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Wyszukujesz frazę ""Mechanistic Target of Rapamycin Complex 1"" wg kryterium: Temat


Tytuł:
Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling.
Autorzy:
Rahman M; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Nguyen TM; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Lee GJ; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Kim B; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
Park MK; Department of BioHealthcare, Hwasung Medi-Science University, Hwaseong-si 18274, Republic of Korea.
Lee CH; College of Pharmacy, Dongguk University, Seoul 04620, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 25; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 25.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/metabolism
Ras Homolog Enriched in Brain Protein*/genetics
Ras Homolog Enriched in Brain Protein*/metabolism
Mechanistic Target of Rapamycin Complex 1*/metabolism
Brain/metabolism ; Neurons/metabolism ; Neuropeptides/metabolism ; Sirolimus
Czasopismo naukowe
Tytuł:
PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells.
Autorzy:
Kohyanagi N; Laboratory of Veterinary Pharmacology, Yamaguchi University Joint Graduate School of Veterinary Medicine, Yamaguchi, Japan.
Kitamura N; Laboratory of Veterinary Pharmacology, Yamaguchi University Joint Graduate School of Veterinary Medicine, Yamaguchi, Japan.
Ikeda S; Laboratory of Veterinary Pharmacology, Yamaguchi University Joint Graduate School of Veterinary Medicine, Yamaguchi, Japan.
Shibutani S; Laboratory of Veterinary Hygiene, Yamaguchi University Joint Graduate School of Veterinary Medicine, Yamaguchi, Japan.
Sato K; Laboratory of Veterinary Pharmacology, Yamaguchi University Joint Graduate School of Veterinary Medicine, Yamaguchi, Japan.
Ohama T; Laboratory of Veterinary Pharmacology, Yamaguchi University Joint Graduate School of Veterinary Medicine, Yamaguchi, Japan. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105584. Date of Electronic Publication: 2023 Dec 22.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Inhibitors*/metabolism
Mechanistic Target of Rapamycin Complex 1*/metabolism
Neoplasms*/metabolism
Neoplasms*/pathology
Polycomb Repressive Complex 1*/metabolism
Protein Phosphatase 2*/antagonists & inhibitors
Protein Phosphatase 2*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
DNA-Binding Proteins*/deficiency
DNA-Binding Proteins*/genetics
DNA-Binding Proteins*/metabolism
Histone Chaperones*/deficiency
Histone Chaperones*/genetics
Histone Chaperones*/metabolism
Humans ; Phosphorylation ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Signal Transduction ; Enzyme Activation ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
E3 ubiquitin ligase STUB1 affects the mTORC1 pathway through p62 and participates in regulating the differentiation of follicular helper T cells in rheumatoid arthritis.
Autorzy:
Wang W; Department of Rheumatology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yang Y; Department of Rheumatology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Shi Y; Department of Rheumatology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xiang T; Department of Rheumatology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xie J; Department of Rheumatology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address: .
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Źródło:
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2023 Oct; Vol. 255, pp. 109736. Date of Electronic Publication: 2023 Aug 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arthritis, Rheumatoid*/genetics
Arthritis, Rheumatoid*/metabolism
Mechanistic Target of Rapamycin Complex 1*/genetics
Mechanistic Target of Rapamycin Complex 1*/metabolism
Ubiquitin-Protein Ligases*/genetics
Ubiquitin-Protein Ligases*/metabolism
Humans ; Cell Differentiation ; T Follicular Helper Cells/metabolism ; T-Lymphocytes, Helper-Inducer/physiology ; Ubiquitination/genetics
Czasopismo naukowe
Tytuł:
CBAP regulates the function of Akt-associated TSC protein complexes to modulate mTORC1 signaling.
Autorzy:
Liao WT; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chiang YJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yang-Yen HF; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Hsu LC; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chang ZF; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: .
Yen JJY; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105455. Date of Electronic Publication: 2023 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
Mechanistic Target of Rapamycin Complex 1*/metabolism
Membrane Proteins*/deficiency
Membrane Proteins*/genetics
Membrane Proteins*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Tuberous Sclerosis Complex 1 Protein*/metabolism
Tuberous Sclerosis Complex 2 Protein*/metabolism
Humans ; Cell Proliferation ; Guanosine Triphosphate/metabolism ; Immunoprecipitation ; Lysosomes/metabolism ; Phosphorylation ; Ras Homolog Enriched in Brain Protein/metabolism ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł:
mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction.
