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    Wyświetlanie 1-13 z 13
    Tytuł:
    Evaluation of the Cytotoxic Effect of Pd 2 Spm against Prostate Cancer through Vibrational Microspectroscopies.
    Autorzy:
    Laginha RC; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
    Martins CB; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
    Brandão ALC; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
    Marques J; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
    Marques MPM; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.; Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, 3000-456 Coimbra, Portugal.
    Batista de Carvalho LAE; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
    Santos IP; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
    Batista de Carvalho ALM; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2023 Jan 18; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 18.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents*/pharmacology
    Prostatic Neoplasms*/drug therapy
    Male ; Humans ; Cisplatin/pharmacology ; Spermine/pharmacology ; Spermine/metabolism ; Lipids ; Spectroscopy, Fourier Transform Infrared
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A New Look into the Mode of Action of Metal-Based Anticancer Drugs.
    Autorzy:
    Marques MPM; Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Coimbra 3004-535, Portugal.; Department of Life Sciences, University of Coimbra, Coimbra 3000-456, Portugal.
    Batista de Carvalho ALM; Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Coimbra 3004-535, Portugal.
    Mamede AP; Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Coimbra 3004-535, Portugal.
    Dopplapudi A; ISIS Facility, STFC Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, UK.
    Rudić S; ISIS Facility, STFC Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, UK.
    Tyagi M; NIST Center for Neutron Research, Gaithersburg, Maryland, MD 20899, USA.; Department of Materials Science and Engineering, University of Maryland, College Park, Maryland MD 20742, USA.
    Garcia Sakai V; ISIS Facility, STFC Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, UK.
    Batista de Carvalho LAE; Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Coimbra 3004-535, Portugal.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2020 Jan 07; Vol. 25 (2). Date of Electronic Publication: 2020 Jan 07.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents/*chemistry
    Antineoplastic Agents/*pharmacology
    Cisplatin/*chemistry
    Cisplatin/*pharmacology
    DNA/*chemistry
    DNA/drug effects ; Elasticity/drug effects ; Metals/chemistry ; Metals/pharmacology ; Neutron Diffraction ; Neutrons ; Nucleic Acid Conformation/drug effects ; Palladium/chemistry ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman ; Spermine/chemistry ; Water/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (-)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63).
    Autorzy:
    Dias LD; Coimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. .; Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, 3004⁻535 Coimbra, Portugal. .
    Batista de Carvalho ALM; Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, 3004⁻535 Coimbra, Portugal. .
    Pinto SMA; Coimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. .
    Aquino GLB; Coimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. .; Faculty of Pharmacy, State University of Goiás, 75132-400 Anápolis, Goias, Brazil. .
    Calvete MJF; Coimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. .
    Rossi LM; Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo 05508⁻000, Brazil. .
    Marques MPM; Unidade de I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, 3004⁻535 Coimbra, Portugal. .; Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000⁻456 Coimbra, Portugal. .
    Pereira MM; Coimbra Chemistry Centre, CQC, Departament of Chemistry, Faculdade de Ciências e Tecnologia, Universidad de Coimbra, 3004⁻535 Coimbra, Portugal. .
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2018 Dec 24; Vol. 24 (1). Date of Electronic Publication: 2018 Dec 24.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Biomimetics*
    Magnetic Phenomena*
    Antineoplastic Agents/*pharmacology
    Metalloporphyrins/*chemistry
    Nanocomposites/*chemistry
    Osteosarcoma/*pathology
    Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Calorimetry, Differential Scanning ; Catalysis ; Cell Line, Tumor ; Cyclohexane Monoterpenes ; Epoxy Compounds/chemical synthesis ; Epoxy Compounds/chemistry ; Humans ; Manganese/chemistry ; Nanocomposites/ultrastructure ; Spectrophotometry, Ultraviolet ; Spectroscopy, Fourier Transform Infrared ; Stereoisomerism ; Terpenes/chemical synthesis ; Terpenes/chemistry ; Terpenes/pharmacology ; Thermogravimetry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Novel platinum-based anticancer drug: a complete vibrational study.
    Autorzy:
    Batista de Carvalho ALM; Unidade I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Coimbra 3004-535, Portugal.
    Parker SF; ISIS Facility, Rutherford Appleton Laboratory, OX11 0QX, England.
    Batista de Carvalho LAE; Unidade I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Coimbra 3004-535, Portugal.
    Marques MPM; Unidade I&D Química-Física Molecular, Department of Chemistry, University of Coimbra, Coimbra 3004-535, Portugal.
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    Źródło:
    Acta crystallographica. Section C, Structural chemistry [Acta Crystallogr C Struct Chem] 2018 May 01; Vol. 74 (Pt 5), pp. 628-634. Date of Electronic Publication: 2018 Apr 23.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*chemistry
    Cisplatin/*chemistry
    Diamines/*chemistry
    Platinum/*chemistry
    Antineoplastic Agents/pharmacology ; Cisplatin/pharmacology ; Crystallography, X-Ray ; Humans ; Hydrogen Bonding ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman ; Vibration
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Chemotherapy reduces PARP1 in cancers of the ovary: implications for future clinical trials involving PARP inhibitors.
