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Wyszukujesz frazę ""Melarsoprol"" wg kryterium: Temat


Tytuł :
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Autorzy :
Ndung'u K; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Murilla GA; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.; KAG EAST University, Nairobi, Kenya.
Thuita JK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.; Meru University of Science and Technology, Meru, Kenya.
Ngae GN; Food Crops Research Institute, Kenya Agricultural and Livestock Research Organization, Nairobi, Kenya.
Auma JE; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Gitonga PK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Thungu DK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Kurgat RK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Chemuliti JK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Mdachi RE; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
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Źródło :
PloS one [PLoS One] 2020 Nov 05; Vol. 15 (11), pp. e0229060. Date of Electronic Publication: 2020 Nov 05 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Trypanocidal Agents/*pharmacology
Trypanosoma brucei rhodesiense/*drug effects
Trypanosomiasis, African/*drug therapy
Virulence/*drug effects
Animals ; Diminazene/analogs & derivatives ; Diminazene/pharmacology ; Disease Models, Animal ; Drug Resistance/drug effects ; Kenya ; Male ; Melarsoprol/pharmacology ; Mice ; Pentamidine/pharmacology ; Suramin/pharmacology ; Treatment Outcome ; Trypanosomiasis, African/parasitology ; Uganda
Czasopismo naukowe
Tytuł :
Melarsoprol Resistance in African Trypanosomiasis.
Autorzy :
Fairlamb AH; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK; ORCID: http://orcid.org/0000-0001-5134-0329.
Horn D; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK; ORCID: http://orcid.org/0000-0001-5173-9284. Electronic address: .
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Źródło :
Trends in parasitology [Trends Parasitol] 2018 Jun; Vol. 34 (6), pp. 481-492. Date of Electronic Publication: 2018 Apr 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Melarsoprol/*therapeutic use
Trypanosomiasis, African/*drug therapy
Trypanosomiasis, African/*parasitology
Aquaglyceroporins/genetics ; Drug Resistance/genetics ; Humans ; Melarsoprol/pharmacology ; Mutation ; Trypanosoma brucei gambiense/drug effects ; Trypanosoma brucei gambiense/genetics
Czasopismo naukowe
Tytuł :
Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.
Autorzy :
Steverding D; Bob Champion Research & Education Building, Norwich Medical School, University of East Anglia, Norwich, NR4 7UQ, UK. Electronic address: .
Rushworth SA; Bob Champion Research & Education Building, Norwich Medical School, University of East Anglia, Norwich, NR4 7UQ, UK.
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Źródło :
Experimental parasitology [Exp Parasitol] 2017 Jul; Vol. 178, pp. 45-50. Date of Electronic Publication: 2017 May 25.
Typ publikacji :
Journal Article
MeSH Terms :
Dacarbazine/*analogs & derivatives
Eflornithine/*pharmacology
Melarsoprol/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei brucei/*drug effects
Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; Antineoplastic Agents, Alkylating/toxicity ; Brain Neoplasms/drug therapy ; Dacarbazine/pharmacology ; Dacarbazine/therapeutic use ; Dacarbazine/toxicity ; Drug Therapy, Combination ; Eflornithine/therapeutic use ; Glioblastoma/drug therapy ; HL-60 Cells ; Humans ; Melarsoprol/therapeutic use ; Temozolomide ; Trypanocidal Agents/therapeutic use ; Trypanocidal Agents/toxicity ; Trypanosomiasis, African/drug therapy
Czasopismo naukowe
Tytuł :
Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo.
