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Wyszukujesz frazę ""Mechanistic Target of Rapamycin Complex 2"" wg kryterium: Temat


Tytuł:
WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis.
Autorzy:
Zhang P; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Fu HJ; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Lv LX; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Liu CF; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Han C; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Zhao XF; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China.
Wang JX; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, 266237, Qingdao, Shandong, China. .; State Key Laboratory of Microbial Technology, Shandong University, 266237, Qingdao, Shandong, China. .
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Źródło:
Communications biology [Commun Biol] 2023 Apr 03; Vol. 6 (1), pp. 361. Date of Electronic Publication: 2023 Apr 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
AMP-Activated Protein Kinases*/genetics
AMP-Activated Protein Kinases*/metabolism
Glycolysis*
Mechanistic Target of Rapamycin Complex 2*/metabolism
Penaeidae*/genetics
Penaeidae*/metabolism
Virus Replication*
White spot syndrome virus 1*/physiology
Aerobiosis ; Phosphorylation ; Signal Transduction ; Gene Knockdown Techniques
Czasopismo naukowe
Tytuł:
DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma.
Autorzy:
Harachi M; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Masui K; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan. .
Shimizu E; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Murakami K; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Onizuka H; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Muragaki Y; Department of Neurosurgery, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.; Center for Advanced Medical Engineering Research and Development, Kobe University, Kobe, Hyogo, 650-0047, Japan.
Kawamata T; Department of Neurosurgery, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Nakayama H; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Miyata M; Department of Physiology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Komori T; Department of Neuropathology, Tokyo Metropolitan Neurological Hospital, Musashinodai, Tokyo, 156-8506, Japan.
Cavenee WK; Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, 92093, USA.
Mischel PS; Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kurata A; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
Shibata N; Department of Pathology, Tokyo Women's Medical University, Shinjuku, Tokyo, 162-8666, Japan.
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Mar 13; Vol. 12 (1), pp. 40. Date of Electronic Publication: 2024 Mar 13.
Typ publikacji:
Journal Article
MeSH Terms:
Glioblastoma*/pathology
Brain Neoplasms*/pathology
Mice ; Animals ; Cell Line, Tumor ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; DNA Methylation ; Phenotype ; DNA/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Protein-Tyrosine Kinases/genetics
Czasopismo naukowe
Tytuł:
Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets.
Autorzy:
Jhanwar-Uniyal M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Zeller SL; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Spirollari E; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Das M; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Hanft SJ; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
Gandhi CD; Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY 10595, USA.
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Źródło:
Cells [Cells] 2024 Feb 27; Vol. 13 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Glioblastoma*/metabolism
Sirolimus*/pharmacology
Neoplastic Stem Cells*/metabolism
Humans ; Intercellular Signaling Peptides and Proteins/therapeutic use ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł:
Unmasking the tumourigenic role of SIN1/MAPKAP1 in the mTOR complex 2.
Autorzy:
Ezine E; INSERM, U976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), Paris, France.; Département de Dermatologie, Hôpital Saint Louis, AP-HP, Paris, France.
Lebbe C; INSERM, U976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), Paris, France.; Département de Dermatologie, Hôpital Saint Louis, AP-HP, Paris, France.; Université Paris Cité, Institut de Recherche Saint Louis (IRSL), Paris, France.
Dumaz N; INSERM, U976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), Paris, France.; Université Paris Cité, Institut de Recherche Saint Louis (IRSL), Paris, France.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Oct; Vol. 13 (10), pp. e1464.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Neoplasms*/genetics
Proto-Oncogene Proteins c-akt*/metabolism
Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Humans ; Carcinogenesis ; Cell Transformation, Neoplastic ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł:
Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth.
Autorzy:
Frappaolo A; Istituto di Biologia e Patologia Molecolari del CNR, c/o Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.
Giansanti MG; Istituto di Biologia e Patologia Molecolari del CNR, c/o Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.
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Źródło:
Cells [Cells] 2023 Nov 14; Vol. 12 (22). Date of Electronic Publication: 2023 Nov 14.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Drosophila melanogaster*/metabolism
TOR Serine-Threonine Kinases*/metabolism
Animals ; Signal Transduction/physiology ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Sirolimus
Czasopismo naukowe
Tytuł:
L-Type Amino Acid Transporter 1 (LAT1) Promotes PMA-Induced Cell Migration through mTORC2 Activation at the Lysosome.
