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Wyszukujesz frazę ""Martuza, Robert L."" wg kryterium: Autor


Tytuł :
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
Autorzy :
Ning JF; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center and Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA. .; Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, 55455, MN, USA. .
Stanciu M; The David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, MA, USA.
Humphrey MR; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center and Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.
Gorham J; Department of Genetics, Harvard Medical School, Boston, 02115, MA, USA.
Wakimoto H; Department of Genetics, Harvard Medical School, Boston, 02115, MA, USA.
Nishihara R; Department of Pathology, Brigham's and Women's Hospital and Harvard Medical School, Boston, 02115, MA, USA.
Lees J; The David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, MA, USA.
Zou L; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, 02129, MA, USA.
Martuza RL; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center and Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.
Wakimoto H; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center and Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA. .; Brain Tumor Stem Cell Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA. .
Rabkin SD; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center and Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA. .
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Źródło :
Nature communications [Nat Commun] 2019 Jul 02; Vol. 10 (1), pp. 2910. Date of Electronic Publication: 2019 Jul 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Homologous Recombination*
Ataxia Telangiectasia Mutated Proteins/*genetics
Cyclin-Dependent Kinases/*genetics
Glioblastoma/*metabolism
Poly(ADP-ribose) Polymerase Inhibitors/*administration & dosage
Proto-Oncogene Proteins c-myc/*metabolism
Animals ; Antigens, Surface/genetics ; Antigens, Surface/metabolism ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cyclin-Dependent Kinases/metabolism ; Female ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Humans ; Mice ; Mice, SCID ; N-Myc Proto-Oncogene Protein/genetics ; N-Myc Proto-Oncogene Protein/metabolism ; Neoplastic Stem Cells/metabolism ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Protein Binding ; Proto-Oncogene Proteins c-myc/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy.
Autorzy :
Tanaka S; Divisions of Neuro-Oncology and Hematology/Oncology, Harvard Medical School, Boston, Massachusetts, USA. .; Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan. .
Luk S; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
Kiyokawa J; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
Onozato ML; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Shah K; Center for Stem Cell Therapeutics and Imaging, Department of Neurosurgery, Brigham and Women's Hospital, Harvard medical School, Boston, Massachusetts, USA.
Martuza RL; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
Rabkin SD; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
Batchelor TT; Divisions of Neuro-Oncology and Hematology/Oncology, Harvard Medical School, Boston, Massachusetts, USA.
Cahill DP; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
Chi AS; Divisions of Neuro-Oncology and Hematology/Oncology, Harvard Medical School, Boston, Massachusetts, USA.; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health and NYU School of Medicine, New York, NY, USA.
Wakimoto H; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA. .
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Źródło :
Scientific reports [Sci Rep] 2019 Jan 15; Vol. 9 (1), pp. 139. Date of Electronic Publication: 2019 Jan 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glioblastoma/*drug therapy
Molecular Targeted Therapy/*methods
Animals ; Brain Neoplasms ; ErbB Receptors/antagonists & inhibitors ; Glioblastoma/pathology ; Glioma/pathology ; Heterografts ; Humans ; Mice ; Neoplasm Recurrence, Local/drug therapy ; Quinazolinones/pharmacology ; Quinazolinones/therapeutic use ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.
Autorzy :
Chongsathidkiet P; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Jackson C; Department of Neurosurgery, The John Hopkins University School of Medicine, Baltimore, MD, USA.
Koyama S; Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita City, Osaka, Japan.
Loebel F; Department of Neurosurgery, Charité Medical University, Berlin, Germany.
Cui X; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Farber SH; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Woroniecka K; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Elsamadicy AA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Dechant CA; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Kemeny HR; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Sanchez-Perez L; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Cheema TA; Unum Therapeutics, Cambridge, MA, USA.
Souders NC; Dana-Farber Cancer Institute, Boston, MA, USA.
Herndon JE; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA.