Autorzy :
Pyana Pati P; Département de Parasitologie, Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Van Reet N; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Mumba Ngoyi D; Département de Parasitologie, Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Ngay Lukusa I; Département de Parasitologie, Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Karhemere Bin Shamamba S; Département de Parasitologie, Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Büscher P; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2014 Oct 02; Vol. 8 (10), pp. e3212. Date of Electronic Publication: 2014 Oct 02 (Print Publication: 2014).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aquaglyceroporins/*genetics
Melarsoprol/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei gambiense/*drug effects
Trypanosomiasis, African/*parasitology
Adult ; Animals ; Base Sequence ; DNA, Protozoan/chemistry ; DNA, Protozoan/isolation & purification ; Democratic Republic of the Congo ; Drug Resistance/genetics ; Female ; Genotype ; Humans ; Melarsoprol/therapeutic use ; Mice ; Molecular Sequence Data ; Mutant Chimeric Proteins/genetics ; Mutation ; Pentamidine/pharmacology ; Phenotype ; Recurrence ; Sequence Analysis, DNA ; Trypanocidal Agents/therapeutic use ; Trypanosoma brucei gambiense/genetics ; Trypanosomiasis, African/drug therapy
Czasopismo naukowe
Tytuł :
Determination of the trypanocidal drug melarsoprol and its conversion products in biological fluids with HPLC-ICPMS/ESMS.
Autorzy :
Raber G; Institute of Chemistry-Analytical Chemistry, University Graz, Universitaetsplatz 1, 8010 Graz, Austria. Electronic address: .
Raber T
Raml R
Murko M
Magnes C
Francesconi KA
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Źródło :
Talanta [Talanta] 2013 Nov 15; Vol. 116, pp. 876-81. Date of Electronic Publication: 2013 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Arsenic/*blood
Arsenicals/*blood
Blood Cells/*metabolism
Melarsoprol/*blood
Serum/*metabolism
Trypanocidal Agents/*blood
Arsenicals/chemistry ; Biotransformation ; Blood Cells/cytology ; Blood Cells/drug effects ; Blood Proteins/chemistry ; Cells, Cultured ; Chromatography, High Pressure Liquid ; Drug Stability ; Humans ; Limit of Detection ; Melarsoprol/chemistry ; Melarsoprol/pharmacology ; Protein Binding ; Serum/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Atomic ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/pharmacology
Czasopismo naukowe
Tytuł :
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.
Autorzy :
Thomas JA; London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.
Baker N; The Centre for Immunology and Infection, University of York, Heslington, York, United Kingdom.
Hutchinson S; Institut Pasteur, Paris, France.
Dominicus C; The Francis Crick Institute, London, United Kingdom.
Trenaman A; Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Glover L; Institut Pasteur, Paris, France.
Alsford S; London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.
Horn D; Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2018 Nov 26; Vol. 12 (11), pp. e0006980. Date of Electronic Publication: 2018 Nov 26 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanocidal Agents/*pharmacology
Trypanosoma brucei brucei/*drug effects
Cell Biology ; Humans ; Lysosomes/drug effects ; Lysosomes/metabolism ; Melarsoprol/pharmacology ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Mitosis/drug effects ; Nifurtimox/pharmacology ; Pentamidine/pharmacology ; Suramin/pharmacology ; Trypanosoma brucei brucei/cytology ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/metabolism ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo.
Autorzy :
Kazumba LM; Départment de Neurologie, Université de Kinshasa, Kinshasa, République Démocratique du Congo (RDC).
Kaka JT; Institut Supérieur de Techniques Médicales, Kinshasa, Démocratique du Congo (RDC).
Ngoyi DM; Départment de Médecine Tropicale, Université de Kinshasa, Kinshasa, Démocratique du Congo (RDC).; Institut National de Recherches Biomédicales (INRB), Kinshasa, Démocratique du Congo (RDC).
Tshala-Katumbay D; Départment de Neurologie, Université de Kinshasa, Kinshasa, République Démocratique du Congo (RDC).; Institut National de Recherches Biomédicales (INRB), Kinshasa, Démocratique du Congo (RDC).; Départment of Neurology and School of Public Health, Oregon Health & Science University, Portland, OR, United States of America.
