Retinoic Acid-Mediated Inhibition of Mouse Coronavirus Replication Is Dependent on IRF3 and CaMKK.
Autorzy:
Franco JH; Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Harris RA; Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Ryan WG; Department of Neurosciences and Neurological Disorders, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Taylor RT; Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. McCullumsmithRE; Department of Neurosciences and Neurological Disorders, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Chattopadhyay S; Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.; Department of Microbiology Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536, USA. Pan ZK; Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
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Źródło:
Viruses [Viruses] 2024 Jan 18; Vol. 16 (1). Date of Electronic Publication: 2024 Jan 18.
Activity of Protein Kinase A in the Frontal Cortex in Schizophrenia.
Autorzy:
Sahay S; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Henkel ND; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Vargas CF; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. McCullumsmithRE; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.; Neuroscience Institute, Promedica, Toledo, OH 43606, USA. O'Donovan SM; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
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Źródło:
Brain sciences [Brain Sci] 2023 Dec 22; Vol. 14 (1). Date of Electronic Publication: 2023 Dec 22.
Adenosine Receptor mRNA Expression in Frontal Cortical Neurons in Schizophrenia.
Autorzy:
Sahay S; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA. Devine EA; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. McCullumsmithRE; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.; Neuroscience Institute Promedica, Toledo, OH 43606, USA. O'Donovan SM; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
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Źródło:
Cells [Cells] 2023 Dec 22; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Gene Enrichment Analysis of Astrocyte Subtypes in Psychiatric Disorders and Psychotropic Medication Datasets.
Autorzy:
Zhang X; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Wolfinger A; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Wu X; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Alnafisah R; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Imami A; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Hamoud AR; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Lundh A; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Parpura V; Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. McCullumsmithRE; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA.; Promedica Neurosciences Institute, Toledo, OH 43606, USA. Shukla R; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. O'Donovan SM; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA.
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Źródło:
Cells [Cells] 2022 Oct 21; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment?
Autorzy:
Hamoud AR; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Bach K; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Kakrecha O; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Henkel N; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. Wu X; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA. McCullumsmithRE; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA.; Neurosciences Institute, ProMedica, Toledo, OH 43606, USA. O'Donovan SM; Department of Neurosciences, University of Toledo, Toledo, OH 43614, USA.
KRSA: An R package and R Shiny web application for an end-to-end upstream kinase analysis of kinome array data.
Autorzy:
DePasquale EAK; Division of Hematology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America.; Broad Institute of MIT and Harvard, Boston, Massachusetts, United States of America. Alganem K; Department of Neurosciences, University of Toledo College of Medicine, Toledo, Ohio, United States of America. Bentea E; Neuro-Aging & Viro-Immunotherapy, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Nawreen N; Department of Neuroscience, University of Cincinnati, Cincinnati, Ohio, United States of America. McGuire JL; Department of Neurosurgery, University of Cincinnati, Cincinnati, Ohio, United States of America. Tomar T; PamGene International B.V., s'-Hertogenbosch, The Netherlands. Naji F; Tercen Data Analytics Ltd, Co Waterford, Ireland. Hilhorst R; PamGene International B.V., s'-Hertogenbosch, The Netherlands. Meller J; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.; Department of Electrical Engineering and Computing Systems, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.; Department of Informatics, Nicolaus Copernicus University, Torun, Poland. McCullumsmithRE; Department of Neurosciences, University of Toledo College of Medicine, Toledo, Ohio, United States of America.; Neurosciences institute, ProMedica, Toledo, Ohio, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Dec 17; Vol. 16 (12), pp. e0260440. Date of Electronic Publication: 2021 Dec 17 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy.
Autorzy:
Henkel ND; Department of Neuroscience, College of Medicine and Life Sciences, University of Toledo, 3000 Arlington Avenue, Room 182, Toledo, OH, 43614, USA. Smail MA; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH, 45267, USA. Wu X; Department of Neuroscience, College of Medicine and Life Sciences, University of Toledo, 3000 Arlington Avenue, Room 182, Toledo, OH, 43614, USA. Enright HA; Bioscience and Biotechnology Division, Lawrence Livermore National Lab, Livermore, CA, 94550, USA. Fischer NO; Bioscience and Biotechnology Division, Lawrence Livermore National Lab, Livermore, CA, 94550, USA. Eby HM; Department of Neuroscience, College of Medicine and Life Sciences, University of Toledo, 3000 Arlington Avenue, Room 182, Toledo, OH, 43614, USA. McCullumsmithRE; Department of Neuroscience, College of Medicine and Life Sciences, University of Toledo, 3000 Arlington Avenue, Room 182, Toledo, OH, 43614, USA.; ProMedica, Neurosciences Institute, Toledo, OH, 43606, USA. Shukla R; Department of Neuroscience, College of Medicine and Life Sciences, University of Toledo, 3000 Arlington Avenue, Room 182, Toledo, OH, 43614, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Sep 27; Vol. 11 (1), pp. 19102. Date of Electronic Publication: 2021 Sep 27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
KEOPS complex expression in the frontal cortex in major depression and schizophrenia.
