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Tytuł:
Dimer Interface in Natural Variant NK1 Is Dispensable for HGF-Dependent Met Receptor Activation.
Autorzy:
Tahira Y; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
Sakai K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
Sato H; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
Imamura R; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
Matsumoto K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.; Institute for Frontier Science Initiative, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 26; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 26.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocyte Growth Factor/*chemistry
Proto-Oncogene Proteins c-met/*metabolism
Animals ; Binding Sites ; Cell Line, Tumor ; Dogs ; HEK293 Cells ; Hepatocyte Growth Factor/genetics ; Hepatocyte Growth Factor/metabolism ; Humans ; Madin Darby Canine Kidney Cells ; Mutation ; Protein Binding ; Protein Multimerization ; Proto-Oncogene Proteins c-met/chemistry ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cyclic Peptide-Based Biologics Regulating HGF-MET.
Autorzy:
Sato H; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa 920-1192, Japan.
Imamura R; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa 920-1192, Japan.
Suga H; Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
Matsumoto K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa 920-1192, Japan.; Tumor Microenvironment Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan.
Sakai K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa 920-1192, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 27; Vol. 21 (21). Date of Electronic Publication: 2020 Oct 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biological Products/*pharmacology
Hepatocyte Growth Factor/*metabolism
Neoplasms/*metabolism
Peptides, Cyclic/*pharmacology
Proto-Oncogene Proteins c-met/*metabolism
Animals ; Binding Sites ; Biological Products/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Hepatocyte Growth Factor/antagonists & inhibitors ; Humans ; Neoplasms/drug therapy ; Peptides, Cyclic/therapeutic use ; Protein Binding ; Proto-Oncogene Proteins c-met/agonists ; Proto-Oncogene Proteins c-met/chemistry ; Signal Transduction/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The constitutive high-affinity Met-binding site in the kringle domain is dispensable for the signalling activity of hepatocyte growth factor.
Autorzy:
Umitsu M; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Sakai K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
Tamura-Kawakami K; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Matsumoto K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
Takagi J; Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
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Źródło:
Journal of biochemistry [J Biochem] 2020 Jun 01; Vol. 167 (6), pp. 577-586.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocyte Growth Factor/*metabolism
Kringles/*genetics
Proto-Oncogene Proteins c-met/*metabolism
Signal Transduction/*genetics
Animals ; Binding Sites ; Cell Line, Tumor ; Cell Movement/genetics ; Dogs ; HEK293 Cells ; Humans ; Ligands ; Madin Darby Canine Kidney Cells ; Mice ; Mutagenesis, Site-Directed ; Phosphorylation ; Protein Binding ; Proto-Oncogene Proteins c-met/genetics ; Transfection
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.
Autorzy:
Jangphattananont N; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Sato H; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Imamura R; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Sakai K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. k_.; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. k_.
Terakado Y; Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Murakami K; Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Barker N; Division of Epithelial Stem Cell Biology, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; A*STAR Institute of Medical Biology, Singapore 138648, Singapore. .
Oshima H; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; Division of Genetics, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Oshima M; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; Division of Genetics, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Takagi J; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan. .
Kato Y; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine/New Industry Creation Hatchery Center, Tohoku University, Sendai 980-8575, Japan. .
Yano S; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Matsumoto K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; WPI-Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; Tumor Microenvironment Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2019 Jun 17; Vol. 20 (12). Date of Electronic Publication: 2019 Jun 17.
Typ publikacji:
Journal Article
MeSH Terms:
Organogenesis*/genetics
Wound Healing*/genetics
Hepatocyte Growth Factor/*metabolism
Animals ; Biomarkers ; Hepatocyte Growth Factor/genetics ; Humans ; Immunohistochemistry ; Mice ; Mice, Transgenic ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; Phosphorylation ; Protein Transport ; Proto-Oncogene Proteins c-met/metabolism ; Regeneration ; Stem Cells/cytology ; Stem Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.
