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Wyszukujesz frazę ""Marioni, Riccardo E."" wg kryterium: Autor


Tytuł :
Attitudes to ageing, biomarkers of ageing and mortality: the Lothian Birth Cohort 1936.
Autorzy :
McLachlan KJJ; Medical School, The University of Edinburgh, Edinburgh, UK.
Cole JH; Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, London, UK.; Centre for Medical Imaging Computing, Computer Science, University College London, London, UK.; Dementia Research Centre, Institute of Neurology, University College London, London, UK.
Harris SE; Psychology, The University of Edinburgh, Edinburgh, UK.
Marioni RE; Psychology, The University of Edinburgh, Edinburgh, UK.; MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK.
Deary IJ; Psychology, The University of Edinburgh, Edinburgh, UK.
Gale CR; Psychology, The University of Edinburgh, Edinburgh, UK .; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, Hampshire, UK.
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Źródło :
Journal of epidemiology and community health [J Epidemiol Community Health] 2020 Apr; Vol. 74 (4), pp. 377-383. Date of Electronic Publication: 2020 Jan 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Mortality*
Aging/*genetics
DNA Methylation/*genetics
Longevity/*genetics
Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Genetic Markers ; Humans ; Male ; Middle Aged ; Real-Time Polymerase Chain Reaction ; United Kingdom
Czasopismo naukowe
Tytuł :
Epigenetic Age Acceleration and Cognitive Function in African American Adults in Midlife: The Atherosclerosis Risk in Communities Study.
Autorzy :
Bressler J; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, UK.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK.
Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK.
Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Baltimore, Maryland, UK.
Gottesman RF; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, UK.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, UK.
Windham BG; Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, UK.
Grove ML; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, UK.
Guan W; Division of Biostatistics, School of Public Health, Minneapolis, UK.
Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, UK.
Evans KL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK.
Mcintosh AM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK.; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK.; Department of Psychology, University of Edinburgh, UK.
Mosley TH; Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, UK.
Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, UK.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas.
Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, UK.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Baltimore, Maryland, UK.
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Źródło :
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2020 Feb 14; Vol. 75 (3), pp. 473-480.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cognition*
Epigenesis, Genetic*
African Americans/*genetics
African Americans/*psychology
Aging/*genetics
Aged ; Aging/blood ; Atherosclerosis/blood ; Atherosclerosis/epidemiology ; Atherosclerosis/genetics ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Risk Assessment ; Time Factors
Czasopismo naukowe
Tytuł :
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age.
Autorzy :
Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK. .; Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK. .
Cox SR; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, 300 Bath St, Glasgow, UK.
Bell S; UK Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.; The National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge Neurology Unit, Cambridge Biomedical Campus, Cambridge, CB20QQ, UK.
Marioni RE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
Prins BP; UK Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
Pattie A; Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Corley J; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Muñoz Maniega S; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, UK.; UK Dementia Research Institute at the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, UK.
Valdés Hernández M; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, UK.; UK Dementia Research Institute at the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, UK.
Morris Z; Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, UK.
John S; Translational Biology, Biogen, Cambridge, MA, 02142, USA.
Bronson PG; Translational Biology, Biogen, Cambridge, MA, 02142, USA.
Tucker-Drob EM; Department of Psychology, University of Texas, 108 E Dean Keeton St, Austin, TX, USA.
Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Bastin ME; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, 300 Bath St, Glasgow, UK.; Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, UK.
Wardlaw JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, 300 Bath St, Glasgow, UK.; Brain Research Imaging Centre, Neuroimaging Sciences, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, UK.; UK Dementia Research Institute at the University of Edinburgh, Edinburgh BioQuarter, Edinburgh, UK.
Butterworth AS; UK Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.; The National Institute for Health Research Blood and Transplant Unit in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
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Źródło :
Nature communications [Nat Commun] 2020 Feb 10; Vol. 11 (1), pp. 800. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
Biomarkers/*blood
Brain/*pathology
Cognition/*physiology
Nerve Tissue Proteins/*blood
Aged ; Aged, 80 and over ; Biomarkers/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Female ; Humans ; Male ; Nerve Tissue Proteins/metabolism ; Proteomics
Czasopismo naukowe
Tytuł :
Age-dependent DNA methylation patterns on the Y chromosome in elderly males.