Coumans JV; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Everitt JI; Department of Pathology, Duke University Medical Center, Durham, NC, USA.
Nahed BV; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sampson JH; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.; Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.; Department of Immunology, Duke University Medical Center, Durham, NC, USA.
Gunn MD; Department of Pathology, Duke University Medical Center, Durham, NC, USA.; Department of Immunology, Duke University Medical Center, Durham, NC, USA.; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Martuza RL; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dranoff G; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
Curry WT; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Fecci PE; Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA. .; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA. .; Department of Pathology, Duke University Medical Center, Durham, NC, USA. .
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Źródło :
Nature medicine [Nat Med] 2018 Sep; Vol. 24 (9), pp. 1459-1468. Date of Electronic Publication: 2018 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Marrow/*immunology
Brain Neoplasms/*immunology
Glioblastoma/*immunology
T-Lymphocytes/*immunology
Animals ; Brain Neoplasms/pathology ; Endocytosis ; Glioblastoma/pathology ; Humans ; Lymphoid Tissue/pathology ; Lymphopenia/immunology ; Lysophospholipids/metabolism ; Mice, Inbred C57BL ; Sphingosine/analogs & derivatives ; Sphingosine/metabolism ; Spleen/pathology
Czasopismo naukowe
Tytuł :
Restriction of Replication of Oncolytic Herpes Simplex Virus with a Deletion of γ34.5 in Glioblastoma Stem-Like Cells.
Autorzy :
Peters C; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Virology, Harvard Medical School, Boston, Massachusetts, USA.
Paget M; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Virology, Harvard Medical School, Boston, Massachusetts, USA.
Tshilenge KT; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Saha D; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
Antoszczyk S; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Baars A; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Frost T; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Virology, Harvard Medical School, Boston, Massachusetts, USA.
Martuza RL; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
Wakimoto H; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
Rabkin SD; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA .; Program in Virology, Harvard Medical School, Boston, Massachusetts, USA.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.
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Źródło :
Journal of virology [J Virol] 2018 Jul 17; Vol. 92 (15). Date of Electronic Publication: 2018 Jul 17 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Deletion*
Brain Neoplasms/*virology
Glioblastoma/*virology
Neoplastic Stem Cells/*virology
Simplexvirus/*physiology
Viral Proteins/*genetics
Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/therapy ; Cell Culture Techniques/methods ; Cell Line, Tumor ; Chlorocebus aethiops ; Glioblastoma/metabolism ; Glioblastoma/therapy ; Herpes Simplex/genetics ; Neoplastic Stem Cells/metabolism ; Oncolytic Viruses/genetics ; Oncolytic Viruses/physiology ; RNA-Binding Proteins/metabolism ; Simplexvirus/genetics ; Vero Cells ; Viral Proteins/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models.
Autorzy :
Saha D; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Wakimoto H; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Peters CW; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Antoszczyk SJ; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Rabkin SD; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Martuza RL; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts. .; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Jul 15; Vol. 24 (14), pp. 3409-3422. Date of Electronic Publication: 2018 Mar 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncolytic Virotherapy*/methods
Glioblastoma/*metabolism
Neoplastic Stem Cells/*drug effects
Neoplastic Stem Cells/*metabolism
Protein Kinase Inhibitors/*pharmacology
Receptors, Vascular Endothelial Growth Factor/*antagonists & inhibitors
Animals ; Antineoplastic Agents, Immunological/pharmacology ; Axitinib/pharmacology ; Cell Line, Tumor ; Combined Modality Therapy ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Genetic Vectors/administration & dosage ; Genetic Vectors/genetics ; Glioblastoma/mortality ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Immunohistochemistry ; Interleukin-12/genetics ; Interleukin-12/metabolism ; Mice ; Neoplastic Stem Cells/pathology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/therapy ; Oncolytic Viruses/genetics ; Signal Transduction ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Oncolytic herpes simplex virus immunovirotherapy in combination with immune checkpoint blockade to treat glioblastoma.
