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Wyszukujesz frazę ""McColl, Barry W."" wg kryterium: Autor


Tytuł :
Preceding infection and risk of stroke: An old concept revived by the COVID-19 pandemic.
Autorzy :
South K; Division of Neuroscience and Experimental Psychology, Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, 5292The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
McCulloch L; Centre for Discovery Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
McColl BW; Centre for Discovery Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Elkind MS; Vagelos College of Physicians and Surgeons and Mailman School of Public Health, 5798Columbia University, New York, NY, USA.
Allan SM; Division of Neuroscience and Experimental Psychology, Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, 5292The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Smith CJ; Division of Cardiovascular Sciences, Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, 5292The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.; Manchester Centre for Clinical Neurosciences, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Salford, UK.
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Źródło :
International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2020 Oct; Vol. 15 (7), pp. 722-732. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Betacoronavirus*
Coronavirus Infections/*complications
Coronavirus Infections/*diagnosis
Pneumonia, Viral/*complications
Pneumonia, Viral/*diagnosis
Stroke/*diagnosis
Stroke/*etiology
COVID-19 ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; Risk Factors ; SARS-CoV-2 ; Stroke/prevention & control
Czasopismo naukowe
Tytuł :
Characterisation of an inflammation-related epigenetic score and its association with cognitive ability.
Autorzy :
Stevenson AJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Hillary RF; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Morris SW; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Bermingham ML; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Evans KL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Boutin TS; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
McColl BW; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Spires-Jones TL; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
McIntosh AM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, EH10 5HF, UK.
Deary IJ; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. .; Lothian Birth Cohorts, University of Edinburgh, Edinburgh, EH8 9JZ, UK. .
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Źródło :
Clinical epigenetics [Clin Epigenetics] 2020 Jul 27; Vol. 12 (1), pp. 113. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings.
Autorzy :
McFall A; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Hietamies TM; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Bernard A; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Aimable M; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Allan SM; Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Bath PM; Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Brezzo G; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Carare RO; Faculty of Medicine, University of Southampton, Southampton, UK.
Carswell HV; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, Glasgow, UK.
Clarkson AN; The Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, Dunedin, New Zealand.
Currie G; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Farr TD; School of Life Sciences, University of Nottingham, Nottingham , UK.
Fowler JH; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Good M; School of Psychology, Cardiff University, Cardiff, UK.
Hainsworth AH; Molecular & Clinical Sciences Research Institute, St George's University of London, London, UK.
Hall C; School of Psychology, University of Sussex, Brighton, UK.
Horsburgh K; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
Kalaria R; Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.
Kehoe P; Institute of Clinical Neurosciences, University of Bristol, Bristol, UK.
Lawrence C; Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Macleod M; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
McColl BW; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
McNeilly A; School of Medicine, University of Dundee, Ninewells Hospital, Dundee, Scotland.
Miller AA; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Miners S; Institute of Clinical Neurosciences, University of Bristol, Bristol, UK.
Mok V; Gerald Choa Neuroscience Centre, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
O'Sullivan M; Faculty of Medicine, The University of Queensland, Queensland, Australia.
Platt B; Institute of Medical Sciences, University of Aberdeen, Aberdeen, Scotland.
Sena ES; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Sharp M; Faculty of Medicine, University of Southampton, Southampton, UK.
Strangward P; Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Szymkowiak S; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Touyz RM; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Trueman RC; School of Life Sciences, University of Nottingham, Nottingham , UK.
White C; Lydia Becker Institute of Immunology and Inflammation, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
McCabe C; Institute of Neuroscience & Psychology, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Work LM; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Quinn TJ; Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2020 Jul; Vol. 40 (7), pp. 1402-1414. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Consensus Development Conference; Journal Article; Research Support, Non-U.S. Gov't; Systematic Review
MeSH Terms :
Dementia, Vascular*
Disease Models, Animal*
Research Design/*standards
Animals ; Consensus ; Recovery of Function ; Surveys and Questionnaires ; United Kingdom
Czasopismo naukowe
Tytuł :
Biallelic mutations in NRROS cause an early onset lethal microgliopathy.
