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Wyświetlanie 1-13 z 13
Tytuł:
DNA methylation profiles in the blood of newborn term infants born to mothers with obesity.
Autorzy:
Sasaki A; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Murphy KE; Department of Obstetrics & Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Briollais L; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
McGowan PO; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Departments of Biological Sciences and Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Matthews SG; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.; Department of Obstetrics & Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
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Źródło:
PloS one [PLoS One] 2022 May 02; Vol. 17 (5), pp. e0267946. Date of Electronic Publication: 2022 May 02 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Mothers*
Pediatric Obesity*/genetics
Animals ; Child ; Cohort Studies ; DNA Methylation ; Female ; Humans ; Longitudinal Studies ; Male ; Ontario ; Pregnancy
Czasopismo naukowe
Tytuł:
DNA methylation mediates the association between breastfeeding and early-life growth trajectories.
Autorzy:
Briollais L; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street - Room 5-237, Toronto, ON, M5T 3L9, Canada. .; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. .
Rustand D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street - Room 5-237, Toronto, ON, M5T 3L9, Canada.; Biostatistics Team, Bordeaux Population Health Center, ISPED, Centre INSERM U1219, Bordeaux, France.
Allard C; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
Wu Y; Department of Public Health Sciences, University of Hawai'i at Manoa, Honolulu, HI, USA.
Xu J; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street - Room 5-237, Toronto, ON, M5T 3L9, Canada.
Rajan SG; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Hivert MF; Division of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA, 02215, USA.; Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.
Doyon M; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
Bouchard L; Department of Medical Biology, CIUSSS Saguenay-Lac-Saint-Jean, Hôpital Universitaire de Chicoutimi, Saguenay, QC, G7H 5H6, Canada.; Department of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada.
McGowan PO; Department of Biological Sciences, University of Toronto - Scarborough, Toronto, ON, Canada.
Matthews S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street - Room 5-237, Toronto, ON, M5T 3L9, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.
Lye S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street - Room 5-237, Toronto, ON, M5T 3L9, Canada.
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2021 Dec 22; Vol. 13 (1), pp. 231. Date of Electronic Publication: 2021 Dec 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Feeding/*statistics & numerical data
Growth Disorders/*diagnosis
Age Factors ; Body Mass Index ; Child ; Child, Preschool ; Correlation of Data ; DNA Methylation/genetics ; DNA Methylation/physiology ; Female ; Genome-Wide Association Study ; Growth Disorders/epidemiology ; Humans ; Male
Czasopismo naukowe
Tytuł:
Comparison of methods for pre-processing, exosome isolation, and RNA extraction in unpasteurized bovine and human milk.
Autorzy:
Wijenayake S; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.
Eisha S; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Tawhidi Z; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.
Pitino MA; Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.; Translational Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Steele MA; Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada.
Fleming AS; Department of Psychology, University of Toronto, Mississauga, Mississauga, Ontario, Canada.
McGowan PO; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
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Źródło:
PloS one [PLoS One] 2021 Sep 30; Vol. 16 (9), pp. e0257633. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fractional Precipitation*
Ultracentrifugation*
Exosomes/*chemistry
Milk/*metabolism
Milk, Human/*metabolism
RNA/*isolation & purification
Animals ; Cattle ; Exosomes/metabolism ; Female ; Filtration ; Humans ; Microscopy, Electron, Transmission ; RNA/metabolism
Czasopismo naukowe
Tytuł:
The role of interindividual licking received and dopamine genotype on later-life licking provisioning in female rat offspring.
Autorzy:
Lauby SC; Department of Biological Sciences, University of Toronto Scarborough Campus, Scarborough, ON, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Ashbrook DG; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA.
Malik HR; Department of Biological Sciences, University of Toronto Scarborough Campus, Scarborough, ON, Canada.
Chatterjee D; The Peter Gilgan Centre for Research and Learning, Sickkids Hospital, Toronto, ON, Canada.
Pan P; Department of Biological Sciences, University of Toronto Scarborough Campus, Scarborough, ON, Canada.
Fleming AS; Department of Psychology, University of Toronto, Toronto, ON, Canada.; Department of Psychology, University of Toronto Mississauga, Mississauga, ON, Canada.
McGowan PO; Department of Biological Sciences, University of Toronto Scarborough Campus, Scarborough, ON, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.; Department of Psychology, University of Toronto, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.
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Źródło:
Brain and behavior [Brain Behav] 2021 Apr; Vol. 11 (4), pp. e02069. Date of Electronic Publication: 2021 Feb 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Behavior, Animal*
Dopamine*
Animals ; Female ; Genotype ; Humans ; Maternal Behavior ; Rats ; Rats, Long-Evans
Czasopismo naukowe
Tytuł:
Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in adult rat offspring.
Autorzy:
Wijenayake S; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada.
