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Wyszukujesz frazę ""Medulloblastoma"" wg kryterium: Temat


Tytuł :
Adult Medulloblastoma Depicted With 99mTc-HYNIC-[D-Phe1, Tyr3-Octreotide] SPECT/CT.
Autorzy :
Spyridonidis T; From the Department of Nuclear Medicine, University Hospital of Patras, Rion Patras, Greece.
Papathanasiou N
Spiliotopoulou M
Papadimitropoulos C
Apostolopoulos DJ
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Źródło :
Clinical nuclear medicine [Clin Nucl Med] 2020 Dec; Vol. 45 (12), pp. 1001-1002.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Organotechnetium Compounds*
Single Photon Emission Computed Tomography Computed Tomography*
Cerebellar Neoplasms/*diagnostic imaging
Medulloblastoma/*diagnostic imaging
Octreotide/*analogs & derivatives
Aged ; Cerebellar Neoplasms/metabolism ; Cerebellar Neoplasms/pathology ; Humans ; Male ; Medulloblastoma/metabolism ; Medulloblastoma/pathology ; Neoplasm Staging ; Receptors, Somatostatin/metabolism
Czasopismo naukowe
Tytuł :
Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study.
Autorzy :
Hill RM; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.
Richardson S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.
Schwalbe EC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK.
Hicks D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.
Lindsey JC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.
Crosier S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.
Rafiee G; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK; School of Electronics, Electrical Engineering and Computer Science, Queen's University Belfast, Centre for Cancer Research & Cell Biology, UK.
Grabovska Y; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.
Wharton SB; Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Jacques TS; Neural Development Unit, UCL Institute of Child Health, London, UK.
Michalski A; Neural Development Unit, UCL Institute of Child Health, London, UK.
Joshi A; Department of Neuropathology, Royal Victoria Infirmary, Newcastle University Teaching Hospitals, NHS Foundation Trust, Newcastle upon Tyne, UK.
Pizer B; Institute of Translational Research, University of Liverpool, Liverpool, UK.
Williamson D; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.
Bailey S; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK.
Clifford SC; Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK. Electronic address: .
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Źródło :
The Lancet. Child & adolescent health [Lancet Child Adolesc Health] 2020 Dec; Vol. 4 (12), pp. 865-874. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebellar Neoplasms/*therapy
Medulloblastoma/*therapy
Neoplasm Recurrence, Local/*therapy
Adolescent ; Case-Control Studies ; Cerebellar Neoplasms/classification ; Cerebellar Neoplasms/mortality ; Cerebellar Neoplasms/pathology ; Child ; Child, Preschool ; Craniospinal Irradiation/statistics & numerical data ; Disease-Free Survival ; Female ; Humans ; Infant ; Male ; Medulloblastoma/classification ; Medulloblastoma/mortality ; Medulloblastoma/pathology ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies ; Time Factors
Czasopismo naukowe
Tytuł :
Medulloblastoma: Improving cure rates in tandem with reduction in short-term toxicities and long-term treatment-related morbidities.
Autorzy :
Gajjar A; Department of Pediatric Medicine, St. Jude Children's Hospital, Memphis, Tennessee.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Nov; Vol. 67 (11), pp. e28645. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Cerebellar Neoplasms*/drug therapy
Craniospinal Irradiation*
Medulloblastoma*/drug therapy
Child ; Drug Therapy, Combination ; Humans ; Japan ; Morbidity
Czasopismo naukowe
Tytuł :
Prolongation of radiotherapy duration is associated with inferior overall survival in patients with pediatric medulloblastoma and central nervous system primitive neuroectodermal tumors.
Autorzy :
Baliga S; Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, Ohio, 43210, United States.
Bajaj BVM; Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Kabarriti R; Department of Radiation Oncology, Montefiore Medical Center, Bronx, New York.
Grassberger C; Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Patteson B; Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Yeap B; Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Fox JL; Department of Radiation Oncology, Montefiore Medical Center, Bronx, New York.