Autorzy :
Smith C; Academic Department of Neuropathology, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
McColl BW; Centre for Discovery Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Patir A; The Roslin Institute, University of Edinburgh, Edinburgh, UK.
Barrington J; Academic Department of Neuropathology, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Armishaw J; Department of Paediatrics, Bay of Plenty District Health Board, Tauranga Hospital, Tauranga, New Zealand.
Clarke A; Paediatric Neurology Department, St Georges Healthcare NHS Trust, London, UK.
Eaton J; Genetic Health Service New Zealand, Auckland District Health Board, Auckland City Hospital, Auckland, New Zealand.
Hobbs V; Department of Paediatrics, Bay of Plenty District Health Board, Tauranga Hospital, Tauranga, New Zealand.
Mansour S; Department of Clinical Genetics, SW Thames Regional Genetics Service, St George's Hospital, University of London, London, UK.
Nolan M; Department of Paediatric Neurology, Starship Children's Health, Auckland, New Zealand.
Rice GI; Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Rodero MP; Laboratory of Neurogenetics and Neuroinflammation, Institut Imagine, Paris, France.
Seabra L; Laboratory of Neurogenetics and Neuroinflammation, Institut Imagine, Paris, France.
Uggenti C; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Livingston JH; Department of Paediatric Neurology, Leeds General Infirmary, Leeds, UK.
Bridges LR; Department of Cellular Pathology, St George's University Hospitals NHS Foundation Trust, London, UK.
Jeffrey IJM; Department of Cellular Pathology, St George's University Hospitals NHS Foundation Trust, London, UK.
Crow YJ; Laboratory of Neurogenetics and Neuroinflammation, Institut Imagine, Paris, France. .; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. .
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Źródło :
Acta neuropathologica [Acta Neuropathol] 2020 May; Vol. 139 (5), pp. 947-951. Date of Electronic Publication: 2020 Feb 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Interleukin-1 receptor antagonist treatment in acute ischaemic stroke does not alter systemic markers of anti-microbial defence.
Autorzy :
McCulloch L; UK Dementia Research Institute, University of Edinburgh, Edinburgh, EH16 4SB, UK.
Allan SM; Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, M13 9PT, UK.
Emsley HC; Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, LA1 4YW, UK.
Smith CJ; Division of Cardiovascular Sciences, University of Manchester, Manchester, M13 9PT, UK.; Greater Manchester Comprehensive Stroke Centre, Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, M6 8HD, UK.
McColl BW; UK Dementia Research Institute, University of Edinburgh, Edinburgh, EH16 4SB, UK.
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Źródło :
F1000Research [F1000Res] 2019 Jul 10; Vol. 8, pp. 1039. Date of Electronic Publication: 2019 Jul 10 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Ischemia*/drug therapy
Interleukin 1 Receptor Antagonist Protein*/therapeutic use
Stroke*/drug therapy
Biomarkers ; Cytokines ; Humans ; Infections ; Receptors, Interleukin-1/metabolism
Czasopismo naukowe
Tytuł :
A core transcriptional signature of human microglia: Derivation and utility in describing region-dependent alterations associated with Alzheimer's disease.
Autorzy :
Patir A; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, Scotland, United Kingdom.
Shih B; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, Scotland, United Kingdom.
McColl BW; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, Scotland, United Kingdom.; UK Dementia Research Institute at The University of Edinburgh, Edinburgh Medical School, The Chancellor's Building, 49 Little France Crescent, Edinburgh, United Kingdom.
Freeman TC; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, Scotland, United Kingdom.
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Źródło :
Glia [Glia] 2019 Jul; Vol. 67 (7), pp. 1240-1253. Date of Electronic Publication: 2019 Feb 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Alzheimer Disease/*genetics
Alzheimer Disease/*metabolism
Microglia/*metabolism
Transcriptome/*physiology
Alzheimer Disease/pathology ; Animals ; Central Nervous System/metabolism ; Central Nervous System/pathology ; Gene Expression Profiling/methods ; Gene Expression Profiling/trends ; Humans ; Mice ; Microglia/pathology
Czasopismo naukowe
Tytuł :
Myeloid Cell and Transcriptome Signatures Associated With Inflammation Resolution in a Model of Self-Limiting Acute Brain Inflammation.
