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Wyszukujesz frazę ""Melarsoprol"" wg kryterium: Temat

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Wyświetlanie 1-20 z 289
Tytuł:
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model.
Autorzy:
Ndung'u K; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Murilla GA; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.; KAG EAST University, Nairobi, Kenya.
Thuita JK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.; Meru University of Science and Technology, Meru, Kenya.
Ngae GN; Food Crops Research Institute, Kenya Agricultural and Livestock Research Organization, Nairobi, Kenya.
Auma JE; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Gitonga PK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Thungu DK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Kurgat RK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Chemuliti JK; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
Mdachi RE; Biotechnology Research Institute, Kenya Agricultural and Livestock Research Organization, Kikuyu, Kenya.
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Źródło:
PloS one [PLoS One] 2020 Nov 05; Vol. 15 (11), pp. e0229060. Date of Electronic Publication: 2020 Nov 05 (Print Publication: 2020).
Typ publikacji:
Journal Article
MeSH Terms:
Trypanocidal Agents/*pharmacology
Trypanosoma brucei rhodesiense/*drug effects
Trypanosomiasis, African/*drug therapy
Virulence/*drug effects
Animals ; Diminazene/analogs & derivatives ; Diminazene/pharmacology ; Disease Models, Animal ; Drug Resistance/drug effects ; Kenya ; Male ; Melarsoprol/pharmacology ; Mice ; Pentamidine/pharmacology ; Suramin/pharmacology ; Treatment Outcome ; Trypanosomiasis, African/parasitology ; Uganda
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Melarsoprol sensitivity profile of Trypanosoma brucei gambiense isolates from cured and relapsed sleeping sickness patients from the Democratic Republic of the Congo.
Autorzy:
Pyana Pati P; Département de Parasitologie, Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Van Reet N; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Mumba Ngoyi D; Département de Parasitologie, Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Ngay Lukusa I; Département de Parasitologie, Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Karhemere Bin Shamamba S; Département de Parasitologie, Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Büscher P; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2014 Oct 02; Vol. 8 (10), pp. e3212. Date of Electronic Publication: 2014 Oct 02 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aquaglyceroporins/*genetics
Melarsoprol/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei gambiense/*drug effects
Trypanosomiasis, African/*parasitology
Adult ; Animals ; Base Sequence ; DNA, Protozoan/chemistry ; DNA, Protozoan/isolation & purification ; Democratic Republic of the Congo ; Drug Resistance/genetics ; Female ; Genotype ; Humans ; Melarsoprol/therapeutic use ; Mice ; Molecular Sequence Data ; Mutant Chimeric Proteins/genetics ; Mutation ; Pentamidine/pharmacology ; Phenotype ; Recurrence ; Sequence Analysis, DNA ; Trypanocidal Agents/therapeutic use ; Trypanosoma brucei gambiense/genetics ; Trypanosomiasis, African/drug therapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Investigation of the biotransformation of melarsoprol by electrochemistry coupled to complementary LC/ESI-MS and LC/ICP-MS analysis.
Autorzy:
Baumann A; Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 30, 48149 Münster, Germany.
Pfeifer T
Melles D
Karst U
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2013 Jun; Vol. 405 (15), pp. 5249-58. Date of Electronic Publication: 2013 Apr 04.
Typ publikacji:
Journal Article
MeSH Terms:
Chromatography, Liquid/*methods
Mass Spectrometry/*methods
Melarsoprol/*metabolism
Trypanocidal Agents/*metabolism
Arsenicals/chemistry ; Arsenicals/metabolism ; Hemoglobins/chemistry ; Hemoglobins/metabolism ; Humans ; Melarsoprol/chemistry ; Molecular Structure ; Protein Binding ; Serum Albumin/chemistry ; Serum Albumin/metabolism ; Trypanocidal Agents/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo.
Autorzy:
Kazumba LM; Départment de Neurologie, Université de Kinshasa, Kinshasa, République Démocratique du Congo (RDC).