    Autorzy:
    Marques M; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste, Catherine Road, Montréal, QC, H3T 1E2, Canada. maud.marques@mail.mcgill.ca.
    Beauchamp MC; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste, Catherine Road, Montréal, QC, H3T 1E2, Canada. .
    Fleury H; Centre de recherche du Centre hospitalier de l'Université de Montréal/Institut du cancer de Montréal, Montréal, Canada. .
    Laskov I; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste, Catherine Road, Montréal, QC, H3T 1E2, Canada. .; Division of Gynecologic Oncology, Jewish General Hospital, McGill University, Montréal, Canada. .
    Qiang S; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste, Catherine Road, Montréal, QC, H3T 1E2, Canada. .
    Pelmus M; Division of Pathology, Jewish General Hospital, Montréal, Canada. .
    Provencher D; Centre de recherche du Centre hospitalier de l'Université de Montréal/Institut du cancer de Montréal, Montréal, Canada. .; Department of Obstetric-Gynecology, Université de Montréal, Montreal, Canada. .; Department of Medicine, Université de Montréal, Montreal, Canada. .
    Mes-Masson AM; Department of Obstetric-Gynecology, Université de Montréal, Montreal, Canada. .; Department of Medicine, Université de Montréal, Montreal, Canada. .
    Gotlieb WH; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste, Catherine Road, Montréal, QC, H3T 1E2, Canada. .; Division of Gynecologic Oncology, Jewish General Hospital, McGill University, Montréal, Canada. .
    Witcher M; Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste, Catherine Road, Montréal, QC, H3T 1E2, Canada. .
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    Źródło:
    BMC medicine [BMC Med] 2015 Sep 09; Vol. 13, pp. 217. Date of Electronic Publication: 2015 Sep 09.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*therapeutic use
    Ovarian Neoplasms/*drug therapy
    Ovarian Neoplasms/*enzymology
    Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
    Poly(ADP-ribose) Polymerases/*biosynthesis
    Aged ; Cohort Studies ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerases/analysis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Gallotannin imposes S phase arrest in breast cancer cells and suppresses the growth of triple-negative tumors in vivo.
    Autorzy:
    Zhao T; The Lady Davis Institute and Segal Cancer Center of the Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
    Sun Q; The Lady Davis Institute and Segal Cancer Center of the Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
    del Rincon SV; The Lady Davis Institute and Segal Cancer Center of the Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
    Lovato A; The Lady Davis Institute and Segal Cancer Center of the Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
    Marques M; The Lady Davis Institute and Segal Cancer Center of the Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
    Witcher M; The Lady Davis Institute and Segal Cancer Center of the Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
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    Źródło:
    PloS one [PLoS One] 2014 Mar 21; Vol. 9 (3), pp. e92853. Date of Electronic Publication: 2014 Mar 21 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Hydrolyzable Tannins/*pharmacology
    S Phase Cell Cycle Checkpoints/*drug effects
    Triple Negative Breast Neoplasms/*pathology
    Animals ; Antineoplastic Agents/administration & dosage ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Checkpoint Kinase 2/metabolism ; Cluster Analysis ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enzyme Activation ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hydrolyzable Tannins/administration & dosage ; Mice ; Triple Negative Breast Neoplasms/genetics ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin.
    Autorzy:
    Vojtek, Martin
    Martins, Clara B.
    Ramos, Raquel
    Duarte, Sara Gomes
    Ferreira, Isabel M. P. L. V. O.
    Batista de Carvalho, Ana L. M.
    Marques, M. Paula M.
    Diniz, Carmen
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    Temat:
    CARBOPLATIN
    ANTINEOPLASTIC agents
    CHELATES
    TRIPLE-negative breast cancer
    DRUG resistance in cancer cells
    SPERMIDINE
    Źródło:
    Pharmaceutics; Apr2023, Vol. 15 Issue 4, p1205, 15p
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent.
    Autorzy:
    Carneiro, Tatiana J.
    Araújo, Rita
    Vojtek, Martin
    Gonçalves-Monteiro, Salomé
    Diniz, Carmen
    Batista de Carvalho, Ana L. M.
    Marques, M. Paula M.
    Gil, Ana M.
    Wilson, Ian D
    Pokaż więcej
    Temat:
    NUCLEAR magnetic resonance
    METABOLISM
    MICE
    ANTINEOPLASTIC agents
    LIPID metabolism
    CISPLATIN
    Źródło:
    Metabolites (2218-1989); Feb2021, Vol. 11 Issue 2, p114, 1p
    Czasopismo naukowe
    Szczegóły
    Tytuł:
    Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (−)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63).
    Autorzy:
    Dias, Lucas D.
    Batista de Carvalho, Ana L. M.
    Pinto, Sara M. A.
    Aquino, Gilberto L. B.
    Calvete, Mário J. F.
    Rossi, Liane M.
    Marques, M. P. M.
    Pereira, Mariette M.
    Pokaż więcej
    Temat:
    METALLOPORPHYRINS
    NANOCOMPOSITE materials
    EPOXY compounds
    OSTEOSARCOMA
    ANTINEOPLASTIC agents
    EPOXIDATION
    Źródło:
    Molecules; Jan2019, Vol. 24 Issue 1, p52, 1p, 4 Diagrams, 6 Graphs
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-13 z 13

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