Autorzy:
Miao W; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Sakai K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. k_.
Imamura R; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .
Ito K; Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. .
Suga H; Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. .
Sakuma T; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan. .
Yamamoto T; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan. .
Matsumoto K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; Nano Life Science Institute, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan. .; Tumor Microenvironment Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Oct 12; Vol. 19 (10). Date of Electronic Publication: 2018 Oct 12.
Typ publikacji:
Journal Article
MeSH Terms:
Transcriptional Activation*
Hepatocyte Growth Factor/*metabolism
Peptides/*pharmacology
Proto-Oncogene Proteins c-met/*metabolism
Cell Line, Tumor ; Cell Movement/drug effects ; Humans ; MAP Kinase Signaling System/drug effects ; Macrocyclic Compounds/chemistry ; Macrocyclic Compounds/pharmacology ; Peptides/chemistry ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt ; Proto-Oncogene Proteins c-met/agonists
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies.
Autorzy:
Umitsu M; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan.
Sakai K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Ishikawa, 920-1192, Japan.
Ogasawara S; Department of Regional Innovation, Tohoku University Graduate School of Medicine, Miyagi, 980-8575, Japan.
Kaneko MK; Department of Regional Innovation, Tohoku University Graduate School of Medicine, Miyagi, 980-8575, Japan.
Asaki R; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan.
Tamura-Kawakami K; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan.
Kato Y; Department of Regional Innovation, Tohoku University Graduate School of Medicine, Miyagi, 980-8575, Japan.
Matsumoto K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Ishikawa, 920-1192, Japan.
Takagi J; Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan.
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Źródło:
Scientific reports [Sci Rep] 2016 Sep 09; Vol. 6, pp. 33149. Date of Electronic Publication: 2016 Sep 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal, Murine-Derived/*chemistry
Epitopes/*chemistry
Hepatocyte Growth Factor/*chemistry
Animals ; Antibodies, Monoclonal, Murine-Derived/immunology ; Antibodies, Monoclonal, Murine-Derived/pharmacology ; Dogs ; Epitopes/immunology ; Hepatocyte Growth Factor/immunology ; Humans ; Madin Darby Canine Kidney Cells ; Mice ; Protein Conformation ; Proto-Oncogene Proteins c-met/immunology ; Signal Transduction/drug effects ; Signal Transduction/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hepatocyte growth factor and Met in drug discovery.
Autorzy:
Sakai K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; and Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka-shi, Fukuoka 820-8502, Japan.
Aoki S; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; and Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka-shi, Fukuoka 820-8502, Japan.
Matsumoto K; Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; and Department of Bioscience and Bioinformatics, Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka-shi, Fukuoka 820-8502, Japan .
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Źródło:
Journal of biochemistry [J Biochem] 2015 May; Vol. 157 (5), pp. 271-84. Date of Electronic Publication: 2015 Mar 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Drug Discovery*
Hepatocyte Growth Factor/*metabolism
Proto-Oncogene Proteins c-met/*metabolism
Animals ; Homeostasis ; Humans ; Mice ; Mice, Knockout ; Models, Molecular ; Protein Binding ; Proto-Oncogene Proteins c-met/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Recombinant human hepatocyte growth factor (HGF), but not rat HGF, elicits glomerular injury and albuminuria in normal rats via an immune complex-dependent mechanism.
Autorzy:
Mizuno S; Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, OsakaSaito Laboratory, Research & Development, Kringle Pharma Inc., IbarakiKringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, SuitaDivision of Tumor Dynamics and Regulation, Kanazawa University Cancer Research Institute, Kanazawa, Japan.