Autorzy :
Davies CL; Centre for Reproductive Health, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Patir A; The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, United Kingdom.
McColl BW; Centre for Discovery Brain Sciences, UK Dementia Research Institute at The University of Edinburgh, The Chancellor's Building, Edinburgh BioQuarter, Edinburgh, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2019 May 17; Vol. 10, pp. 1048. Date of Electronic Publication: 2019 May 17 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Immunological*
Central Nervous System/*immunology
Encephalitis/*genetics
Microglia/*physiology
Myeloid Cells/*immunology
Acute Disease ; Animals ; Cells, Cultured ; Gene Expression Profiling ; Humans ; Lipopolysaccharides/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Regional Molecular Mapping of Primate Synapses during Normal Healthy Aging.
Autorzy :
Graham LC; The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, Edinburgh EH25 9RG, UK; Euan MacDonald Centre, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
Naldrett MJ; Donald Danforth Plant Science Center, 975 N Warson Rd., St. Louis, MO 63132, USA; Proteomics and Metabolomics Facility, Center for Biotechnology, Beadle Center, University of Nebraska, Lincoln, 1901 Vine St., Lincoln, NE 68588, USA.
Kohama SG; Oregon National Primate Research Center, 505 NW 185th Ave., Beaverton, OR 97006, USA.
Smith C; Euan MacDonald Centre, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Edinburgh Medical School, Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
Lamont DJ; FingerPrints Proteomic Facility, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
McColl BW; The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, Edinburgh EH25 9RG, UK; Centre for Dementia Prevention, University of Edinburgh, 9A Bioquarter, 9 Little France Road, Edinburgh EH16 4UX, UK.
Gillingwater TH; Euan MacDonald Centre, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Edinburgh Medical School, Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
Skehel P; Euan MacDonald Centre, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK.
Urbanski HF; Oregon National Primate Research Center, 505 NW 185th Ave., Beaverton, OR 97006, USA.
Wishart TM; The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, Edinburgh EH25 9RG, UK; Euan MacDonald Centre, Chancellor's Building, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK; Centre for Dementia Prevention, University of Edinburgh, 9A Bioquarter, 9 Little France Road, Edinburgh EH16 4UX, UK. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Apr 23; Vol. 27 (4), pp. 1018-1026.e4.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
Proteome*
Synapses/*metabolism
Animals ; Hippocampus/metabolism ; Humans ; Macaca mulatta ; Occipital Lobe/metabolism ; Proteomics ; Signal Transduction ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/physiology
Czasopismo naukowe
Tytuł :
Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing.
Autorzy :
Stevenson AJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. .; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK. .; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK. .
McCartney DL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Harris SE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Taylor AM; Department for Psychology, University of Edinburgh, Edinburgh, UK.
Redmond P; Department for Psychology, University of Edinburgh, Edinburgh, UK.
Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
Zhang Q; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Spires-Jones TL; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
McColl BW; UK Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.
McIntosh AM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department for Psychology, University of Edinburgh, Edinburgh, UK.
Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
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Źródło :
Clinical epigenetics [Clin Epigenetics] 2018 Dec 20; Vol. 10 (1), pp. 159. Date of Electronic Publication: 2018 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Methylation*
Genetic Markers*
Aging/*genetics
C-Reactive Protein/*metabolism
Inflammation/*genetics
Interleukin-6/*metabolism
Aged ; Aged, 80 and over ; Aging/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cross-Sectional Studies ; Epigenesis, Genetic ; Female ; Granulocytes/immunology ; Humans ; Linear Models ; Longitudinal Studies ; Lymphocyte Count ; Male ; Plasma Cells/immunology
Czasopismo naukowe
Tytuł :
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury.
Autorzy :
Greenhalgh AD; Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Quebec, Canada.; Laboratory of Nutrition and Integrated Neurobiology, UMR INRA 1286, University of Bordeaux, Bordeaux, France.
