Autor: "McLaughlin KM" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.
Autorzy:: Rothenburger T; Institute for Medical Virology, Goethe-University, Frankfurt am Main, Germany.; Faculty of Biological Sciences, Goethe-University, Frankfurt am Main, Germany.
Thomas D; Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University of Frankfurt, Frankfurt, Germany.
Schreiber Y; Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University of Frankfurt, Frankfurt, Germany.
Wratil PR; Max von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.
Pflantz T; Max von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.
Knecht K; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Digianantonio K; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Temple J; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Schneider C; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Baldauf HM; Max von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
McLaughlin KM; School of Biosciences, University of Kent, Canterbury, UK.
Rothweiler F; Institute for Medical Virology, Goethe-University, Frankfurt am Main, Germany.
Bilen B; Faculty of Biological Sciences, Goethe-University, Frankfurt am Main, Germany.
Farmand S; Faculty of Biological Sciences, Goethe-University, Frankfurt am Main, Germany.
Bojkova D; Institute for Medical Virology, Goethe-University, Frankfurt am Main, Germany.
Costa R; Institute for Medical Virology, Goethe-University, Frankfurt am Main, Germany.
Ferreirós N; Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University of Frankfurt, Frankfurt, Germany.
Geisslinger G; Pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University of Frankfurt, Frankfurt, Germany.; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project group Translational Medicine and Pharmacology (TMP), Frankfurt am Main, Germany.
Oellerich T; Department of Hematology/Oncology, Goethe-University, Frankfurt am Main, Germany.; Molecular Diagnostics Unit, Frankfurt Cancer Institute, Frankfurt am Main, Germany.; German Cancer Consortium/German Cancer Research Center, Heidelberg, Germany.
Xiong Y; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Keppler OT; Max von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.
Wass MN; School of Biosciences, University of Kent, Canterbury, UK.
Michaelis M; School of Biosciences, University of Kent, Canterbury, UK. .
Cinatl J Jr; Institute for Medical Virology, Goethe-University, Frankfurt am Main, Germany. .; Pokaż więcej
Źródło:: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2021 Oct 12; Vol. 40 (1), pp. 317. Date of Electronic Publication: 2021 Oct 12.
Typ publikacji:: Journal Article
MeSH Terms:: Leukemia, Myeloid, Acute/*drug therapy
Nucleosides/*pharmacology
Cell Line, Tumor ; Drug Resistance, Neoplasm ; Humans

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Skocz do pozycji: 2.

Tytuł:: Constitutive Cell Proliferation Regulating Inhibitor of Protein Phosphatase 2A (CIP2A) Mediates Drug Resistance to Erlotinib in an EGFR Activating Mutated NSCLC Cell Line.
Autorzy:: Saafan H; Institute of Pharmacy, Clinical Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany.
Alahdab A; Institute of Pharmacy, Clinical Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany.
Michelet R; Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 14195 Berlin, Germany.
Gohlke L; Institute of Pharmacy, Clinical Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany.
Ziemann J; Central Unit for Infection Prevention and Control, University Medicine Greifswald, 17475 Greifswald, Germany.
Holdenrieder S; Institute of Laboratory Medicine, German Heart Center, Munich Technical University, 80636 Munich, Germany.
McLaughlin KM; Industrial Biotechnology Centre, School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Wass MN; Industrial Biotechnology Centre, School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Cinatl J Jr; Institute of Medical Virology, Goethe-University, 60596 Frankfurt am Main, Germany.
Michaelis M; Industrial Biotechnology Centre, School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Kloft C; Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universitaet Berlin, 14195 Berlin, Germany.
Ritter CA; Institute of Pharmacy, Clinical Pharmacy, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Mar 24; Vol. 10 (4). Date of Electronic Publication: 2021 Mar 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Resistance, Neoplasm*/drug effects
Autoantigens/*metabolism
Carcinoma, Non-Small-Cell Lung/*genetics
ErbB Receptors/*genetics
Erlotinib Hydrochloride/*pharmacology
Intracellular Signaling Peptides and Proteins/*metabolism
Lung Neoplasms/*genetics
Membrane Proteins/*metabolism
Mutation/*genetics
Bortezomib/pharmacology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; G2 Phase/drug effects ; Humans ; Lung Neoplasms/pathology ; Mitosis/drug effects ; Phosphorylation/drug effects ; Protein Phosphatase 2/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects

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Skocz do pozycji: 3.