Autorzy:
Tae K; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kim SJ; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Cho SW; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Lee H; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Cha HS; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Choi CY; Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
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Źródło:
Cells [Cells] 2023 Oct 23; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lysosomes*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Large Neutral Amino Acid-Transporter 1*/metabolism
Cell Movement/physiology ; Mechanistic Target of Rapamycin Complex 1 ; Mechanistic Target of Rapamycin Complex 2/metabolism
Czasopismo naukowe
Tytuł:
mTORC1 and SGLT2 Inhibitors-A Therapeutic Perspective for Diabetic Cardiomyopathy.
Autorzy:
Saha S; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Fang X; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Green CD; Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Das A; Division of Cardiology, Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 11; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Diabetes Mellitus, Type 2*/complications
Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/metabolism
Sodium-Glucose Transporter 2 Inhibitors*/pharmacology
Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use
Diabetic Cardiomyopathies*/metabolism
Insulin Resistance*
Hyperlipidemias*/drug therapy
Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Sodium-Glucose Transporter 2 ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Sodium/metabolism
Czasopismo naukowe
Tytuł:
Expression of mTOR in normal and pathological conditions.
Autorzy:
Marques-Ramos A; H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal. .
Cervantes R; H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal.; Public Health Research Centre, NOVA National School of Public Health, Universidade Nova de Lisboa, Lisbon, Portugal.; Comprehensive Health Research Center (CHRC), Lisbon, Portugal.
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Źródło:
Molecular cancer [Mol Cancer] 2023 Jul 15; Vol. 22 (1), pp. 112. Date of Electronic Publication: 2023 Jul 15.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Multiprotein Complexes*/metabolism
Sirolimus*
Humans ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Signal Transduction ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism
Czasopismo naukowe
Tytuł:
Structural Insights into the Giardia lamblia Target of Rapamycin Homolog: A Bioinformatics Approach.
Autorzy:
Muñoz-Muñoz PLA; Biotechnology and Biosciences Research Group, School of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana 22390, Mexico.
Mares-Alejandre RE; Biotechnology and Biosciences Research Group, School of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana 22390, Mexico.
Meléndez-López SG; Biotechnology and Biosciences Research Group, School of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana 22390, Mexico.
Ramos-Ibarra MA; Biotechnology and Biosciences Research Group, School of Chemical Sciences and Engineering, Autonomous University of Baja California, Tijuana 22390, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 26; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 26.
Typ publikacji:
Journal Article
MeSH Terms:
Giardia lamblia*/metabolism
Giardiasis*
Humans ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Signal Transduction ; Mechanistic Target of Rapamycin Complex 2/metabolism
Czasopismo naukowe
Tytuł:
Regulation of mTOR Signaling: Emerging Role of Cyclic Nucleotide-Dependent Protein Kinases and Implications for Cardiometabolic Disease.
Autorzy:
Shi F; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Collins S; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 15; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cardiovascular Diseases*
Multiprotein Complexes*/metabolism
Sirolimus*
TOR Serine-Threonine Kinases*/metabolism
Animals ; Mice ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Nucleotides, Cyclic/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Rapamycin-Insensitive Companion of mTOR Protein/metabolism
Czasopismo naukowe
Tytuł:
Central Suppression of the GH/IGF Axis and Abrogation of Exercise-Related mTORC1/2 Activation in the Muscle of Phenotype-Selected Male Marathon Mice (DUhTP).
Autorzy:
Brenmoehl J; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Walz C; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Caffier C; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.; Department of Neurology, Neuroimmunological Section, University Medicine Rostock, Gehlsheimer Str. 20, 18147 Rostock, Germany.
Brosig E; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.; Department of Neurology, Neuroimmunological Section, University Medicine Rostock, Gehlsheimer Str. 20, 18147 Rostock, Germany.
Walz M; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Ohde D; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Trakooljul N; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Langhammer M; Lab Animal Facility, Research Institute for Genetics and Biometry, Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Ponsuksili S; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Wimmers K; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Zettl UK; Department of Neurology, Neuroimmunological Section, University Medicine Rostock, Gehlsheimer Str. 20, 18147 Rostock, Germany.
Hoeflich A; Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
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Źródło:
Cells [Cells] 2021 Dec 04; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Growth Hormone*/metabolism
Insulin-Like Growth Factor I*/metabolism
Mechanistic Target of Rapamycin Complex 1*/metabolism
Mechanistic Target of Rapamycin Complex 2*/metabolism
Muscles*/metabolism
Physical Conditioning, Animal*
Signal Transduction*
Animals ; Male ; Mice ; Phenotype ; Phosphorylation ; Physical Endurance ; Pituitary Gland/metabolism ; PTEN Phosphohydrolase/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł:
Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1.
Autorzy:
Ghomlaghi M; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia.; Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
Yang G; Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia.
