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Wyszukujesz frazę ""Martuza, Robert L."" wg kryterium: Autor


Tytuł :
Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models.
Autorzy :
Saha D; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Wakimoto H; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Peters CW; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Antoszczyk SJ; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Rabkin SD; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
Martuza RL; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts. .; Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts.
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Jul 15; Vol. 24 (14), pp. 3409-3422. Date of Electronic Publication: 2018 Mar 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncolytic Virotherapy*/methods
Glioblastoma/*metabolism
Neoplastic Stem Cells/*drug effects
Neoplastic Stem Cells/*metabolism
Protein Kinase Inhibitors/*pharmacology
Receptors, Vascular Endothelial Growth Factor/*antagonists & inhibitors
Animals ; Antineoplastic Agents, Immunological/pharmacology ; Axitinib/pharmacology ; Cell Line, Tumor ; Combined Modality Therapy ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Genetic Vectors/administration & dosage ; Genetic Vectors/genetics ; Glioblastoma/mortality ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Immunohistochemistry ; Interleukin-12/genetics ; Interleukin-12/metabolism ; Mice ; Neoplastic Stem Cells/pathology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/therapy ; Oncolytic Viruses/genetics ; Signal Transduction ; Tumor Microenvironment ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Oncolytic herpes simplex virus immunovirotherapy in combination with immune checkpoint blockade to treat glioblastoma.
Autorzy :
Saha D; Department of Neurosurgery, Molecular Neurosurgery Laboratory & Brain Tumor Research Center, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Martuza RL; Department of Neurosurgery, Molecular Neurosurgery Laboratory & Brain Tumor Research Center, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Rabkin SD; Department of Neurosurgery, Molecular Neurosurgery Laboratory & Brain Tumor Research Center, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
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Źródło :
Immunotherapy [Immunotherapy] 2018 Jul; Vol. 10 (9), pp. 779-786.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncolytic Virotherapy*
Antibodies, Monoclonal/*therapeutic use
Biological Products/*therapeutic use
Brain Neoplasms/*therapy
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Glioblastoma/*therapy
Immunotherapy/*methods
Macrophages/*immunology
Simplexvirus/*physiology
Animals ; CTLA-4 Antigen/immunology ; Disease Models, Animal ; Herpesvirus 1, Human ; Humans ; Immunity, Cellular ; Interleukin-12/genetics ; Interleukin-12/metabolism ; Mice ; Mice, Inbred C57BL ; Programmed Cell Death 1 Receptor/immunology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Blockade of transforming growth factor-β signaling enhances oncolytic herpes simplex virus efficacy in patient-derived recurrent glioblastoma models.
Autorzy :
Esaki S; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.; Department of Otolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan.
Nigim F; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Moon E; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Luk S; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Kiyokawa J; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Curry W Jr; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Cahill DP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Chi AS; Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY.
Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Martuza RL; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Rabkin SD; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Źródło :
International journal of cancer [Int J Cancer] 2017 Dec 01; Vol. 141 (11), pp. 2348-2358. Date of Electronic Publication: 2017 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Brain Neoplasms/*pathology
Glioblastoma/*pathology
Oncolytic Virotherapy/*methods
Transforming Growth Factor beta/*antagonists & inhibitors
Animals ; Blotting, Western ; Humans ; Immunohistochemistry ; Mice ; Mice, SCID ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Real-Time Polymerase Chain Reaction ; Signal Transduction/drug effects ; Simplexvirus ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.
Autorzy :
Saha D; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Martuza RL; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Rabkin SD; Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA. Electronic address: .
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Źródło :
Cancer cell [Cancer Cell] 2017 Aug 14; Vol. 32 (2), pp. 253-267.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy*
Oncolytic Virotherapy*
Antibodies, Monoclonal/*therapeutic use
CTLA-4 Antigen/*antagonists & inhibitors
Glioblastoma/*therapy
Interleukin-12/*genetics
Macrophages/*immunology
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Animals ; B7-H1 Antigen/antagonists & inhibitors ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Cell Cycle Checkpoints/drug effects ; Combined Modality Therapy ; Disease Models, Animal ; Female ; Glioblastoma/immunology ; Humans ; Macrophage Activation ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Mice, Inbred C57BL ; Oncolytic Viruses/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma.
Autorzy :
Ning J; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Wakimoto H; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Peters C; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Program in Virology, Harvard Medical School, Boston, MA, USA.