Tytuł:: Aprotinin Inhibits SARS-CoV-2 Replication.
Autorzy:: Bojkova D; Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.
Bechtel M; Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.
McLaughlin KM; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
McGreig JE; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Klann K; Faculty of Medicine, Institute of Biochemistry II, Goethe University, 60590 Frankfurt am Main, Germany.
Bellinghausen C; Department of Respiratory Medicine and Allergology, University Hospital, Goethe University, 60590 Frankfurt am Main, Germany.
Rohde G; Department of Respiratory Medicine and Allergology, University Hospital, Goethe University, 60590 Frankfurt am Main, Germany.
Jonigk D; Institute of Pathology, Hannover Medical School (MHH), 30625 Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), The German Center for Lung Research (Deutsches Zentrum für Lungenforschung, DZL), Hannover Medical School (MHH), 30625 Hannover, Germany.
Braubach P; Institute of Pathology, Hannover Medical School (MHH), 30625 Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), The German Center for Lung Research (Deutsches Zentrum für Lungenforschung, DZL), Hannover Medical School (MHH), 30625 Hannover, Germany.
Ciesek S; Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.; German Center for Infection Research, DZIF, External Partner Site, 60596 Frankfurt am Main, Germany.; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine und Pharmacology, 60596 Frankfurt am Main, Germany.
Münch C; Faculty of Medicine, Institute of Biochemistry II, Goethe University, 60590 Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany.; Cardio-Pulmonary Institute, Goethe University, 60590 Frankfurt am Main, Germany.
Wass MN; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Michaelis M; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Cinatl J Jr; Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Oct 30; Vol. 9 (11). Date of Electronic Publication: 2020 Oct 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: COVID-19 Drug Treatment*
Aprotinin/*pharmacology
SARS-CoV-2/*drug effects
Virus Replication/*drug effects
Animals ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; Caco-2 Cells ; Chlorocebus aethiops ; Epithelial Cells/drug effects ; Humans ; Pandemics ; SARS-CoV-2/physiology ; Serine Proteinase Inhibitors/pharmacology ; Vero Cells

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Skocz do pozycji: 4.

Tytuł:: COVID-19-Related Coagulopathy-Is Transferrin a Missing Link?
Autorzy:: McLaughlin KM; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Bechtel M; Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.
Bojkova D; Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.
Münch C; Institute of Biochemistry II, Faculty of Medicine, Goethe University, 60590 Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, 60590 Frankfurt am Main, Germany.; Cardio-pulmonary Institute, Goethe University, 60590 Frankfurt am Main, Germany.
Ciesek S; Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.; German Center for Infection Research, DZIF, External Partner Site, 60590 Frankfurt am Main, Germany.; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine und Pharmacology, 60590 Frankfurt am Main, Germany.
Wass MN; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Michaelis M; School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Cinatl J Jr; Institute for Medical Virology, University Hospital, Goethe University, 60596 Frankfurt am Main, Germany.; Pokaż więcej
Źródło:: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2020 Jul 30; Vol. 10 (8). Date of Electronic Publication: 2020 Jul 30.
Typ publikacji:: Journal Article

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Skocz do pozycji: 5.