Kaka JT; Institut Supérieur de Techniques Médicales, Kinshasa, Démocratique du Congo (RDC).
Ngoyi DM; Départment de Médecine Tropicale, Université de Kinshasa, Kinshasa, Démocratique du Congo (RDC).; Institut National de Recherches Biomédicales (INRB), Kinshasa, Démocratique du Congo (RDC).
Tshala-Katumbay D; Départment de Neurologie, Université de Kinshasa, Kinshasa, République Démocratique du Congo (RDC).; Institut National de Recherches Biomédicales (INRB), Kinshasa, Démocratique du Congo (RDC).; Départment of Neurology and School of Public Health, Oregon Health & Science University, Portland, OR, United States of America.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2018 Jun 13; Vol. 12 (6), pp. e0006504. Date of Electronic Publication: 2018 Jun 13 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Trypanosomiasis, African/*epidemiology
Trypanosomiasis, African/*mortality
Adolescent ; Adult ; Democratic Republic of the Congo/epidemiology ; Disease Management ; Drug Therapy, Combination ; Eflornithine/administration & dosage ; Eflornithine/therapeutic use ; Female ; Hospital Records ; Humans ; Male ; Melarsoprol/administration & dosage ; Melarsoprol/therapeutic use ; Middle Aged ; Multivariate Analysis ; Nifurtimox/administration & dosage ; Nifurtimox/therapeutic use ; Recurrence ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Trypanocidal Agents/administration & dosage ; Trypanocidal Agents/therapeutic use ; Trypanosoma brucei gambiense/drug effects ; Trypanosomiasis, African/drug therapy ; Trypanosomiasis, African/parasitology ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis.
Autorzy:
Rodgers J; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Jones A
Gibaud S
Bradley B
McCabe C
Barrett MP
Gettinby G
Kennedy PG
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2011 Sep; Vol. 5 (9), pp. e1308. Date of Electronic Publication: 2011 Sep 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiprotozoal Agents/*administration & dosage
Cyclodextrins/*administration & dosage
Melarsoprol/*administration & dosage
Trypanosoma brucei brucei/*drug effects
Trypanosomiasis, African/*drug therapy
Administration, Oral ; Africa South of the Sahara ; Animals ; Antiprotozoal Agents/chemistry ; Antiprotozoal Agents/pharmacology ; Blood-Brain Barrier/physiology ; Brain/diagnostic imaging ; Brain/parasitology ; Brain/pathology ; Cyclodextrins/chemistry ; Cyclodextrins/pharmacology ; Disease Models, Animal ; Humans ; Magnetic Resonance Imaging ; Male ; Melarsoprol/chemistry ; Melarsoprol/pharmacology ; Mice ; Models, Molecular ; Molecular Structure ; Parasite Load ; Parasitic Sensitivity Tests ; Radiography ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.
Autorzy:
Thomas JA; London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.
Baker N; The Centre for Immunology and Infection, University of York, Heslington, York, United Kingdom.
Hutchinson S; Institut Pasteur, Paris, France.
Dominicus C; The Francis Crick Institute, London, United Kingdom.
Trenaman A; Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Glover L; Institut Pasteur, Paris, France.
Alsford S; London School of Hygiene & Tropical Medicine, Keppel Street, London, United Kingdom.
Horn D; Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2018 Nov 26; Vol. 12 (11), pp. e0006980. Date of Electronic Publication: 2018 Nov 26 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Trypanocidal Agents/*pharmacology
Trypanosoma brucei brucei/*drug effects
Cell Biology ; Humans ; Lysosomes/drug effects ; Lysosomes/metabolism ; Melarsoprol/pharmacology ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Mitosis/drug effects ; Nifurtimox/pharmacology ; Pentamidine/pharmacology ; Suramin/pharmacology ; Trypanosoma brucei brucei/cytology ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/metabolism ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trypanosomiasis relapse after melarsoprol therapy, Democratic Republic of Congo, 1982-2001.