Autorzy :
Saha D; Department of Neurosurgery, Molecular Neurosurgery Laboratory & Brain Tumor Research Center, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Martuza RL; Department of Neurosurgery, Molecular Neurosurgery Laboratory & Brain Tumor Research Center, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Rabkin SD; Department of Neurosurgery, Molecular Neurosurgery Laboratory & Brain Tumor Research Center, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
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Źródło :
Immunotherapy [Immunotherapy] 2018 Jul; Vol. 10 (9), pp. 779-786.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncolytic Virotherapy*
Antibodies, Monoclonal/*therapeutic use
Biological Products/*therapeutic use
Brain Neoplasms/*therapy
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Glioblastoma/*therapy
Immunotherapy/*methods
Macrophages/*immunology
Simplexvirus/*physiology
Animals ; CTLA-4 Antigen/immunology ; Disease Models, Animal ; Herpesvirus 1, Human ; Humans ; Immunity, Cellular ; Interleukin-12/genetics ; Interleukin-12/metabolism ; Mice ; Mice, Inbred C57BL ; Programmed Cell Death 1 Receptor/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Blockade of transforming growth factor-β signaling enhances oncolytic herpes simplex virus efficacy in patient-derived recurrent glioblastoma models.
Autorzy :
Esaki S; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.; Department of Otolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan.
Nigim F; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Moon E; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Luk S; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Kiyokawa J; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Curry W Jr; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Chi AS; Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY.
Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Martuza RL; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Rabkin SD; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Źródło :
International journal of cancer [Int J Cancer] 2017 Dec 01; Vol. 141 (11), pp. 2348-2358. Date of Electronic Publication: 2017 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Brain Neoplasms/*pathology
Glioblastoma/*pathology
Oncolytic Virotherapy/*methods
Transforming Growth Factor beta/*antagonists & inhibitors
Animals ; Blotting, Western ; Humans ; Immunohistochemistry ; Mice ; Mice, SCID ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Real-Time Polymerase Chain Reaction ; Signal Transduction/drug effects ; Simplexvirus ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.
Autorzy :
Saha D; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Martuza RL; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Rabkin SD; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA. Electronic address: .
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Źródło :
Cancer cell [Cancer Cell] 2017 Aug 14; Vol. 32 (2), pp. 253-267.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy*
Oncolytic Virotherapy*
Antibodies, Monoclonal/*therapeutic use
CTLA-4 Antigen/*antagonists & inhibitors
Glioblastoma/*therapy
Interleukin-12/*genetics
Macrophages/*immunology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Animals ; B7-H1 Antigen/antagonists & inhibitors ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Cell Cycle Checkpoints/drug effects ; Combined Modality Therapy ; Disease Models, Animal ; Female ; Glioblastoma/immunology ; Humans ; Macrophage Activation ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Mice, Inbred C57BL ; Oncolytic Viruses/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma.
Autorzy :
Ning J; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Wakimoto H; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Peters C; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Virology, Harvard Medical School, Boston, MA, USA.
Martuza RL; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Rabkin SD; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.; Program in Virology, Harvard Medical School, Boston, MA, USA.
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Źródło :
Journal of the National Cancer Institute [J Natl Cancer Inst] 2017 Mar 01; Vol. 109 (3), pp. 1-13.
Typ publikacji :
Journal Article
MeSH Terms :
Oncolytic Virotherapy*
Brain Neoplasms/*therapy
DNA, Viral/*biosynthesis
Glioblastoma/*therapy
Phthalazines/*therapeutic use
Piperazines/*therapeutic use
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
Rad51 Recombinase/*metabolism
Simplexvirus/*physiology
Animals ; Apoptosis ; Brain Neoplasms/enzymology ; Cell Cycle ; Cell Survival/drug effects ; Checkpoint Kinase 1/metabolism ; Combined Modality Therapy ; DNA Repair ; DNA Replication ; Drug Resistance, Neoplasm ; Female ; Glioblastoma/enzymology ; Humans ; Mice ; Neoplasm Transplantation ; Neoplastic Stem Cells ; Oncolytic Viruses/physiology ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Signal Transduction ; Tumor Cells, Cultured ; Tumor Stem Cell Assay
Czasopismo naukowe
Tytuł :
Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment.