Tytuł:: SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.
Autorzy:: Rothenburger T; Institut für Medizinische Virologie, Klinikum der Goethe-Universität, Paul Ehrlich-Straße 40, 60596, Frankfurt am Main, Germany.
McLaughlin KM; School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK.
Herold T; Department of Medicine III, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.; Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Feodor-Lynenstraße 21, 81377, Munich, Germany.
Schneider C; Institut für Medizinische Virologie, Klinikum der Goethe-Universität, Paul Ehrlich-Straße 40, 60596, Frankfurt am Main, Germany.; Department of Medicine II, Hematology/Oncology, Goethe-Universität, Frankfurt am Main, Germany; Frankfurt Cancer Institute, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Oellerich T; Department of Medicine II, Hematology/Oncology, Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.; German Cancer Consortium/German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Rothweiler F; Institut für Medizinische Virologie, Klinikum der Goethe-Universität, Paul Ehrlich-Straße 40, 60596, Frankfurt am Main, Germany.
Feber A; Division of Surgery and Interventional Science, University College London, Gower Street, London, WC1E 6BT, UK.
Fenton TR; School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK.
Wass MN; School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK.
Keppler OT; Faculty of Medicine, Max von Pettenkofer Institute, Virology, LMU München, Pettenkoferstraße 9a, 80336, Munich, Germany.
Michaelis M; School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK. .
Cinatl J Jr; Institut für Medizinische Virologie, Klinikum der Goethe-Universität, Paul Ehrlich-Straße 40, 60596, Frankfurt am Main, Germany. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2020 Jun 24; Vol. 3 (1), pp. 324. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Arabinonucleosides/*pharmacology
Drug Resistance, Neoplasm/*genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
SAM Domain and HD Domain-Containing Protein 1/*genetics
Antineoplastic Agents/pharmacology ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; DNA Methylation ; Drug Resistance, Neoplasm/drug effects ; Gene Expression Regulation, Leukemic ; Humans ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Promoter Regions, Genetic ; SAM Domain and HD Domain-Containing Protein 1/metabolism

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Skocz do pozycji: 6.

Tytuł:: Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin.
Autorzy:: Dilruba S; Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, 53113 Bonn, Germany.
Grondana A; Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, 53113 Bonn, Germany.
Schiedel AC; Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, University of Bonn, 53113 Bonn, Germany.
Ueno NT; Section of Translational Breast Cancer Research, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Bartholomeusz C; Section of Translational Breast Cancer Research, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cinatl J Jr; Institute of Medical Virology, Goethe University Hospital Frankfurt, 60323 Frankfurt/Main, Germany.
McLaughlin KM; Industrial Biotechnology Centre and School of Biosciences, School of Biosciences, University of Kent, Canterbury CT2 7NZ, UK.
Wass MN; Industrial Biotechnology Centre and School of Biosciences, School of Biosciences, University of Kent, Canterbury CT2 7NZ, UK.
Michaelis M; Industrial Biotechnology Centre and School of Biosciences, School of Biosciences, University of Kent, Canterbury CT2 7NZ, UK.
Kalayda GV; Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, 53113 Bonn, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Feb 24; Vol. 9 (2). Date of Electronic Publication: 2020 Feb 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*therapeutic use
Apoptosis Regulatory Proteins/*metabolism
Cisplatin/*therapeutic use
Ovarian Neoplasms/*drug therapy
Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cisplatin/pharmacology ; Female ; Humans ; Signal Transduction ; Transfection

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Skocz do pozycji: 7.

Tytuł:: National needs assessment of patients treated at the United States Federally-Funded Hemophilia Treatment Centers.
Autorzy:: Butler RB; The Children's Hospital of Philadelphia Hemostasis and Thrombosis Center, Philadelphia, PA, USA.
Cheadle A; Center for Community Health and Evaluation, Seattle, WA, USA.
Aschman DJ; National Hemophilia Program Coordinating Center, Riverwoods, IL, USA.
Riske B; University of Colorado Hemophilia and Thrombosis Center, Aurora, CO, USA.
Senter S; Center for Community Health and Evaluation, Seattle, WA, USA.
McLaughlin KM; Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA.
Young G; Hemostasis and Thrombosis Center, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Ahuja S; Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
Forsberg AD; National Hemophilia Program Coordinating Center, Riverwoods, IL, USA.; Pokaż więcej
Źródło:: Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2016 Jan; Vol. 22 (1), pp. e11-7. Date of Electronic Publication: 2015 Oct 30.
Typ publikacji:: Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Needs Assessment*
Surveys and Questionnaires*
Hemophilia A/*therapy
Patient Care/*economics
Adolescent ; Adult ; Child ; Child, Preschool ; Delivery of Health Care ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; United States ; Young Adult