Zarruk JG; Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Quebec, Canada.
Healy LM; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Baskar Jesudasan SJ; Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Quebec, Canada.
Jhelum P; Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Quebec, Canada.
Salmon CK; Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Quebec, Canada.
Formanek A; Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Quebec, Canada.
Russo MV; Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America.
Antel JP; Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
McGavern DB; Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America.
McColl BW; UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
David S; Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center, Quebec, Canada.
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Źródło :
PLoS biology [PLoS Biol] 2018 Oct 17; Vol. 16 (10), pp. e2005264. Date of Electronic Publication: 2018 Oct 17 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Macrophages/*physiology
Microglia/*physiology
Spinal Cord Injuries/*immunology
Adult ; Animals ; Central Nervous System/immunology ; Central Nervous System/injuries ; Female ; Healthy Volunteers ; Humans ; Inflammation/immunology ; Leukocyte Count ; Male ; Mice ; Mice, Inbred C57BL ; Microglia/immunology ; Monocytes ; Phagocytosis ; Recovery of Function
Czasopismo naukowe
Tytuł :
Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIbα.
Autorzy :
Giles JA; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Greenhalgh AD; Centre for Research in Neuroscience, Montreal General Hospital, McGill University Health Centre, Montreal, QC, Canada.
Denes A; 'Momentum' Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
Nieswandt B; Department of Vascular Medicine, University Hospital and Rudolf Virchow Centre for Experimental Biomedicine, University of Würzburg, Würzburg, Germany.
Coutts G; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
McColl BW; The Roslin Institute & R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, UK.; Edinburgh Medical School, UK Dementia Research Institute at The University of Edinburgh, Edinburgh, UK.
Allan SM; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
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Źródło :
Immunology [Immunology] 2018 Jun; Vol. 154 (2), pp. 322-328. Date of Electronic Publication: 2018 Feb 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Platelets/*drug effects
Blood Platelets/*metabolism
Brain/*immunology
Brain/*metabolism
Neutrophil Infiltration/*immunology
Neutrophils/*immunology
Neutrophils/*metabolism
Platelet Glycoprotein GPIb-IX Complex/*antagonists & inhibitors
Animals ; Antibodies, Monoclonal/pharmacology ; Brain/pathology ; Chemokine CCL5/genetics ; Chemokine CCL5/metabolism ; Chemokine CXCL1/genetics ; Chemokine CXCL1/metabolism ; Disease Models, Animal ; Immunoglobulin G/immunology ; Immunoglobulin G/pharmacology ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Lipopolysaccharides/immunology ; Mice
Czasopismo naukowe
Tytuł :
Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages.
Autorzy :
McCulloch L; UK Dementia Research Institute, Edinburgh Medcial School, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Alfieri A; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
McColl BW; UK Dementia Research Institute, Edinburgh Medcial School, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2018 May 22; Vol. 9, pp. 1108. Date of Electronic Publication: 2018 May 22 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Macrophages/*immunology
Macrophages/*metabolism
Spleen/*cytology
Spleen/*immunology
Stroke/*etiology
Stroke/*metabolism
Animals ; Antigens/immunology ; Biomarkers ; Bone Marrow/immunology ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Cell Movement/immunology ; Disease Models, Animal ; Gene Expression ; Gene Expression Profiling ; Histocompatibility Antigens Class II/immunology ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Immunohistochemistry ; Immunophenotyping ; Leukocyte Count ; Lysosomes/metabolism ; Macrophage Activation ; Male ; Mice ; Mice, Transgenic ; Phagocytosis ; Spleen/metabolism ; Stroke/pathology
Czasopismo naukowe
Tytuł :
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
Autorzy :
Horsburgh K; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, U.K. .
Wardlaw JM; Centre for Clinical Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, U.K.
van Agtmael T; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Allan SM; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, U.K.
Ashford MLJ; School of Medicine, University of Dundee, Dundee, U.K.
Bath PM; Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, U.K.