Autorzy:
de Souza GO; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
Teixeira PDS; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
Câmara NOS; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
Donato J Jr; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508-000, SP, Brazil.
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Źródło:
Cells [Cells] 2023 Oct 12; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Eating*/physiology
Mechanistic Target of Rapamycin Complex 1*/metabolism
Neurons*/metabolism
Animals ; Female ; Male ; Mice ; Agouti-Related Protein/metabolism ; Glucose/metabolism
Czasopismo naukowe
Tytuł:
Design of negative-regulating proteins of Rheb/mTORC1 with much-reduced sizes of the tuberous sclerosis protein complex.
Autorzy:
Fu W; State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, the Joint International Research Laboratory of Metabolic & Developmental Sciences MOE, Shanghai Jiao Tong University, Shanghai, China.
Wu G; State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, the Joint International Research Laboratory of Metabolic & Developmental Sciences MOE, Shanghai Jiao Tong University, Shanghai, China.
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Źródło:
Protein science : a publication of the Protein Society [Protein Sci] 2023 Aug; Vol. 32 (8), pp. e4731.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mechanistic Target of Rapamycin Complex 1*/metabolism
Neuropeptides*/genetics
Neuropeptides*/metabolism
Tuberous Sclerosis*/genetics
Tuberous Sclerosis*/metabolism
Tuberous Sclerosis Complex 2 Protein*/genetics
Tuberous Sclerosis Complex 2 Protein*/metabolism
Humans ; Guanosine Triphosphate ; Multiprotein Complexes/metabolism ; Ras Homolog Enriched in Brain Protein/genetics ; Ras Homolog Enriched in Brain Protein/metabolism ; Tumor Suppressor Proteins
Czasopismo naukowe
Tytuł:
Redundant electrostatic interactions between GATOR1 and the Rag GTPase heterodimer drive efficient amino acid sensing in human cells.
Autorzy:
Doxsey DD; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Tettoni SD; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Egri SB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Shen K; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA; Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104880. Date of Electronic Publication: 2023 Jun 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Amino Acids*/metabolism
Mechanistic Target of Rapamycin Complex 1*/metabolism
Monomeric GTP-Binding Proteins*/metabolism
Humans ; Lysosomes/metabolism ; Nucleotides/metabolism ; Signal Transduction/physiology ; Static Electricity
Czasopismo naukowe
Tytuł:
An affinity tool for the isolation of endogenous active mTORC1 from various cellular sources.
Autorzy:
Ibrahim YH; Araucaria Laboratories, Inc, New York, New York, USA. Electronic address: .
Pantelios S; Department of Immunology, Pathology and Genetics, Uppsala University, Uppsala, Sweden.
Mutvei AP; Department of Immunology, Pathology and Genetics, Uppsala University, Uppsala, Sweden; Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 May; Vol. 299 (5), pp. 104644. Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mechanistic Target of Rapamycin Complex 1*/chemistry
Mechanistic Target of Rapamycin Complex 1*/isolation & purification
Mechanistic Target of Rapamycin Complex 1*/metabolism
Monomeric GTP-Binding Proteins*/chemistry
Monomeric GTP-Binding Proteins*/genetics
Monomeric GTP-Binding Proteins*/metabolism
Recombinant Proteins*/genetics
Recombinant Proteins*/metabolism
Biotechnology*/methods
Animals ; Cattle ; Humans ; Mice ; Mammals/metabolism ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Models, Molecular
Czasopismo naukowe
Tytuł:
Circadian regulation of mTORC1 signaling via Per2 dependent mechanism disrupts folliculogenesis and oocyte maturation in female mice.
Autorzy:
Bora G; Department of Histology and Embryology, Yeditepe University Faculty of Medicine, 34755, İstanbul, Turkey.
Önel T; Department of Histology and Embryology, Yeditepe University Faculty of Medicine, 34755, İstanbul, Turkey.
Yıldırım E; Department of Histology and Embryology, Yeditepe University Faculty of Medicine, 34755, İstanbul, Turkey.
Yaba A; Department of Histology and Embryology, Yeditepe University Faculty of Medicine, 34755, İstanbul, Turkey. .
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Źródło:
Journal of molecular histology [J Mol Histol] 2023 Jun; Vol. 54 (3), pp. 217-229. Date of Electronic Publication: 2023 May 10.
