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Wyświetlanie 1-20 z 439
Tytuł:
Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis.
Autorzy:
Yasui H; Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Iizuka D; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Hiraoka W; Laboratory of Biophysics, School of Science and Technology, Meiji University, Kawasaki, Japan.
Kuwabara M; Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Matsuda A; Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Inanami O; Laboratory of Radiation Biology, Department of Applied Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
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Źródło:
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2020; Vol. 39 (1-3), pp. 439-452. Date of Electronic Publication: 2019 Sep 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell Cycle Checkpoints/*drug effects
DNA Repair/*drug effects
Nucleosides/*analogs & derivatives
Nucleosides/*pharmacology
Radiation-Sensitizing Agents/*pharmacology
Animals ; Cell Line, Tumor ; DNA Damage ; Disease Models, Animal ; Humans ; Molecular Structure ; Purines/chemistry ; Purines/pharmacology ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Radiation, Ionizing ; Radiotherapy/adverse effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro.
Autorzy:
Motomura K; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.; Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Okada N; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Morita H; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Hara M; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Tamari M; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Orimo K; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Matsuda G; Division of Advanced Medicine for Virus Infections, National Research Institute for Child Health and Development, Tokyo, Japan.
Imadome KI; Division of Advanced Medicine for Virus Infections, National Research Institute for Child Health and Development, Tokyo, Japan.
Matsuda A; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Nagamatsu T; Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Fujieda M; Department of Pediatrics, Kochi Medical School, Kochi, Japan.
Sago H; Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Saito H; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Matsumoto K; Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2017 May 19; Vol. 12 (5), pp. e0177994. Date of Electronic Publication: 2017 May 19 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Amides/*pharmacology
Apoptosis/*drug effects
Cell Adhesion/*drug effects
Cell Differentiation/*drug effects
Placenta/*pathology
Protein Kinase Inhibitors/*pharmacology
Pyridines/*pharmacology
Trophoblasts/*pathology
rho-Associated Kinases/*antagonists & inhibitors
Cell Proliferation/drug effects ; Cells, Cultured ; Female ; Humans ; Placenta/drug effects ; Placenta/enzymology ; Pregnancy ; Trophoblasts/drug effects ; Trophoblasts/enzymology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Nuclear factor-ĸB plays a critical role in both intrinsic and acquired resistance against endocrine therapy in human breast cancer cells.
Autorzy:
Oida K; 1] Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan [2] Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna, University of Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
Matsuda A; Laboratory of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Jung K; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Xia Y; Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Jang H; Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Amagai Y; Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Ahn G; Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Nishikawa S; Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Ishizaka S; Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Jensen-Jarolim E; 1] Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna, University of Vienna, Veterinaerplatz 1, 1210 Vienna, Austria [2] Comparative Immunology and Oncology, Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
Matsuda H; 1] Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan [2] Laboratory of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
Tanaka A; 1] Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan [2] Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
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Źródło:
Scientific reports [Sci Rep] 2014 Feb 17; Vol. 4, pp. 4057. Date of Electronic Publication: 2014 Feb 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Neoplasm*
Antineoplastic Agents, Hormonal/*toxicity
Apoptosis/*drug effects
NF-kappa B/*metabolism
Tamoxifen/*toxicity
Animals ; Antineoplastic Agents, Hormonal/therapeutic use ; Benzamides/therapeutic use ; Benzamides/toxicity ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Female ; Humans ; MCF-7 Cells ; Matrix Metalloproteinase 9 ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/genetics ; RNA Interference ; RNA, Small Interfering/metabolism ; Receptors, Estrogen/metabolism ; Tamoxifen/therapeutic use ; Transplantation, Heterologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line.
Autorzy:
Kojima R; Department of Basic Pathology, National Defense Medical College, Saitama, Japan ; Department of Pediatrics, National Defense Medical College, Saitama, Japan ; Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Ohno T; Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Iikura M; Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Niki T; Departments of Immunology and Immunopathology, Faculty of Medicine, Kagawa University, Takamatsu, Japan ; Research Center, GalPharma Company, Takamatsu, Japan.
Hirashima M; Departments of Immunology and Immunopathology, Faculty of Medicine, Kagawa University, Takamatsu, Japan ; Research Center, GalPharma Company, Takamatsu, Japan.
Iwaya K; Department of Basic Pathology, National Defense Medical College, Saitama, Japan.
