Study in Parkinson's disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial.
Autorzy:
Patterson CG; Department of Physical Therapy, University of Pittsburgh, School of Health and Rehabilitation Sciences, 100 Technology Drive, Suite 500, Pittsburgh, PA, 15219, USA. . Joslin E; Department of Physical Therapy and Human Science, Northwestern University, Feinberg School of Medicine, Suite 1100, 645 North Michigan Avenue, Chicago, IL, 60305, USA. Gil AB; Department of Physical Therapy, University of Pittsburgh, School of Health and Rehabilitation Sciences, 100 Technology Drive, Suite 500, Pittsburgh, PA, 15219, USA. Spigle W; Department of Physical Therapy, University of Pittsburgh, School of Health and Rehabilitation Sciences, 100 Technology Drive, Suite 500, Pittsburgh, PA, 15219, USA. Nemet T; Department of Physical Therapy, University of Pittsburgh, School of Health and Rehabilitation Sciences, 100 Technology Drive, Suite 500, Pittsburgh, PA, 15219, USA. Chahine L; Department of Neurology, University of Pittsburgh, School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA, 15213, USA. Christiansen CL; Department of Physical Medicine & Rehabilitation, University of Colorado, School of Medicine, Aurora, CO, 80217, USA. Melanson E; Division of Endocrinology, Metabolism and Diabetes, and Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Eastern Colorado VA Health Care System, Geriatric Research Education and Clinical Center (GRECC), Denver, CO, USA. Kohrt WM; Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Eastern Colorado Geriatric Research, Education, and Clinical Center, Rocky Mountain Regional VAMC, Aurora, USA. Mancini M; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Road, Portland, OR, 97219, USA. Josbeno D; Department of Physical Therapy, University of Pittsburgh, School of Health and Rehabilitation Sciences, 100 Technology Drive, Suite 500, Pittsburgh, PA, 15219, USA. Balfany K; Department of Physical Medicine & Rehabilitation, University of Colorado, School of Medicine, Aurora, CO, 80217, USA. Griffith G; Department of Physical Therapy and Human Science, Northwestern University, Feinberg School of Medicine, Suite 1100, 645 North Michigan Avenue, Chicago, IL, 60305, USA. Dunlap MK; Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA. Lamotte G; Movement Disorders Division, Department of Neurology, University of Utah, 175 Medical Dr N, Salt Lake City, UT, 84132, USA. Suttman E; Department of Physical Therapy & Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT, 84115, USA. Larson D; Department of Neurology, Feinberg School of Medicine, Northwestern University, Suite 115, 710 N Lake Shore Drive, Chicago, IL, 60611, USA. Branson C; Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA, 30310, USA. McKee KE; Neurosciences Clinical Program, Intermountain Healthcare, 5171 S Cottonwood Street, Suite 810, Murray, UT, 84107, USA. Goelz L; Department of Kinesiology and Nutrition, UIC College of Applied Health Sciences, 919 W Taylor Street, Chicago, IL, 60612, USA. Poon C; Department of Neurology, Feinberg School of Medicine, Northwestern University, Suite 115, 710 N Lake Shore Drive, Chicago, IL, 60611, USA. Tilley B; Department of Biostatistics and Data Science, University of Texas Health Science Center School of Public Health, 1200 Pressler Street E835, Houston, TX, 77030, USA. Kang UJ; NYU Langone Health, NYU Grossman School of Medicine, 435 E 30th Street, Science Building 1305, New York, NY, 10016, USA. Tansey MG; Department of Neuroscience and Neurology, Normal Fixel Institute for Neurological Diseases and College of Medicine, University of Florida, 4911 Newell Road, Gainesville, FL, 32610, USA. Luthra N; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, 1651 4th Street, San Francisco, CA, 94158, USA. Tanner CM; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, 1651 4th Street, San Francisco, CA, 94158, USA. Haus JM; School of Kinesiology, University of Michigan, 830 N. University Ave, Ann Arbor, MI, 48109, USA. Fantuzzi G; Department of Kinesiology and Nutrition, UIC College of Applied Health Sciences, 919 W Taylor Street, Chicago, IL, 60612, USA. McFarlandNR; Department of Neurology, Norman Fixel Institute for Neurological Diseases, College of Medicine, University of Florida, Gainesville, FL, 32608, USA. Gonzalez-Latapi P; Department of Neurology, Feinberg School of Medicine, Northwestern University, Suite 115, 710 N Lake Shore Drive, Chicago, IL, 60611, USA. Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, 410 W. 10th Street, Indianapolis, IN, 46220, USA. Motl R; Department of Kinesiology and Nutrition, UIC College of Applied Health Sciences, 919 W Taylor Street, Chicago, IL, 60612, USA. Schwarzschild MA; Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Rm 3002, 114 16th Street, Boston, MA, 02129, USA. Simuni T; Department of Neurology, Feinberg School of Medicine, Northwestern University, Suite 115, 710 N Lake Shore Drive, Chicago, IL, 60611, USA. Marek K; Institute for Neurodegenerative Disorders, 60 Temple St, New Haven, CT, 06510, USA. Naito A; Parkinson's Foundation 200 SE 1st Street Suite 800, Miami, FL, 33131, USA. Lungu C; National Institute of Neurological Disorders and Stroke, NIH, 6001 Executive Blvd, #2188, Rockville, MD, 20852, USA. Corcos DM; Department of Physical Therapy and Human Science, Northwestern University, Feinberg School of Medicine, Suite 1100, 645 North Michigan Avenue, Chicago, IL, 60305, USA.
Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy.
Autorzy:
Hass EW; Department of Neuroscience, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. Sorrentino ZA; Department of Neuroscience, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. Lloyd GM; Department of Neuroscience, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA.; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. McFarlandNR; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. Prokop S; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.; Department of Pathology, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. Giasson BI; Department of Neuroscience, College of Medicine, University of Florida, BMS J483/CTRND, 1275 Center Drive, Gainesville, FL, 32610, USA. .; Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. .; McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, 32610, USA. .
The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.
Autorzy:
Park HJ; Center for Translational Research in Neurodegenerative Disease, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States of America.; Division of Biology of Aging, Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL, United States of America. Ryu D; Center for Translational Research in Neurodegenerative Disease, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States of America. Parmar M; Center for Translational Research in Neurodegenerative Disease, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States of America. Giasson BI; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, United States of America. McFarlandNR; Center for Translational Research in Neurodegenerative Disease, Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Sep 06; Vol. 12 (9), pp. e0184262. Date of Electronic Publication: 2017 Sep 06 (Print Publication: 2017).
Depressive Symptoms are Frequent in Atypical Parkinsonian Disorders.
Autorzy:
Almeida L; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States. Ahmed B; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States. Walz R; Department of Neurology, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil. De Jesus S; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States. Patterson A; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States. Martinez-Ramirez D; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States. Vaillancourt D; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States.; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States. Bowers D; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States.; Department of Clinical & Health Psychology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States. Ward H; Department of Psychiatry, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States. Okun MS; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States. McFarlandNR; Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States.
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Źródło:
Movement disorders clinical practice [Mov Disord Clin Pract] 2017 Mar-Apr; Vol. 4 (2), pp. 191-197. Date of Electronic Publication: 2016 Jun 24.
Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.
Autorzy:
Ceballos-Diaz C; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. Rosario AM; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. Park HJ; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA.; Department of Neurology, College of Medicine, University of Florida, 1149 S Newell Dr, L3-100, PO Box 100236, Gainesville, FL, 32610, USA. Chakrabarty P; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. Sacino A; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. Cruz PE; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. Siemienski Z; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. Lara N; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. Moran C; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. Ravelo N; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA.; Department of Neurology, College of Medicine, University of Florida, 1149 S Newell Dr, L3-100, PO Box 100236, Gainesville, FL, 32610, USA. Golde TE; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. McFarlandNR; Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, 1275 Center Dr, PO Box 100159, Gainesville, FL, 32610, USA. nikolaus.mcfarland@neurology.ufl.edu.; Department of Neurology, College of Medicine, University of Florida, 1149 S Newell Dr, L3-100, PO Box 100236, Gainesville, FL, 32610, USA. nikolaus.mcfarland@neurology.ufl.edu.