Garg MK; Department of Radiation Oncology, Montefiore Medical Center, Bronx, New York.
Yock TI; Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Oct; Vol. 67 (10), pp. e28558. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article
MeSH Terms :
Duration of Therapy*
Central Nervous System Neoplasms/*mortality
Cerebellar Neoplasms/*mortality
Craniospinal Irradiation/*mortality
Medulloblastoma/*mortality
Neuroectodermal Tumors, Primitive/*mortality
Adolescent ; Adult ; Central Nervous System Neoplasms/pathology ; Central Nervous System Neoplasms/radiotherapy ; Cerebellar Neoplasms/pathology ; Cerebellar Neoplasms/radiotherapy ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Medulloblastoma/pathology ; Medulloblastoma/radiotherapy ; Neuroectodermal Tumors, Primitive/pathology ; Neuroectodermal Tumors, Primitive/radiotherapy ; Prognosis ; Retrospective Studies ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
Radiation-Induced Spinal Cord Cavernous Malformations Associated with Medulloblastoma: Case Report and Review of the Literature.
Autorzy :
Oishi M; Department of Neurosurgery, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan. Electronic address: .
Fujisawa H; Department of Neurosurgery, National Hospital Organization Kanazawa Medical Center, Kanazawa, Ishikawa, Japan.
Tsuchiya K; Department of Neurosurgery, National Hospital Organization Kanazawa Medical Center, Kanazawa, Ishikawa, Japan.
Nakajima Y; Department of Neurosurgery, National Hospital Organization Kanazawa Medical Center, Kanazawa, Ishikawa, Japan.
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Źródło :
World neurosurgery [World Neurosurg] 2020 Sep; Vol. 141, pp. 318-322. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Case Reports; Journal Article; Review
MeSH Terms :
Radiation*
Arteriovenous Malformations/*surgery
Cerebellar Neoplasms/*surgery
Medulloblastoma/*pathology
Neoplasm Recurrence, Local/*pathology
Adult ; Arteriovenous Malformations/diagnosis ; Arteriovenous Malformations/pathology ; Cerebellar Neoplasms/diagnosis ; Cerebellar Neoplasms/pathology ; Humans ; Male ; Medulloblastoma/complications ; Medulloblastoma/surgery ; Neoplasm Recurrence, Local/surgery ; Spinal Cord Neoplasms/diagnosis ; Spinal Cord Neoplasms/etiology ; Spinal Cord Neoplasms/surgery
Czasopismo naukowe
Tytuł :
Development of second primary tumors and outcomes in medulloblastoma by treatment modality: A Surveillance, Epidemiology, and End Results analysis.
Autorzy :
Nantavithya C; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Division of Radiation and Oncology, Department of Radiology, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Paulino AC; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Liao K; Departments of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
McGovern SL; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Grosshans DR; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
McAleer MF; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Woodhouse KD; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Khatua S; Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Chintagumpala MM; Department of Pediatrics, Texas Children's Hospital, Houston, Texas.; Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Majd NK; Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Yeboa DN; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Departments of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Aug; Vol. 67 (8), pp. e28373. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cerebellar Neoplasms*/diagnosis
Cerebellar Neoplasms*/mortality
Cerebellar Neoplasms*/therapy
Databases, Factual*
Medulloblastoma*/diagnosis
Medulloblastoma*/mortality
Medulloblastoma*/therapy
Neoplasms, Second Primary*/diagnosis
Neoplasms, Second Primary*/mortality
Adolescent ; Adult ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Retrospective Studies ; Risk Factors ; Survival Rate
Czasopismo naukowe
Tytuł :
Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma.
Autorzy :
Escudero L; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Llort A; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Arias A; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Diaz-Navarro A; Dpto. de Bioquímica y Biología Molecular, IUOPA-Universidad de Oviedo, 33006, Oviedo, Spain.; CIBERONC, Barcelona, Spain.
