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Wyświetlanie 1-20 z 1950
Tytuł:
Applied physiologically-based pharmacokinetic modeling to assess uridine diphosphate-glucuronosyltransferase-mediated drug-drug interactions for Vericiguat.
Autorzy:
Frechen S; Pharmacometrics/Modeling and Simulation, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
Ince I; Pharmacometrics/Modeling and Simulation, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
Dallmann A; Pharmacometrics/Modeling and Simulation, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
Gerisch M; DMPK, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
Jungmann NA; DMPK, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
Becker C; Clinical Pharmacology, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
Lobmeyer M; Clinical Pharmacology, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
Trujillo ME; Merck & Co., Inc., Rahway, New Jersey, USA.
Xu S; Merck & Co., Inc., Rahway, New Jersey, USA.
Burghaus R; Pharmacometrics/Modeling and Simulation, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
Meyer M; Pharmacometrics/Modeling and Simulation, Research and Development, Pharmaceuticals, Bayer AG, Leverkusen, Germany.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Jan; Vol. 13 (1), pp. 79-92. Date of Electronic Publication: 2023 Oct 12.
Typ publikacji:
Journal Article
MeSH Terms:
Mefenamic Acid*
Glucuronosyltransferase*/metabolism
Heterocyclic Compounds, 2-Ring*
Pyrimidines*
Humans ; Atazanavir Sulfate ; Drug Interactions
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis.
Autorzy:
Khodov I; G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia.
Sobornova V; G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia.
Mulloyarova V; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 198504, Russia.
Belov K; G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia.
Dyshin A; G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia.
de Carvalho LB; Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
Tolstoy P; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 198504, Russia.
Kiselev M; G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 07; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 07.
Typ publikacji:
Journal Article
MeSH Terms:
Mefenamic Acid*
Silicon Dioxide*
Kinetics ; Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Imaging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mitochondrial protective effects caused by the administration of mefenamic acid in sepsis.
Autorzy:
Dominguini D; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil. diogo_.
Michels M; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil.
Wessler LB; Laboratory of Bioenergetics, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil.
Streck EL; Laboratory of Bioenergetics, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil.
Barichello T; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil.; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.
Dal-Pizzol F; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, 88806-000, Brazil.
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2022 Nov 04; Vol. 19 (1), pp. 268. Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article
MeSH Terms:
Mefenamic Acid*/metabolism
Mefenamic Acid*/pharmacology
Sepsis*/complications
Sepsis*/drug therapy
Animals ; Rats ; Male ; Reactive Oxygen Species/metabolism ; Rats, Wistar ; Inflammasomes/metabolism ; Nerve Growth Factor/metabolism ; Mitochondria ; DNA, Mitochondrial ; Cytokines/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neocuproine-Based Sensitive Flow Injection Method for Mefenamic Acid Determination in Aqueous Solutions and Pharmaceutical Formulations.
Autorzy:
Nayef, Ali Naser
Hussain, Alaa Frak
Taha, Dakhil Nassir
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Alternatywny tytuł:
Método de inyección de flujo sensible a base de neocuproina para la determinación de ácido mefenámico en soluciones acuosas y formulaciones farmacéuticas.
Źródło:
Ars Pharmaceutica. ene-mar2024, Vol. 65 Issue 1, p45-55. 11p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies.
Autorzy:
Sid D; Département de Génie des Procédés, Faculté de Technologie, Laboratoire de Préparation, Modification et Applications des Matériaux Polymériques Multiphasiques, Université Ferhat Abbas Sétif-1, Sétif, Algérie.
Baitiche M; Département de Génie des Procédés, Faculté de Technologie, Laboratoire de Préparation, Modification et Applications des Matériaux Polymériques Multiphasiques, Université Ferhat Abbas Sétif-1, Sétif, Algérie.
Elbahri Z; Faculty of Exact Sciences, Laboratory of Materials and Catalysis, Djillali Liabès University of Sidi Bel Abbès, Sidi Bel Abbès, Algeria.
Djerboua F; Département de Génie des Procédés, Faculté de Technologie, Laboratoire de Préparation, Modification et Applications des Matériaux Polymériques Multiphasiques, Université Ferhat Abbas Sétif-1, Sétif, Algérie.
Boutahala M; Département de Génie des Procédés, Faculté de Technologie, Laboratoire de Génie des Procédés Chimiques, Université Ferhat Abbas Sétif-1, Sétif, Algérie.
Bouaziz Z; EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453 - INSERM US7, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, France.
Le Borgne M; EA 4446 Bioactive Molecules and Medicinal Chemistry, SFR Santé Lyon-Est CNRS UMS3453 - INSERM US7, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, France.; Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Small Molecules for Biological Targets Team, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, France.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 605-617.