Typ publikacji:
Journal Article
MeSH Terms:
Mechanistic Target of Rapamycin Complex 1*
Oocytes*
Period Circadian Proteins*/genetics
Period Circadian Proteins*/metabolism
Animals ; Female ; Mice ; Mammals/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł:
Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast.
Autorzy:
Valenti M; Departamento de Microbiología y Parasitología, Facultad de Farmacia, and Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Madrid 28040, Spain.
Molina M; Departamento de Microbiología y Parasitología, Facultad de Farmacia, and Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Madrid 28040, Spain.
Cid VJ; Departamento de Microbiología y Parasitología, Facultad de Farmacia, and Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Universidad Complutense de Madrid, Madrid 28040, Spain.
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Źródło:
Open biology [Open Biol] 2023 May; Vol. 13 (5), pp. 220366. Date of Electronic Publication: 2023 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gasdermins*
Protein Kinases*
Saccharomyces cerevisiae*
Endocytosis*
Mechanistic Target of Rapamycin Complex 1*
Humans ; Mitochondria ; Transcription Factors
Czasopismo naukowe
Tytuł:
MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolism.
Autorzy:
Sun X; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Yang Y; From the Department of Pharmacy, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Zhao W; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Wang M; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Chen Y; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Wang J; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Yang D; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China. Electronic address: .
Yang Y; Department of Cardiology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China. Electronic address: .
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Źródło:
Atherosclerosis [Atherosclerosis] 2024 Mar; Vol. 390, pp. 117470. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Muscle, Smooth, Vascular*/pathology
Neointima*/metabolism
Mice ; Animals ; Becaplermin/pharmacology ; Becaplermin/metabolism ; Cell Proliferation ; Hyperplasia/pathology ; Mice, Transgenic ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 1/pharmacology ; Glucose/metabolism ; Myocytes, Smooth Muscle/pathology ; Cell Movement ; Cells, Cultured ; Mammals
Czasopismo naukowe
Tytuł:
Role of mammalian target of rapamycin in the formation and progression of retinopathy of prematurity-like vascular abnormalities in neonatal rats.
Autorzy:
Nakano A; Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Morita A; Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Arima S; Department of Organic Synthesis, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Nagamitsu T; Department of Organic Synthesis, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Nakahara T; Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Electronic address: .
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Źródło:
Microvascular research [Microvasc Res] 2024 Mar; Vol. 152, pp. 104626. Date of Electronic Publication: 2023 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Phenylurea Compounds*
Quinazolines*
Retinopathy of Prematurity*/drug therapy
Retinopathy of Prematurity*/prevention & control
Animals ; Rats ; Animals, Newborn ; Disease Models, Animal ; Endothelial Cells/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 1/pharmacology ; Retinal Vessels ; Sirolimus/pharmacology ; Sirolimus/metabolism ; Sirolimus/therapeutic use ; TOR Serine-Threonine Kinases/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł:
Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5'TOP mRNAs.
Autorzy:
Hochstoeger T; Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.; University of Basel, 4003 Basel, Switzerland.
Papasaikas P; Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Piskadlo E; Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Chao JA; Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
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Źródło:
Science advances [Sci Adv] 2024 Feb 16; Vol. 10 (7), pp. eadi7830. Date of Electronic Publication: 2024 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Biosynthesis*
TOR Serine-Threonine Kinases*/genetics
TOR Serine-Threonine Kinases*/metabolism
RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs.
Autorzy:
Yang S; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Ting CY; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Lilly MA; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Feb 15; Vol. 84 (4), pp. 727-743.e8. Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Microphthalmia-Associated Transcription Factor*/genetics
Microphthalmia-Associated Transcription Factor*/metabolism
Kidney Neoplasms*/metabolism
Humans ; HeLa Cells ; Proteolysis ; Autophagy/genetics ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Proteins/metabolism ; Lysosomes/genetics ; Lysosomes/metabolism ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.
Autorzy:
Muller M; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Bélanger J; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Hadj-Aissa I; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Zhang C; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Sephton CF; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
Dutchak PA; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Phosphatidylinositol 3-Kinases*/genetics
Phosphatidylinositol 3-Kinases*/metabolism
Epilepsy*
Humans ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Signal Transduction ; GTPase-Activating Proteins/metabolism ; Mutation ; Phosphatidylinositol 3-Kinase/metabolism ; Amino Acids/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Membrane Transport Proteins/metabolism ; Nitrogen/metabolism
Czasopismo naukowe
Tytuł:
Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis.
Autorzy:
Li H; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Pan T; Hepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou 325035, Zhejiang, China.