Martínez-Ricarte F; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), 08193, Cerdanyola del Vallès, Spain.
Rubio-Perez C; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Mayor R; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Caratù G; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Martínez-Sáez E; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Vázquez-Méndez É; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Lesende-Rodríguez I; Universidade de A Coruña (UDC), 15006, A Coruña, Spain.
Hladun R; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Gros L; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Ramón Y Cajal S; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Poca MA; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), 08193, Cerdanyola del Vallès, Spain.
Puente XS; Dpto. de Bioquímica y Biología Molecular, IUOPA-Universidad de Oviedo, 33006, Oviedo, Spain.; CIBERONC, Barcelona, Spain.
Sahuquillo J; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), 08193, Cerdanyola del Vallès, Spain.
Gallego S; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron University Hospital, 08035, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), 08193, Cerdanyola del Vallès, Spain.
Seoane J; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035, Barcelona, Spain. .; CIBERONC, Barcelona, Spain. .; Universitat Autònoma de Barcelona (UAB), 08193, Cerdanyola del Vallès, Spain. .; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain. .
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Źródło :
Nature communications [Nat Commun] 2020 Oct 27; Vol. 11 (1), pp. 5376. Date of Electronic Publication: 2020 Oct 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Neoplasms/*cerebrospinal fluid
Circulating Tumor DNA/*cerebrospinal fluid
Medulloblastoma/*cerebrospinal fluid
Biomarkers, Tumor/cerebrospinal fluid ; Biomarkers, Tumor/genetics ; Brain Neoplasms/diagnosis ; Brain Neoplasms/genetics ; Circulating Tumor DNA/genetics ; DNA, Neoplasm/cerebrospinal fluid ; DNA, Neoplasm/genetics ; Genomics ; Humans ; Medulloblastoma/diagnosis ; Medulloblastoma/genetics
Czasopismo naukowe
Tytuł :
Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix.
Autorzy :
Cheng Y; College of Pharmaceutical Sciences, Soochow University, Suzhou, China.; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA.
Franco-Barraza J; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA.
Wang Y; College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Zheng C; College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Zhang L; College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Qu Y; College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Long Y; College of Pharmaceutical Sciences, Soochow University, Suzhou, China.
Cukierman E; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA. .
Yang ZJ; Cancer biology program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA, USA. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2020 Sep; Vol. 100 (9), pp. 1208-1222. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Astrocytes/*metabolism
Cerebellar Neoplasms/*genetics
Extracellular Matrix/*metabolism
Hedgehog Proteins/*genetics
Medulloblastoma/*genetics
Signal Transduction/*genetics
Animals ; Astrocytes/pathology ; Cell Line, Tumor ; Cerebellar Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Hedgehog Proteins/metabolism ; Humans ; Medulloblastoma/metabolism ; Medulloblastoma/pathology ; Mice, Knockout ; Mice, SCID ; Mice, Transgenic ; Patched-2 Receptor/genetics ; Patched-2 Receptor/metabolism ; Tumor Microenvironment/genetics ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism
Czasopismo naukowe
Tytuł :
Wnt activation as a therapeutic strategy in medulloblastoma.
Autorzy :
Manoranjan B; Section of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, AB, T2N 1N4, Canada.; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Venugopal C; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Bakhshinyan D; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Adile AA; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Richards L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2M9, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Kameda-Smith MM; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Whitley O; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Dvorkin-Gheva A; Department of Pathology, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Subapanditha M; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.
Savage N; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.
Tatari N; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.
McKenna D; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Bassey-Archibong B; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.
Winegarden N; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2M9, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Hallett R; Northern Biologics, Toronto, ON, M5G 1L7, Canada.
Provias JP; Department of Pathology, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Yarascavitch B; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Ajani O; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Fleming A; Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Bader GD; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Computer Science, University of Toronto, Toronto, ON, M5S 1A8, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada.