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2018 Jun 13; Vol. 12 (6), pp. e0006504. Date of Electronic Publication: 2018 Jun 13 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Trypanosomiasis, African/*epidemiology
Trypanosomiasis, African/*mortality
Adolescent ; Adult ; Democratic Republic of the Congo/epidemiology ; Disease Management ; Drug Therapy, Combination ; Eflornithine/administration & dosage ; Eflornithine/therapeutic use ; Female ; Hospital Records ; Humans ; Male ; Melarsoprol/administration & dosage ; Melarsoprol/therapeutic use ; Middle Aged ; Multivariate Analysis ; Nifurtimox/administration & dosage ; Nifurtimox/therapeutic use ; Recurrence ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Trypanocidal Agents/administration & dosage ; Trypanocidal Agents/therapeutic use ; Trypanosoma brucei gambiense/drug effects ; Trypanosomiasis, African/drug therapy ; Trypanosomiasis, African/parasitology ; Young Adult
Czasopismo naukowe
Tytuł :
Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis.
Autorzy :
Baumann A; Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 30, 48149 Münster, Germany.
Pfeifer T
Melles D
Karst U
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Źródło :
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2013 Jun; Vol. 405 (15), pp. 5249-58. Date of Electronic Publication: 2013 Apr 04.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, Liquid/*methods
Mass Spectrometry/*methods
Melarsoprol/*metabolism
Trypanocidal Agents/*metabolism
Arsenicals/chemistry ; Arsenicals/metabolism ; Hemoglobins/chemistry ; Hemoglobins/metabolism ; Humans ; Melarsoprol/chemistry ; Molecular Structure ; Protein Binding ; Serum Albumin/chemistry ; Serum Albumin/metabolism ; Trypanocidal Agents/chemistry
Czasopismo naukowe
Tytuł :
An alternative form of melarsoprol in sleeping sickness.
Autorzy :
Kennedy PG; Department of Neurology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Southern General Hospital, Glasgow G51 4TF, Scotland, UK.
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Źródło :
Trends in parasitology [Trends Parasitol] 2012 Aug; Vol. 28 (8), pp. 307-10. Date of Electronic Publication: 2012 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Melarsoprol/*administration & dosage
Trypanocidal Agents/*administration & dosage
Administration, Oral ; Animals ; Clinical Trials as Topic ; Humans ; Infusion Pumps ; Melarsoprol/adverse effects ; Mice ; Trypanosoma brucei gambiense ; Trypanosoma brucei rhodesiense ; Trypanosomiasis, African/drug therapy
Czasopismo naukowe
Tytuł :
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
Autorzy :
Rodgers J; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Jones A
Gibaud S
Bradley B
McCabe C
Barrett MP
Gettinby G
Kennedy PG
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Źródło :
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2011 Sep; Vol. 5 (9), pp. e1308. Date of Electronic Publication: 2011 Sep 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiprotozoal Agents/*administration & dosage
Cyclodextrins/*administration & dosage
Melarsoprol/*administration & dosage
Trypanosoma brucei brucei/*drug effects
Trypanosomiasis, African/*drug therapy
Administration, Oral ; Africa South of the Sahara ; Animals ; Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/pharmacology ; Blood-Brain Barrier/physiology ; Brain/diagnostic imaging ; Brain/parasitology ; Brain/pathology ; Cyclodextrins/chemistry ; Cyclodextrins/pharmacology ; Disease Models, Animal ; Humans ; Magnetic Resonance Imaging ; Male ; Melarsoprol/chemistry ; Melarsoprol/pharmacology ; Mice ; Models, Molecular ; Molecular Structure ; Parasite Load ; Parasitic Sensitivity Tests ; Radiography ; Treatment Outcome
Czasopismo naukowe
Tytuł :
In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani: A comparison with Trypanosoma cruzi.
Autorzy :
Botero A; School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia. Electronic address: .
Keatley S; School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia.
Peacock C; The Marshall Center, School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, WA 6009, Australia; Telethon Kids Institute, 100 Roberts Road, Subiaco, WA 6008, Australia.
Thompson RC; School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia.
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Źródło :
International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2017 Apr; Vol. 7 (1), pp. 34-41. Date of Electronic Publication: 2016 Dec 23.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Animals, Wild/*parasitology
Trypanocidal Agents/*pharmacology
Trypanosoma/*drug effects
Trypanosoma cruzi/*drug effects
Animals ; Australia ; Cell Line ; Drug Discovery ; High-Throughput Screening Assays ; Inhibitory Concentration 50 ; Melarsoprol/pharmacology ; Melarsoprol/toxicity ; Nitroimidazoles/pharmacology ; Phosphorylcholine/analogs & derivatives ; Phosphorylcholine/pharmacology ; Phosphorylcholine/toxicity ; Potoroidae/parasitology ; Pyrimidines/pharmacology ; Triazoles/pharmacology ; Trypanosoma/isolation & purification ; Trypanosoma cruzi/isolation & purification
Czasopismo naukowe
Tytuł :
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.