Shin SY; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia.; Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
James DE; Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia.
Nguyen LK; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia.; Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2021 Sep 16; Vol. 17 (9), pp. e1008513. Date of Electronic Publication: 2021 Sep 16 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mechanistic Target of Rapamycin Complex 1/*metabolism
Mechanistic Target of Rapamycin Complex 2/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Animals ; Cell Line ; Intracellular Signaling Peptides and Proteins ; Mechanistic Target of Rapamycin Complex 2/chemistry ; Reproducibility of Results ; Signal Transduction ; mTOR Associated Protein, LST8 Homolog/metabolism
Czasopismo naukowe
Tytuł:
Starvation Protects Hepatocytes from Inflammatory Damage through Paradoxical mTORC1 Signaling.
Autorzy:
Hussain I; Department for Anesthesiology & Intensive Care Medicine, Jena University Hospital, Member of the Leibniz Center for Photonics in Infection Research (LPI), 07747 Jena, Germany.
Sureshkumar HK; Department for Anesthesiology & Intensive Care Medicine, Jena University Hospital, Member of the Leibniz Center for Photonics in Infection Research (LPI), 07747 Jena, Germany.
Bauer M; Department for Anesthesiology & Intensive Care Medicine, Jena University Hospital, Member of the Leibniz Center for Photonics in Infection Research (LPI), 07747 Jena, Germany.; Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
Rubio I; Department for Anesthesiology & Intensive Care Medicine, Jena University Hospital, Member of the Leibniz Center for Photonics in Infection Research (LPI), 07747 Jena, Germany.; Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany.
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Źródło:
Cells [Cells] 2023 Jun 20; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
AMP-Activated Protein Kinases*/metabolism
Liver Failure*
Animals ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Hepatocytes/metabolism
Czasopismo naukowe
Tytuł:
A Novel Bioactive Peptide, T14, Selectively Activates mTORC1 Signalling: Therapeutic Implications for Neurodegeneration and Other Rapamycin-Sensitive Applications.
Autorzy:
Ranglani S; Neuro Bio Ltd., Building F5, Culham Science Centre, Abingdon OX14 3DB, UK.
Ashton A; Neuro Bio Ltd., Building F5, Culham Science Centre, Abingdon OX14 3DB, UK.
Mahfooz K; Neuro Bio Ltd., Building F5, Culham Science Centre, Abingdon OX14 3DB, UK.
Komorowska J; Neuro Bio Ltd., Building F5, Culham Science Centre, Abingdon OX14 3DB, UK.
Graur A; School of Systems Biology, George Mason University, Fairfax, VA 22030, USA.
Kabbani N; School of Systems Biology, George Mason University, Fairfax, VA 22030, USA.
Garcia-Rates S; Neuro Bio Ltd., Building F5, Culham Science Centre, Abingdon OX14 3DB, UK.
Greenfield S; Neuro Bio Ltd., Building F5, Culham Science Centre, Abingdon OX14 3DB, UK.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 09; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 09.
Typ publikacji:
Journal Article
MeSH Terms:
Neuroblastoma*
Alzheimer Disease*/pathology
Rats ; Animals ; Humans ; Sirolimus/pharmacology ; Mechanistic Target of Rapamycin Complex 1/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Peptides ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mammals/metabolism
Czasopismo naukowe
Tytuł:
mTOR Regulation of N-Myc Downstream Regulated 1 (NDRG1) Phosphorylation in Clear Cell Renal Cell Carcinoma.
Autorzy:
Valluri A; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA.
Wellman J; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA.
McCallister CL; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA.
Brown KC; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA.
Lawrence L; Cabell Huntington Hospital Laboratory, Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
Russell R; Cabell Huntington Hospital Laboratory, Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
Jensen J; Edwards Comprehensive Cancer Center, Department of Oncology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
Denvir J; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA.
Valentovic MA; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA.
Denning KL; Cabell Huntington Hospital Laboratory, Department of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA.
Salisbury TB; Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, 1 John Marshall Drive, Huntington, WV 25755, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 27; Vol. 24 (11). Date of Electronic Publication: 2023 May 27.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Renal Cell*/genetics
Kidney Neoplasms*/genetics
Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Multiprotein Complexes/metabolism ; Phosphorylation ; Proteomics ; Proto-Oncogene Proteins c-akt/metabolism ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Transcriptomic Analysis of the Effect of Torin-2 on the Central Nervous System of Drosophila melanogaster .
Autorzy:
Vershinina YS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Krasnov GS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Garbuz DG; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Shaposhnikov MV; Institute of Biology, Komi Science Center, Ural Branch of RAS, 167000 Syktyvkar, Russia.