Autorzy:
Abel ME; Department of Neuroscience, University of Toledo, Toledo, OH, USA. Zhang X; Department of Neuroscience, University of Toledo, Toledo, OH, USA. Asah SM; Department of Neuroscience, University of Toledo, Toledo, OH, USA. Wolfinger A; Department of Neuroscience, University of Toledo, Toledo, OH, USA. McCullumsmithRE; Department of Neuroscience, University of Toledo, Toledo, OH, USA.; Neurosciences Institute, Promedica, Toledo, OH, USA. O'Donovan SM; Department of Neuroscience, University of Toledo, Toledo, OH, USA.
Activation of acid-sensing ion channels by carbon dioxide regulates amygdala synaptic protein degradation in memory reconsolidation.
Autorzy:
Lin B; Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA.; Department of Biological Sciences, The University of Toledo, 43606, Toledo, OH, USA. Alganem K; Department of Neurosciences, The University of Toledo Medical Center, 43614, Toledo, OH, USA. O'Donovan SM; Department of Neurosciences, The University of Toledo Medical Center, 43614, Toledo, OH, USA. Jin Z; Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA. Naghavi F; Department of Neurosciences, The University of Toledo Medical Center, 43614, Toledo, OH, USA. Miller OA; Department of Biological Sciences, The University of Toledo, 43606, Toledo, OH, USA. Ortyl TC; Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA. Ruan YC; Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China. McCullumsmithRE; Department of Neurosciences, The University of Toledo Medical Center, 43614, Toledo, OH, USA.; Neurosciences Institute, ProMedica, OH, 43614, Toledo, USA. Du J; Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA. .; Neuroscience Institute, The University of Tennessee Health Science Center, 38163, Memphis, TN, USA. .
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Źródło:
Molecular brain [Mol Brain] 2021 May 07; Vol. 14 (1), pp. 78. Date of Electronic Publication: 2021 May 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach.
Autorzy:
O'Donovan SM; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Imami A; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Eby H; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Henkel ND; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Creeden JF; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Asah S; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Zhang X; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Wu X; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Alnafisah R; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Taylor RT; Department of Medical Microbiology and Immunology, University of Toledo, Toledo, OH, USA. Reigle J; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; Department of Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Thorman A; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Shamsaei B; Department of Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Meller J; Department of Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Electrical Engineering and Computing Systems, University of Cincinnati College of Medicine, Cincinnati, OH, USA.; Department of Informatics, Nicolaus Copernicus University, Torun, Poland. McCullumsmithRE; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Mail Stop #1007, 3000 Arlington Avenue, Toledo, OH, 43614-2598, USA. Robert.mccullumsmith@utoledo.edu.; Neurosciences Institute, Promedica, Toledo, OH, USA. Robert.mccullumsmith@utoledo.edu.
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Źródło:
Scientific reports [Sci Rep] 2021 Feb 24; Vol. 11 (1), pp. 4495. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Using protein turnover to expand the applications of transcriptomics.
Autorzy:
Smail MA; Department of Pharmacology and Systems Physiology, University of Cincinnati, 2170 E. Galbraith Rd. Bldg E. Room 216, Cincinnati, OH, 45237-0506, USA. .; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH, USA. . Reigle JK; Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. McCullumsmithRE; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.; Neurosciences Institute, ProMedica, Toledo, OH, USA.
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Źródło:
Scientific reports [Sci Rep] 2021 Feb 23; Vol. 11 (1), pp. 4403. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia.
Autorzy:
Creeden JF; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Department of Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 6038, USA. Alganem K; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Imami AS; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Henkel ND; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Brunicardi FC; Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Department of Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 6038, USA. Liu SH; Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Department of Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 6038, USA. Shukla R; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Tomar T; PamGene International BV, 5200 BJ's-Hertogenbosch, The Netherlands. Naji F; PamGene International BV, 5200 BJ's-Hertogenbosch, The Netherlands. McCullumsmithRE; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Neurosciences Institute, ProMedica, Toledo, OH 6038, USA.
Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases.
Autorzy:
Creeden JF; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Department of Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Alganem K; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Imami AS; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Brunicardi FC; Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Department of Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Liu SH; Department of Cancer Biology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Department of Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Shukla R; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA. Tomar T; PamGene International BV, 5200 BJ's-Hertogenbosch, The Netherlands. Naji F; PamGene International BV, 5200 BJ's-Hertogenbosch, The Netherlands. McCullumsmithRE; Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA.; Neurosciences Institute, ProMedica, Toledo, OH 43606, USA.
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