Autorzy :
Lund JB; Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Li S; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Christensen K; Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Mengel-From J; Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Soerensen M; Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Marioni RE; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Starr J; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Pattie A; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Deary IJ; Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Baumbach J; Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.
Tan Q; Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
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Źródło :
Aging cell [Aging Cell] 2020 Feb; Vol. 19 (2), pp. e12907. Date of Electronic Publication: 2019 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CpG Islands*
DNA Methylation*
Aging/*genetics
Aging/*metabolism
Chromosomes, Human, Y/*genetics
Chromosomes, Human, Y/*metabolism
Aged ; Aged, 80 and over ; Databases, Genetic ; Epigenesis, Genetic ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Mortality ; Regression Analysis ; Risk Factors
Czasopismo naukowe
Tytuł :
An epigenome-wide association study of sex-specific chronological ageing.
Autorzy :
McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Zhang F; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Zhang Q; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Stevenson AJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK.
Bermingham ML; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Boutin T; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Morris SW; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Murray AD; Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland, UK.
Whalley HC; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, Scotland, UK.
Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK.
Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Evans KL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK.
Chandra T; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK.; Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK.
McIntosh AM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK.; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, Scotland, UK.
Yang J; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.; Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK. Riccardo.Marioni@ed.ac.uk.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland, UK. Riccardo.Marioni@ed.ac.uk.
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Źródło :
Genome medicine [Genome Med] 2019 Dec 31; Vol. 12 (1), pp. 1. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Genome-Wide Association Study*
Aging/*genetics
Adult ; Aged ; Chromosomes, Human, X/genetics ; CpG Islands ; Female ; Gene Expression Regulation ; Humans ; Linear Models ; Male ; Middle Aged ; Quantitative Trait Loci ; Sex Characteristics
Czasopismo naukowe
Tytuł :
Childhood intelligence attenuates the association between biological ageing and health outcomes in later life.
Autorzy :
Stevenson AJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Redmond P; Department for Psychology, University of Edinburgh, Edinburgh, UK.
Taylor AM; Department for Psychology, University of Edinburgh, Edinburgh, UK.
Zhang Q; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.
McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.
Spires-Jones TL; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
McIntosh AM; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Deary IJ; Department for Psychology, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.
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Źródło :
Translational psychiatry [Transl Psychiatry] 2019 Nov 28; Vol. 9 (1), pp. 323. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Educational Status*
Genetic Association Studies*
Health Status*
Aging/*physiology
DNA Methylation/*physiology
Epigenesis, Genetic/*physiology
Intelligence/*physiology
Aged ; Aging/genetics ; Biomarkers ; Child ; DNA Methylation/genetics ; Epigenesis, Genetic/genetics ; Female ; Humans ; Longitudinal Studies ; Male ; Phenotype
Czasopismo naukowe
Tytuł :
DNA methylation aging clocks: challenges and recommendations.
Autorzy :
Bell CG; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. .
Lowe R; The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. .
Adams PD; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. .; Beatson Institute for Cancer Research and University of Glasgow, Glasgow, UK. .
Baccarelli AA; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. .
Beck S; Medical Genomics, Paul O'Gorman Building, UCL Cancer Institute, University College London, London, UK. .
Bell JT; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. .
Christensen BC; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA. .; Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA. .; Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA. .
Gladyshev VN; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. .
Heijmans BT; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands. .
Horvath S; Department of Human Genetics, Gonda Research Center, David Geffen School of Medicine, Los Angeles, CA, USA. .; Department of Biostatistics, School of Public Health, University of California-Los Angeles, Los Angeles, CA, USA. .
Ideker T; San Diego Center for Systems Biology, University of California-San Diego, San Diego, CA, USA. .
Issa JJ; Fels Institute for Cancer Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. .
Kelsey KT; Department of Epidemiology, Brown University, Providence, RI, USA. .; Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA. .
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.
Reik W; Epigenetics Programme, The Babraham Institute, Cambridge, UK. .; The Wellcome Trust Sanger Institute, Cambridge, UK. .
Relton CL; Medical Research Council Integrative Epidemiology Unit (MRC IEU), School of Social and Community Medicine, University of Bristol, Bristol, UK. .
Schalkwyk LC; School of Biological Sciences, University of Essex, Colchester, UK. .
Teschendorff AE; CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China. .; UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street, London, WC1E 6BT, UK. .
Wagner W; Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen Faculty of Medicine, Aachen, Germany. .