Typ publikacji:
Journal Article
MeSH Terms:
Mefenamic Acid/*chemistry
beta-Cyclodextrins/*chemistry
Animals ; Cattle ; Erythrocytes/drug effects ; Humans ; Mefenamic Acid/pharmacology ; Models, Molecular ; Molecular Structure ; Protein Denaturation/drug effects ; Serum Albumin, Bovine/chemistry ; Solubility ; beta-Cyclodextrins/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of effect of auriculotherapy and mefenamic acid on the severity and systemic symptoms of primary dysmenorrhea: a randomized clinical trial.
Autorzy:
Vahedi M; Department of Midwifery and Reproductive, Nursing Care Research Center (NCRC), School of Nursing and Midwifery, Iran University of Medical Sciences, Rashid Yasemi st., Valiasr St, Tehran, 1996713883, Iran.
Hasanpoor-Azghady SB; Department of Midwifery and Reproductive, Nursing Care Research Center (NCRC), School of Nursing and Midwifery, Iran University of Medical Sciences, Rashid Yasemi st., Valiasr St, Tehran, 1996713883, Iran. .
Amiri-Farahani L; Department of Midwifery and Reproductive, Nursing Care Research Center (NCRC), School of Nursing and Midwifery, Iran University of Medical Sciences, Rashid Yasemi st., Valiasr St, Tehran, 1996713883, Iran.
Khaki I; Department of Midwifery and Reproductive, Nursing Care Research Center (NCRC), School of Nursing and Midwifery, Iran University of Medical Sciences, Rashid Yasemi st., Valiasr St, Tehran, 1996713883, Iran.
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Źródło:
Trials [Trials] 2021 Sep 26; Vol. 22 (1), pp. 655. Date of Electronic Publication: 2021 Sep 26.
Typ publikacji:
Journal Article; Randomized Controlled Trial
MeSH Terms:
Auriculotherapy*
Dysmenorrhea*/therapy
Mefenamic Acid*
Adolescent ; Anti-Inflammatory Agents, Non-Steroidal ; Female ; Humans ; Menstruation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Model-Informed Pediatric Dose Selection for Dapagliflozin by Incorporating Developmental Changes.
Autorzy:
Jo H; Modelling and Simulation, Early Oncology, Oncology R&D, AstraZeneca, Cambridge, UK.
Pilla Reddy V; Modelling and Simulation, Early Oncology, Oncology R&D, AstraZeneca, Cambridge, UK.; Clinical Pharmacology and Quantitative Pharmacology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Parkinson J; Clinical Pharmacology and Quantitative Pharmacology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Boulton DW; Clinical Pharmacology and Quantitative Pharmacology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.
Tang W; Clinical Pharmacology and Quantitative Pharmacology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Feb; Vol. 10 (2), pp. 108-118. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Benzhydryl Compounds/*pharmacokinetics
Glucosides/*pharmacokinetics
Glucuronosyltransferase/*metabolism
Mefenamic Acid/*pharmacokinetics
Rifampin/*pharmacokinetics
Sodium-Glucose Transporter 2 Inhibitors/*pharmacokinetics
UDP-Glucuronosyltransferase 1A9/*metabolism
Administration, Oral ; Adolescent ; Antibiotics, Antitubercular/administration & dosage ; Antibiotics, Antitubercular/adverse effects ; Antibiotics, Antitubercular/pharmacokinetics ; Area Under Curve ; Child ; Child, Preschool ; Computer Simulation ; Cyclooxygenase Inhibitors/administration & dosage ; Cyclooxygenase Inhibitors/adverse effects ; Cyclooxygenase Inhibitors/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Interactions ; Female ; Healthy Volunteers/statistics & numerical data ; Hepatic Insufficiency/drug therapy ; Humans ; Infant ; Infant, Newborn ; Male ; Mefenamic Acid/administration & dosage ; Mefenamic Acid/adverse effects ; Models, Biological ; Predictive Value of Tests ; Renal Insufficiency/drug therapy ; Rifampin/administration & dosage ; Rifampin/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid.
Autorzy:
Callegari E; Department of Medicine Design-Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Lin J; Department of Medicine Design-Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Tse S; Department of Medicine Design-Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Goosen TC; Department of Medicine Design-Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Sahasrabudhe V; Department of Clinical Pharmacology, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
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Źródło:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Feb; Vol. 10 (2), pp. 127-136. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bridged Bicyclo Compounds, Heterocyclic/*pharmacokinetics
Cyclooxygenase Inhibitors/*pharmacokinetics
Glucuronosyltransferase/*metabolism
Mefenamic Acid/*pharmacokinetics
Sodium-Glucose Transporter 2 Inhibitors/*pharmacokinetics
Adult ; Area Under Curve ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Bridged Bicyclo Compounds, Heterocyclic/metabolism ; Cyclooxygenase Inhibitors/administration & dosage ; Cyclooxygenase Inhibitors/metabolism ; Drug Interactions ; Female ; Healthy Volunteers ; Humans ; Male ; Mefenamic Acid/administration & dosage ; Mefenamic Acid/metabolism ; Middle Aged ; Models, Biological ; Sodium-Glucose Transporter 2 Inhibitors/administration & dosage ; Sodium-Glucose Transporter 2 Inhibitors/metabolism ; UDP-Glucuronosyltransferase 1A9 ; Uridine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/COX-2 inhibitors with potentially reduced gastric toxicity.