Martuza RL; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.
Rabkin SD; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA.; Program in Virology, Harvard Medical School, Boston, MA, USA.
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Źródło :
Journal of the National Cancer Institute [J Natl Cancer Inst] 2017 Mar 01; Vol. 109 (3), pp. 1-13.
Typ publikacji :
Journal Article
MeSH Terms :
Oncolytic Virotherapy*
Brain Neoplasms/*therapy
DNA, Viral/*biosynthesis
Glioblastoma/*therapy
Phthalazines/*therapeutic use
Piperazines/*therapeutic use
Poly(ADP-ribose) Polymerase Inhibitors/*therapeutic use
Rad51 Recombinase/*metabolism
Simplexvirus/*physiology
Animals ; Apoptosis ; Brain Neoplasms/enzymology ; Cell Cycle ; Cell Survival/drug effects ; Checkpoint Kinase 1/metabolism ; Combined Modality Therapy ; DNA Repair ; DNA Replication ; Drug Resistance, Neoplasm ; Female ; Glioblastoma/enzymology ; Humans ; Mice ; Neoplasm Transplantation ; Neoplastic Stem Cells ; Oncolytic Viruses/physiology ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerases/metabolism ; Signal Transduction ; Tumor Cells, Cultured ; Tumor Stem Cell Assay
Czasopismo naukowe
Tytuł :
A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus.
Autorzy :
Nigim F; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Esaki S; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Hood M; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Lelic N; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
James MF; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Ramesh V; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Stemmer-Rachamimov A; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Cahill DP; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Brastianos PK; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Rabkin SD; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Martuza RL; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Wakimoto H; Department of Neurosurgery (F.N., S.-i.E., M.H., N.L., D.P.C., S.D.R., R.L.M., H.W.), Center for Human Genetic Research (M.F.J., V.R.), Department of Neuropathology (A.S.-R.), Division of Neuro-Oncology (P.K.B.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts .
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Źródło :
Neuro-oncology [Neuro Oncol] 2016 Sep; Vol. 18 (9), pp. 1278-87. Date of Electronic Publication: 2016 Mar 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncolytic Virotherapy*
Genetic Vectors/*administration & dosage
Meningeal Neoplasms/*therapy
Meningioma/*therapy
Simplexvirus/*genetics
Animals ; Apoptosis ; Cell Proliferation ; Female ; Humans ; Meningeal Neoplasms/genetics ; Meningeal Neoplasms/pathology ; Meningioma/genetics ; Meningioma/pathology ; Mice ; Mice, SCID ; Tumor Cells, Cultured ; Virus Replication ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Treatment of orthotopic malignant peripheral nerve sheath tumors with oncolytic herpes simplex virus.
Autorzy :
Antoszczyk S; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.A., R.L.M., S.D.R.); Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (A.O.S.R.); Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.S., V.F.M.); Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University, Berlin, Germany (A.K.); College of Veterinary Medicine, Seoul National University, Seoul, Korea (A.K.).
Spyra M; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.A., R.L.M., S.D.R.); Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (A.O.S.R.); Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.S., V.F.M.); Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University, Berlin, Germany (A.K.); College of Veterinary Medicine, Seoul National University, Seoul, Korea (A.K.).
Mautner VF; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.A., R.L.M., S.D.R.); Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (A.O.S.R.); Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.S., V.F.M.); Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University, Berlin, Germany (A.K.); College of Veterinary Medicine, Seoul National University, Seoul, Korea (A.K.).
Kurtz A; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.A., R.L.M., S.D.R.); Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (A.O.S.R.); Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.S., V.F.M.); Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University, Berlin, Germany (A.K.); College of Veterinary Medicine, Seoul National University, Seoul, Korea (A.K.).
Stemmer-Rachamimov AO; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.A., R.L.M., S.D.R.); Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (A.O.S.R.); Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.S., V.F.M.); Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University, Berlin, Germany (A.K.); College of Veterinary Medicine, Seoul National University, Seoul, Korea (A.K.).
Martuza RL; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.A., R.L.M., S.D.R.); Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (A.O.S.R.); Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.S., V.F.M.); Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University, Berlin, Germany (A.K.); College of Veterinary Medicine, Seoul National University, Seoul, Korea (A.K.).
Rabkin SD; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.A., R.L.M., S.D.R.); Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (A.O.S.R.); Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.S., V.F.M.); Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University, Berlin, Germany (A.K.); College of Veterinary Medicine, Seoul National University, Seoul, Korea (A.K.).