Zhang K; Faculty of Medicine, Macau University of Science and Technology, Taipa, Macau. .
Rakyan VK; The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. .
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Źródło :
Genome biology [Genome Biol] 2019 Nov 25; Vol. 20 (1), pp. 249. Date of Electronic Publication: 2019 Nov 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biological Clocks*
DNA Methylation*
Epigenesis, Genetic*
Aging/*metabolism
Animals ; Genome, Human ; Genome-Wide Association Study ; Humans
Czasopismo naukowe
Tytuł :
A meta-analysis of genome-wide association studies of epigenetic age acceleration.
Autorzy :
Gibson J; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Russ TC; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Dementia Prevention, University of Edinburgh, Edinburgh, United Kingdom.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Cognitive Ageing & Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
Clarke TK; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Howard DM; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Evans KL; Centre for Cognitive Ageing & Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Walker RM; Centre for Cognitive Ageing & Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Bermingham ML; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Morris SW; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.; Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Murray AD; Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom.
Porteous DJ; Centre for Cognitive Ageing & Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Horvath S; Department of Human Genetics, David Geffen School of Medicine, Los Angeles, CA, United States of America.; Department of Biostatistics, School of Public Health, University of California-Los Angeles, Los Angeles, CA, United States of America.
Lu AT; Department of Human Genetics, David Geffen School of Medicine, Los Angeles, CA, United States of America.
McIntosh AM; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Cognitive Ageing & Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
Whalley HC; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Marioni RE; Centre for Cognitive Ageing & Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
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Źródło :
PLoS genetics [PLoS Genet] 2019 Nov 18; Vol. 15 (11), pp. e1008104. Date of Electronic Publication: 2019 Nov 18 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Genetic Predisposition to Disease*
Aging/*genetics
Longevity/*genetics
Aging/pathology ; DNA Methylation/genetics ; Gene Expression Regulation/genetics ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide/genetics
Czasopismo naukowe
Tytuł :
Epigenome-wide association study of leukocyte telomere length.
Autorzy :
Lee Y; Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway.
Sun D; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.; Department of Epidemiology, Tulane University, New Orleans, LA 70118, USA.
Ori APS; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA.
Lu AT; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 9009, USA.
Seeboth A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Soerensen M; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense C, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.; Center for Individualized Medicine in Arterial Diseases, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense C, Denmark.
Mengel-From J; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense C, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Hjelmborg J; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense C, Denmark.
Christensen K; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense C, Denmark.; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.; Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Levy D; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.; The Framingham Heart Study, Framingham, MA 01702, USA.
Reiner AP; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Chen W; Department of Epidemiology, Tulane University, New Orleans, LA 70118, USA.
Li S; Children's Minnesota Research Institute, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN 55404, USA.
Harris JR; Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway.; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Magnus P; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Aviv A; Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA.
Jugessur A; Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway.; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Horvath S; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 9009, USA.; Department of of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA.
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Źródło :
Aging [Aging (Albany NY)] 2019 Aug 26; Vol. 11 (16), pp. 5876-5894. Date of Electronic Publication: 2019 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Epigenome*
Aging/*genetics
Leukocytes/*metabolism
Telomere/*metabolism
CpG Islands/genetics ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing.
Autorzy :
Zhang Q; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Vallerga CL; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Lin T; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Henders AK; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Montgomery GW; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
He J; Department of Neurology, Peking University, Third Hospital, No. 49, North Garden Road, Haidian District, Beijing, 100191, China.
Fan D; Department of Neurology, Peking University, Third Hospital, No. 49, North Garden Road, Haidian District, Beijing, 100191, China.
Fowdar J; Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia.
Kennedy M; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Pitcher T; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand.
Pearson J; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Halliday G; Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.
Kwok JB; Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.
Hickie I; Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.
Lewis S; Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.
Anderson T; New Zealand Brain Research Institute, Christchurch, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand.
Silburn PA; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Mellick GD; Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia.
Harris SE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Redmond P; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Murray AD; Aberdeen Biomedical Imaging Centre, University of Aberdeen, Lilian Sutton Building, Foresterhill, Aberdeen, AB25 2ZD, UK.
Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Haley CS; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Evans KL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
McIntosh AM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, EH10 5HF, UK.
Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Gratten J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
McRae AF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia. .