Pugh TJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2M9, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Doble BW; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, R3E 0W2, Canada.; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, R3E 0W2, Canada.
Singh SK; McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada. .; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada. .; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, L8N 3Z5, Canada. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 28; Vol. 11 (1), pp. 4323. Date of Electronic Publication: 2020 Aug 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebellar Neoplasms/*therapy
Medulloblastoma/*therapy
Wnt Proteins/*pharmacology
Wnt Proteins/*therapeutic use
Animals ; Carcinogenesis ; Cell Line, Tumor ; Cell Proliferation ; Cerebellar Neoplasms/pathology ; Disease Models, Animal ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Heterografts ; Humans ; Medulloblastoma/genetics ; Medulloblastoma/pathology ; Mice ; Stem Cells ; Wnt Proteins/genetics ; Wnt Signaling Pathway ; beta Catenin/therapeutic use
Czasopismo naukowe
Tytuł :
Anesthesia Exposure during Therapy Predicts Neurocognitive Outcomes in Survivors of Childhood Medulloblastoma.
Autorzy :
Jacola LM; Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN. Electronic address: .
Anghelescu DL; Department of Anesthesiology, St. Jude Children's Research Hospital, Memphis, TN.
Hall L; Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN.
Russell K; Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN.
Zhang H; Department of Biostatics, St. Jude Children's Research Hospital, Memphis, TN.
Wang F; Department of Biostatics, St. Jude Children's Research Hospital, Memphis, TN.
Peters JB; Department of Psychology, St. Jude Children's Research Hospital, Memphis, TN.
Rossi M; Department of Anesthesiology, St. Jude Children's Research Hospital, Memphis, TN.
Schreiber JE; Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, PA.
Gajjar A; Department of Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN.
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Źródło :
The Journal of pediatrics [J Pediatr] 2020 Aug; Vol. 223, pp. 141-147.e4. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anesthesia/*methods
Attention/*physiology
Cerebellar Neoplasms/*therapy
Cognition Disorders/*etiology
Medulloblastoma/*therapy
Memory, Short-Term/*physiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*therapy
Adolescent ; Cerebellar Neoplasms/complications ; Cerebellar Neoplasms/physiopathology ; Child ; Child, Preschool ; Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Combined Modality Therapy/methods ; Female ; Humans ; Male ; Medulloblastoma/complications ; Medulloblastoma/physiopathology ; Mental Status and Dementia Tests ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/physiopathology ; Prognosis ; Retrospective Studies ; Risk Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Survival difference between brainstem and cerebellum medulloblastoma: the surveillance, epidemiology, and end results-based study.
Autorzy :
Qin Q; Department of neurosurgery, Second Xiangya Hospital of Central South University, Changsha, China.
Huang D
Jiang Y
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Źródło :
Medicine [Medicine (Baltimore)] 2020 Oct 09; Vol. 99 (41), pp. e22366.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Brain Stem Neoplasms/*mortality
Medulloblastoma/*mortality
Brain Stem Neoplasms/therapy ; Case-Control Studies ; Cerebellar Neoplasms/mortality ; Cerebellar Neoplasms/therapy ; Child, Preschool ; China/epidemiology ; Female ; Humans ; Infant ; Male ; Medulloblastoma/therapy ; Prognosis ; Propensity Score ; Registries ; Retrospective Studies ; SEER Program ; Survival Rate
Czasopismo naukowe
Tytuł :
Possible association between the integrity of cerebellar pathways and neurocognitive performance in children with posterior fossa tumors.
Autorzy :
Liguoro I; Division of Pediatrics, Department of Medicine-DAME, University of Udine, Udine, Italy.
Passone E; Division of Pediatrics, University Hospital of Udine, Udine, Italy.
Zilli T; San Vito al Tagliamento, Pordenone, Scientific Institute Eugenio Medea, Italy.
Maieron M; Department of Medical Physics, University Hospital of Udine, Udine, Italy.