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Źródło :
Neuro-oncology [Neuro Oncol] 2014 Aug; Vol. 16 (8), pp. 1057-66. Date of Electronic Publication: 2014 Jan 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Oncolytic Virotherapy*/methods
Simplexvirus*
Brain Neoplasms/*therapy
Nerve Sheath Neoplasms/*therapy
Animals ; Cell Line, Tumor ; Disease Models, Animal ; Genetic Vectors/genetics ; Injections, Intralesional/methods ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Nude ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model.
Autorzy :
Cheema TA; Brain Tumor Research Center and Molecular Neurosurgery Laboratory, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Wakimoto H
Fecci PE
Ning J
Kuroda T
Jeyaretna DS
Martuza RL
Rabkin SD
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Jul 16; Vol. 110 (29), pp. 12006-11. Date of Electronic Publication: 2013 Jun 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Glioblastoma/*therapy
Immunotherapy/*methods
Interleukin-12/*metabolism
Oncolytic Virotherapy/*methods
Simplexvirus/*metabolism
Animals ; Blotting, Western ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Glioblastoma/virology ; Immunohistochemistry ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred C57BL ; Neoplastic Stem Cells
Czasopismo naukowe
Tytuł :
Multimechanistic tumor targeted oncolytic virus overcomes resistance in brain tumors.
Autorzy :
Tamura K; Molecular Neurotherapy and Imaging Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.
Wakimoto H
Agarwal AS
Rabkin SD
Bhere D
Martuza RL
Kuroda T
Kasmieh R
Shah K
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2013 Jan; Vol. 21 (1), pp. 68-77. Date of Electronic Publication: 2012 Aug 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm*
Oncolytic Virotherapy*
Brain Neoplasms/*therapy
Glioblastoma/*therapy
Neoplastic Stem Cells/*pathology
Animals ; Apoptosis ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Glioblastoma/pathology ; Humans ; MAP Kinase Signaling System ; Mice ; Neoplasm Invasiveness ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Expression of FMS-like tyrosine kinase 3 ligand by oncolytic herpes simplex virus type I prolongs survival in mice bearing established syngeneic intracranial malignant glioma.
Autorzy :
Barnard Z; Simches Brain Tumor Research Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Wakimoto H
Zaupa C
Patel AP
Klehm J
Martuza RL
Rabkin SD
Curry WT Jr
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Źródło :
Neurosurgery [Neurosurgery] 2012 Sep; Vol. 71 (3), pp. 741-8; discussion 748.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*therapy
Glioma/*therapy
Immunotherapy/*methods
Oncolytic Virotherapy/*methods
fms-Like Tyrosine Kinase 3/*biosynthesis
Animals ; Chromosomes, Artificial, Bacterial ; Disease Models, Animal ; Herpesvirus 1, Human ; Mice ; Mice, Inbred C57BL ; Transplantation, Isogeneic
Czasopismo naukowe
Tytuł :
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Autorzy :
Kanai R; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 , USA.
Rabkin SD
Yip S
Sgubin D
Zaupa CM
Hirose Y
Louis DN
Wakimoto H
Martuza RL
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Źródło :
Journal of the National Cancer Institute [J Natl Cancer Inst] 2012 Jan 04; Vol. 104 (1), pp. 42-55. Date of Electronic Publication: 2011 Dec 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Damage*
Oncolytic Virotherapy*/methods
Simplexvirus*/genetics
Antineoplastic Agents, Alkylating/*pharmacology
Brain Neoplasms/*drug therapy
Brain Neoplasms/*genetics
DNA-Binding Proteins/*metabolism
Dacarbazine/*analogs & derivatives
Glioblastoma/*drug therapy
Glioblastoma/*genetics
Neoplastic Stem Cells/*drug effects
Animals ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Survival ; Chlorocebus aethiops ; DNA Modification Methylases/metabolism ; DNA Repair/drug effects ; DNA Repair Enzymes/metabolism ; DNA-Binding Proteins/genetics ; Dacarbazine/pharmacology ; Female ; Gene Knockdown Techniques ; Genetic Vectors ; Humans ; Immunoblotting ; Immunohistochemistry ; Methylation ; Mice ; Mice, Nude ; Polymerase Chain Reaction ; Protein-Serine-Threonine Kinases/metabolism ; Temozolomide ; Tumor Suppressor Proteins/metabolism ; Vero Cells ; Virus Replication
Czasopismo naukowe
Tytuł :
Enhanced antitumor efficacy of low-dose Etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts.