Autorzy:
Pépin J; Centre for International Health and Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada.
Mpia B
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Źródło:
Emerging infectious diseases [Emerg Infect Dis] 2005 Jun; Vol. 11 (6), pp. 921-7.
Typ publikacji:
Journal Article
MeSH Terms:
Melarsoprol/*therapeutic use
Trypanocidal Agents/*therapeutic use
Trypanosomiasis, African/*drug therapy
Trypanosomiasis, African/*prevention & control
Adolescent ; Adult ; Animals ; Democratic Republic of the Congo ; Female ; Humans ; Male ; Melarsoprol/administration & dosage ; Middle Aged ; Secondary Prevention ; Treatment Failure ; Trypanocidal Agents/administration & dosage ; Trypanosoma brucei gambiense/drug effects ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial.
Autorzy:
Burri C; Swiss Tropical Institute, Basel. />Nkunku S
Merolle A
Smith T
Blum J
Brun R
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Źródło:
Lancet (London, England) [Lancet] 2000 Apr 22; Vol. 355 (9213), pp. 1419-25.
Typ publikacji:
Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial
MeSH Terms:
Trypanosoma brucei gambiense*
Melarsoprol/*administration & dosage
Trypanocidal Agents/*administration & dosage
Trypanosomiasis, African/*drug therapy
Adult ; Angola/epidemiology ; Animals ; Brain Diseases/parasitology ; Drug Administration Schedule ; Female ; Humans ; Injections, Intramuscular ; Length of Stay/statistics & numerical data ; Male ; Melarsoprol/adverse effects ; Middle Aged ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; Trypanocidal Agents/adverse effects ; Trypanosomiasis, African/complications ; Trypanosomiasis, African/mortality ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.
Autorzy:
Jeacock L; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom.
Baker N; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom.
Wiedemar N; Parasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Mäser P; Parasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland.
Horn D; The Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom.
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Źródło:
PLoS pathogens [PLoS Pathog] 2017 Mar 30; Vol. 13 (3), pp. e1006307. Date of Electronic Publication: 2017 Mar 30 (Print Publication: 2017).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aquaglyceroporins/*metabolism
Drug Resistance/*physiology
Trypanosomiasis, African/*metabolism
Animals ; Biological Transport/drug effects ; Disease Models, Animal ; Drug Resistance/drug effects ; Gene Knockout Techniques ; Glycerol/metabolism ; Melarsoprol/pharmacology ; Mice ; Mice, Inbred BALB C ; Trypanocidal Agents/pharmacology ; Trypanosoma brucei gambiense/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
From health advice to taboo: community perspectives on the treatment of sleeping sickness in the Democratic Republic of Congo, a qualitative study.
Autorzy:
Mpanya A; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Kinshasa, Democratic Republic of Congo; Institute of Tropical Medicine, Antwerp, Belgium.
Hendrickx D; Institute of Tropical Medicine, Antwerp, Belgium; Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.
Baloji S; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Kinshasa, Democratic Republic of Congo; Université Pédagogique Nationale, Kinshasa, Democratic Republic of Congo.
Lumbala C; Programme National de Lutte contre la Trypanosomiase Humaine Africaine, Kinshasa, Democratic Republic of Congo.
da Luz RI; University of Antwerp, Antwerp, Belgium.
Boelaert M; Institute of Tropical Medicine, Antwerp, Belgium.
Lutumba P; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo; Université de Kinshasa, Kinshasa, Democratic Republic of Congo.
Pokaż więcej
Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2015 Apr 09; Vol. 9 (4), pp. e0003686. Date of Electronic Publication: 2015 Apr 09 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Taboo*
Trypanosomiasis, African/*drug therapy
Trypanosomiasis, African/*epidemiology
Animals ; Democratic Republic of the Congo/epidemiology ; Focus Groups ; Humans ; Male ; Melarsoprol/therapeutic use ; Middle Aged ; Qualitative Research ; Trypanocidal Agents/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.
