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Wyszukujesz frazę ""McIntosh, Lawrence P."" wg kryterium: Autor


Tytuł :
A Multipronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization.
Autorzy :
Gerak CAN; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Zhang SM; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Balgi AD; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Sadowski IJ; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
Sessions RB; School of Biochemistry, University of Bristol, Bristol, UK.
McIntosh LP; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.
Roberge M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.
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Źródło :
SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Jun; Vol. 26 (5), pp. 698-711. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Characterization of the Pilotin-Secretin Complex from the Salmonella enterica Type III Secretion System Using Hybrid Structural Methods.
Autorzy :
Majewski DD; Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, BC, Canada.
Okon M; Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, and Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.
Heinkel F; Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, and Department of Chemistry, University of British Columbia, Vancouver, BC, Canada.
Robb CS; Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, BC, Canada.
Vuckovic M; Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, BC, Canada.
McIntosh LP; Michael Smith Laboratories, Department of Biochemistry and Molecular Biology, and Department of Chemistry, University of British Columbia, Vancouver, BC, Canada. Electronic address: mcintosh@chem.ubc.ca.
Strynadka NCJ; Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, BC, Canada. Electronic address: .
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Źródło :
Structure (London, England : 1993) [Structure] 2021 Feb 04; Vol. 29 (2), pp. 125-138.e5. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Conformational Plasticity and DNA-Binding Specificity of the Eukaryotic Transcription Factor Pax5.
Autorzy :
Perez-Borrajero C; Genome Sciences and Technology Program, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.; Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Heinkel F; Genome Sciences and Technology Program, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.; Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Gsponer J; Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
McIntosh LP; Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.; Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
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Źródło :
Biochemistry [Biochemistry] 2021 Jan 19; Vol. 60 (2), pp. 104-117. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Molecular Dynamics Simulation*
DNA/*chemistry
DNA/*metabolism
PAX5 Transcription Factor/*chemistry
PAX5 Transcription Factor/*metabolism
Binding Sites ; Humans ; Protein Binding ; Protein Conformation
Czasopismo naukowe
Tytuł :
Biophysical characterization of the ETV6 PNT domain polymerization interfaces.
Autorzy :
Gerak CAN; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Cho SY; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Kolesnikov M; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Okon M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Murphy MEP; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Sessions RB; School of Biochemistry, University of Bristol, Bristol, United Kingdom.
Roberge M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
McIntosh LP; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: mcintosh@chem.ubc.ca.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100284. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcription, Genetic*
Alanine/*chemistry
Aspartic Acid/*chemistry
Glutamic Acid/*chemistry
Proto-Oncogene Proteins c-ets/*chemistry
Repressor Proteins/*chemistry
Valine/*chemistry
Alanine/metabolism ; Amino Acid Substitution ; Aspartic Acid/metabolism ; Binding Sites ; Cloning, Molecular ; Crystallography, X-Ray ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Glutamic Acid/metabolism ; Humans ; Models, Molecular ; Mutagenesis, Site-Directed ; Mutation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Proto-Oncogene Proteins c-ets/genetics ; Proto-Oncogene Proteins c-ets/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Thermodynamics ; Valine/metabolism
Czasopismo naukowe
Tytuł :
Peptidoglycan binding by a pocket on the accessory NTF2-domain of Pgp2 directs helical cell shape of Campylobacter jejuni.
Autorzy :
Lin CS; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Chan ACK; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Vermeulen J; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
Brockerman J; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Soni AS; Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
Tanner ME; Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
Gaynor EC; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.
McIntosh LP; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
Simorre JP; University of Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
Murphy MEP; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100528. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Campylobacter jejuni/*cytology
Carboxypeptidases/*metabolism
Nucleocytoplasmic Transport Proteins/*metabolism
Peptidoglycan/*metabolism
Campylobacter jejuni/metabolism ; Carboxypeptidases/chemistry ; Catalytic Domain ; Humans ; Protein Conformation
Czasopismo naukowe
Tytuł :
Ligand- and pH-Induced Structural Transition of Gypsy Moth Lymantria dispar Pheromone-Binding Protein 1 (LdisPBP1).
Autorzy :
Terrado M; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Okon M; Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
McIntosh LP; Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Plettner E; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
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Źródło :
Biochemistry [Biochemistry] 2020 Sep 22; Vol. 59 (37), pp. 3411-3426. Date of Electronic Publication: 2020 Sep 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carrier Proteins/*metabolism
Insect Proteins/*chemistry
Insect Proteins/*metabolism
Pheromones/*metabolism
Animals ; Hydrogen-Ion Concentration ; Ligands ; Moths ; Protein Binding ; Protein Conformation ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis .
Autorzy :
Heinkel F; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Abraham L; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Ko M; Department of Medicine, University of British Columbia, Vancouver, BC, Canada V6H 3Z6.