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Źródło :
Genome medicine [Genome Med] 2019 Aug 23; Vol. 11 (1), pp. 54. Date of Electronic Publication: 2019 Aug 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Epigenesis, Genetic*
Aging/*genetics
Epigenomics/methods ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Organ Specificity/genetics ; Proportional Hazards Models ; Reproducibility of Results ; Saliva
Czasopismo naukowe
Tytuł :
Age-related clonal haemopoiesis is associated with increased epigenetic age.
Autorzy :
Robertson NA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Terradas-Terradas M; Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.
Higham J; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Sproul D; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK; Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. Electronic address: .
Kirschner K; Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK. Electronic address: .
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. Electronic address: riccardo.marioni@ed.ac.uk.
Chandra T; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. Electronic address: .
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Źródło :
Current biology : CB [Curr Biol] 2019 Aug 19; Vol. 29 (16), pp. R786-R787.
Typ publikacji :
Letter
MeSH Terms :
Aging*
Epigenesis, Genetic/*physiology
Hematopoiesis/*physiology
Aged ; Aged, 80 and over ; Female ; Hematopoiesis/genetics ; Humans ; Longitudinal Studies ; Male ; Risk Factors ; Scotland
Opinia redakcyjna
Tytuł :
DNA methylation-based estimator of telomere length.
Autorzy :
Lu AT; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Seeboth A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Tsai PC; Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.; Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan.; Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan.
Sun D; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Quach A; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Reiner AP; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Kooperberg C; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ferrucci L; Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Hou L; Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Baccarelli AA; Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Li Y; Departments of Genetics, Biostatistics, Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA.
Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Corley J; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Taylor A; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Stewart JD; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.
Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA.; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Assimes TL; VA Palo Alto Health Care System, Palo Alto, CA 94304, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chen W; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Li S; Children's Minnesota Research Institute, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN 55404, USA.
Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
Bell JT; Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Aviv A; Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Raj K; Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, UK.
Horvath S; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA.
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Źródło :
Aging [Aging (Albany NY)] 2019 Aug 18; Vol. 11 (16), pp. 5895-5923. Date of Electronic Publication: 2019 Aug 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Telomere*
Aging/*genetics
Leukocytes/*metabolism
Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; Diet ; Female ; Humans ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Tytuł :
Brain age and other bodily 'ages': implications for neuropsychiatry.
Autorzy :
Cole JH; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. .; Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, London, UK. .
Marioni RE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.
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Źródło :
Molecular psychiatry [Mol Psychiatry] 2019 Feb; Vol. 24 (2), pp. 266-281. Date of Electronic Publication: 2018 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging/*physiology
Brain/*physiology
Cellular Senescence/*physiology
Biomarkers ; Brain/diagnostic imaging ; Epigenomics ; Humans ; Neurodegenerative Diseases/diagnostic imaging ; Neurodegenerative Diseases/physiopathology ; Neuroimaging/methods ; Neuropsychiatry
Czasopismo naukowe
Tytuł :
Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data.
Autorzy :
Marioni RE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK.; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.
Suderman M; Medical Research Council Integrative Epidemiology Unit, University of Bristol, UK.
Chen BH; The National Institute on Aging, NIH, Baltimore, Maryland.
Horvath S; Human Genetics, David Geffen School of Medicine, University of California Los Angeles.; Department of Biostatistics, School of Public Health, University of California Los Angeles.
Bandinelli S; Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy.
Morris T; UCL Cancer Institute, University College London, UK.
Beck S; UCL Cancer Institute, University College London, UK.
Ferrucci L; The National Institute on Aging, NIH, Baltimore, Maryland.
Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Relton CL; Medical Research Council Integrative Epidemiology Unit, University of Bristol, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK.; Department of Psychology, University of Edinburgh, UK.
Hägg S; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Źródło :
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2019 Jan 01; Vol. 74 (1), pp. 57-61.
Typ publikacji :
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Epigenesis, Genetic*
Aging/*genetics
DNA/*genetics
Longevity/*genetics
DNA Methylation ; Humans
Czasopismo naukowe
Tytuł :
Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing.
Autorzy :
Stevenson AJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. .; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK. .; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK. .
McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Harris SE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Taylor AM; Department for Psychology, University of Edinburgh, Edinburgh, UK.
Redmond P; Department for Psychology, University of Edinburgh, Edinburgh, UK.
Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Zhang Q; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Spires-Jones TL; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
McColl BW; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
McIntosh AM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department for Psychology, University of Edinburgh, Edinburgh, UK.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
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Źródło :
Clinical epigenetics [Clin Epigenetics] 2018 Dec 20; Vol. 10 (1), pp. 159. Date of Electronic Publication: 2018 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Genetic Markers*
Aging/*genetics
C-Reactive Protein/*metabolism
Inflammation/*genetics
Interleukin-6/*metabolism
Aged ; Aged, 80 and over ; Aging/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cross-Sectional Studies ; Epigenesis, Genetic ; Female ; Granulocytes/immunology ; Humans ; Linear Models ; Longitudinal Studies ; Lymphocyte Count ; Male ; Plasma Cells/immunology
Czasopismo naukowe
Tytuł :
Association of facial ageing with DNA methylation and epigenetic age predictions.
Autorzy :
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. riccardo.marioni@ed.ac.uk.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK. riccardo.marioni@ed.ac.uk.
Belsky DW; Department of Population Health Sciences, School of Medicine, Duke University, Durham, NC, 27710, USA.; Social Science Research Institute, Duke University, Durham, NC, 27710, USA.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Wagner W; Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen Faculty of Medicine, Aachen, Germany. .
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Źródło :
Clinical epigenetics [Clin Epigenetics] 2018 Nov 08; Vol. 10 (1), pp. 140. Date of Electronic Publication: 2018 Nov 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Aging/*genetics
Genome-Wide Association Study/*methods
Aged ; Aged, 80 and over ; CpG Islands ; Epigenesis, Genetic ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
Autorzy :
Lu AT; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Xue L; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Salfati EL; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Chen BH; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.; National Heart, Lung and Blood Institute, Bethesda, MD, 20824-0105, USA.
Ferrucci L; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
Levy D; National Heart, Lung and Blood Institute, Bethesda, MD, 20824-0105, USA.
Joehanes R; National Heart, Lung and Blood Institute, Bethesda, MD, 20824-0105, USA.
Murabito JM; Department of Medicine, Section of General Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Kiel DP; Institute for Aging Research, Hebrew SeniorLife, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, 02215, USA.
Tsai PC; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
Yet I; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
Bell JT; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
Mangino M; Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
Tanaka T; Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.
McRae AF; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.
Marioni RE; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.; Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.
Wray NR; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, QLD, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, 4072, QLD, Australia.
Deary IJ; Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Levine ME; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Quach A; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Assimes T; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Tsao PS; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Absher D; HudsonAlpha Institute for Biotechnology, Huntsville, AL, 35806, USA.
Stewart JD; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.
Li Y; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.
Reiner AP; Fred Hutchinson Cancer Research Center Box 358080, WHI Clinical Coordinating Ctr/Public Health Sciences M3-A4, Seattle, WA, 98109, USA.
Hou L; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Chicago, Evanston, IL, 60611, USA.; Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University Chicago, Evanston, IL, 60611, USA.
Baccarelli AA; Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences Epidemiology, Columbia University Mailman School of Public Health, New York, NY, 10032, USA.
Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, 27516, USA.
Aviv A; The Center for Human Development and Aging, University of Medicine and Dentistry, New Jersey Medical School, Rutgers, Newark, NJ, 07103, USA.
Cardona A; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Day FR; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Wareham NJ; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Perry JRB; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.
Ong KK; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0SL, UK.; Department of Paediatrics, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0SP, UK.
Raj K; Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.
Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA.
Horvath S; Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .; Biostatistics, School of Public Health, University of California, Los Angeles, Los Angeles, CA, 90095, USA. .
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Źródło :
Nature communications [Nat Commun] 2018 Jan 26; Vol. 9 (1), pp. 387. Date of Electronic Publication: 2018 Jan 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Aging/*genetics
DNA Methylation/*genetics
Epigenesis, Genetic/*genetics
Telomerase/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cells, Cultured ; Child ; CpG Islands/genetics ; Female ; Fibroblasts ; Genome-Wide Association Study ; Humans ; Leukocytes/metabolism ; Male ; Menarche ; Mendelian Randomization Analysis ; Menopause ; Middle Aged ; Telomere/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Epigenetic influences on aging: a longitudinal genome-wide methylation study in old Swedish twins.
Autorzy :
Wang Y; a Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Karlsson R; a Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Lampa E; b Department of Medical Sciences , Cardiovascular Epidemiology, Uppsala University , Uppsala , Sweden.
Zhang Q; c Institute for Molecular Bioscience , The University of Queensland , Brisbane , Australia.