Gao L; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Ding R; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Yu Y; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Ma M; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Wang Y; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Jin S; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China.
Chen Y; Hepatology Diagnosis and Treatment Center, The First Affiliated Hospital of Wenzhou Medical University & Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou 325035, Zhejiang, China. Electronic address: .
Ding C; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China. Electronic address: .
Xu L; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China. Electronic address: .
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Źródło:
Metabolism: clinical and experimental [Metabolism] 2024 Feb; Vol. 151, pp. 155758. Date of Electronic Publication: 2023 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/metabolism
Phenylurea Compounds*
Piperidines*
Animals ; Humans ; Mice ; Choline/metabolism ; Choline/pharmacology ; Disease Models, Animal ; Liver/metabolism ; Liver Cirrhosis/pathology ; Macrophage Activation ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Methionine/metabolism ; Methionine/pharmacology ; Mice, Inbred C57BL ; Receptors, CCR1/genetics ; Receptors, CCR1/metabolism ; Receptors, Chemokine/metabolism
Czasopismo naukowe
Tytuł:
mTORC1 regulates the metabolic switch of postnatal cardiomyocytes during regeneration.
Autorzy:
Paltzer WG; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Aballo TJ; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Bae J; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, United States.
Flynn CGK; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Wanless KN; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Hubert KA; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Nuttall DJ; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Perry C; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Nahlawi R; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Ge Y; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, United States; Human Proteomics Program, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States.
Mahmoud AI; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, United States. Electronic address: .
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Źródło:
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Feb; Vol. 187, pp. 15-25. Date of Electronic Publication: 2023 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Myocytes, Cardiac*/metabolism
Proteomics*
Animals ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Animals, Newborn ; Heart/physiology ; Sirolimus ; Fatty Acids/metabolism ; Cell Proliferation ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
MORG1 limits mTORC1 signaling by inhibiting Rag GTPases.
Autorzy:
Abudu YP; Autophagy Research Group, Department of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway; Nanoscopy Group, Department of Physics and Technology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway. Electronic address: .
Kournoutis A; Autophagy Research Group, Department of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.
Brenne HB; Autophagy Research Group, Department of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.
Lamark T; Autophagy Research Group, Department of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.
Johansen T; Autophagy Research Group, Department of Medical Biology, University of Tromsø-The Arctic University of Norway, Tromsø, Norway. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2024 Feb 01; Vol. 84 (3), pp. 552-569.e11. Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Journal Article
MeSH Terms:
GTP Phosphohydrolases*/genetics
GTP Phosphohydrolases*/metabolism
Monomeric GTP-Binding Proteins*/genetics
Monomeric GTP-Binding Proteins*/metabolism
Humans ; HeLa Cells ; Sequestosome-1 Protein/metabolism ; Signal Transduction ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Lysosomes/metabolism
Czasopismo naukowe
Tytuł:
Phosphoregulation of the yeast Pma1 H+-ATPase autoinhibitory domain involves the Ptk1/2 kinases and the Glc7 PP1 phosphatase and is under TORC1 control.
Autorzy:
Guarini N; Molecular Physiology of the Cell, Université Libre de Bruxelles (ULB), Biopark, Gosselies, Belgium.
Saliba E; Molecular Physiology of the Cell, Université Libre de Bruxelles (ULB), Biopark, Gosselies, Belgium.
André B; Molecular Physiology of the Cell, Université Libre de Bruxelles (ULB), Biopark, Gosselies, Belgium.
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Źródło:
PLoS genetics [PLoS Genet] 2024 Jan 16; Vol. 20 (1), pp. e1011121. Date of Electronic Publication: 2024 Jan 16 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Saccharomyces cerevisiae*/metabolism
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/metabolism ; Cell Membrane/genetics ; Cell Membrane/metabolism
Czasopismo naukowe
Tytuł:
Rosmarinic acid enhances CHO cell productivity and proliferation through activation of the unfolded protein response and the mTOR pathway.
Autorzy:
Mao L; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Schneider JW; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Robinson AS; Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
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Źródło:
Biotechnology journal [Biotechnol J] 2024 Jan; Vol. 19 (1), pp. e2300397. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Journal Article
MeSH Terms:
Rosmarinic Acid*
TOR Serine-Threonine Kinases*/genetics
Cricetinae ; Animals ; Cricetulus ; CHO Cells ; Unfolded Protein Response ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 1/pharmacology ; Cell Proliferation
Czasopismo naukowe

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