Chao J; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.; Department of Medicine, University of British Columbia, Vancouver, BC, Canada V6H 3Z6.
Bach H; Department of Medicine, University of British Columbia, Vancouver, BC, Canada V6H 3Z6.
Hui LT; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Li H; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Zhu M; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Ling YM; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Rogalski JC; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
Scurll J; Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, BC, Canada V6T 1Z2.
Bui JM; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Mayor T; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Gold MR; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Chou KC; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
Av-Gay Y; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.; Department of Medicine, University of British Columbia, Vancouver, BC, Canada V6H 3Z6.
McIntosh LP; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4; mcintosh@chem.ubc.ca .; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
Gsponer J; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4; mcintosh@chem.ubc.ca .; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Aug 13; Vol. 116 (33), pp. 16326-16331. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
ATP-Binding Cassette Transporters/*genetics
Membrane Proteins/*genetics
Mycobacterium tuberculosis/*genetics
Tuberculosis/*genetics
ATP-Binding Cassette Transporters/chemistry ; Cytosol/metabolism ; Gene Expression Regulation, Bacterial/genetics ; Humans ; Lipid Bilayers/metabolism ; Membrane Proteins/ultrastructure ; Mycobacterium smegmatis/genetics ; Mycobacterium smegmatis/pathogenicity ; Mycobacterium tuberculosis/pathogenicity ; Mycobacterium tuberculosis/ultrastructure ; Nuclear Proteins/genetics ; Phosphorylation/genetics ; Signal Transduction/genetics ; Single Molecule Imaging ; Tuberculosis/microbiology
Czasopismo naukowe
Tytuł :
The pK a values of the catalytic residues in the retaining glycoside hydrolase T26H mutant of T4 lysozyme.
Autorzy :
Brockerman JA; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.
Okon M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Department of Chemistry, University of British Columbia, Vancouver, British Columbia, V6T 1Z1, Canada.
Withers SG; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Department of Chemistry, University of British Columbia, Vancouver, British Columbia, V6T 1Z1, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada.
McIntosh LP; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.; Department of Chemistry, University of British Columbia, Vancouver, British Columbia, V6T 1Z1, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada.
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Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2019 Mar; Vol. 28 (3), pp. 620-632. Date of Electronic Publication: 2019 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacteriophage T4/*metabolism
Glycoside Hydrolases/*metabolism
Muramidase/*metabolism
Viral Proteins/*metabolism
Amino Acid Substitution ; Bacteriophage T4/chemistry ; Bacteriophage T4/genetics ; Catalytic Domain ; Glycoside Hydrolases/chemistry ; Glycoside Hydrolases/genetics ; Hydrogen-Ion Concentration ; Models, Molecular ; Muramidase/chemistry ; Muramidase/genetics ; Nuclear Magnetic Resonance, Biomolecular ; Peptidoglycan/metabolism ; Point Mutation ; Protons ; Viral Proteins/chemistry ; Viral Proteins/genetics
Czasopismo naukowe
Tytuł :
The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor.
Autorzy :
Perez-Borrajero C; Genome Sciences and Technology Program, University of British Columbia, Vancouver, BC, Canada V6T 1Z3; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Lin CS; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Okon M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
Scheu K; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Graves BJ; Department of Oncological Sciences, School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112-5550, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.
Murphy MEP; Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
McIntosh LP; Genome Sciences and Technology Program, University of British Columbia, Vancouver, BC, Canada V6T 1Z3; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4. Electronic address: mcintosh@chem.ubc.ca.
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Źródło :
Journal of molecular biology [J Mol Biol] 2019 Feb 01; Vol. 431 (3), pp. 593-614. Date of Electronic Publication: 2018 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA/*metabolism
Protein Binding/*physiology
Proto-Oncogene Protein c-ets-1/*metabolism
Transcription Factors/*metabolism
Binding Sites/physiology ; Biophysics/methods ; Crystallography, X-Ray/methods ; Magnetic Resonance Spectroscopy/methods ; Models, Molecular ; Phosphorylation ; Protein Conformation ; Protein Domains/physiology ; Serine/metabolism
Czasopismo naukowe
Tytuł :
Characterization of the two conformations adopted by the T3SS inner-membrane protein PrgK.
Autorzy :
Bergeron JRC; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Brockerman JA; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Vuckovic M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Deng W; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Okon M; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
Finlay BB; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
McIntosh LP; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.
Strynadka NCJ; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
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Źródło :
Protein science : a publication of the Protein Society [Protein Sci] 2018 Sep; Vol. 27 (9), pp. 1680-1691. Date of Electronic Publication: 2018 Aug 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Salmonella enterica/*chemistry
Type III Secretion Systems/*chemistry
Hydrogen-Ion Concentration ; Models, Molecular ; Protein Conformation
Czasopismo naukowe

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