Autorzy:
Graf FE; Swiss Tropical and Public Health Institute, Basel, Switzerland ; University of Basel, Basel, Switzerland.
Ludin P
Wenzler T
Kaiser M
Brun R
Pyana PP
Büscher P
de Koning HP
Horn D
Mäser P
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Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2013 Oct 10; Vol. 7 (10), pp. e2475. Date of Electronic Publication: 2013 Oct 10 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance*
Mutation*
Aquaporin 2/*genetics
Melarsoprol/*pharmacology
Pentamidine/*pharmacology
Trypanocidal Agents/*pharmacology
Trypanosoma brucei gambiense/*drug effects
Aquaporin 2/metabolism ; DNA, Protozoan/chemistry ; DNA, Protozoan/genetics ; Humans ; Molecular Sequence Data ; Protozoan Proteins/genetics ; Sequence Analysis, DNA ; Trypanosoma brucei gambiense/genetics ; Trypanosoma brucei gambiense/isolation & purification ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage Rhodesiense sleeping sickness.
Autorzy:
Kuepfer I; Swiss Tropical and Public Heath Institute, Basel, Switzerland. />Schmid C
Allan M
Edielu A
Haary EP
Kakembo A
Kibona S
Blum J
Burri C
Pokaż więcej
Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2012 Aug; Vol. 6 (8), pp. e1695. Date of Electronic Publication: 2012 Aug 28.
Typ publikacji:
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Trypanosoma brucei rhodesiense*
Melarsoprol/*administration & dosage
Melarsoprol/*adverse effects
Trypanocidal Agents/*administration & dosage
Trypanocidal Agents/*adverse effects
Trypanosomiasis, African/*drug therapy
Adolescent ; Adult ; Aged ; Brain Diseases/etiology ; Child ; Drug Administration Schedule ; Endemic Diseases ; Female ; Humans ; Male ; Middle Aged ; Suramin/therapeutic use ; Tanzania/epidemiology ; Trypanosomiasis, African/complications ; Trypanosomiasis, African/epidemiology ; Uganda/epidemiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Isolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory mice.
Autorzy:
Pyana PP; Institut National de Recherche Biomédicale, Kinshasa Gombe, Democratic Republic of the Congo.
Ngay Lukusa I
Mumba Ngoyi D
Van Reet N
Kaiser M
Karhemere Bin Shamamba S
Büscher P
Pokaż więcej
Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2011 Apr 19; Vol. 5 (4), pp. e1025. Date of Electronic Publication: 2011 Apr 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiprotozoal Agents/*administration & dosage
Melarsoprol/*administration & dosage
Trypanosoma brucei gambiense/*growth & development
Trypanosoma brucei gambiense/*isolation & purification
Trypanosomiasis, African/*drug therapy
Trypanosomiasis, African/*parasitology
Adaptation, Biological ; Animals ; Blood/parasitology ; Cerebrospinal Fluid/parasitology ; Female ; Humans ; Male ; Mice ; Recurrence
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A CATT negative result after treatment for human African trypanosomiasis is no indication for cure.
Autorzy:
Lejon V; Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium. />Ngoyi DM
Boelaert M
Büscher P
Pokaż więcej
Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2010 Jan 26; Vol. 4 (1), pp. e590. Date of Electronic Publication: 2010 Jan 26.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Agglutination Tests/*methods
Trypanosomiasis, African/*drug therapy
Antibodies, Protozoan/blood ; Eflornithine/therapeutic use ; Humans ; Melarsoprol/therapeutic use ; Pentamidine/therapeutic use ; Treatment Outcome ; Trypanocidal Agents/therapeutic use ; Trypanosomiasis, African/immunology ; Trypanosomiasis, African/parasitology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 289

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