Ikebuchi F
Fukuta K
Kato T
Matsumoto K
Adachi K
Abe T
Nakamura T
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Źródło:
Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2011 Mar; Vol. 38 (3), pp. 192-201.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Albuminuria/*chemically induced
Albuminuria/*drug therapy
Hepatocyte Growth Factor/*adverse effects
Kidney Diseases/*chemically induced
Kidney Diseases/*drug therapy
Albuminuria/metabolism ; Animals ; Antigen-Antibody Complex/metabolism ; Glomerular Mesangium/drug effects ; Glomerular Mesangium/metabolism ; Hepatocyte Growth Factor/pharmacology ; Humans ; Hypertrophy/chemically induced ; Hypertrophy/metabolism ; Immunoglobulin G/metabolism ; Kidney Diseases/metabolism ; Rats ; Recombinant Proteins/adverse effects ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.
Autorzy:
Onimaru M; Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.
Ohuchida K
Egami T
Mizumoto K
Nagai E
Cui L
Toma H
Matsumoto K
Hashizume M
Tanaka M
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Źródło:
Cancer gene therapy [Cancer Gene Ther] 2010 Aug; Vol. 17 (8), pp. 541-9. Date of Electronic Publication: 2010 Apr 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antimetabolites, Antineoplastic/*pharmacology
Deoxycytidine/*analogs & derivatives
Genetic Therapy/*methods
Hepatocyte Growth Factor/*genetics
Pancreatic Neoplasms/*therapy
Adenoviridae/genetics ; Animals ; Cell Line, Tumor ; Combined Modality Therapy ; Cytomegalovirus/genetics ; Deoxycytidine/pharmacology ; Drug Synergism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Genetic Vectors/genetics ; Hepatocyte Growth Factor/biosynthesis ; Humans ; Mice ; Mice, Nude ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Promoter Regions, Genetic ; Transgenes ; Gemcitabine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells.
Autorzy:
Kanehira M; Department of Molecular Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryomachi Aobaku, Sendai, Japan.
Xin H
Hoshino K
Maemondo M
Mizuguchi H
Hayakawa T
Matsumoto K
Nakamura T
Nukiwa T
Saijo Y
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Źródło:
Cancer gene therapy [Cancer Gene Ther] 2007 Nov; Vol. 14 (11), pp. 894-903. Date of Electronic Publication: 2007 Aug 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cell Transplantation*
Genetic Therapy/*methods
Hepatocyte Growth Factor/*genetics
Lung Neoplasms/*therapy
Adenoviridae/genetics ; Animals ; Apoptosis ; Bone Marrow Cells/physiology ; Cell Movement ; Humans ; Lung Neoplasms/blood supply ; Lung Neoplasms/secondary ; Lymphangiogenesis ; Mesenchymal Stem Cells/physiology ; Mice ; Mice, Inbred BALB C ; Neovascularization, Pathologic/therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Stimulation of hepatocyte growth factor production by heparin-derived oligosaccharides.
Autorzy:
Sakiyama R; Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
Fukuta K
Matsumoto K
Furukawa M
Takahashi Y
Nakamura T
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Źródło:
Journal of biochemistry [J Biochem] 2007 May; Vol. 141 (5), pp. 653-60. Date of Electronic Publication: 2007 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Heparin/*pharmacology
Hepatocyte Growth Factor/*biosynthesis
Oligosaccharides/*pharmacology
Animals ; Anticoagulants/pharmacology ; Cells, Cultured ; Chromatography, Ion Exchange ; Culture Media, Conditioned ; Humans ; Sus scrofa
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A genomic analysis of adult T-cell leukemia.
Autorzy:
Choi YL; Division of Functional Genomics, Jichi Medical University, Shimotsukeshi, Tochigi, Japan.
Tsukasaki K
O'Neill MC
Yamada Y
Onimaru Y
Matsumoto K
Ohashi J
Yamashita Y
Tsutsumi S
Kaneda R
Takada S
Aburatani H
Kamihira S
Nakamura T
Tomonaga M
Mano H
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Źródło:
Oncogene [Oncogene] 2007 Feb 22; Vol. 26 (8), pp. 1245-55. Date of Electronic Publication: 2006 Aug 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Profiling*
Genome, Human/*genetics
Hepatocyte Growth Factor/*genetics
Leukemia-Lymphoma, Adult T-Cell/*genetics
Proto-Oncogene Proteins/*genetics
Receptors, Growth Factor/*genetics
Cell Line, Tumor ; Gene Dosage ; Genomics ; Humans ; Oligonucleotide Array Sequence Analysis ; Proto-Oncogene Proteins c-met ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy.
