphocytes/pathology ; Chronic Disease ; Female ; Gene Expression Regulation/immunology ; HIV Infections/drug therapy ; HIV Infections/pathology ; Humans ; Male ; Mice ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection.
Autorzy:
Vaidya SA
Streeck H
Beckwith N
Ghebremichael M
Pereyra F
Kwon DS
Addo MM
Rychert J
Routy JP
Jessen H
Kelleher AD
Hecht F
Sekaly RP
Carrington M
Walker BD
Allen TM
Rosenberg ES
Altfeld M; Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Boston, MA, USA. .
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Źródło:
Retrovirology [Retrovirology] 2013 Nov 18; Vol. 10, pp. 139. Date of Electronic Publication: 2013 Nov 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
HIV Infections/*immunology
HIV Infections/*virology
HIV-1/*immunology
HLA-B Antigens/*immunology
Adult ; Amino Acid Substitution ; Female ; HLA-B Antigens/genetics ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Point Mutation ; Polymorphism, Genetic ; Time Factors ; Viral Load
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection.
Autorzy:
Jost S; Ragon Institute of MGH, MIT and Harvard, 400 Technology Square, Cambridge, MA 02139, USA.
Moreno-Nieves UY
Garcia-Beltran WF
Rands K
Reardon J
Toth I
Piechocka-Trocha A
Altfeld M
Addo MM
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Źródło:
Retrovirology [Retrovirology] 2013 Jul 18; Vol. 10, pp. 74. Date of Electronic Publication: 2013 Jul 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Host-Pathogen Interactions*
Galectins/*blood
HIV-1/*immunology
HIV-1/*physiology
Killer Cells, Natural/*immunology
Membrane Proteins/*genetics
Anti-Retroviral Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Dendritic Cells/immunology ; Galectins/genetics ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; Hepatitis A Virus Cellular Receptor 2 ; Humans ; Monocytes/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Changes in Natural Killer cell activation and function during primary HIV-1 Infection.
Autorzy:
Naranbhai V; CAPRISA - Centre for the AIDS Programme of Research in South Africa, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Altfeld M
Karim SS
Ndung'u T
Karim QA
Carr WH
Pokaż więcej
Źródło:
PloS one [PLoS One] 2013; Vol. 8 (1), pp. e53251. Date of Electronic Publication: 2013 Jan 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections/*immunology
HIV Infections/*physiopathology
HIV-1/*immunology
Killer Cells, Natural/*immunology
Lymphocyte Activation/*immunology
Adolescent ; Adult ; Female ; HIV Infections/blood ; Humans ; Lymphocyte Count ; Lymphoid Tissue/immunology ; Lymphoid Tissue/pathology ; Male ; Receptors, KIR/immunology ; Receptors, Lymphocyte Homing/metabolism ; T-Lymphocytes/immunology ; Viral Load/immunology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Characterization of HIV-specific CD4+ T cell responses against peptides selected with broad population and pathogen coverage.
Autorzy:
Buggert M; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Norström MM
Czarnecki C
Tupin E
Luo M
Gyllensten K
Sönnerborg A
Lundegaard C
Lund O
Nielsen M
Karlsson AC
Pokaż więcej
Źródło:
PloS one [PLoS One] 2012; Vol. 7 (7), pp. e39874. Date of Electronic Publication: 2012 Jul 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-Positive T-Lymphocytes/*immunology
Epitopes/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Peptides/*immunology
Adult ; Epitope Mapping ; Female ; HIV Infections/virology ; Histocompatibility Antigens Class II/immunology ; Human Immunodeficiency Virus Proteins/chemistry ; Humans ; Male ; Middle Aged ; Peptides/chemistry ; Viral Load ; Young Adult ; gag Gene Products, Human Immunodeficiency Virus/chemistry ; nef Gene Products, Human Immunodeficiency Virus/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
HLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function.
Autorzy:
Fadda L; Ragon Institute of MGH, MIT and Harvard, Charlestown, Massachusetts, United States of America.
Körner C
Kumar S
van Teijlingen NH
Piechocka-Trocha A
Carrington M
Altfeld M
Pokaż więcej
Źródło:
PLoS pathogens [PLoS Pathog] 2012; Vol. 8 (7), pp. e1002805. Date of Electronic Publication: 2012 Jul 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Core Protein p24/*immunology
HIV-1/*immunology
HLA-C Antigens/*immunology
Killer Cells, Natural/*immunology
Receptors, KIR2DL2/*metabolism
Cell Line ; Cytotoxicity, Immunologic ; Genetic Variation ; HIV Core Protein p24/genetics ; HIV Core Protein p24/metabolism ; HIV Infections/immunology ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; Immune Evasion ; Protein Binding ; Sequence Alignment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 42

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