Autorzy :
Nigim F; From the Department of Neurosurgery (FN, JC, APP, WTC, SE, RLM, SDR, HW), and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (EMK); Division of Hematology/Oncology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Department of Neurology (ASC), Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (DNL).
Cavanaugh J
Patel AP
Curry WT Jr
Esaki S
Kasper EM
Chi AS
Louis DN
Martuza RL
Rabkin SD
Wakimoto H
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Źródło :
Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2015 Jul; Vol. 74 (7), pp. 710-22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Tumor Microenvironment*
Brain Neoplasms/*metabolism
Gene Expression Regulation, Neoplastic/*physiology
Glioblastoma/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Animals ; Antigens, CD/metabolism ; Cell Hypoxia/physiology ; Cell Line, Tumor ; Cohort Studies ; Digoxin/pharmacology ; Disease Models, Animal ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Ki-67 Antigen/metabolism ; Mice ; Mice, SCID ; Middle Aged ; SOXB1 Transcription Factors/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Single agent efficacy of the VEGFR kinase inhibitor axitinib in preclinical models of glioblastoma.
Autorzy :
Lu L; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Saha D
Martuza RL
Rabkin SD
Wakimoto H
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Źródło :
Journal of neuro-oncology [J Neurooncol] 2015 Jan; Vol. 121 (1), pp. 91-100. Date of Electronic Publication: 2014 Sep 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiogenesis Inhibitors/*pharmacology
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Imidazoles/*pharmacology
Indazoles/*pharmacology
Animals ; Apoptosis/drug effects ; Axitinib ; Brain Neoplasms/physiopathology ; Cell Line, Tumor ; Female ; Glioblastoma/physiopathology ; Humans ; Mice ; Mice, Inbred C57BL ; Neoplasm Transplantation ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/physiology ; Neovascularization, Pathologic/drug therapy ; Protein Kinase Inhibitors/pharmacology ; Random Allocation ; Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Survival Analysis
Czasopismo naukowe
Tytuł :
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
Autorzy :
Patel AP; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA.
Tirosh I; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
Trombetta JJ; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
Shalek AK; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
Gillespie SM; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA.
Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Cahill DP; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Nahed BV; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Curry WT; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Martuza RL; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Louis DN; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Rozenblatt-Rosen O; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA.
Suvà ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. .
Regev A; Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA. Department of Biology, MIT, Cambridge, MA 02139, USA. .
Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Broad Institute of Harvard and Massachusetts Institute of Techonology (MIT), Cambridge, MA 02142, USA. Howard Hughes Medical Institute Chevy Chase, MD 20815, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2014 Jun 20; Vol. 344 (6190), pp. 1396-401. Date of Electronic Publication: 2014 Jun 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Variation*
Brain Neoplasms/*genetics
Glioblastoma/*genetics
RNA, Messenger/*genetics
Brain Neoplasms/classification ; Brain Neoplasms/drug therapy ; Gene Expression Profiling ; Glioblastoma/classification ; Glioblastoma/drug therapy ; Humans ; Prognosis ; Sequence Analysis, RNA/methods ; Single-Cell Analysis/methods
Czasopismo naukowe
Tytuł :
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.
Autorzy :
Suvà ML; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: .
Rheinbay E; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Gillespie SM; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Patel AP; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Rabkin SD; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Riggi N; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Chi AS; Divisions of Neuro-Oncology and Hematology/Oncology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Cahill DP; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Nahed BV; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Curry WT; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Martuza RL; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Rivera MN; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Rossetti N; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Kasif S; Bioinformatics Program, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Beik S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Kadri S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Tirosh I; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Wortman I; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Shalek AK; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Rozenblatt-Rosen O; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Regev A; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02140, USA.