Autorzy :
Graf FE; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.; University of Basel, 4000, Basel, Switzerland.
Ludin P; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.; University of Basel, 4000, Basel, Switzerland.
Arquint C; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.; University of Basel, 4000, Basel, Switzerland.
Schmidt RS; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.; University of Basel, 4000, Basel, Switzerland.
Schaub N; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.; University of Basel, 4000, Basel, Switzerland.
Kunz Renggli C; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.; University of Basel, 4000, Basel, Switzerland.
Munday JC; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
Krezdorn J; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
Baker N; Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.; The University of Kent, Canterbury, Kent, CT2 7NZ, UK.
Horn D; Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.
Balmer O; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland.; University of Basel, 4000, Basel, Switzerland.
Caccone A; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
de Koning HP; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
Mäser P; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051, Basel, Switzerland. .; University of Basel, 4000, Basel, Switzerland. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2016 Sep; Vol. 73 (17), pp. 3387-400. Date of Electronic Publication: 2016 Mar 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms :
Genome, Protozoan*
Drug Resistance/*genetics
Trypanosoma brucei rhodesiense/*genetics
Amino Acid Sequence ; Aquaporins/genetics ; Aquaporins/metabolism ; Comparative Genomic Hybridization ; DNA, Protozoan/chemistry ; DNA, Protozoan/isolation & purification ; DNA, Protozoan/metabolism ; Heterozygote ; Humans ; Male ; Melarsoprol/pharmacology ; Nucleoside Transport Proteins/genetics ; Nucleoside Transport Proteins/metabolism ; Parasitic Sensitivity Tests ; Pentamidine/pharmacology ; Phenotype ; Polymorphism, Single Nucleotide ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Sequence Alignment ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei rhodesiense/drug effects ; Trypanosoma brucei rhodesiense/isolation & purification ; Trypanosomiasis, African/diagnosis ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense.
Autorzy :
Ngotho M; Institute of Primate Research, Nairobi, Kenya.
Kagira JM
Kariuki C
Maina N
Thuita JK
Mwangangi DM
Farah IO
Hau J
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Źródło :
Acta tropica [Acta Trop] 2011 Jul; Vol. 119 (1), pp. 14-8. Date of Electronic Publication: 2011 Mar 21.
Typ publikacji :
Journal Article
MeSH Terms :
Chlorocebus aethiops/*parasitology
Diminazene/*analogs & derivatives
Melarsoprol/*pharmacology
Trypanosoma brucei rhodesiense/*parasitology
Trypanosomiasis, African/*drug therapy
Anemia, Macrocytic/parasitology ; Animals ; Blood Platelets/drug effects ; Cerebrospinal Fluid/parasitology ; Chlorocebus aethiops/blood ; Chlorocebus aethiops/cerebrospinal fluid ; Diminazene/pharmacology ; Diminazene/therapeutic use ; Disease Models, Animal ; Female ; Hematology ; Leukocytes/drug effects ; Male ; Melarsoprol/therapeutic use ; Thrombocytopenia/parasitology ; Trypanosoma brucei rhodesiense/drug effects
Czasopismo naukowe
Tytuł :
Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.
Autorzy :
Jeacock L; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom.
Baker N; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom.
Wiedemar N; Parasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Mäser P; Parasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Horn D; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom.