Brown R; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Berwick J; Department of Psychology, University of Sheffield, Sheffield, U.K.
Cader MZ; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Carare RO; Faculty of Medicine, University of Southampton, Southampton, U.K.
Davis JB; Alzheimer's Research UK Oxford Drug Discovery Institute, University of Oxford, Oxford, U.K.
Duncombe J; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Farr TD; School of Life Sciences, Nottingham University, Nottingham, U.K.
Fowler JH; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Goense J; Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, U.K.
Granata A; Department of Clinical Neurosciences, University of Cambridge, Cambridge, U.K.
Hall CN; School of Psychology, University of Sussex, Brighton, U.K.
Hainsworth AH; Molecular and Clinical Sciences Research Institute, St Georges University of London, London, U.K.
Harvey A; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Hawkes CA; Faculty of Science, Technology, Engineering & Mathematics, Open University, Milton Keynes, U.K.
Joutel A; Genetics and Pathogenesis of Cerebrovascular Diseases, INSERM, Université Paris Diderot-Paris 7, Paris, France.
Kalaria RN; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
Kehoe PG; Bristol Medical School, University of Bristol, Bristol, U.K.
Lawrence CB; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, U.K.
Lockhart A; GSK (currently Heptares Therapeutics), U.K.
Love S; Clinical Neurosciences, University of Bristol, Bristol, U.K.
Macleod MR; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Macrae IM; Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, U.K.
Markus HS; Department of Clinical Neurosciences, University of Cambridge, Cambridge, U.K.
McCabe C; Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, U.K.
McColl BW; The Roslin Institute & R(D)SVS, UK Dementia Research Institute, University of Edinburgh, Edinburgh, U.K.
Meakin PJ; Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, U.K.
Miller A; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Nedergaard M; University of Rochester Medical Center, Rochester, NY, USA and University of Copenhagen's Center of Basic and Translational Neuroscience, Copenhagen, Denmark.
O'Sullivan M; Mater Centre for Neuroscience and Queensland Brain Institute, Brisbane, Australia.
Quinn TJ; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Rajani R; Genetics and Pathogenesis of Cerebrovascular Diseases, INSERM, Université Paris Diderot-Paris 7, Paris, France.
Saksida LM; Robarts Research Institute, Western University, London, Ontario, Canada.
Smith C; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.
Smith KJ; Department of Neuroinflammation, UCL Institute of Neurology, London, U.K.
Touyz RM; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
Trueman RC; School of Life Sciences, Nottingham University, Nottingham, U.K.
Wang T; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, U.K.
Williams A; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, U.K.
Williams SCR; Institute of Psychiatry, Kings College London, London, U.K.
Work LM; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
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Źródło :
Clinical science (London, England : 1979) [Clin Sci (Lond)] 2018 Apr 30; Vol. 132 (8), pp. 851-868. Date of Electronic Publication: 2018 Apr 30 (Print Publication: 2018).
Typ publikacji :
Congress; Research Support, Non-U.S. Gov't
MeSH Terms :
Translational Medical Research*
Cerebral Small Vessel Diseases/*etiology
Animals ; Humans
Raport
Tytuł :
Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease.
Autorzy :
Manso Y; Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.
Holland PR; Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.
Kitamura A; Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.
Szymkowiak S; University of Edinburgh, The Roslin Institute, Easter Bush, Edinburgh, EH25 9RG.
Duncombe J; Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.
Hennessy E; Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.
Searcy JL; Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.
Marangoni M; Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.
Randall AD; University of Exeter Medical School, University of Exeter, Exeter, UK.
Brown JT; University of Exeter Medical School, University of Exeter, Exeter, UK.
McColl BW; University of Edinburgh, The Roslin Institute, Easter Bush, Edinburgh, EH25 9RG.; UK Dementia Research Institute, University of Edinburgh, Edinburgh Medical School, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Horsburgh K; Centre for Neuroregeneration, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, United Kingdom.