Fedorova MS; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Pudova EA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Katunina IV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Kornev AB; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Zemskaya NV; Institute of Biology, Komi Science Center, Ural Branch of RAS, 167000 Syktyvkar, Russia.
Kudryavtsev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Bulavkina EV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Matveeva AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Ulyasheva NS; Institute of Biology, Komi Science Center, Ural Branch of RAS, 167000 Syktyvkar, Russia.
Guvatova ZG; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Anurov AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Moskalev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Kudryavtseva AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 22; Vol. 24 (10). Date of Electronic Publication: 2023 May 22.
Typ publikacji:
Journal Article
MeSH Terms:
Drosophila melanogaster*/genetics
Drosophila melanogaster*/metabolism
TOR Serine-Threonine Kinases*/metabolism
Male ; Animals ; Female ; Transcriptome ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Sirolimus/pharmacology ; Central Nervous System/metabolism
Czasopismo naukowe
Tytuł:
mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
Autorzy:
Chantaravisoot N; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Pathumwan, Bangkok, 10330, Thailand. .; Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. .
Wongkongkathep P; Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.; Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Kalpongnukul N; Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Pacharakullanon N; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Pathumwan, Bangkok, 10330, Thailand.
Kaewsapsak P; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Pathumwan, Bangkok, 10330, Thailand.; Research Unit of Systems Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Ariyachet C; Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Pathumwan, Bangkok, 10330, Thailand.; Center of Excellence in Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Loo JA; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.; UCLA/DOE Institute of Genomics and Proteomics, University of California, Los Angeles, CA, 90095, USA.; Department of Biological Chemistry, University of California, Los Angeles, CA, 90095, USA.
Tamanoi F; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, 90095, USA.; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, 606-8501, Japan.
Pisitkun T; Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. .; Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. .
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Źródło:
Scientific reports [Sci Rep] 2023 Apr 29; Vol. 13 (1), pp. 7037. Date of Electronic Publication: 2023 Apr 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gelsolin*/metabolism
Glioblastoma*/metabolism
Humans ; Signal Transduction ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Proteins/metabolism ; Cell Movement/genetics ; Cell Line, Tumor
Czasopismo naukowe
Tytuł:
Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability.
Autorzy:
Rosario FJ; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Chopra A; Institute of Biochemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Biggar K; Institute of Biochemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Powell TL; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Department of Biochemistry, University of Western Ontario, London, ON N6A 3K7, Canada.
Gupta MB; Department of Biochemistry, University of Western Ontario, London, ON N6A 3K7, Canada.; Department of Pediatrics, University of Western Ontario, London, ON N6A 3K7, Canada.; Children's Health Research Institute, University of Western Ontario, London, ON N6A 3K7, Canada.
Jansson T; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 14; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 14.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin-Like Growth Factor I*/metabolism
Placenta*/metabolism
Female ; Humans ; Pregnancy ; Biological Availability ; Insulin-Like Growth Factor Binding Protein 1/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Liver/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Phosphorylation ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł:
Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression.
Autorzy:
Qin S; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Wang G; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Chen L; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Geng H; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Zheng Y; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Xia C; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Wu S; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yao J; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Deng L; College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
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Źródło:
PLoS genetics [PLoS Genet] 2023 Feb 14; Vol. 19 (2), pp. e1010629. Date of Electronic Publication: 2023 Feb 14 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ascorbic Acid*/pharmacology
Neoplasms*/drug therapy
Neoplasms*/genetics
Humans ; F-Box-WD Repeat-Containing Protein 7/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Rapamycin-Insensitive Companion of mTOR Protein/genetics ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Transcription Factors/metabolism ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism
Czasopismo naukowe
Tytuł:
Aft1 Nuclear Localization and Transcriptional Response to Iron Starvation Rely upon TORC2/Ypk1 Signaling and Sphingolipid Biosynthesis.
Autorzy:
Montellà-Manuel S; Cell Signalling in Yeast Unit, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLleida), University of Lleida, 25198 Lleida, Spain.
Pujol-Carrion N; Cell Signalling in Yeast Unit, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLleida), University of Lleida, 25198 Lleida, Spain.
de la Torre-Ruiz MA; Cell Signalling in Yeast Unit, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLleida), University of Lleida, 25198 Lleida, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 26; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 26.
Typ publikacji:
Journal Article
MeSH Terms:
Saccharomyces cerevisiae Proteins*/genetics
Saccharomyces cerevisiae Proteins*/metabolism
Iron/metabolism ; Mechanistic Target of Rapamycin Complex 2/genetics ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Signal Transduction ; Sphingolipids/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe

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