Louis DN; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Bernstein BE; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: .
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Źródło :
Cell [Cell] 2014 Apr 24; Vol. 157 (3), pp. 580-94. Date of Electronic Publication: 2014 Apr 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*genetics
Brain Neoplasms/*pathology
Glioblastoma/*genetics
Glioblastoma/*pathology
Neoplastic Stem Cells/*pathology
Basic Helix-Loop-Helix Transcription Factors/metabolism ; Brain Neoplasms/metabolism ; Cell Differentiation ; Cell Line, Tumor ; Cells, Cultured ; Co-Repressor Proteins/metabolism ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Glioblastoma/metabolism ; Humans ; Neoplastic Stem Cells/metabolism ; Nerve Tissue Proteins/metabolism ; Oligodendrocyte Transcription Factor 2 ; Regulatory Elements, Transcriptional ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model.
Autorzy :
Cheema TA; Brain Tumor Research Center and Molecular Neurosurgery Laboratory, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Wakimoto H
Fecci PE
Ning J
Kuroda T
Jeyaretna DS
Martuza RL
Rabkin SD
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Jul 16; Vol. 110 (29), pp. 12006-11. Date of Electronic Publication: 2013 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Glioblastoma/*therapy
Immunotherapy/*methods
Interleukin-12/*metabolism
Oncolytic Virotherapy/*methods
Simplexvirus/*metabolism
Animals ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Glioblastoma/virology ; Immunohistochemistry ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred C57BL ; Neoplastic Stem Cells
Czasopismo naukowe
Tytuł :
Combination of oncolytic herpes simplex viruses armed with angiostatin and IL-12 enhances antitumor efficacy in human glioblastoma models.
Autorzy :
Zhang W; Brain Tumor Research Center, Molecular Neurosurgery Laboratory, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Fulci G
Wakimoto H
Cheema TA
Buhrman JS
Jeyaretna DS
Stemmer Rachamimov AO
Rabkin SD
Martuza RL
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Źródło :
Neoplasia (New York, N.Y.) [Neoplasia] 2013 Jun; Vol. 15 (6), pp. 591-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiogenesis Inhibitors/*pharmacology
Angiostatins/*pharmacology
Brain Neoplasms/*drug therapy
Glioblastoma/*drug therapy
Interleukin-12/*pharmacology
Oncolytic Viruses/*genetics
Simplexvirus/*genetics
Angiostatins/genetics ; Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/virology ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Glioblastoma/metabolism ; Glioblastoma/virology ; Humans ; Injections, Intralesional ; Interleukin-12/genetics ; Mice ; Mice, Nude ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Multimechanistic tumor targeted oncolytic virus overcomes resistance in brain tumors.
Autorzy :
Tamura K; Molecular Neurotherapy and Imaging Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.
Wakimoto H
Agarwal AS
Rabkin SD
Bhere D
Martuza RL
Kuroda T
Kasmieh R
Shah K
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2013 Jan; Vol. 21 (1), pp. 68-77. Date of Electronic Publication: 2012 Aug 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Oncolytic Virotherapy*
Brain Neoplasms/*therapy
Glioblastoma/*therapy
Neoplastic Stem Cells/*pathology
Animals ; Apoptosis ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Glioblastoma/pathology ; Humans ; MAP Kinase Signaling System ; Mice ; Neoplasm Invasiveness ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Oncolytic herpes simplex virus counteracts the hypoxia-induced modulation of glioblastoma stem-like cells.