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Źródło:
Molecular neurodegeneration [Mol Neurodegener] 2015 Jul 08; Vol. 10, pp. 25. Date of Electronic Publication: 2015 Jul 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Unexpected dual task benefits on cycling in Parkinson disease and healthy adults: a neuro-behavioral model.
Autorzy:
Altmann LJ; Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Florida, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Stegemöller E; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America; Department of Kinesiology, Iowa State University, Ames, Iowa, United States of America. Hazamy AA; Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Florida, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Wilson JP; Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, Florida, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America; Department of Speech-Language Pathology, Midwestern University, Downers Grove, Illinois, United States of America. Okun MS; Department of Neurology and Neurosurgery, University of Florida, Gainesville, Florida, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. McFarlandNR; Department of Neurology and Neurosurgery, University of Florida, Gainesville, Florida, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Wagle Shukla A; Department of Neurology and Neurosurgery, University of Florida, Gainesville, Florida, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Hass CJ; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America.
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Źródło:
PloS one [PLoS One] 2015 May 13; Vol. 10 (5), pp. e0125470. Date of Electronic Publication: 2015 May 13 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Weight loss and impact on quality of life in Parkinson's disease.
Autorzy:
Akbar U; Department of Neurology, Brown University, Providence, Rhode Island, United States of America. He Y; Department of Mathematics, Clarkson University, Potsdam, New York, United States of America. Dai Y; Department of Biostatistics, University of Florida, Gainesville, Florida, United States of America. Hack N; Department of Neurology, University of Florida, Gainesville, Florida, United States of America. Malaty I; Department of Neurology, University of Florida, Gainesville, Florida, United States of America. McFarlandNR; Department of Neurology, University of Florida, Gainesville, Florida, United States of America. Hess C; Department of Neurology, University of Florida, Gainesville, Florida, United States of America. Schmidt P; National Parkinson Foundation, Miami, Florida, United States of America. Wu S; Department of Biostatistics, University of Florida, Gainesville, Florida, United States of America. Okun MS; Department of Neurology, University of Florida, Gainesville, Florida, United States of America.
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Źródło:
PloS one [PLoS One] 2015 May 04; Vol. 10 (5), pp. e0124541. Date of Electronic Publication: 2015 May 04 (Print Publication: 2015).
The "brittle response" to Parkinson's disease medications: characterization and response to deep brain stimulation.
Autorzy:
Martinez-Ramirez D; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Giugni J; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Vedam-Mai V; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America; Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Wagle Shukla A; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Malaty IA; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. McFarlandNR; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Rodriguez RL; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Foote KD; Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America. Okun MS; Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America; Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Apr 14; Vol. 9 (4), pp. e94856. Date of Electronic Publication: 2014 Apr 14 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss.
Autorzy:
McFarlandNR; Center for Translational Research in Neurodegenerative Disease, Department of Neurology, University of Florida, Gainesville, Florida, United States of America. Dimant H; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America. Kibuuka L; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America. Ebrahimi-Fakhari D; Division of Neurology and Inherited Metabolic Diseases, Children's Hospital, Heidelberg University Hospital, Ruprecht-Karls University Heidelberg, Heidelberg, Germany. Desjardins CA; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America. Danzer KM; Deparment of Neurology, Universitatsklinikum Ulm, Ulm, Germany. Danzer M; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America. Fan Z; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America. Schwarzschild MA; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America. Hirst W; Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America. McLean PJ; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Jan 20; Vol. 9 (1), pp. e86048. Date of Electronic Publication: 2014 Jan 20 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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