Tsuda H; Department of Basic Pathology, National Defense Medical College, Saitama, Japan.
Nonoyama S; Department of Pediatrics, National Defense Medical College, Saitama, Japan.
Matsuda A; Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Saito H; Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Matsumoto K; Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Nakae S; Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan ; Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan ; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama, Japan.
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Źródło:
PloS one [PLoS One] 2014 Jan 20; Vol. 9 (1), pp. e86106. Date of Electronic Publication: 2014 Jan 20 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Cell Degranulation*
Cytokines/*metabolism
Galectins/*metabolism
Mast Cells/*physiology
Cell Line ; Cell Survival ; Enzyme Activation ; Humans ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Association of RNase L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line.
Autorzy:
Sato A; Department of Molecular Drug Informatics, Faculty of Pharmaceutical Sciences, Tsushima, Okayama, Okayama University, Japan.
Naito T
Hiramoto A
Goda K
Omi T
Kitade Y
Sasaki T
Matsuda A
Fukushima M
Wataya Y
Kim HS
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Źródło:
The FEBS journal [FEBS J] 2010 Nov; Vol. 277 (21), pp. 4464-73. Date of Electronic Publication: 2010 Sep 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Endoribonucleases/*metabolism
ras GTPase-Activating Proteins/*metabolism
Blotting, Western ; Cell Line, Tumor ; Cell Survival ; Cytidine/analogs & derivatives ; Cytidine/pharmacology ; Endoribonucleases/genetics ; Humans ; Immunoprecipitation ; In Situ Nick-End Labeling ; JNK Mitogen-Activated Protein Kinases/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Phosphorylation/drug effects ; Protein Binding ; Protein Interaction Mapping/methods ; RNA Interference ; ras GTPase-Activating Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibition of HIF-1alpha by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo.
Autorzy:
Yasui H; Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Sapporo 060-0818, Japan.
Ogura A
Asanuma T
Matsuda A
Kashiwakura I
Kuwabara M
Inanami O
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Źródło:
British journal of cancer [Br J Cancer] 2008 Nov 04; Vol. 99 (9), pp. 1442-52. Date of Electronic Publication: 2008 Oct 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors
Radiation-Sensitizing Agents/*pharmacology
Animals ; Cell Cycle ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Mice ; Mice, SCID ; Neoplasms, Experimental/pathology ; Neoplasms, Experimental/therapy ; Oligonucleotides, Antisense/pharmacology ; Transcription, Genetic/drug effects ; Uridine Kinase/genetics ; Uridine Kinase/physiology ; Vascular Endothelial Growth Factor A/genetics ; X-Ray Therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
2-Chloro-2'-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4.
Autorzy:
Nomura Y; Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Inanami O
Takahashi K
Matsuda A
Kuwabara M
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Źródło:
Leukemia [Leukemia] 2000 Feb; Vol. 14 (2), pp. 299-306.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Caspases/*metabolism
Cladribine/*pharmacology
Leukemia/*drug therapy
Leukemia/*metabolism
fas Receptor/*drug effects
Antineoplastic Agents/antagonists & inhibitors ; Blotting, Western ; Caspase 3 ; Caspase 8 ; Caspase 9 ; Caspase Inhibitors ; Cladribine/antagonists & inhibitors ; Cycloheximide/pharmacology ; Cysteine Proteinase Inhibitors/pharmacology ; DNA Fragmentation ; DNA, Neoplasm ; Deoxycytidine/pharmacology ; Enzyme Activation/drug effects ; Flow Cytometry ; Fluorometry ; Humans ; In Situ Nick-End Labeling ; Leukemia/enzymology ; Oligopeptides/pharmacology ; Phosphorylation/drug effects ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lipidome and metabolome analyses reveal metabolic alterations associated with MCF-7 apoptosis upon 4-hydroxytamoxifen treatment.
Autorzy:
Nishimoto, Kazuki
Okahashi, Nobuyuki
Maruyama, Masaharu
Izumi, Yoshihiro
Nakatani, Kohta
Ito, Yuki
Iida, Junko
Bamba, Takeshi
Matsuda, Fumio
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Temat:
CELL death inhibition
METABOLOMICS
CANCER cells
APOPTOSIS
MEMBRANE potential
MITOCHONDRIAL membranes
Źródło:
Scientific Reports; 10/29/2023, Vol. 13 Issue 1, p1-10, 10p
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 439

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