De Colle MC; Department of Neuroradiology, University Hospital of Udine, Udine, Italy.
Skrap M; Department of Neurosurgery, University Hospital of Udine, Udine, Italy.
Dolcemascolo V; Division of Pediatrics, Department of Medicine-DAME, University of Udine, Udine, Italy.
Sommariva G; Division of Pediatrics, Department of Medicine-DAME, University of Udine, Udine, Italy.; Child Neuropsychiatry, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.
Cogo P; Division of Pediatrics, Department of Medicine-DAME, University of Udine, Udine, Italy.; Division of Pediatrics, University Hospital of Udine, Udine, Italy.
Tomasino B; San Vito al Tagliamento, Pordenone, Scientific Institute Eugenio Medea, Italy.
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Źródło :
Pediatric blood & cancer [Pediatr Blood Cancer] 2020 Sep; Vol. 67 (9), pp. e28538. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebellar Neoplasms/*surgery
Cognition Disorders/*pathology
Infratentorial Neoplasms/*surgery
Medulloblastoma/*surgery
Memory Disorders/*pathology
Neurosurgical Procedures/*adverse effects
Adolescent ; Cerebellar Neoplasms/pathology ; Child ; Child, Preschool ; Cognition Disorders/etiology ; Diffusion Tensor Imaging ; Female ; Follow-Up Studies ; Humans ; Infratentorial Neoplasms/pathology ; Intelligence Tests ; Male ; Medulloblastoma/pathology ; Memory Disorders/etiology ; Neuroimaging ; Neuropsychological Tests ; Pilot Projects ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
Autorzy :
Hwang GH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Segal RA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Developmental cell [Dev Cell] 2020 Aug 24; Vol. 54 (4), pp. 425-426.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Cerebellar Neoplasms*
Medulloblastoma*/genetics
Carcinogenesis ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Humans ; Mutation ; Rhombencephalon/metabolism
Czasopismo naukowe
Tytuł :
Aggressive Medulloblastoma-Derived Exosomal miRNAs Promote In Vitro Invasion and Migration of Tumor Cells Via Ras/MAPK Pathway.
Autorzy :
Zhu LY; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center.
Wu XY; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center.
Liu XD; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center.; Beijing Key Laboratory of Research and Transformation of Biomarkers for Neurodegenerative Diseases, Peking University Third Hospital, Peking University Health Science Center.
Zheng DF; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center.; Beijing Key Laboratory of Research and Transformation of Biomarkers for Neurodegenerative Diseases, Peking University Third Hospital, Peking University Health Science Center.
Li HS; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center.
Yang B; Department of Neuro-surgery, Tiantan Hospital, Capital University of Medical Science (BY), Beijing, China.
Zhang J; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center.; Beijing Key Laboratory of Research and Transformation of Biomarkers for Neurodegenerative Diseases, Peking University Third Hospital, Peking University Health Science Center.; Department of Pathology, University of Washington, Seattle, Washington.
Chang Q; Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center.; Beijing Key Laboratory of Research and Transformation of Biomarkers for Neurodegenerative Diseases, Peking University Third Hospital, Peking University Health Science Center.
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Źródło :
Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2020 Jul 01; Vol. 79 (7), pp. 734-745.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Movement/*physiology
Cerebellar Neoplasms/*metabolism
Exosomes/*metabolism
Genes, ras/*physiology
MAP Kinase Signaling System/*physiology
Medulloblastoma/*metabolism
MicroRNAs/*metabolism
Cell Line, Tumor ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/pathology ; Exosomes/genetics ; Humans ; Medulloblastoma/genetics ; Medulloblastoma/pathology ; MicroRNAs/genetics ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology
Czasopismo naukowe
Tytuł :
Advances in the molecular classification of pediatric brain tumors: a guide to the galaxy.