Autorzy:
Jones Lipinski RA; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, USA.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, WI, USA.
Thillier Y; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, USA.
Morisseau C; Department of Entomology and Nematology, U.C. Davis Comprehensive Cancer Center, University of California Davis, Davis, CA, USA.
Sebastiano CS Jr; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, USA.
Smith BC; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.; Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, WI, USA.
Hall CD; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, USA.
Katritzky AR; Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, USA.; Chemistry Department, Faculty of Science, King Adbulaziz University, Jeddah, Saudi Arabia.
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Źródło:
Chemical biology & drug design [Chem Biol Drug Des] 2021 Jul; Vol. 98 (1), pp. 102-113. Date of Electronic Publication: 2021 May 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents, Non-Steroidal/*chemistry
Cyclooxygenase 1/*metabolism
Cyclooxygenase 2/*metabolism
Cyclooxygenase Inhibitors/*chemistry
Glucosamine/*chemistry
Glycoconjugates/*chemistry
Mefenamic Acid/*chemistry
Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Catalytic Domain ; Cyclooxygenase Inhibitors/adverse effects ; Diclofenac/chemistry ; Drug Design ; Glycoconjugates/adverse effects ; Mefenamic Acid/adverse effects ; Molecular Docking Simulation ; Protein Binding ; Protein Conformation ; Stomach ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: a randomized clinical trial.
Autorzy:
Amzajerdi A; School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Keshavarz M; Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Reproductive Sciences and Technology Research Center, Department of Midwifery and Reproductive Health, Iran University of Medical Sciences, Rashid Yasemi St., Valiasr St, Tehran, 1996713883, Iran. .
Ghorbali E; School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.
Pezaro S; Centre for Healthcare Research, Coventry University, Coventry, UK.; The University of Notre Dame, Fremantle, Australia.
Sarvi F; Department of Public Health, School of Health, Larestan University of Medical Sciences, Shiraz, Fars, Iran.
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Źródło:
BMC women's health [BMC Womens Health] 2023 Mar 27; Vol. 23 (1), pp. 138. Date of Electronic Publication: 2023 Mar 27.
Typ publikacji:
Randomized Controlled Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dysmenorrhea*/drug therapy
Menstruation*
Female ; Humans ; Adolescent ; Young Adult ; Adult ; Vitamin D/therapeutic use ; Iran ; Mefenamic Acid/pharmacology ; Mefenamic Acid/therapeutic use ; Hemorrhage
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A composite adsorbent of graphene quantum dots, mesoporous carbon, and molecularly imprinted polymer to extract nonsteroidal anti-inflammatory drugs in milk.
Autorzy:
Orachorn N; Center of Excellence for Innovation in Chemistry, Division of Physical Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Bunkoed O; Center of Excellence for Innovation in Chemistry, Division of Physical Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. .
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Źródło:
Mikrochimica acta [Mikrochim Acta] 2022 Nov 12; Vol. 189 (12), pp. 446. Date of Electronic Publication: 2022 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Graphite*/chemistry
Molecular Imprinting*/methods
Quantum Dots*/analysis
Flurbiprofen*
Diflunisal*/analysis
Animals ; Milk/chemistry ; Molecularly Imprinted Polymers ; Solid Phase Extraction/methods ; Mefenamic Acid/analysis ; Silicon Dioxide/chemistry ; Carbon ; Reproducibility of Results ; Anti-Inflammatory Agents, Non-Steroidal/analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Toxicity and Therapeutic Efficacy of Mefenamic Acid and its Hydroxyethyl Ester in Mice: In Vivo Comparative Study: A promising Drug Derivative.
Autorzy:
Adel, Islam
Jarrar, Qais
Ayoub, Rami
Jilani, Jamal
Moshawih, Said
Al-Qadi, Enas
Zihlif, Malek
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Alternatywny tytuł:
السمية والفعالية العلاجية لكل من حمض الميفيناميك وهيدروكسي إيثيل إيستر حمض الميفيناميك في الفئران: دراسة مقارنة داخل الجسم الحي.
Źródło:
Jordan Journal of Pharmaceutical Sciences. Dec2022, Vol. 15 Issue 4, p507-522. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 1950

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