Hedman ÅK; d Department of Medical Sciences , Molecular Epidemiology and Science for Life Laboratory, Uppsala University , Uppsala , Sweden.; e Cardiovascular Medicine unit, Department of Medicine Solna , Karolinska Institute , Stockholm , Sweden.
Almgren M; f Department of Clinical Neuroscience , Centrum for Molecular Medicine, Karolinska Institutet , Stockholm , Sweden.
Almqvist C; a Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.; g Astrid Lindgren Children's Hospital, Karolinska University Hospital , Stockholm , Sweden.
McRae AF; c Institute for Molecular Bioscience , The University of Queensland , Brisbane , Australia.
Marioni RE; h Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine , University of Edinburgh , Edinburgh , United Kingdom.; i Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology , University of Edinburgh , Edinburgh , United Kingdom.
Ingelsson E; d Department of Medical Sciences , Molecular Epidemiology and Science for Life Laboratory, Uppsala University , Uppsala , Sweden.; j Department of Medicine, Division of Cardiovascular Medicine , Stanford University School of Medicine , Stanford , CA , USA.; k Stanford Cardiovascular Institute , Stanford University , Stanford , CA , USA.
Visscher PM; c Institute for Molecular Bioscience , The University of Queensland , Brisbane , Australia.; l The Queensland Brain Institute , The University of Queensland , St Lucia , Brisbane , Australia.
Deary IJ; i Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology , University of Edinburgh , Edinburgh , United Kingdom.
Lind L; b Department of Medical Sciences , Cardiovascular Epidemiology, Uppsala University , Uppsala , Sweden.
Morris T; m Cancer Institute , University College London , London , United Kingdom.
Beck S; m Cancer Institute , University College London , London , United Kingdom.
Pedersen NL; a Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
Hägg S; a Department of Medical Epidemiology and Biostatistics , Karolinska Institutet , Stockholm , Sweden.
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Źródło :
Epigenetics [Epigenetics] 2018; Vol. 13 (9), pp. 975-987. Date of Electronic Publication: 2018 Oct 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Twin Study
MeSH Terms :
DNA Methylation*
Epigenesis, Genetic*
Aging/*genetics
Aged ; CpG Islands ; Female ; Genome-Wide Association Study ; Humans ; Male ; Twins, Dizygotic/genetics ; Twins, Monozygotic/genetics
Czasopismo naukowe
Tytuł :
Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936.
Autorzy :
Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK.
Riggio V; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK.
Evenden L; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Gilchrist T; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
McCafferty S; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Murphy L; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Wrobel N; Edinburgh Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Taylor AM; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Corley J; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Pattie A; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Cox SR; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Martin-Ruiz C; Institute for Ageing, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.
Prendergast J; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK.
Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Marioni RE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK.; Queensland Brain Institute, The University of Queensland, Brisbane 4072, QLD, Australia.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
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Źródło :
Aging [Aging (Albany NY)] 2017 Dec 01; Vol. 9 (12), pp. 2489-2503.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*genetics
Cognitive Aging/*physiology
Aged ; Female ; Gene Expression Profiling/methods ; Humans ; Male ; Transcriptome ; United Kingdom
Czasopismo naukowe
Tytuł :
Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis.
Autorzy :
Li S; Department of Clinical Research, Unit of Human Genetics, University of Southern Denmark, Odense, Denmark.
Christiansen L; Department of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.
Christensen K; Department of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark.
Kruse TA; Department of Clinical Research, Unit of Human Genetics, University of Southern Denmark, Odense, Denmark.
Redmond P; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Marioni RE; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.; Queensland Brain Institute, The University of Queensland, Queensland, Australia.
Deary IJ; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
Tan Q; Department of Clinical Research, Unit of Human Genetics, University of Southern Denmark, Odense, Denmark. .; Department of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Odense, Denmark. .
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Źródło :
Scientific reports [Sci Rep] 2017 Aug 15; Vol. 7 (1), pp. 8183. Date of Electronic Publication: 2017 Aug 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Epigenomics*/methods
Aging/*genetics
CpG Islands ; Cross-Sectional Studies ; DNA Methylation ; Exons ; Genetics, Population ; Genome-Wide Association Study ; Humans ; Introns ; Longitudinal Studies ; Signal Transduction ; Untranslated Regions
Czasopismo naukowe

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