A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus.
Autorzy:
Hardcastle AJ; UCL Institute of Ophthalmology, London, UK. .; Moorfields Eye Hospital, NHS Foundation Trust, London, UK. . Liskova P; UCL Institute of Ophthalmology, London, UK.; Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.; Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. Bykhovskaya Y; The Cornea Eye Institute, Beverly Hills, CA, USA.; Department of Surgery and Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. McComish BJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia. Davidson AE; UCL Institute of Ophthalmology, London, UK. Inglehearn CF; Division of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, UK. Li X; Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. Choquet H; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. Habeeb M; Department of Ophthalmology, Erasmus Medical Center GD, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center GD, Rotterdam, The Netherlands. Lucas SEM; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia. Sahebjada S; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Department of Surgery, Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia. Pontikos N; UCL Institute of Ophthalmology, London, UK. Lopez KER; UCL Institute of Ophthalmology, London, UK. Khawaja AP; UCL Institute of Ophthalmology, London, UK.; Moorfields Eye Hospital, NHS Foundation Trust, London, UK.; NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, UK. Ali M; Division of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, UK. Dudakova L; Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. Skalicka P; Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. Van Dooren BTH; Department of Ophthalmology, Erasmus Medical Center GD, Rotterdam, The Netherlands.; Amphia Hospital, Breda, The Netherlands. Geerards AJM; The Rotterdam Eye Hospital, Rotterdam, The Netherlands. Haudum CW; Division of Endocrinology and Diabetology, Endocrinology Lab Platform, Department of Internal Medicine, Medical University of Graz, Graz, Austria. Faro VL; Department of Ophthalmology, University Medical Center Groningen (UMCG), Groningen, the Netherlands.; Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands. Tenen A; Vision Eye Institute, Melbourne, VIC, Australia.; School of Primary and Allied Health Care, Monash University, Melbourne, VIC, Australia.; Melbourne Stem Cell Centre, Melbourne, VIC, 3800, Australia. Simcoe MJ; Section of Ophthalmology, School of Life Course Sciences, King's College London, London, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Patasova K; Section of Ophthalmology, School of Life Course Sciences, King's College London, London, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Yarrand D; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Yin J; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. Siddiqui S; Division of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, UK.; Department of Ophthalmology, St James's University Hospital, Leeds, UK. Rice A; Division of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, UK. Farraj LA; Division of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, UK. Chen YI; Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. Rahi JS; UCL Great Ormond Street Hospital Institute of Child Health, London, UK. Krauss RM; Oakland Research Institute, Oakland, CA, USA. Theusch E; Oakland Research Institute, Oakland, CA, USA. Charlesworth JC; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia. Szczotka-Flynn L; Department of Ophthalmology, Case Western Reserve University, Cleveland, OH, USA. Toomes C; Division of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, UK. Meester-Smoor MA; Department of Ophthalmology, Erasmus Medical Center GD, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center GD, Rotterdam, The Netherlands. Richardson AJ; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia. Mitchell PA; Centre for Vision Research, Department of Ophthalmology, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia. Taylor KD; Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. MellesRB; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. Aldave AJ; The Jules Stein Institute, University of California Los Angeles, Los Angeles, CA, USA. Mills RA; Department of Ophthalmology, Flinders University, Adelaide, SA, Australia. Cao K; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Department of Surgery, Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia. Chan E; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Department of Surgery, Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia. Daniell MD; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia.; Department of Surgery, Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia. Wang JJ; Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore. Rotter JI; Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.; Vision Eye Institute, Melbourne, VIC, Australia.; School of Primary and Allied Health Care, Monash University, Melbourne, VIC, Australia.; Melbourne Stem Cell Centre, Melbourne, VIC, 3800, Australia. MacGregor S; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Klaver CCW; Department of Ophthalmology, Erasmus Medical Center GD, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus Medical Center GD, Rotterdam, The Netherlands. Ramdas WD; Department of Ophthalmology, Erasmus Medical Center GD, Rotterdam, The Netherlands. Craig JE; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.; Department of Ophthalmology, Flinders University, Adelaide, SA, Australia. Iyengar SK; Department of Ophthalmology, Case Western Reserve University, Cleveland, OH, USA. O'Brart D; Section of Ophthalmology, School of Life Course Sciences, King's College London, London, UK.; St Thomas Hospital, Guy's and St. Thomas NHS Trust, London, London, UK. Jorgenson E; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. Baird PN; Department of Surgery, Ophthalmology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia. Rabinowitz YS; The Cornea Eye Institute, Beverly Hills, CA, USA.; Department of Surgery and Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Burdon KP; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.; Department of Ophthalmology, Flinders University, Adelaide, SA, Australia. Hammond CJ; Section of Ophthalmology, School of Life Course Sciences, King's College London, London, UK.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; St Thomas Hospital, Guy's and St. Thomas NHS Trust, London, London, UK. Tuft SJ; UCL Institute of Ophthalmology, London, UK. .; Moorfields Eye Hospital, NHS Foundation Trust, London, UK. . Hysi PG; Section of Ophthalmology, School of Life Course Sciences, King's College London, London, UK. .; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. .; UCL Great Ormond Street Hospital Institute of Child Health, London, UK. .
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Źródło:
Communications biology [Commun Biol] 2021 Mar 01; Vol. 4 (1), pp. 266. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji:
Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness.
Autorzy:
Choquet H; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, 94612, USA. . MellesRB; KPNC, Department of Ophthalmology, Redwood City, CA, 94063, USA. Yin J; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, 94612, USA. Hoffmann TJ; Institute for Human Genetics, University of California San Francisco (UCSF), San Francisco, CA, 94143, USA.; Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, 94158, USA. Thai KK; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, 94612, USA. Kvale MN; Institute for Human Genetics, University of California San Francisco (UCSF), San Francisco, CA, 94143, USA. Banda Y; Institute for Human Genetics, University of California San Francisco (UCSF), San Francisco, CA, 94143, USA. Hardcastle AJ; UCL Institute of Ophthalmology, University College London, London, UK.; National Institute of Health Research Biomedical Research Centre for Ophthalmology, and UCL Institute of Ophthalmology, London, UK. Tuft SJ; Moorfields Eye Hospital, London, UK. Glymour MM; Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, 94158, USA. Schaefer C; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, 94612, USA. Risch N; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, 94612, USA.; Institute for Human Genetics, University of California San Francisco (UCSF), San Francisco, CA, 94143, USA.; Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, 94158, USA. Nair KS; Departments of Ophthalmology and Anatomy, School of Medicine, UCSF, San Francisco, CA, 94143, USA. Hysi PG; King's College London, Section of Ophthalmology, School of Life Course Sciences, London, UK.; King's College London, Department of Twin Research and Genetic Epidemiology, London, UK.; University College London, Great Ormond Street Hospital Institute of Child Health, London, UK. Jorgenson E; Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, 94612, USA. .
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Źródło:
Communications biology [Commun Biol] 2020 Jun 11; Vol. 3 (1), pp. 301. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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