Autorzy :
Cacciotti C; Division of Pediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton, ON, Canada.; Dana Farber/Boston Children's Cancer and Blood Disorder Center, Boston, MA, USA.
Fleming A; Division of Pediatric Hematology/Oncology, McMaster Children's Hospital, Hamilton, ON, Canada.
Ramaswamy V; Division of Haematology/Oncology, Department of Pediatrics, University of Toronto and The Hospital for Sick Children, Toronto, ON, Canada.; Programme in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics and Pediatrics, University of Toronto, Toronto, ON, Canada.
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Źródło :
The Journal of pathology [J Pathol] 2020 Jul; Vol. 251 (3), pp. 249-261. Date of Electronic Publication: 2020 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biomarkers, Tumor/*genetics
Brain Neoplasms/*genetics
Cerebellar Neoplasms/*genetics
Ependymoma/*genetics
Glioma/*genetics
Medulloblastoma/*genetics
Rhabdoid Tumor/*genetics
Teratoma/*genetics
Age of Onset ; Brain Neoplasms/classification ; Brain Neoplasms/mortality ; Brain Neoplasms/pathology ; Cerebellar Neoplasms/classification ; Cerebellar Neoplasms/mortality ; Cerebellar Neoplasms/pathology ; Ependymoma/classification ; Ependymoma/mortality ; Ependymoma/pathology ; Genetic Predisposition to Disease ; Glioma/classification ; Glioma/mortality ; Glioma/pathology ; Humans ; Medulloblastoma/classification ; Medulloblastoma/mortality ; Medulloblastoma/pathology ; Neoplasm Grading ; Phenotype ; Rhabdoid Tumor/classification ; Rhabdoid Tumor/mortality ; Rhabdoid Tumor/pathology ; Teratoma/classification ; Teratoma/mortality ; Teratoma/pathology
SCR Disease Name :
Teratoid Tumor, Atypical
Czasopismo naukowe
Tytuł :
Cerebrospinal fluid cytokines in metastatic group 3 and 4 medulloblastoma.
Autorzy :
Low SYY; Neurosurgical Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore. .; Department of Neurosurgery, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore. .; SingHealth Duke-NUS Neuroscience Academic Clinical Program, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore. .; VIVA-KKH Paediatric Brain and Solid Tumours Laboratory, 100 Bukit Timah Road, Singapore, 229899, Singapore. .
Bte Syed Sulaiman N; Department of Neurosurgery, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.; VIVA-KKH Paediatric Brain and Solid Tumours Laboratory, 100 Bukit Timah Road, Singapore, 229899, Singapore.
Tan EEK; Paediatric Haematology/Oncology Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
Ng LP; Neurosurgical Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
Kuick CH; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
Chang KTE; VIVA-KKH Paediatric Brain and Solid Tumours Laboratory, 100 Bukit Timah Road, Singapore, 229899, Singapore.; Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
Tang PH; Department of Diagnostic and Interventional Imaging, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.
Wong RX; Department of Radiation Oncology, 11 Hospital Drive, Singapore, 169610, Singapore.
Looi WS; Department of Radiation Oncology, 11 Hospital Drive, Singapore, 169610, Singapore.
Low DCY; Neurosurgical Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.; Department of Neurosurgery, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.; SingHealth Duke-NUS Neuroscience Academic Clinical Program, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
Seow WT; Neurosurgical Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.; Department of Neurosurgery, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.; SingHealth Duke-NUS Neuroscience Academic Clinical Program, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
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Źródło :
BMC cancer [BMC Cancer] 2020 Jun 15; Vol. 20 (1), pp. 554. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Biomarkers, Tumor/*cerebrospinal fluid
Cerebellar Neoplasms/*pathology
Cytokines/*cerebrospinal fluid
Medulloblastoma/*diagnosis
Biomarkers, Tumor/immunology ; Brain/diagnostic imaging ; Cerebellar Neoplasms/cerebrospinal fluid ; Cerebellar Neoplasms/immunology ; Cerebellar Neoplasms/surgery ; Child ; Child, Preschool ; Cytokines/immunology ; Female ; Follow-Up Studies ; Gene Expression Profiling ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Medulloblastoma/cerebrospinal fluid ; Medulloblastoma/secondary ; Medulloblastoma/surgery ; Proof of Concept Study ; Prospective Studies ; Proteomics ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Prognostic role of chemotherapy, radiotherapy dose, and extent of surgical resection in adult medulloblastoma.