Autorzy :
Sgubin D; Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Wakimoto H
Kanai R
Rabkin SD
Martuza RL
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Źródło :
Stem cells translational medicine [Stem Cells Transl Med] 2012 Apr; Vol. 1 (4), pp. 322-32. Date of Electronic Publication: 2012 Mar 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*metabolism
Glioblastoma/*metabolism
Neoplastic Stem Cells/*metabolism
Oncolytic Viruses/*physiology
Simplexvirus/*physiology
Virus Replication/*physiology
Animals ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Brain Neoplasms/virology ; Cell Hypoxia ; Glioblastoma/pathology ; Glioblastoma/therapy ; Glioblastoma/virology ; Humans ; Mice ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/virology ; Oncolytic Virotherapy/methods
Czasopismo naukowe
Tytuł :
Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells.
Autorzy :
Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA. />Mohapatra G
Kanai R
Curry WT Jr
Yip S
Nitta M
Patel AP
Barnard ZR
Stemmer-Rachamimov AO
Louis DN
Martuza RL
Rabkin SD
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Źródło :
Neuro-oncology [Neuro Oncol] 2012 Feb; Vol. 14 (2), pp. 132-44. Date of Electronic Publication: 2011 Nov 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Neoplasms/*genetics
Brain Neoplasms/*pathology
Glioblastoma/*genetics
Glioblastoma/*pathology
Neoplastic Stem Cells/*pathology
Animals ; Brain Neoplasms/metabolism ; Cell Differentiation/physiology ; Female ; Genotype ; Glioblastoma/metabolism ; Humans ; Immunohistochemistry ; Mice ; Mice, SCID ; Neoplasm Invasiveness/pathology ; Neoplastic Stem Cells/metabolism ; Phenotype ; Proto-Oncogene Proteins c-akt/metabolism ; Transplantation, Heterologous ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Autorzy :
Kanai R; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 , USA.
Rabkin SD
Yip S
Sgubin D
Zaupa CM
Hirose Y
Louis DN
Wakimoto H
Martuza RL
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Źródło :
Journal of the National Cancer Institute [J Natl Cancer Inst] 2012 Jan 04; Vol. 104 (1), pp. 42-55. Date of Electronic Publication: 2011 Dec 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Damage*
Oncolytic Virotherapy*/methods
Simplexvirus*/genetics
Antineoplastic Agents, Alkylating/*pharmacology
Brain Neoplasms/*drug therapy
Brain Neoplasms/*genetics
DNA-Binding Proteins/*metabolism
Dacarbazine/*analogs & derivatives
Glioblastoma/*drug therapy
Glioblastoma/*genetics
Neoplastic Stem Cells/*drug effects
Animals ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Survival ; Chlorocebus aethiops ; DNA Modification Methylases/metabolism ; DNA Repair/drug effects ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/genetics ; Dacarbazine/pharmacology ; Female ; Gene Knockdown Techniques ; Genetic Vectors ; Humans ; Immunoblotting ; Immunohistochemistry ; Methylation ; Mice ; Mice, Nude ; Polymerase Chain Reaction ; Protein-Serine-Threonine Kinases/metabolism ; Temozolomide ; Tumor Suppressor Proteins/metabolism ; Vero Cells ; Virus Replication
Czasopismo naukowe
Tytuł :
Enhanced antitumor efficacy of low-dose Etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts.
Autorzy :
Cheema TA; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, USA.
Kanai R
Kim GW
Wakimoto H
Passer B
Rabkin SD
Martuza RL
Pokaż więcej
Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2011 Dec 01; Vol. 17 (23), pp. 7383-93. Date of Electronic Publication: 2011 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*therapy
Etoposide/*administration & dosage
Glioblastoma/*therapy
Oncolytic Virotherapy/*methods
Topoisomerase I Inhibitors/*pharmacology
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Brain Neoplasms/drug therapy ; Camptothecin/analogs & derivatives ; Camptothecin/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Combined Modality Therapy ; Etoposide/therapeutic use ; Glioblastoma/drug therapy ; Humans ; Irinotecan ; Mice ; Mice, Nude ; Neural Stem Cells/pathology ; Oncolytic Viruses/metabolism ; Simplexvirus/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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