Autorzy:
Azuma J; Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Taniyama Y
Takeya Y
Iekushi K
Aoki M
Dosaka N
Matsumoto K
Nakamura T
Ogihara T
Morishita R
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Źródło:
Gene therapy [Gene Ther] 2006 Aug; Vol. 13 (16), pp. 1206-13. Date of Electronic Publication: 2006 Apr 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA/*administration & dosage
Genetic Therapy/*methods
Heart/*physiopathology
Hepatocyte Growth Factor/*genetics
Myocardial Ischemia/*therapy
Animals ; Coronary Angiography ; Echocardiography ; Fibrosis ; Hepatocyte Growth Factor/metabolism ; Male ; Models, Animal ; Myocardial Ischemia/metabolism ; Myocardial Ischemia/physiopathology ; Neovascularization, Physiologic ; Reverse Transcriptase Polymerase Chain Reaction ; Swine ; Transduction, Genetic ; Transfection/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival.
Autorzy:
Ogura Y; Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Mizumoto K
Nagai E
Murakami M
Inadome N
Saimura M
Matsumoto K
Nakamura T
Maemondo M
Nukiwa T
Tanaka M
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Źródło:
Cancer gene therapy [Cancer Gene Ther] 2006 May; Vol. 13 (5), pp. 520-9.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Therapy*
Antimetabolites, Antineoplastic/*therapeutic use
Carcinoma/*prevention & control
Deoxycytidine/*analogs & derivatives
Hepatocyte Growth Factor/*genetics
Liver Neoplasms/*prevention & control
Pancreatic Neoplasms/*therapy
Adenoviridae/genetics ; Animals ; Carcinoma/secondary ; Combined Modality Therapy ; Deoxycytidine/therapeutic use ; Genetic Vectors/administration & dosage ; Humans ; Injections ; Liver Neoplasms/secondary ; Mice ; Mice, Nude ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/pathology ; Proto-Oncogene Proteins c-met/genetics ; RNA, Messenger/analysis ; Xenograft Model Antitumor Assays ; Gemcitabine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation.
Autorzy:
Hosseinkhani H; Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.
Kushibiki T
Matsumoto K
Nakamura T
Tabata Y
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Źródło:
Cancer gene therapy [Cancer Gene Ther] 2006 May; Vol. 13 (5), pp. 479-89.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
MeSH Terms:
Ultrasonics*
Carcinoma, Lewis Lung/*therapy
Dextrans/*administration & dosage
Gene Expression/*radiation effects
Genetic Therapy/*methods
Hepatocyte Growth Factor/*genetics
Plasmids/*administration & dosage
Polyethylene Glycols/*administration & dosage
Animals ; DNA/administration & dosage ; DNA/chemistry ; DNA/genetics ; Dextrans/chemistry ; Male ; Mice ; Mice, Inbred C57BL ; Plasmids/chemistry ; Plasmids/genetics ; Polyethylene Glycols/chemistry ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Suppression of tumor metastasis by NK4 plasmid DNA released from cationized gelatin.
Autorzy:
Kushibiki T; Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan.
Matsumoto K
Nakamura T
Tabata Y
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Źródło:
Gene therapy [Gene Ther] 2004 Aug; Vol. 11 (15), pp. 1205-14.
Typ publikacji:
Journal Article
MeSH Terms:
DNA/*pharmacology
Genetic Therapy/*methods
Hepatocyte Growth Factor/*antagonists & inhibitors
Hepatocyte Growth Factor/*genetics
Lung Neoplasms/*secondary
Lung Neoplasms/*therapy
Mitogens/*genetics
Animals ; Apoptosis ; Cations ; Chromosomes, Artificial, Bacterial ; Delayed-Action Preparations ; Gelatin ; Injections, Subcutaneous ; Male ; Mice ; Mice, Inbred C57BL ; Microspheres ; Neoplasm Transplantation ; Neovascularization, Pathologic ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice.
