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Tytuł:: Subcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an 'Immune Cold' Phenotype Associated with Poor Survival.
Autorzy:: Porter RJ; Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Murray GI; Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Hapca S; Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Hay A; Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Craig SG; Precision Medicine Centre of Excellence, Centre for Cell Research and Cell Biology, Queen's University Belfast, Belfast BT9 7BL, UK.
Humphries MP; Precision Medicine Centre of Excellence, Centre for Cell Research and Cell Biology, Queen's University Belfast, Belfast BT9 7BL, UK.
James JA; Precision Medicine Centre of Excellence, Centre for Cell Research and Cell Biology, Queen's University Belfast, Belfast BT9 7BL, UK.; Department of Cellular Pathology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast BT12 6BA, UK.
Salto-Tellez M; Precision Medicine Centre of Excellence, Centre for Cell Research and Cell Biology, Queen's University Belfast, Belfast BT9 7BL, UK.; Department of Cellular Pathology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast BT12 6BA, UK.
Brice DP; Lydia Becker Institute of Immunology and Inflammation and Wellcome Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9WU, UK.
Berry SH; Institute of Medical Sciences, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.
McLean MH; Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UK.; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2023 Mar 20; Vol. 15 (6). Date of Electronic Publication: 2023 Mar 20.
Typ publikacji:: Journal Article

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Skocz do pozycji: 2.

Tytuł:: Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression: a marker of malignant potential?
Autorzy:: McLean MH; Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. m.h.mclean@abdn.ac.uk
Thomson AJ
Murray GI
Fyfe N
Hold GL
El-Omar EM; Pokaż więcej
Źródło:: British journal of cancer [Br J Cancer] 2013 Jun 25; Vol. 108 (12), pp. 2537-41. Date of Electronic Publication: 2013 Jun 04.
Typ publikacji:: Journal Article
MeSH Terms:: Acute-Phase Proteins/*metabolism
Adenoma/*pathology
Biomarkers, Tumor/*metabolism
Cell Transformation, Neoplastic/*metabolism
Colorectal Neoplasms/*pathology
Lipocalins/*metabolism
Proto-Oncogene Proteins/*metabolism
Adenoma/metabolism ; Biomarkers, Tumor/genetics ; Cohort Studies ; Colorectal Neoplasms/metabolism ; Disease Progression ; Humans ; Immunohistochemistry ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Lipocalin-2 ; Tumor Burden

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Skocz do pozycji: 3.

Tytuł:: Enterohepatic helicobacter in ulcerative colitis: potential pathogenic entities?
Autorzy:: Thomson JM; Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom.
Hansen R
Berry SH
Hope ME
Murray GI
Mukhopadhya I
McLean MH
Shen Z
Fox JG
El-Omar E
Hold GL; Pokaż więcej
Źródło:: PloS one [PLoS One] 2011 Feb 23; Vol. 6 (2), pp. e17184. Date of Electronic Publication: 2011 Feb 23.
Typ publikacji:: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Colitis, Ulcerative/*complications
Colitis, Ulcerative/*etiology
Helicobacter/*isolation & purification
Helicobacter Infections/*complications
Intestines/*microbiology
Liver/*microbiology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cohort Studies ; Colitis, Ulcerative/epidemiology ; Colitis, Ulcerative/microbiology ; Female ; Helicobacter/physiology ; Helicobacter Infections/diagnosis ; Helicobacter Infections/epidemiology ; Helicobacter Infections/pathology ; Humans ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Intestines/pathology ; Liver/pathology ; Male ; Microbiological Techniques ; Middle Aged ; Molecular Diagnostic Techniques ; Validation Studies as Topic ; Young Adult

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Skocz do pozycji: 4.

Tytuł:: The inflammatory microenvironment in colorectal neoplasia.
Autorzy:: McLean MH; Gastrointestinal Research Group, School of Medicine and Dentistry, Aberdeen University, Aberdeen, United Kingdom.
Murray GI
Stewart KN
Norrie G
Mayer C
Hold GL
Thomson J
Fyfe N
Hope M
Mowat NA
Drew JE
El-Omar EM; Pokaż więcej
Źródło:: PloS one [PLoS One] 2011 Jan 07; Vol. 6 (1), pp. e15366. Date of Electronic Publication: 2011 Jan 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Tumor Microenvironment*
Colorectal Neoplasms/*pathology
Precancerous Conditions/*pathology
Adenoma/genetics ; Adenoma/pathology ; Colonic Polyps/genetics ; Colonic Polyps/pathology ; Cytokines/genetics ; Gene Expression Regulation ; Humans ; Inflammation/etiology ; Inflammation/pathology ; Lymphocytes, Tumor-Infiltrating/immunology ; Macrophages/immunology ; Prognosis

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Skocz do pozycji: 5.

Tytuł:: The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
Autorzy:: Jeffery N; Department of Pathology, University of Aberdeen, Aberdeen, UK.
McLean MH
El-Omar EM
Murray GI; Pokaż więcej
Źródło:: Histopathology [Histopathology] 2009 Jun; Vol. 54 (7), pp. 820-8.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Colorectal Neoplasms/*metabolism
Intestinal Polyps/*metabolism
Matrix Metalloproteinases/*metabolism
Tissue Inhibitor of Metalloproteinases/*metabolism
Adenoma/etiology ; Adenoma/metabolism ; Adenoma/pathology ; Adult ; Aged ; Carcinoma/etiology ; Carcinoma/metabolism ; Carcinoma/pathology ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/pathology ; Female ; Humans ; Immunohistochemistry ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Intestinal Polyps/etiology ; Intestinal Polyps/pathology ; Male ; Middle Aged

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Skocz do pozycji: 6.

Tytuł:: COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics.
Autorzy:: McLean MH; GI Research Group, Department of Medicine & Therapeutics, University of Aberdeen, Aberdeen, UK.
Murray GI
Fyfe N
Hold GL
Mowat NA
El-Omar EM; Pokaż więcej
Źródło:: Histopathology [Histopathology] 2008 Jun; Vol. 52 (7), pp. 806-15. Date of Electronic Publication: 2008 May 06.
Typ publikacji:: Journal Article
MeSH Terms:: Adenomatous Polyps/*enzymology
Colonic Polyps/*enzymology
Colorectal Neoplasms/*enzymology
Cyclooxygenase 2/*metabolism
Intestinal Mucosa/*enzymology
Adenomatous Polyps/chemistry ; Biomarkers, Tumor/analysis ; Cell Transformation, Neoplastic ; Colonic Polyps/chemistry ; Colorectal Neoplasms/chemistry ; Epithelial Cells/chemistry ; Epithelial Cells/enzymology ; Fluorescent Antibody Technique, Direct ; Humans ; Immunoenzyme Techniques ; Intestinal Mucosa/chemistry ; Precancerous Conditions/chemistry ; Precancerous Conditions/enzymology ; Tissue Array Analysis

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