Autorzy :
Cheema TA; Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, USA.
Kanai R
Kim GW
Wakimoto H
Passer B
Rabkin SD
Martuza RL
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2011 Dec 01; Vol. 17 (23), pp. 7383-93. Date of Electronic Publication: 2011 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*therapy
Etoposide/*administration & dosage
Glioblastoma/*therapy
Oncolytic Virotherapy/*methods
Topoisomerase I Inhibitors/*pharmacology
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Brain Neoplasms/drug therapy ; Camptothecin/analogs & derivatives ; Camptothecin/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Combined Modality Therapy ; Etoposide/therapeutic use ; Glioblastoma/drug therapy ; Humans ; Irinotecan ; Mice ; Mice, Nude ; Neural Stem Cells/pathology ; Oncolytic Viruses/metabolism ; Simplexvirus/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication.
Autorzy :
Passer BJ; Departments of Neurosurgery and Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. />Cheema T
Zhou B
Wakimoto H
Zaupa C
Razmjoo M
Sarte J
Wu S
Wu CL
Noah JW
Li Q
Buolamwini JK
Yen Y
Rabkin SD
Martuza RL
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Źródło :
Cancer research [Cancer Res] 2010 May 15; Vol. 70 (10), pp. 3890-5. Date of Electronic Publication: 2010 Apr 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Oncolytic Virotherapy*
Dilazep/*pharmacology
Dipyridamole/*pharmacology
Equilibrative Nucleoside Transporter 1/*antagonists & inhibitors
Herpesvirus 1, Human/*physiology
Prostatic Neoplasms/*therapy
Virus Replication/*drug effects
Animals ; Combinatorial Chemistry Techniques ; Equilibrative Nucleoside Transporter 1/metabolism ; Gene Expression Profiling ; Herpes Simplex/metabolism ; Herpes Simplex/therapy ; Herpes Simplex/virology ; Humans ; Male ; Mice ; Mice, Nude ; Organ Culture Techniques ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/virology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonucleotide Reductases/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors.
Autorzy :
Wakimoto H; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA. />Kesari S
Farrell CJ
Curry WT Jr
Zaupa C
Aghi M
Kuroda T
Stemmer-Rachamimov A
Shah K
Liu TC
Jeyaretna DS
Debasitis J
Pruszak J
Martuza RL
Rabkin SD
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Źródło :
Cancer research [Cancer Res] 2009 Apr 15; Vol. 69 (8), pp. 3472-81. Date of Electronic Publication: 2009 Apr 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Neoplasms/*pathology
Brain Neoplasms/*therapy
Embryonic Stem Cells/*pathology
Glioblastoma/*pathology
Glioblastoma/*therapy
Neoplastic Stem Cells/*pathology
Oncolytic Virotherapy/*methods
Simplexvirus/*physiology
Animals ; Brain Neoplasms/virology ; Embryonic Stem Cells/virology ; Glioblastoma/virology ; Humans ; Mice ; Mutation ; Neoplastic Stem Cells/virology ; Simplexvirus/genetics ; Simplexvirus/growth & development ; Tumor Cells, Cultured ; Virus Replication ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Combination immunotherapy for tumors via sequential intratumoral injections of oncolytic herpes simplex virus 1 and immature dendritic cells.
Autorzy :
Farrell CJ; Brain Tumor Research Center, Simches Research Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Zaupa C
Barnard Z
Maley J
Martuza RL
Rabkin SD
Curry WT Jr
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2008 Dec 01; Vol. 14 (23), pp. 7711-6.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendritic Cells/*immunology
Immunotherapy/*methods
Neoplasms, Experimental/*therapy
Oncolytic Virotherapy/*methods
Animals ; Antineoplastic Agents/immunology ; Antineoplastic Agents/therapeutic use ; Combined Modality Therapy ; Cytotoxicity, Immunologic ; Herpesvirus 1, Human/immunology ; Immunohistochemistry ; Interferon-gamma/biosynthesis ; Mice
Czasopismo naukowe
Tytuł :
Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects.