Autorzy:
Wen J; Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Matsumoto K
Taniura N
Tomioka D
Nakamura T
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Źródło:
Cancer gene therapy [Cancer Gene Ther] 2004 Jun; Vol. 11 (6), pp. 419-30.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Angiogenesis Inhibitors/*pharmacology
Colonic Neoplasms/*pathology
Hepatocyte Growth Factor/*biosynthesis
Liver/*metabolism
Liver Neoplasms/*metabolism
Liver Neoplasms/*pathology
Mitogens/*biosynthesis
Animals ; Blotting, Western ; CHO Cells ; Cell Line, Tumor ; Cell Proliferation ; Colonic Neoplasms/drug therapy ; Cricetinae ; Culture Media, Conditioned/pharmacology ; Gene Transfer Techniques ; Humans ; Immunoprecipitation ; In Situ Nick-End Labeling ; Liver/pathology ; Liver Neoplasms/drug therapy ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Transplantation ; Neovascularization, Pathologic ; Plasmids/metabolism ; Proto-Oncogene Proteins c-met/metabolism ; Recombinant Proteins/chemistry ; Time Factors ; Transgenes
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Recombinant hepatocyte growth factor accelerates cutaneous wound healing in a diabetic mouse model.
Autorzy:
Yoshida S; Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Yamadaoka 2-2-B7, Suita 565-0871, Osaka, Japan.
Matsumoto K
Tomioka D
Bessho K
Itami S
Yoshikawa K
Nakamura T
Pokaż więcej
Źródło:
Growth factors (Chur, Switzerland) [Growth Factors] 2004 Jun; Vol. 22 (2), pp. 111-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Diabetes Mellitus, Experimental/*metabolism
Hepatocyte Growth Factor/*metabolism
Recombinant Proteins/*chemistry
Animals ; Bromodeoxyuridine/pharmacology ; CHO Cells ; Cricetinae ; DNA/metabolism ; DNA, Complementary/metabolism ; Epithelial Cells/cytology ; Extracellular Matrix/metabolism ; Female ; Fibroblast Growth Factor 2/metabolism ; Fibroblasts/metabolism ; Gelatin/pharmacology ; Gelatinases/metabolism ; Gene Deletion ; Humans ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL ; Neovascularization, Pathologic ; Time Factors ; Wound Healing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model.
Autorzy:
Tanaka T; First Department of Surgery, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
Shimura H
Sasaki T
Narumi K
Maemondo M
Nukiwa T
Matsumoto K
Nakamura T
Ikeda S
Pokaż więcej
Źródło:
Cancer gene therapy [Cancer Gene Ther] 2004 Jun; Vol. 11 (6), pp. 431-40.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Promoter Regions, Genetic*
Adenoviridae/*genetics
Gallbladder Neoplasms/*therapy
Genetic Therapy/*methods
Hepatocyte Growth Factor/*genetics
Mitogens/*genetics
Animals ; CHO Cells ; Cell Line, Tumor ; Coculture Techniques ; Cricetinae ; DNA, Complementary/metabolism ; Epithelium/metabolism ; Gene Transfer Techniques ; Genetic Vectors ; Humans ; Mice ; Neoplasm Invasiveness ; Neoplasm Metastasis ; RNA, Messenger/metabolism ; Recombinant Proteins/chemistry ; Reverse Transcriptase Polymerase Chain Reaction ; Time Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Hepatocyte growth factor gene transfer into the liver via the portal vein using electroporation attenuates rat liver cirrhosis.
Autorzy:
Matsuno Y; First Department of Surgery, Gifu University School of Medicine, Gifu, Japan.