Rahman MF; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Lum CMW; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
De Vega WC; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Sasaki A; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
McGowan PO; Center for Environmental Epigenetics and Development, Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.; Department of Psychology, Department of Physiology, University of Toronto, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2020 Apr 15; Vol. 17 (1), pp. 116. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji:
Journal Article
MeSH Terms:
Sex Characteristics*
Corticosterone/*toxicity
Diet, High-Fat/*adverse effects
Glucocorticoids/*metabolism
Inflammation Mediators/*metabolism
Prenatal Exposure Delayed Effects/*metabolism
Animals ; Female ; Lipopolysaccharides/toxicity ; Male ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Rats ; Rats, Long-Evans ; Signal Transduction/drug effects ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł:
Inter-individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring.
Autorzy:
Lauby SC; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Chatterjee D; The Peter Gilgan Centre for Research and Learning, Sickkids Hospital, Toronto, Ontario, Canada.
Pan P; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.
McGowan PO; Department of Biological Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Fleming AS; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
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Źródło:
Journal of neuroendocrinology [J Neuroendocrinol] 2019 Sep; Vol. 31 (9), pp. e12706. Date of Electronic Publication: 2019 Apr 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene-Environment Interaction*
Dopamine/*genetics
Dopamine/*physiology
Maternal Behavior/*physiology
Animals ; Behavior, Animal/physiology ; Catechol O-Methyltransferase/genetics ; Dopamine Plasma Membrane Transport Proteins/genetics ; Female ; Genotype ; Phenotype ; Rats, Long-Evans ; Receptors, Dopamine D2/genetics
Czasopismo naukowe
Tytuł:
Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness.
Autorzy:
Ashbrook DG; Department of Biological Sciences and Center for Environmental Epigenetics and Development and Department of Cell and Systems Biology, University of Toronto, Scarborough campus, Toronto, ON, Canada.; Present address: Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, 38103, USA.
Hing B; Department of Biological Sciences and Center for Environmental Epigenetics and Development and Department of Cell and Systems Biology, University of Toronto, Scarborough campus, Toronto, ON, Canada.; Present address: Department of Psychiatry, Medical Laboratories, The University of Iowa, Iowa City, Iowa, 52246, USA.
Michalovicz LT; CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV, 26505, USA.
Kelly KA; CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV, 26505, USA.
Miller JV; CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV, 26505, USA.
de Vega WC; Department of Biological Sciences and Center for Environmental Epigenetics and Development and Department of Cell and Systems Biology, University of Toronto, Scarborough campus, Toronto, ON, Canada.
Miller DB; CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV, 26505, USA.
Broderick G; Center for Clinical Systems Biology, Rochester General Hospital Research Institute, Rochester, NY, USA.
O'Callaghan JP; CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV, 26505, USA.
McGowan PO; Department of Biological Sciences and Center for Environmental Epigenetics and Development and Department of Cell and Systems Biology, University of Toronto, Scarborough campus, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.; Department of Psychology, University of Toronto, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.; Department of Physiology, University of Toronto, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2018 Mar 17; Vol. 15 (1), pp. 86. Date of Electronic Publication: 2018 Mar 17.
Typ publikacji:
Journal Article
MeSH Terms:
Brain/*metabolism
Cytokines/*metabolism
Epigenesis, Genetic/*physiology
Persian Gulf Syndrome/*drug therapy
Persian Gulf Syndrome/*pathology
Stress, Psychological/*metabolism
Animals ; Anti-Inflammatory Agents/toxicity ; Brain/drug effects ; Brain/pathology ; Cholinesterase Inhibitors/pharmacology ; Chromatin Immunoprecipitation ; Corticosterone/toxicity ; DNA Methylation/drug effects ; Disease Models, Animal ; Epigenesis, Genetic/drug effects ; Histones/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Phosphoric Triester Hydrolases/pharmacology ; Time Factors
Czasopismo naukowe
Tytuł:
Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
Autorzy:
de Vega WC; Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, M1C 1A4, Canada.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Herrera S; Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, M1C 1A4, Canada.; Present affiliation: Department of Biological Sciences, Lehigh University, Bethlehem, PA, USA.
Vernon SD; Solve ME/CFS Initiative, Los Angeles, CA, USA.; Present affiliation: The Bateman Horne Center of Excellence, Salt Lake City, UT, USA.
McGowan PO; Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, M1C 1A4, Canada. patrick.mcgowan@utoronto.ca.; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.; Department of Psychology, University of Toronto, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. patrick.mcgowan@utoronto.ca.