Autorzy :
Liu TC; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. />Castelo-Branco P
Rabkin SD
Martuza RL
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2008 Jun; Vol. 16 (6), pp. 1041-7. Date of Electronic Publication: 2008 Apr 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Angiogenesis Inhibitors/*pharmacology
Antineoplastic Agents/*pharmacology
Hydroxamic Acids/*pharmacology
Oncolytic Virotherapy/*methods
Simplexvirus/*genetics
Animals ; Chlorocebus aethiops ; Combined Modality Therapy ; Cyclin D1/metabolism ; Endothelium, Vascular/cytology ; HeLa Cells ; Humans ; Neoplasm Transplantation ; Protein Synthesis Inhibitors/pharmacology ; Vascular Endothelial Growth Factor A/metabolism ; Virus Replication
Czasopismo naukowe
Tytuł :
Systemic therapy of spontaneous prostate cancer in transgenic mice with oncolytic herpes simplex viruses.
Autorzy :
Varghese S; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Rabkin SD
Nielsen GP
MacGarvey U
Liu R
Martuza RL
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Źródło :
Cancer research [Cancer Res] 2007 Oct 01; Vol. 67 (19), pp. 9371-9.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Adenocarcinoma/*therapy
Adenocarcinoma/*virology
Oncolytic Virotherapy/*methods
Prostatic Neoplasms/*therapy
Prostatic Neoplasms/*virology
Simplexvirus/*physiology
Adenocarcinoma/pathology ; Animals ; Cell Growth Processes/physiology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neoplasm Metastasis ; Prostatic Neoplasms/pathology ; Simplexvirus/genetics
Czasopismo naukowe
Tytuł :
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Autorzy :
Fulci G; Molecular Neuro-oncology Laboratories, Neurosurgery Service, and Center for Molecular Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA. />Dmitrieva N
Gianni D
Fontana EJ
Pan X
Lu Y
Kaufman CS
Kaur B
Lawler SE
Lee RJ
Marsh CB
Brat DJ
van Rooijen N
Stemmer-Rachamimov AO
Hochberg FH
Weissleder R
Martuza RL
Chiocca EA
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Źródło :
Cancer research [Cancer Res] 2007 Oct 01; Vol. 67 (19), pp. 9398-406.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Brain Neoplasms/*virology
Glioma/*virology
Macrophages/*virology
Oncolytic Virotherapy/*methods
Animals ; Brain Neoplasms/blood ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Glioma/blood ; Glioma/pathology ; Glioma/therapy ; Male ; Mice ; Mice, Nude ; Microglia/pathology ; Phagocytosis ; Rats ; Rats, Inbred F344
Czasopismo naukowe
Tytuł :
Oncolytic herpes simplex virus therapy for peripheral nerve tumors.
Autorzy :
Jeyaretna DS; Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. />Rabkin SD
Martuza RL
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Źródło :
Neurosurgical focus [Neurosurg Focus] 2007 Jun 15; Vol. 22 (6), pp. E4. Date of Electronic Publication: 2007 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
MeSH Terms :
Oncolytic Virotherapy/*methods
Peripheral Nervous System Neoplasms/*therapy
Simplexvirus/*genetics
Animals ; Genetic Vectors/therapeutic use ; Humans ; Oncolytic Viruses/genetics ; Peripheral Nervous System Neoplasms/chemistry ; Peripheral Nervous System Neoplasms/genetics ; Peripheral Nervous System Neoplasms/virology
Czasopismo naukowe
Tytuł :
Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide.
Autorzy :
Aghi M; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. />Rabkin SD
Martuza RL
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Źródło :
Cancer research [Cancer Res] 2007 Jan 15; Vol. 67 (2), pp. 440-4.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Glioma/*blood supply
Glioma/*therapy
Herpesvirus 1, Human/*physiology
Oncolytic Virotherapy/*methods
Peptide Fragments/*pharmacology
Thrombospondin 1/*metabolism
Thrombospondin 1/*pharmacology
Thrombospondins/*metabolism
Animals ; Cell Growth Processes/physiology ; Cell Line, Tumor ; Chlorocebus aethiops ; Glioma/pathology ; Glioma/virology ; Herpesvirus 1, Human/genetics ; Humans ; Mice ; Mice, Nude ; Neovascularization, Pathologic/pathology ; Neovascularization, Pathologic/virology ; Oncolytic Virotherapy/adverse effects ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Thrombospondin 1/biosynthesis ; Thrombospondin 1/genetics ; Thrombospondins/biosynthesis ; Thrombospondins/genetics ; Vero Cells ; Xenograft Model Antitumor Assays
Czasopismo naukowe

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