Autorzy :
Haque W; Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA. Electronic address: .
Verma V; Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA, USA.
Brian Butler E; Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA.
Teh BS; Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA.
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Źródło :
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2020 Jun; Vol. 76, pp. 154-160. Date of Electronic Publication: 2020 Apr 11.
Typ publikacji :
Journal Article
MeSH Terms :
Chemoradiotherapy*
Cerebellar Neoplasms/*therapy
Craniospinal Irradiation/*methods
Medulloblastoma/*diagnosis
Medulloblastoma/*therapy
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Cerebellar Neoplasms/diagnosis ; Cerebellar Neoplasms/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Medulloblastoma/mortality ; Middle Aged ; Neurosurgical Procedures ; Prognosis ; Proportional Hazards Models ; Radiotherapy Dosage ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Texture Analysis of T1-Weighted Contrast-Enhanced Magnetic Resonance Imaging Potentially Predicts Outcomes of Patients with Non-Wingless-Type/Non-Sonic Hedgehog Medulloblastoma.
Autorzy :
Li J; Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China.
Chen C; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Fu R; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang Y; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Fan Y; Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Xu J; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Cen Y; Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu, China. Electronic address: .
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Źródło :
World neurosurgery [World Neurosurg] 2020 May; Vol. 137, pp. e27-e33. Date of Electronic Publication: 2019 Oct 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cerebellar Neoplasms/*diagnostic imaging
Medulloblastoma/*diagnostic imaging
Adolescent ; Adult ; Cerebellar Neoplasms/metabolism ; Cerebellar Neoplasms/mortality ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Medulloblastoma/metabolism ; Medulloblastoma/mortality ; Prognosis ; Retrospective Studies ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate.
Autorzy :
Zagozewski J; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Shahriary GM; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Morrison LC; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Saulnier O; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Stromecki M; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.
Fresnoza A; Central Animal Care Services, University of Manitoba, Winnipeg, MB, Canada.
Palidwor G; Ottawa Bioinformatics Core Facility, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Porter CJ; Ottawa Bioinformatics Core Facility, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Forget A; Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.; Université Paris Sud, Orsay France, Université Paris-Saclay, CNRS UMR 3347, INSERM, U1021, Orsay, France.
Ayrault O; Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.; Université Paris Sud, Orsay France, Université Paris-Saclay, CNRS UMR 3347, INSERM, U1021, Orsay, France.
Hawkins C; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Chan JA; Department of Pathology & Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
Vladoiu MC; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Sundaresan L; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Arsenio J; Departments of Internal Medicine and Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.; Manitoba Centre for Proteomics and Systems Biology, Winnipeg, MB, Canada.
Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
Ramaswamy V; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Haematology/Oncology, University of Toronto and The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Werbowetski-Ogilvie TE; Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 20; Vol. 11 (1), pp. 3627. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebellar Neoplasms*/genetics
Cerebellar Neoplasms*/metabolism
Medulloblastoma*/genetics
Medulloblastoma*/metabolism
Carcinogenesis/*genetics
Otx Transcription Factors/*metabolism
PAX3 Transcription Factor/*genetics
Animals ; Carcinogenesis/metabolism ; Cell Differentiation/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplastic Stem Cells/metabolism ; Oncogenes ; PAX3 Transcription Factor/metabolism ; PAX6 Transcription Factor/genetics ; PAX6 Transcription Factor/metabolism ; Signal Transduction/genetics
Czasopismo naukowe

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