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Źródło :
Glia [Glia] 2018 Jan; Vol. 66 (1), pp. 34-46. Date of Electronic Publication: 2017 Jul 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carotid Stenosis*/complications
Carotid Stenosis*/drug therapy
Carotid Stenosis*/pathology
Anti-Inflammatory Agents/*therapeutic use
Gliosis/*drug therapy
Gliosis/*etiology
Microglia/*drug effects
Minocycline/*therapeutic use
White Matter/*drug effects
Action Potentials/drug effects ; Action Potentials/physiology ; Animals ; Arginase/genetics ; Arginase/metabolism ; Axons/pathology ; Corpus Callosum/drug effects ; Corpus Callosum/pathology ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Ki-67 Antigen/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Myelin-Associated Glycoprotein/metabolism ; Nerve Fibers/drug effects ; Nerve Fibers/physiology ; White Matter/pathology ; White Matter/physiology
Czasopismo naukowe
Tytuł :
Isolation and Phenotyping of Adult Mouse Microglial Cells.
Autorzy :
Grabert K; The Roslin Institute and R(D)SVS, University of Edinburgh, Edinburgh, UK. .
McColl BW; The Roslin Institute and R(D)SVS, University of Edinburgh, Edinburgh, UK.; Dementia Research Institute, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1784, pp. 77-86.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain/*cytology
Cell Culture Techniques/*methods
Cell Separation/*methods
Microglia/*cytology
Animals ; Flow Cytometry ; Mice ; Myelin Sheath/chemistry ; Phagocytosis/drug effects ; Povidone/chemistry ; Silicon Dioxide/chemistry
Czasopismo naukowe
Tytuł :
The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).
Autorzy :
Percie du Sert N; 1 National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), London, UK.
Alfieri A; 2 The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, UK.
Allan SM; 3 Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Carswell HV; 4 Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, Glasgow, UK.
Deuchar GA; 5 Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK.
Farr TD; 6 School of Life Sciences, University of Nottingham Medical School, Nottingham, UK.
Flecknell P; 7 Comparative Biology Centre, Newcastle University, UK.
Gallagher L; 5 Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK.
Gibson CL; 8 Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.
Haley MJ; 3 Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Macleod MR; 9 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
McColl BW; 2 The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, UK.
McCabe C; 5 Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK.
Morancho A; 10 Neurovascular Research Laboratory. Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona; Barcelona, Spain.
Moon LD; 11 Wolfson Centre for Age-Related Diseases, King's College London, London, UK.
O'Neill MJ; 12 Eli Lilly and Co., Windlesham, Surrey, UK.
Pérez de Puig I; 13 Institut d'Investigacions Biomèdiques de Barcelona (IIBB), Consejo Superior de Investigaciones Científicas (CSIC), IDIBAPS, Barcelona, Spain.
Planas A; 13 Institut d'Investigacions Biomèdiques de Barcelona (IIBB), Consejo Superior de Investigaciones Científicas (CSIC), IDIBAPS, Barcelona, Spain.
Ragan CI; 14 NC3Rs Board, London, UK.
Rosell A; 10 Neurovascular Research Laboratory. Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona; Barcelona, Spain.
Roy LA; 5 Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK.
Ryder KO; 15 Home Office, London, UK.
Simats A; 10 Neurovascular Research Laboratory. Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona; Barcelona, Spain.
Sena ES; 9 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Sutherland BA; 16 Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; 17 School of Medicine, Faculty of Health, University of Tasmania, Hobart, Australia.
Tricklebank MD; 18 Centre for Neuroimaging Sciences, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.
Trueman RC; 6 School of Life Sciences, University of Nottingham Medical School, Nottingham, UK.
Whitfield L; 19 Royal Veterinary College, London, UK.
Wong R; 3 Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Macrae IM; 5 Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow/Arum Biosciences, Glasgow, UK.
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Źródło :
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2017 Nov; Vol. 37 (11), pp. 3488-3517. Date of Electronic Publication: 2017 Aug 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Animal Welfare/*standards
Brain Ischemia/*pathology
Stroke/*pathology
Animals ; Disease Models, Animal ; Guidelines as Topic ; Humans ; Infarction, Middle Cerebral Artery/pathology
Czasopismo naukowe
Tytuł :
Corrigendum: Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB.