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Źródło :
PLoS pathogens [PLoS Pathog] 2017 Mar 30; Vol. 13 (3), pp. e1006307. Date of Electronic Publication: 2017 Mar 30 (Print Publication: 2017).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aquaglyceroporins/*metabolism
Drug Resistance/*physiology
Trypanosomiasis, African/*metabolism
Animals ; Biological Transport/drug effects ; Disease Models, Animal ; Drug Resistance/drug effects ; Gene Knockout Techniques ; Glycerol/metabolism ; Melarsoprol/pharmacology ; Mice ; Mice, Inbred BALB C ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei gambiense/metabolism
Czasopismo naukowe
Tytuł :
Comparison of nanosuspensions and hydroxypropyl-beta-cyclodextrin complex of melarsoprol: pharmacokinetics and tissue distribution in mice.
Autorzy :
Ben Zirar S; Laboratoire de Pharmacie Clinique - Nancy Université, Nancy, France.
Astier A
Muchow M
Gibaud S
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Źródło :
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2008 Oct; Vol. 70 (2), pp. 649-56. Date of Electronic Publication: 2008 Jun 06.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nanoparticles*
Melarsoprol/*pharmacokinetics
Trypanocidal Agents/*pharmacokinetics
beta-Cyclodextrins/*chemistry
2-Hydroxypropyl-beta-cyclodextrin ; Animals ; Antineoplastic Agents/pharmacology ; Chemistry, Pharmaceutical ; Female ; Humans ; K562 Cells ; Lethal Dose 50 ; Melarsoprol/chemistry ; Melarsoprol/pharmacology ; Mice ; Suspensions ; Tissue Distribution ; U937 Cells
Czasopismo naukowe
Tytuł :
Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis.
Autorzy :
Rodgers J; Division of Infection and Immunity, Faculty of Veterinary Medicine, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, UK.
Bradley B
Kennedy PG
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Źródło :
Parasitology international [Parasitol Int] 2007 Dec; Vol. 56 (4), pp. 321-4. Date of Electronic Publication: 2007 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Melarsoprol*/adverse effects
Melarsoprol*/therapeutic use
Morpholines*/adverse effects
Morpholines*/therapeutic use
Neurokinin-1 Receptor Antagonists*
Trypanocidal Agents*/adverse effects
Trypanocidal Agents*/therapeutic use
Trypanosomiasis, African/*drug therapy
Animals ; Aprepitant ; Drug Therapy, Combination ; Humans ; Mice ; Treatment Outcome ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Tytuł :
Melarsoprol-free drug combinations for second-stage Gambian sleeping sickness: the way to go.
Autorzy :
Chappuis F; Travel and Migration Medicine Unit, Geneva University Hospital, and Medecins Sans Frontieres, Swiss Section, 1202 Geneva, Switzerland.
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Źródło :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2007 Dec 01; Vol. 45 (11), pp. 1443-5. Date of Electronic Publication: 2007 Oct 22.
Typ publikacji :
Comment; Journal Article
MeSH Terms :
Melarsoprol*/adverse effects
Melarsoprol*/therapeutic use
Eflornithine/*therapeutic use
Nifurtimox/*therapeutic use
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*drug therapy
Drug Resistance ; Drug Therapy, Combination ; Eflornithine/administration & dosage ; Eflornithine/adverse effects ; Gambia ; Humans ; Nifurtimox/administration & dosage ; Nifurtimox/adverse effects ; Trypanocidal Agents/administration & dosage ; Trypanocidal Agents/adverse effects
Czasopismo naukowe
Tytuł :
Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness.
Autorzy :
Bisser S; Institute of Tropical Medicine, Department of Parasitology, Antwerp, B-2000 Antwerp, Belgium.
N'Siesi FX
Lejon V
Preux PM
Van Nieuwenhove S
Miaka Mia Bilenge C
Būscher P
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Źródło :
The Journal of infectious diseases [J Infect Dis] 2007 Feb 01; Vol. 195 (3), pp. 322-9. Date of Electronic Publication: 2006 Dec 21.
Typ publikacji :
Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Trypanosoma brucei gambiense*
Melarsoprol/*therapeutic use
Nifurtimox/*therapeutic use
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*drug therapy
Administration, Oral ; Adult ; Animals ; Brain Diseases/chemically induced ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Humans ; Injections, Intravenous ; Male ; Melarsoprol/administration & dosage ; Melarsoprol/adverse effects ; Recurrence ; Treatment Outcome
Czasopismo naukowe

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