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Źródło:
BMC medical genomics [BMC Med Genomics] 2017 Feb 23; Vol. 10 (1), pp. 11. Date of Electronic Publication: 2017 Feb 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epigenesis, Genetic/*drug effects
Fatigue Syndrome, Chronic/*genetics
Glucocorticoids/*pharmacology
Case-Control Studies ; Cohort Studies ; DNA Methylation/drug effects ; Fatigue Syndrome, Chronic/blood ; Fatigue Syndrome, Chronic/pathology ; Fatigue Syndrome, Chronic/physiopathology ; Female ; Genetic Loci/genetics ; Humans ; Hypothalamus/drug effects ; Hypothalamus/physiopathology ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Middle Aged ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/physiopathology ; Quality of Life ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
DNA methylation modifications associated with chronic fatigue syndrome.
Autorzy:
de Vega WC; Centre for Environmental Epigenetics and Development, University of Toronto, Scarborough, ON, Canada; Department of Biological Sciences, University of Toronto, Scarborough, ON, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Vernon SD; CFIDS Association of America, Charlotte, North Carolina, United States of America.
McGowan PO; Centre for Environmental Epigenetics and Development, University of Toronto, Scarborough, ON, Canada; Department of Biological Sciences, University of Toronto, Scarborough, ON, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
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Źródło:
PloS one [PLoS One] 2014 Aug 11; Vol. 9 (8), pp. e104757. Date of Electronic Publication: 2014 Aug 11 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Methylation*
Fatigue Syndrome, Chronic/*genetics
Adult ; CpG Islands/genetics ; Female ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Male
Czasopismo naukowe
Tytuł:
Biological embedding in mental health: an epigenomic perspective.
Autorzy:
Sasaki A; Department of Biological Sciences, University of Toronto, Scarborough, Canada.
de Vega WC
McGowan PO
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Źródło:
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2013 Feb; Vol. 91 (1), pp. 14-21. Date of Electronic Publication: 2013 Feb 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Epigenesis, Genetic*
Epigenomics*
Mental Health*
Mental Disorders/*genetics
Stress, Psychological/*genetics
Animals ; Chromatin Assembly and Disassembly ; DNA Methylation ; Gene Expression Regulation, Developmental ; Gene-Environment Interaction ; Humans ; Phenotype ; Signal Transduction ; Time
Czasopismo naukowe
Tytuł:
Broad epigenetic signature of maternal care in the brain of adult rats.
Autorzy:
McGowan PO; Douglas Mental Health University Institute, Montreal, Quebec, Canada. patrick.mcgowan@utoronto.ca
Suderman M
Sasaki A
Huang TC
Hallett M
Meaney MJ
Szyf M
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Źródło:
PloS one [PLoS One] 2011 Feb 28; Vol. 6 (2), pp. e14739. Date of Electronic Publication: 2011 Feb 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epigenesis, Genetic*
Gene Expression Profiling*
Brain/*metabolism
Maternal Behavior/*physiology
Age Factors ; Animals ; Behavior, Animal/physiology ; DNA Methylation ; Female ; Genetic Loci ; Histones/metabolism ; Male ; Microarray Analysis ; Rats ; Rats, Long-Evans ; Receptors, Glucocorticoid/genetics ; Regulatory Elements, Transcriptional/genetics ; Validation Studies as Topic
Czasopismo naukowe
Tytuł:
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.
Autorzy:
McGowan PO; Douglas Mental Health University Institute, 6875 LaSalle Boulevard, Montreal, Quebec, H4H 1R3, Canada.
Sasaki A
D'Alessio AC
Dymov S
Labonté B
Szyf M
Turecki G
Meaney MJ
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Źródło:
Nature neuroscience [Nat Neurosci] 2009 Mar; Vol. 12 (3), pp. 342-8.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Adult Survivors of Child Abuse/*psychology
Epigenesis, Genetic/*physiology
Hippocampus/*physiology
Receptors, Glucocorticoid/*genetics
Receptors, Glucocorticoid/*metabolism
Adult ; Base Sequence ; Cell Line ; DNA Methylation/genetics ; Female ; Hippocampus/pathology ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Promoter Regions, Genetic/physiology ; Receptors, Glucocorticoid/biosynthesis ; Receptors, Glucocorticoid/physiology ; Suicide/psychology ; Young Adult
Czasopismo naukowe
Tytuł:
Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain.
Autorzy:
McGowan PO; Department of Psychiatry, Douglas Mental Health University Institute, Montreal, Quebec, Canada.
Sasaki A
Huang TC
Unterberger A
Suderman M
Ernst C
Meaney MJ
Turecki G
Szyf M
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Źródło:
PloS one [PLoS One] 2008 May 07; Vol. 3 (5), pp. e2085. Date of Electronic Publication: 2008 May 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Methylation*
Gene Expression*
Promoter Regions, Genetic*
Suicide*
Hippocampus/*physiopathology
Psychotic Disorders/*genetics
RNA, Ribosomal/*genetics
Base Sequence ; Genome, Human ; Genotype ; Humans ; Methylation ; Molecular Sequence Data ; Polymerase Chain Reaction
Czasopismo naukowe
    Wyświetlanie 1-13 z 13

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