Autorzy :
Owens R; The Royal (Dick) School of Veterinary Studies, University of EdinburghMidlothian, UK.
Grabert K; The Royal (Dick) School of Veterinary Studies, University of EdinburghMidlothian, UK.
Davies CL; The Royal (Dick) School of Veterinary Studies, University of EdinburghMidlothian, UK.
Alfieri A; The Royal (Dick) School of Veterinary Studies, University of EdinburghMidlothian, UK.
Antel JP; Neuroimmunology Unit, Montreal Neurological Institute, McGill UniversityMontreal, QC, Canada.
Healy LM; Neuroimmunology Unit, Montreal Neurological Institute, McGill UniversityMontreal, QC, Canada.
McColl BW; The Royal (Dick) School of Veterinary Studies, University of EdinburghMidlothian, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh Medical SchoolEdinburgh, United Kingdom.
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Źródło :
Frontiers in cellular neuroscience [Front Cell Neurosci] 2017 Aug 24; Vol. 11, pp. 256. Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017).
Typ publikacji :
Published Erratum
Tytuł :
Corrigendum: Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.
Autorzy :
McCulloch L
Smith CJ
McColl BW
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Źródło :
Nature communications [Nat Commun] 2017 Aug 18; Vol. 8, pp. 16151. Date of Electronic Publication: 2017 Aug 18.
Typ publikacji :
Journal Article; Published Erratum
Czasopismo naukowe
Tytuł :
Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.
Autorzy :
McQueen J; UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.; Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Ryan TJ; School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland.; Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.; Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, Australia.
McKay S; UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.; Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Marwick K; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Baxter P; UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.; Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Carpanini SM; The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.; nPAD MRC Mouse consortium, University of Edinburgh, Edinburgh, United Kingdom.
Wishart TM; The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.; nPAD MRC Mouse consortium, University of Edinburgh, Edinburgh, United Kingdom.
Gillingwater TH; UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.; Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.; nPAD MRC Mouse consortium, University of Edinburgh, Edinburgh, United Kingdom.
Manson JC; The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.; nPAD MRC Mouse consortium, University of Edinburgh, Edinburgh, United Kingdom.
Wyllie DJA; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Grant SGN; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom.
McColl BW; UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.; Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.; The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
Komiyama NH; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Neuroregeneration, University of Edinburgh, Edinburgh, United Kingdom.
Hardingham GE; UK Dementia Research Institute, University of Edinburgh, Edinburgh, United Kingdom.; Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.; nPAD MRC Mouse consortium, University of Edinburgh, Edinburgh, United Kingdom.
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Źródło :
ELife [Elife] 2017 Jul 21; Vol. 6. Date of Electronic Publication: 2017 Jul 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Death-Associated Protein Kinases/*physiology
Neurons/*pathology
Neuropeptides/*pharmacology
Receptors, N-Methyl-D-Aspartate/*metabolism
Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Brain Ischemia/pathology ; Cell Death ; Cells, Cultured ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Death-Associated Protein Kinases/antagonists & inhibitors ; Male ; Mice ; Mice, Knockout ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotective Agents/pharmacology ; Phosphorylation ; Protein Subunits ; Serine/chemistry ; Serine/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.
Autorzy :
McCulloch L; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Smith CJ; Stroke and Vascular Research Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, UK.
McColl BW; The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
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Źródło :
Nature communications [Nat Commun] 2017 Apr 19; Vol. 8, pp. 15051. Date of Electronic Publication: 2017 Apr 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adrenergic Agents/*metabolism
B-Lymphocytes/*immunology
Communicable Diseases/*etiology
Communicable Diseases/*immunology
Spleen/*pathology
Stroke/*complications
Stroke/*immunology
Animals ; Anti-Bacterial Agents/metabolism ; Communicable Diseases/microbiology ; Disease Susceptibility ; Genome ; Immunoglobulin M/blood ; Male ; Mice, Inbred C57BL ; Signal Transduction ; Stroke/blood ; Transcriptome/genetics
Czasopismo naukowe

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