Iwata H
Umeda Y
Takagi H
Mori Y
Kosugi A
Matsumoto K
Nakamura T
Hirose H
Pokaż więcej
Źródło:
Gene therapy [Gene Ther] 2003 Sep; Vol. 10 (18), pp. 1559-66.
Typ publikacji:
Journal Article
MeSH Terms:
DNA/*administration & dosage
Electroporation/*methods
Genetic Therapy/*methods
Hepatocyte Growth Factor/*genetics
Liver/*metabolism
Liver Cirrhosis, Experimental/*therapy
Animals ; Gene Expression ; Green Fluorescent Proteins ; Humans ; Injections, Intravenous ; Liver Cirrhosis, Experimental/metabolism ; Luminescent Proteins/genetics ; Male ; Portal Vein ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Effects of hepatocyte growth factor on urokinase-type plasminogen activator (uPA) and uPA receptor in DU145 prostate cancer cells.
Autorzy:
Nishimura K; Department of Specific Organ Regulation (Urology), Osaka University Graduate School of Medicine, Suita, Japan.
Matsumiya K
Miura H
Tsujimura A
Nonomura N
Matsumoto K
Nakamura T
Okuyama A
Pokaż więcej
Źródło:
International journal of andrology [Int J Androl] 2003 Jun; Vol. 26 (3), pp. 175-9.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocyte Growth Factor/*pharmacology
Prostatic Neoplasms/*metabolism
Receptors, Cell Surface/*metabolism
Urokinase-Type Plasminogen Activator/*metabolism
Blotting, Western ; Cell Line, Tumor ; Humans ; Male ; Receptors, Urokinase Plasminogen Activator
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice.
Autorzy:
Saimura M; Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.
Nagai E
Mizumoto K
Maehara N
Okino H
Katano M
Matsumoto K
Nakamura T
Narumi K
Nukiwa T
Tanaka M
Pokaż więcej
Źródło:
Cancer gene therapy [Cancer Gene Ther] 2002 Oct; Vol. 9 (10), pp. 799-806.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mitogens*
Adenocarcinoma/*prevention & control
Adenoviruses, Human/*genetics
Genetic Therapy/*methods
Hepatocyte Growth Factor/*genetics
Pancreatic Neoplasms/*therapy
Peritoneal Neoplasms/*prevention & control
Adenocarcinoma/blood supply ; Adenocarcinoma/metabolism ; Adenocarcinoma/secondary ; Animals ; Cell Division/drug effects ; Female ; Genetic Vectors ; Hepatocyte Growth Factor/metabolism ; Hepatocyte Growth Factor/pharmacology ; Humans ; Immunoenzyme Techniques ; Injections, Intraperitoneal ; Lac Operon ; Liver/metabolism ; Mesentery/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Pancreatic Neoplasms/blood supply ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Peritoneal Neoplasms/metabolism ; Peritoneal Neoplasms/secondary ; Spleen/metabolism ; Transfection ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; beta-Galactosidase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas.
Autorzy:
Hirao S; First Department of Surgery, Nara Medical University, Kashihara, Japan.
Yamada Y
Koyama F
Fujimoto H
Takahama Y
Ueno M
Kamada K
Mizuno T
Maemondo M
Nukiwa T
Matsumoto K
Nakamura T
Nakajima Y
Pokaż więcej
Źródło:
Cancer gene therapy [Cancer Gene Ther] 2002 Aug; Vol. 9 (8), pp. 700-7.
Typ publikacji:
Journal Article
MeSH Terms:
Mitogens*
Hepatocyte Growth Factor/*antagonists & inhibitors
Hepatocyte Growth Factor/*genetics
Stomach Neoplasms/*therapy
Adenoviridae/genetics ; Animals ; CHO Cells ; Cell Division/genetics ; Cricetinae ; Cytomegalovirus/genetics ; Genetic Vectors ; Humans ; Mice ; Mice, Nude ; Stomach Neoplasms/pathology ; Transfection ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-25 z 137

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